SIMILAR PATTERNS OF AMINO ACIDS FOR 6NCS_A_ACTA303_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a25 | PROTEIN KINASE C(BETA) (Rattusnorvegicus) |
PF00168(C2) | 3 | ILE A 215THR A 214PRO A 221 | None | 0.62A | 6ncsA-1a25A:undetectable | 6ncsA-1a25A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b35 | PROTEIN (CRICKETPARALYSIS VIRUS,VP1) (Cricketparalysis virus) |
PF08762(CRPV_capsid) | 3 | ILE A 196THR A 76PRO A 201 | None | 0.59A | 6ncsA-1b35A:undetectable | 6ncsA-1b35A:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bw0 | PROTEIN (TYROSINEAMINOTRANSFERASE) (Trypanosomacruzi) |
PF00155(Aminotran_1_2) | 3 | ILE A 381THR A 380PRO A 18 | None | 0.63A | 6ncsA-1bw0A:2.4 | 6ncsA-1bw0A:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bwd | PROTEIN(INOSAMINE-PHOSPHATEAMIDINOTRANSFERASE) (Streptomycesgriseus) |
no annotation | 3 | ILE A 17THR A 334PRO A 82 | None | 0.62A | 6ncsA-1bwdA:undetectable | 6ncsA-1bwdA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eu1 | DIMETHYL SULFOXIDEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | ILE A 572THR A 573PRO A 366 | None | 0.66A | 6ncsA-1eu1A:undetectable | 6ncsA-1eu1A:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f20 | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 3 | ILE A1090THR A1089PRO A1055 | None | 0.48A | 6ncsA-1f20A:undetectable | 6ncsA-1f20A:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyd | ARABINANENDO-1,5-ALPHA-L-ARABINOSIDASE A (Cellvibriojaponicus) |
PF04616(Glyco_hydro_43) | 3 | ILE B 57THR B 58PRO B 96 | None | 0.65A | 6ncsA-1gydB:undetectable | 6ncsA-1gydB:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kkh | MEVALONATE KINASE (Methanocaldococcusjannaschii) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 3 | ILE A 164THR A 163PRO A 11 | None | 0.56A | 6ncsA-1kkhA:undetectable | 6ncsA-1kkhA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgc | PROTEIN (VIRUSCAPSID PROTEIN VP2) (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | ILE 2 158THR 2 159PRO 2 144 | None | 0.48A | 6ncsA-1qgc2:undetectable | 6ncsA-1qgc2:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8w | AMP NUCLEOSIDASE (Escherichiacoli) |
PF01048(PNP_UDP_1)PF10423(AMNp_N) | 3 | ILE A 239THR A 240PRO A 246 | None | 0.48A | 6ncsA-1t8wA:undetectable | 6ncsA-1t8wA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tg5 | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (Arabidopsisthaliana) |
PF00903(Glyoxalase) | 3 | ILE A 155THR A 154PRO A 100 | None | 0.58A | 6ncsA-1tg5A:undetectable | 6ncsA-1tg5A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tll | NITRIC-OXIDESYNTHASE, BRAIN (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00258(Flavodoxin_1)PF00667(FAD_binding_1) | 3 | ILE A1090THR A1089PRO A1055 | None | 0.52A | 6ncsA-1tllA:undetectable | 6ncsA-1tllA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v87 | DELTEX PROTEIN 2 (Mus musculus) |
PF00097(zf-C3HC4) | 3 | ILE A 91THR A 90PRO A 100 | None | 0.54A | 6ncsA-1v87A:undetectable | 6ncsA-1v87A:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x5y | MYOSIN BINDINGPROTEIN C, FAST-TYPE (Mus musculus) |
PF00041(fn3) | 3 | ILE A 103THR A 102PRO A 74 | None | 0.63A | 6ncsA-1x5yA:undetectable | 6ncsA-1x5yA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zba | COAT PROTEIN VP2 (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | ILE 2 158THR 2 159PRO 2 144 | None | 0.49A | 6ncsA-1zba2:undetectable | 6ncsA-1zba2:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b49 | PROTEIN TYROSINEPHOSPHATASE,NON-RECEPTOR TYPE 3 (Homo sapiens) |
PF00102(Y_phosphatase) | 3 | ILE A 662THR A 663PRO A 681 | None | 0.54A | 6ncsA-2b49A:undetectable | 6ncsA-2b49A:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bzu | FIBER PROTEIN 2 (HumanmastadenovirusF) |
PF00541(Adeno_knob) | 3 | ILE A 347THR A 348PRO A 376 | None | 0.62A | 6ncsA-2bzuA:undetectable | 6ncsA-2bzuA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d2r | UNDECAPRENYLPYROPHOSPHATESYNTHASE (Helicobacterpylori) |
PF01255(Prenyltransf) | 3 | ILE A 40THR A 41PRO A 212 | None | 0.65A | 6ncsA-2d2rA:undetectable | 6ncsA-2d2rA:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g28 | PYRUVATEDEHYDROGENASE E1COMPONENT (Escherichiacoli) |
PF00456(Transketolase_N) | 3 | ILE A 439THR A 440PRO A 427 | None | 0.54A | 6ncsA-2g28A:undetectable | 6ncsA-2g28A:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nsq | E3 UBIQUITIN-PROTEINLIGASE NEDD4-LIKEPROTEIN (Homo sapiens) |
PF00168(C2) | 3 | ILE A 66THR A 65PRO A 72 | None | 0.64A | 6ncsA-2nsqA:undetectable | 6ncsA-2nsqA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odk | HYPOTHETICAL PROTEIN (Nitrosomonaseuropaea) |
PF02604(PhdYeFM_antitox) | 3 | ILE A 21THR A 22PRO A 40 | None | 0.57A | 6ncsA-2odkA:undetectable | 6ncsA-2odkA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pnw | MEMBRANE-BOUND LYTICMUREINTRANSGLYCOSYLASE (Agrobacteriumfabrum) |
PF03562(MltA)PF06725(3D) | 3 | ILE A 50THR A 51PRO A 361 | None | 0.63A | 6ncsA-2pnwA:undetectable | 6ncsA-2pnwA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r17 | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 35 (Homo sapiens) |
PF03635(Vps35) | 3 | ILE C 568THR C 567PRO C 580 | None | 0.58A | 6ncsA-2r17C:undetectable | 6ncsA-2r17C:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rb9 | HYPE PROTEIN (Escherichiacoli) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | ILE A 183THR A 182PRO A 64 | None | 0.64A | 6ncsA-2rb9A:undetectable | 6ncsA-2rb9A:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsi | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATECYTIDYLYLTRANSFERASE (Streptococcuspneumoniae) |
PF01128(IspD) | 3 | ILE A 118THR A 119PRO A 170 | None | 0.60A | 6ncsA-2vsiA:3.0 | 6ncsA-2vsiA:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2waw | MOBA RELATE PROTEIN (Mycobacteriumsp. DSM 3803) |
PF12804(NTP_transf_3) | 3 | ILE A 109THR A 110PRO A 138 | None | 0.60A | 6ncsA-2wawA:undetectable | 6ncsA-2wawA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wkn | FORMAMIDASE (Delftiaacidovorans) |
PF03069(FmdA_AmdA) | 3 | ILE A 397THR A 398PRO A 142 | None | 0.51A | 6ncsA-2wknA:undetectable | 6ncsA-2wknA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y27 | PHENYLACETATE-COENZYME A LIGASE (Burkholderiacenocepacia) |
PF00501(AMP-binding)PF14535(AMP-binding_C_2) | 3 | ILE A 387THR A 384PRO A 376 | None | 0.63A | 6ncsA-2y27A:undetectable | 6ncsA-2y27A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1u | HYDROGENASEEXPRESSION/FORMATIONPROTEIN HYPE (Desulfovibriovulgaris) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | ILE A 179THR A 178PRO A 60 | None | 0.58A | 6ncsA-2z1uA:undetectable | 6ncsA-2z1uA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahi | XYLULOSE5-PHOSPHATE/FRUCTOSE6-PHOSPHATEPHOSPHOKETOLASE (Bifidobacteriumbreve) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 3 | ILE A 270THR A 269PRO A 292 | None | 0.62A | 6ncsA-3ahiA:undetectable | 6ncsA-3ahiA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 3 | ILE A 270THR A 269PRO A 292 | None | 0.58A | 6ncsA-3ai7A:undetectable | 6ncsA-3ai7A:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bib | T-CELLIMMUNOGLOBULIN ANDMUCINDOMAIN-CONTAININGPROTEIN 4 (Mus musculus) |
PF07686(V-set) | 3 | ILE X 6THR X 5PRO X 17 | None | 0.65A | 6ncsA-3bibX:undetectable | 6ncsA-3bibX:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cux | MALATE SYNTHASE (Bacillusanthracis) |
PF01274(Malate_synthase) | 3 | ILE A 91THR A 92PRO A 367 | None | 0.66A | 6ncsA-3cuxA:11.9 | 6ncsA-3cuxA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d02 | PUTATIVE LACI-TYPETRANSCRIPTIONALREGULATOR (Klebsiellapneumoniae) |
PF13407(Peripla_BP_4) | 3 | ILE A 261THR A 262PRO A 225 | None | 0.59A | 6ncsA-3d02A:2.8 | 6ncsA-3d02A:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epm | THIAMINEBIOSYNTHESIS PROTEINTHIC (Caulobactervibrioides) |
PF01964(ThiC_Rad_SAM)PF13667(ThiC-associated) | 3 | ILE A 142THR A 143PRO A 180 | None | 0.50A | 6ncsA-3epmA:15.4 | 6ncsA-3epmA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdh | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF12771(SusD-like_2) | 3 | ILE A 412THR A 413PRO A 298 | None | 0.47A | 6ncsA-3fdhA:undetectable | 6ncsA-3fdhA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ho8 | PYRUVATE CARBOXYLASE (Staphylococcusaureus) |
PF00289(Biotin_carb_N)PF00682(HMGL-like)PF02436(PYC_OADA)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | ILE A 367THR A 368PRO A 362 | None | 0.62A | 6ncsA-3ho8A:5.6 | 6ncsA-3ho8A:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4i | 1,3-1,4-BETA-GLUCANASE (unculturedmurine largebowel bacteriumBAC 14) |
PF00722(Glyco_hydro_16) | 3 | ILE A 50THR A 51PRO A 187 | None | 0.55A | 6ncsA-3i4iA:undetectable | 6ncsA-3i4iA:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3it8 | 2L PROTEIN (Tanapox virus) |
no annotation | 3 | ILE D 213THR D 214PRO D 245 | None | 0.57A | 6ncsA-3it8D:undetectable | 6ncsA-3it8D:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jzy | INTERSECTIN 2 (Homo sapiens) |
PF00168(C2) | 3 | ILE A1580THR A1579PRO A1586 | NoneUNX A 3 ( 3.8A)None | 0.66A | 6ncsA-3jzyA:undetectable | 6ncsA-3jzyA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k0b | PREDICTEDN6-ADENINE-SPECIFICDNA METHYLASE (Listeriamonocytogenes) |
PF01170(UPF0020)PF02926(THUMP) | 3 | ILE A 281THR A 282PRO A 205 | None | 0.27A | 6ncsA-3k0bA:undetectable | 6ncsA-3k0bA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksw | STEROL 14-ALPHADEMETHYLASE (Trypanosomacruzi) |
PF00067(p450) | 3 | ILE A 298THR A 297PRO A 464 | None | 0.55A | 6ncsA-3kswA:undetectable | 6ncsA-3kswA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kwu | MUNC13-1 (Rattusnorvegicus) |
PF00168(C2) | 3 | ILE A 728THR A 727PRO A 734 | None | 0.62A | 6ncsA-3kwuA:undetectable | 6ncsA-3kwuA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4d | STEROL 14-ALPHADEMETHYLASE (Leishmaniainfantum) |
PF00067(p450) | 3 | ILE A 297THR A 296PRO A 463 | None | 0.57A | 6ncsA-3l4dA:undetectable | 6ncsA-3l4dA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxq | UNCHARACTERIZEDPROTEIN VP1736 (Vibrioparahaemolyticus) |
PF00884(Sulfatase) | 3 | ILE A 364THR A 363PRO A 546 | None | 0.55A | 6ncsA-3lxqA:undetectable | 6ncsA-3lxqA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m7f | E3 UBIQUITIN-PROTEINLIGASE NEDD4 (Mus musculus) |
PF00168(C2) | 3 | ILE B 164THR B 163PRO B 170 | None | 0.58A | 6ncsA-3m7fB:undetectable | 6ncsA-3m7fB:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3naw | SECRETED EFFECTORPROTEIN (Escherichiacoli) |
PF00805(Pentapeptide)PF13979(SopA_C)PF13981(SopA) | 3 | ILE A 341THR A 333PRO A 311 | None | 0.52A | 6ncsA-3nawA:undetectable | 6ncsA-3nawA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8o | 6-PHOSPHOFRUCTOKINASE SUBUNIT BETA (Saccharomycescerevisiae) |
PF00365(PFK) | 3 | ILE B 476THR B 477PRO B 459 | None | 0.33A | 6ncsA-3o8oB:undetectable | 6ncsA-3o8oB:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oix | PUTATIVEDIHYDROOROTATEDEHYDROGENASE DIHYDROOROTATEOXIDASE (Streptococcusmutans) |
PF01180(DHO_dh) | 3 | ILE A 150THR A 147PRO A 106 | None | 0.34A | 6ncsA-3oixA:6.9 | 6ncsA-3oixA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1x | SERINEACETYLTRANSFERASE (Entamoebahistolytica) |
PF00132(Hexapep) | 3 | ILE A 56THR A 57PRO A 47 | None | 0.60A | 6ncsA-3q1xA:undetectable | 6ncsA-3q1xA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9r | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (Mycobacteroidesabscessus) |
PF01259(SAICAR_synt) | 3 | ILE A 177THR A 176PRO A 138 | ILE A 177 ( 0.7A)THR A 176 ( 0.8A)PRO A 138 ( 1.1A) | 0.65A | 6ncsA-3r9rA:undetectable | 6ncsA-3r9rA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rdj | PROTEIN KINASE CALPHA TYPE (Rattusnorvegicus) |
PF00168(C2) | 3 | ILE A 215THR A 214PRO A 221 | None | 0.44A | 6ncsA-3rdjA:undetectable | 6ncsA-3rdjA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3re2 | PREDICTED PROTEIN (Nematostellavectensis) |
PF05053(Menin) | 3 | ILE A 281THR A 282PRO A 295 | None | 0.64A | 6ncsA-3re2A:undetectable | 6ncsA-3re2A:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rtx | MRNA-CAPPING ENZYME (Mus musculus) |
PF01331(mRNA_cap_enzyme)PF03919(mRNA_cap_C) | 3 | ILE A 236THR A 237PRO A 357 | None | 0.60A | 6ncsA-3rtxA:undetectable | 6ncsA-3rtxA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s47 | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Clostridiumbeijerinckii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | ILE A 15THR A 16PRO A 46 | None | 0.49A | 6ncsA-3s47A:4.7 | 6ncsA-3s47A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6k | ACETYLGLUTAMATEKINASE (Xanthomonascampestris) |
PF00696(AA_kinase)PF04768(NAT) | 3 | ILE A 137THR A 138PRO A 165 | None | 0.40A | 6ncsA-3s6kA:undetectable | 6ncsA-3s6kA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sp1 | CYSTEINYL-TRNASYNTHETASE (Borreliellaburgdorferi) |
PF01406(tRNA-synt_1e) | 3 | ILE A 69THR A 67PRO A 215 | None | 0.64A | 6ncsA-3sp1A:undetectable | 6ncsA-3sp1A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqn | CONSERVED DOMAINPROTEIN (Enterococcusfaecalis) |
PF05043(Mga) | 3 | ILE A 370THR A 369PRO A 373 | None | 0.66A | 6ncsA-3sqnA:undetectable | 6ncsA-3sqnA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sto | SERINE PROTEASEINHIBITOR (Schistosomahaematobium) |
PF00079(Serpin) | 3 | ILE A 220THR A 221PRO A 402 | None | 0.57A | 6ncsA-3stoA:undetectable | 6ncsA-3stoA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tji | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,N-TERMINAL DOMAINPROTEIN (Enterobactersp. 638) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | ILE A 13THR A 14PRO A 44 | None | 0.60A | 6ncsA-3tjiA:9.2 | 6ncsA-3tjiA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uwd | PHOSPHOGLYCERATEKINASE (Bacillusanthracis) |
PF00162(PGK) | 3 | ILE A 268THR A 269PRO A 287 | None | 0.62A | 6ncsA-3uwdA:undetectable | 6ncsA-3uwdA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vay | HAD-SUPERFAMILYHYDROLASE (Pseudomonassyringae groupgenomosp. 3) |
PF13419(HAD_2) | 3 | ILE A 126THR A 127PRO A 160 | None | 0.46A | 6ncsA-3vayA:undetectable | 6ncsA-3vayA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x1l | CMR4 (Archaeoglobusfulgidus) |
PF03787(RAMPs) | 3 | ILE C 245THR C 186PRO C 148 | None | 0.62A | 6ncsA-3x1lC:undetectable | 6ncsA-3x1lC:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zqj | UVRABC SYSTEMPROTEIN A (Mycobacteriumtuberculosis) |
PF00005(ABC_tran) | 3 | ILE A 914THR A 650PRO A 934 | None | 0.62A | 6ncsA-3zqjA:undetectable | 6ncsA-3zqjA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zzf | ACETYLGLUTAMATEKINASE (Saccharomycescerevisiae) |
PF00696(AA_kinase) | 3 | ILE A 193THR A 194PRO A 221 | None | 0.49A | 6ncsA-3zzfA:undetectable | 6ncsA-3zzfA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eg2 | CYTIDINE DEAMINASE (Vibrio cholerae) |
PF00383(dCMP_cyt_deam_1)PF08211(dCMP_cyt_deam_2) | 3 | ILE A 124THR A 123PRO A 128 | NoneNoneURI A 302 (-4.7A) | 0.60A | 6ncsA-4eg2A:undetectable | 6ncsA-4eg2A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gis | ENOLASE (Vibrio harveyi) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | ILE A 13THR A 14PRO A 44 | None | 0.62A | 6ncsA-4gisA:9.3 | 6ncsA-4gisA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gqb | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Homo sapiens) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 3 | ILE A 598THR A 597PRO A 474 | None | 0.63A | 6ncsA-4gqbA:8.7 | 6ncsA-4gqbA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hhr | ALPHA-DIOXYGENASE (Arabidopsisthaliana) |
PF03098(An_peroxidase) | 3 | ILE A 581THR A 580PRO A 89 | None | 0.57A | 6ncsA-4hhrA:undetectable | 6ncsA-4hhrA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikn | AP-3 COMPLEX SUBUNITMU-1 (Rattusnorvegicus) |
PF00928(Adap_comp_sub) | 3 | ILE A 305THR A 304PRO A 297 | ILE A 305 ( 0.6A)THR A 304 ( 0.8A)PRO A 297 ( 1.1A) | 0.65A | 6ncsA-4iknA:undetectable | 6ncsA-4iknA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rsh | LIPOLYTIC PROTEING-D-S-L FAMILY (Desulfitobacteriumhafniense) |
PF13472(Lipase_GDSL_2) | 3 | ILE A 167THR A 166PRO A 157 | None | 0.61A | 6ncsA-4rshA:3.6 | 6ncsA-4rshA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s28 | PHOSPHOMETHYLPYRIMIDINE SYNTHASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF01964(ThiC_Rad_SAM) | 3 | ILE A 174THR A 175PRO A 189 | None | 0.64A | 6ncsA-4s28A:15.1 | 6ncsA-4s28A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wxp | NS3-4 PROTEASE (Hepacivirus C) |
PF07652(Flavi_DEAD) | 3 | ILE A 265THR A 266PRO A 215 | None | 0.45A | 6ncsA-4wxpA:undetectable | 6ncsA-4wxpA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ys8 | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATECYTIDYLYLTRANSFERASE (Burkholderiathailandensis) |
PF01128(IspD) | 3 | ILE A 114THR A 115PRO A 168 | None | 0.55A | 6ncsA-4ys8A:2.4 | 6ncsA-4ys8A:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0z | CHOLINETRIMETHYLAMINE LYASE (Klebsiellapneumoniae) |
PF01228(Gly_radical)PF02901(PFL-like) | 3 | ILE A 379THR A 378PRO A 860 | None | 0.57A | 6ncsA-5a0zA:undetectable | 6ncsA-5a0zA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8d | CARBOHYDRATE BINDINGFAMILY 6 (Ruminiclostridiumthermocellum) |
PF04616(Glyco_hydro_43) | 3 | ILE A 75THR A 76PRO A 108 | None | 0.44A | 6ncsA-5a8dA:undetectable | 6ncsA-5a8dA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bn4 | V-TYPE ATP SYNTHASEALPHA CHAIN (Nanoarchaeumequitans) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N)PF16886(ATP-synt_ab_Xtn) | 3 | ILE A 164THR A 163PRO A 73 | None | 0.63A | 6ncsA-5bn4A:undetectable | 6ncsA-5bn4A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d9a | POLYMERASE BASICPROTEIN 2 (Influenza Cvirus) |
PF00604(Flu_PB2) | 3 | ILE C 533THR C 532PRO C 444 | None | 0.63A | 6ncsA-5d9aC:undetectable | 6ncsA-5d9aC:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f15 | 4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N)TRANSFERASE (Cupriavidusmetallidurans) |
PF13231(PMT_2) | 3 | ILE A 75THR A 74PRO A 87 | None | 0.59A | 6ncsA-5f15A:undetectable | 6ncsA-5f15A:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftw | CHEMOTAXIS PROTEINMETHYLTRANSFERASE (Bacillussubtilis) |
PF01739(CheR)PF03705(CheR_N) | 3 | ILE A 179THR A 180PRO A 108 | None | 0.54A | 6ncsA-5ftwA:undetectable | 6ncsA-5ftwA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fuu | HIV-1 ENVELOPEGLYCOPROTEIN GP160 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 3 | ILE A 161THR A 162PRO A 124 | None | 0.61A | 6ncsA-5fuuA:undetectable | 6ncsA-5fuuA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h71 | ALGQ2 (Sphingomonassp.) |
PF01547(SBP_bac_1) | 3 | ILE A 319THR A 320PRO A 326 | None | 0.61A | 6ncsA-5h71A:undetectable | 6ncsA-5h71A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hpk | E3 UBIQUITIN-PROTEINLIGASE NEDD4-LIKE (Homo sapiens) |
PF00632(HECT) | 3 | ILE A 724THR A 725PRO A 714 | None | 0.59A | 6ncsA-5hpkA:undetectable | 6ncsA-5hpkA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5im3 | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Pseudomonasaeruginosa) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 3 | ILE A 859THR A 856PRO A 787 | None | 0.60A | 6ncsA-5im3A:3.4 | 6ncsA-5im3A:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5im5 | DESIGNEDKETO-HYDROXYGLUTARATE-ALDOLASE/KETO-DEOXY-PHOSPHOGLUCONATEALDOLASE (VibrionalesbacteriumSWAT-3) |
no annotation | 3 | ILE P 203THR P 200PRO P 162 | None | 0.65A | 6ncsA-5im5P:15.0 | 6ncsA-5im5P:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kh1 | INVASION PLASMIDANTIGEN (Shigellaflexneri) |
PF12468(TTSSLRR)PF14496(NEL) | 3 | ILE A 81THR A 62PRO A 78 | None | 0.60A | 6ncsA-5kh1A:undetectable | 6ncsA-5kh1A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kiq | PLATELET-BINDINGGLYCOPROTEIN (Streptococcussanguinis) |
no annotation | 3 | ILE A 426THR A 425PRO A 377 | None | 0.62A | 6ncsA-5kiqA:undetectable | 6ncsA-5kiqA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kiq | PLATELET-BINDINGGLYCOPROTEIN (Streptococcussanguinis) |
no annotation | 3 | ILE A 436THR A 437PRO A 380 | None | 0.58A | 6ncsA-5kiqA:undetectable | 6ncsA-5kiqA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n94 | CG9323, ISOFORM A (Drosophilamelanogaster) |
no annotation | 3 | ILE A 251THR A 252PRO A 187 | None | 0.54A | 6ncsA-5n94A:undetectable | 6ncsA-5n94A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ner | O PANASIA VP2 (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | ILE 2 158THR 2 159PRO 2 144 | None | 0.50A | 6ncsA-5ner2:undetectable | 6ncsA-5ner2:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojs | TRANSCRIPTION-ASSOCIATED PROTEIN 1 (Saccharomycescerevisiae) |
PF00454(PI3_PI4_kinase)PF02259(FAT) | 3 | ILE T 485THR T 484PRO T 579 | None | 0.64A | 6ncsA-5ojsT:undetectable | 6ncsA-5ojsT:5.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5owx | GENOME POLYPROTEIN (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | ILE 2 158THR 2 159PRO 2 144 | None | 0.57A | 6ncsA-5owx2:undetectable | 6ncsA-5owx2:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5szr | PROTEIN PCDHGB2 (Mus musculus) |
PF00028(Cadherin) | 3 | ILE A 247THR A 248PRO A 210 | None | 0.62A | 6ncsA-5szrA:undetectable | 6ncsA-5szrA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj1 | DNA TOPOISOMERASE 1 (Mycobacteriumtuberculosis) |
no annotation | 3 | ILE A 169THR A 166PRO A 81 | None | 0.57A | 6ncsA-5uj1A:undetectable | 6ncsA-5uj1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdx | JFH-1 NS3 (Hepacivirus C) |
no annotation | 3 | ILE A 265THR A 266PRO A 215 | None | 0.44A | 6ncsA-5wdxA:undetectable | 6ncsA-5wdxA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wl3 | ENGINEERED CHALCONEISOMERASE ANCR2 (unidentified) |
no annotation | 3 | ILE A 17THR A 16PRO A 19 | None | 0.60A | 6ncsA-5wl3A:undetectable | 6ncsA-5wl3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmj | SUCCINATEDEHYDROGENASEIRON-SULFUR SUBUNIT (Desulfovibriogigas) |
no annotation | 3 | ILE B 88THR B 89PRO B 85 | None | 0.64A | 6ncsA-5xmjB:undetectable | 6ncsA-5xmjB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e9p | - (-) |
no annotation | 3 | ILE A 72THR A 71PRO A 32 | NoneACT A 502 (-3.8A)None | 0.64A | 6ncsA-6e9pA:16.5 | 6ncsA-6e9pA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ehs | HYDROGENASE-2 LARGECHAIN (Escherichiacoli) |
no annotation | 3 | ILE L 5THR L 6PRO L 533 | None | 0.60A | 6ncsA-6ehsL:undetectable | 6ncsA-6ehsL:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eqn | TRYPTOPHAN SYNTHASEBETA CHAIN 2 (Sulfobacillus) |
no annotation | 3 | ILE B 238THR B 237PRO B 15 | None | 0.45A | 6ncsA-6eqnB:undetectable | 6ncsA-6eqnB:undetectable |