SIMILAR PATTERNS OF AMINO ACIDS FOR 6N7F_A_RBFA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		4 GLY A  76
HIS A  80
ASN A  98
GLY A 126
 None
CUZ  A4801 (-3.3A)
None
None
 0.97A 6n7fA-1fwxA:
undetectable		 6n7fA-1fwxA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 GLY A 123
ASN A 117
GLU A 207
GLY A 206
 None
 0.85A 6n7fA-1hn0A:
undetectable		 6n7fA-1hn0A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 222
HIS A 351
ASN A 216
GLY A  44
 None
FAD  A 800 (-4.2A)
FAD  A 800 (-4.1A)
FAD  A 800 (-3.8A)
 0.97A 6n7fA-1knrA:
10.6		 6n7fA-1knrA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A  49
HIS A  68
GLU A  55
GLY A  53
 None
None
PQQ  A 701 (-2.6A)
None
 0.95A 6n7fA-1lrwA:
undetectable		 6n7fA-1lrwA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A  70
HIS A 368
ASN A  93
GLY A 104
 None
 0.94A 6n7fA-1m53A:
0.8		 6n7fA-1m53A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 GLY A 230
HIS A 782
GLU A 332
GLY A 333
 None
 0.98A 6n7fA-1nl3A:
0.0		 6n7fA-1nl3A:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		4 GLY A  31
HIS A 360
ASN A 385
GLU A  38
 None
 0.98A 6n7fA-1qfxA:
undetectable		 6n7fA-1qfxA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		4 GLY A  32
HIS A 360
ASN A 385
GLU A  38
 None
 0.84A 6n7fA-1qfxA:
undetectable		 6n7fA-1qfxA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1) 		5 GLY D  51
LYS D  22
ASN D  59
GLU D  63
GLY D  62
 None
 1.46A 6n7fA-1qgeD:
0.2		 6n7fA-1qgeD:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans) 		PF13277
(YmdB) 		4 GLY A 195
HIS A  66
ASN A  38
GLY A 205
 None
 0.96A 6n7fA-1t70A:
0.3		 6n7fA-1t70A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF13277
(YmdB) 		4 GLY A 205
HIS A  72
ASN A  44
GLY A 216
 None
None
FE  A 301 (-2.7A)
None
 0.96A 6n7fA-1t71A:
undetectable		 6n7fA-1t71A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A  49
HIS A  68
GLU A  55
GLY A  53
 None
None
PQQ  A1596 (-2.7A)
None
 0.90A 6n7fA-1w6sA:
undetectable		 6n7fA-1w6sA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzp PEROXIDASE
MANGANESE-DEPENDENT
I

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 GLY A  60
HIS A  46
GLU A 143
GLY A 139
 None
 0.97A 6n7fA-1yzpA:
undetectable		 6n7fA-1yzpA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 112
ASN A 272
GLU A 274
GLY A 275
 FAD  A 480 (-3.4A)
None
None
None
 0.83A 6n7fA-2a8xA:
44.1		 6n7fA-2a8xA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		4 GLY A 398
HIS A 405
ASN A 360
GLY A 371
 None
CYR  A 406 ( 4.9A)
CYR  A 406 ( 3.0A)
None
 0.97A 6n7fA-2aafA:
undetectable		 6n7fA-2aafA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 GLY A  48
TYR A 159
GLU A  94
GLY A  95
 None
CBC  A1401 (-4.3A)
None
None
 0.95A 6n7fA-2abjA:
undetectable		 6n7fA-2abjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgs DAZ-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLY A 125
HIS A 176
GLU A 184
GLY A 119
 None
 0.92A 6n7fA-2dgsA:
undetectable		 6n7fA-2dgsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		4 GLY A 153
TYR A 154
ASN A 105
GLY A 293
 None
 0.95A 6n7fA-2drwA:
undetectable		 6n7fA-2drwA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		4 GLY A 309
ASN A   6
GLU A 289
GLY A 267
 None
 0.95A 6n7fA-2exhA:
undetectable		 6n7fA-2exhA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz4 DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII) 		4 GLY A 223
HIS A 202
GLU A 229
GLY A 118
 None
 0.78A 6n7fA-2fz4A:
undetectable		 6n7fA-2fz4A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		4 GLY A 733
ASN A 807
GLU A 804
GLY A 803
 None
 0.85A 6n7fA-2gahA:
14.5		 6n7fA-2gahA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		4 GLY A 131
ASN A 281
GLU A 283
GLY A 284
 SO4  A 601 (-3.4A)
None
None
None
 0.80A 6n7fA-2horA:
undetectable		 6n7fA-2horA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwg 52 KDA RO PROTEIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 GLY B  57
TYR B 130
HIS B  53
GLY B 157
 None
 0.98A 6n7fA-2iwgB:
undetectable		 6n7fA-2iwgB:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 GLY A 333
HIS A  19
GLU A  39
GLY A  40
 None
 0.93A 6n7fA-2mbrA:
undetectable		 6n7fA-2mbrA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 GLY A 279
TYR A  70
GLU A  41
GLY A  40
 None
 0.80A 6n7fA-2p2mA:
3.1		 6n7fA-2p2mA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 GLY A 280
TYR A  70
GLU A  41
GLY A  40
 None
 0.93A 6n7fA-2p2mA:
3.1		 6n7fA-2p2mA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 GLY A  39
TYR A  38
GLU A  18
GLY A  55
 None
 0.92A 6n7fA-2pcqA:
undetectable		 6n7fA-2pcqA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 GLY A  29
HIS A 326
ASN A  52
GLY A  63
 CA  A7001 ( 4.6A)
None
None
None
 0.94A 6n7fA-2pwhA:
undetectable		 6n7fA-2pwhA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 424
ASN A  53
GLU A  51
GLY A  24
 None
 0.97A 6n7fA-2vk4A:
3.1		 6n7fA-2vk4A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 GLY A 360
HIS A 296
GLU A 342
GLY A 339
 ADP  A1490 (-3.6A)
None
None
None
 0.95A 6n7fA-2vosA:
2.6		 6n7fA-2vosA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 GLY A 394
HIS A 401
ASN A 391
GLY A 337
 None
 0.97A 6n7fA-2vz9A:
undetectable		 6n7fA-2vz9A:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 GLY A 286
TYR A 152
ASN A 341
GLU A 342
 None
None
None
GLC  A1417 ( 4.7A)
 0.81A 6n7fA-2xd3A:
undetectable		 6n7fA-2xd3A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 GLY A 286
TYR A 152
ASN A 341
GLY A 271
 None
 0.95A 6n7fA-2xd3A:
undetectable		 6n7fA-2xd3A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 GLY A 347
HIS A  19
ASN A 383
GLY A  16
 None
 0.78A 6n7fA-2xdqA:
undetectable		 6n7fA-2xdqA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE

(Streptococcus
pneumoniae) 		PF08305
(NPCBM) 		4 GLY A 301
TYR A 250
ASN A 242
GLY A 244
 None
 0.97A 6n7fA-2yglA:
undetectable		 6n7fA-2yglA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		4 GLY A   5
HIS A  21
GLU A  28
GLY A  27
 None
 0.88A 6n7fA-2ykfA:
undetectable		 6n7fA-2ykfA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625

(Thermus
thermophilus) 		PF13277
(YmdB) 		4 GLY A 192
HIS A  66
ASN A  38
GLY A 202
 None
 0.93A 6n7fA-2z06A:
undetectable		 6n7fA-2z06A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		4 GLY A 377
HIS A 256
GLU A 150
GLY A 151
 None
 0.89A 6n7fA-2z3tA:
undetectable		 6n7fA-2z3tA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 GLY A   6
HIS A 169
GLU A 165
GLY A 164
 None
HEM  A 354 (-4.0A)
None
None
 0.87A 6n7fA-3a18A:
undetectable		 6n7fA-3a18A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 GLY A 511
TYR A 482
GLU A 544
GLY A 546
 None
 0.88A 6n7fA-3abzA:
undetectable		 6n7fA-3abzA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b12 FLUOROACETATE
DEHALOGENASE

(Burkholderia
sp.) 		PF00561
(Abhydrolase_1) 		4 GLY A 207
TYR A  62
HIS A 149
GLY A  33
 None
None
FAH  A 501 (-4.2A)
None
 0.78A 6n7fA-3b12A:
undetectable		 6n7fA-3b12A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 GLY A 219
HIS A 311
GLU A   2
GLY A   0
 None
 0.80A 6n7fA-3cc1A:
undetectable		 6n7fA-3cc1A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 GLY A  46
LYS A  45
ASN A 419
GLY A 158
 None
 0.86A 6n7fA-3cmmA:
6.4		 6n7fA-3cmmA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF01063
(Aminotran_4) 		4 GLY A  32
TYR A 144
GLU A  78
GLY A  79
 None
 0.94A 6n7fA-3dtgA:
undetectable		 6n7fA-3dtgA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		4 GLY A 493
TYR A 497
HIS A 481
GLY A 443
 None
None
ZN  A 613 (-3.7A)
None
 0.74A 6n7fA-3epmA:
undetectable		 6n7fA-3epmA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A  43
HIS A 341
ASN A  66
GLY A  77
 None
 0.95A 6n7fA-3gbdA:
undetectable		 6n7fA-3gbdA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A 288
LYS A 258
TYR A 287
ASN A 137
 None
 0.94A 6n7fA-3gdoA:
undetectable		 6n7fA-3gdoA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 GLY B1154
TYR B1093
HIS B1105
ASN B1084
GLY B1087
 None
 1.04A 6n7fA-3k70B:
undetectable		 6n7fA-3k70B:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis) 		PF13649
(Methyltransf_25) 		4 GLY A 100
ASN A  88
GLU A  24
GLY A  59
 None
 0.87A 6n7fA-3kkzA:
undetectable		 6n7fA-3kkzA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		4 GLY A 500
ASN A 526
GLU A 576
GLY A 577
 None
None
NAG  A 607 (-3.7A)
NAG  A 607 ( 3.9A)
 0.95A 6n7fA-3l5hA:
undetectable		 6n7fA-3l5hA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3) 		4 GLY A 500
ASN A 526
GLU A 576
GLY A 577
 None
 0.82A 6n7fA-3l5jA:
undetectable		 6n7fA-3l5jA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 GLY A 254
HIS A 345
GLU A 344
GLY A 342
 None
 0.94A 6n7fA-3lv4A:
undetectable		 6n7fA-3lv4A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbr GLUTAMINE
CYCLOTRANSFERASE

(Xanthomonas
campestris) 		PF05096
(Glu_cyclase_2) 		4 GLY X 126
TYR X 124
ASN X 105
GLY X 108
 None
 0.87A 6n7fA-3mbrX:
undetectable		 6n7fA-3mbrX:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 GLY A 537
ASN A 230
GLU A 203
GLY A 531
 None
 0.90A 6n7fA-3mi6A:
undetectable		 6n7fA-3mi6A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nom GLUTAMINE
CYCLOTRANSFERASE

(Zymomonas
mobilis) 		PF05096
(Glu_cyclase_2) 		4 GLY A 127
TYR A 125
ASN A 106
GLY A 109
 None
 0.90A 6n7fA-3nomA:
undetectable		 6n7fA-3nomA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Clostridium
perfringens) 		PF00698
(Acyl_transf_1) 		4 GLY A  17
TYR A  15
GLU A 272
GLY A 276
 None
 0.97A 6n7fA-3ptwA:
undetectable		 6n7fA-3ptwA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A 265
HIS A 191
ASN A 132
GLY A 298
 None
HP7  A 550 ( 3.7A)
HP7  A 550 ( 3.9A)
HP7  A 550 ( 4.4A)
 0.95A 6n7fA-3q2kA:
undetectable		 6n7fA-3q2kA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		5 GLY A  73
TYR A  72
ASN A  50
GLU A  54
GLY A  53
 None
 1.29A 6n7fA-3qufA:
undetectable		 6n7fA-3qufA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 GLY A 297
ASN A 309
GLU A 311
GLY A 313
 None
 0.84A 6n7fA-3tqoA:
undetectable		 6n7fA-3tqoA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 362
TYR A 363
GLU A 332
GLY A 329
 None
 0.88A 6n7fA-3uj2A:
undetectable		 6n7fA-3uj2A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		4 GLY A   5
HIS A 272
GLU A 209
GLY A 208
 None
 0.81A 6n7fA-3vylA:
undetectable		 6n7fA-3vylA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		4 GLY A 299
TYR A 300
GLU A 340
GLY A 337
 None
 0.87A 6n7fA-3wsuA:
undetectable		 6n7fA-3wsuA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TYR A  25
HIS A 111
ASN A 169
GLY A 177
 None
 0.84A 6n7fA-4a0sA:
3.2		 6n7fA-4a0sA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		4 GLY A 293
TYR A 294
GLU A  40
GLY A  67
 SCN  A 602 ( 4.8A)
None
None
SCN  A 601 (-3.5A)
 0.88A 6n7fA-4a6uA:
undetectable		 6n7fA-4a6uA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		4 GLY A 197
HIS A  68
ASN A  40
GLY A 207
 None
PO4  A1265 (-3.7A)
FE2  A1266 ( 2.5A)
None
 0.93A 6n7fA-4b2oA:
undetectable		 6n7fA-4b2oA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		4 GLY A 358
HIS A 225
ASN A 136
GLY A 313
 None
 0.88A 6n7fA-4dzhA:
undetectable		 6n7fA-4dzhA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 GLY A 337
LYS A 338
ASN A  15
GLY A 226
 None
 0.59A 6n7fA-4eclA:
undetectable		 6n7fA-4eclA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		4 GLY A 356
HIS A 217
ASN A 128
GLY A 303
 NOS  A 502 (-3.6A)
None
None
None
 0.89A 6n7fA-4f0sA:
undetectable		 6n7fA-4f0sA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f41 PROTELOMERASE

(Agrobacterium
fabrum) 		PF16684
(Telomere_res) 		4 GLY A 393
ASN A 396
GLU A 291
GLY A 290
 None
 0.88A 6n7fA-4f41A:
undetectable		 6n7fA-4f41A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A  70
HIS A 368
ASN A  93
GLY A 104
 CA  A 701 ( 4.7A)
GLC  A 703 (-4.0A)
None
None
 0.91A 6n7fA-4hozA:
undetectable		 6n7fA-4hozA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		4 GLY A 300
LYS A 299
ASN A 112
GLY A 277
 None
 0.92A 6n7fA-4icqA:
undetectable		 6n7fA-4icqA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB
YENC2

(Yersinia
entomophaga;
Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
no annotation 		4 GLY A1114
ASN B 128
GLU B 127
GLY B 133
 None
 0.83A 6n7fA-4iglA:
undetectable		 6n7fA-4iglA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A3284
TYR A3283
HIS A3404
GLY A3363
 None
 0.85A 6n7fA-4kc5A:
undetectable		 6n7fA-4kc5A:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 GLY A 408
HIS A 501
GLU A 500
GLY A 498
 None
None
None
IOD  A 715 (-4.0A)
 0.91A 6n7fA-4kcaA:
undetectable		 6n7fA-4kcaA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 GLY A 708
TYR A 709
HIS A 764
GLY A 687
 None
 0.98A 6n7fA-4ktpA:
2.0		 6n7fA-4ktpA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1j POLYKETIDE
BIOSYNTHESIS
ENOYL-COA ISOMERASE
PKSI

(Bacillus
subtilis) 		PF00378
(ECH_1) 		4 GLY A 107
HIS A  25
GLU A  69
GLY A  70
 None
 0.97A 6n7fA-4q1jA:
undetectable		 6n7fA-4q1jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1j POLYKETIDE
BIOSYNTHESIS
ENOYL-COA ISOMERASE
PKSI

(Bacillus
subtilis) 		PF00378
(ECH_1) 		4 GLY A 108
HIS A  25
GLU A  69
GLY A  70
 None
 0.92A 6n7fA-4q1jA:
undetectable		 6n7fA-4q1jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqu ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 158
HIS A 127
GLU A  80
GLY A  81
 None
 0.86A 6n7fA-4rquA:
4.2		 6n7fA-4rquA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		4 GLY A 502
TYR A 506
HIS A 490
GLY A 452
 None
None
FE2  A 704 (-3.3A)
None
 0.78A 6n7fA-4s28A:
undetectable		 6n7fA-4s28A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqx SORTASE

(Streptococcus
mutans) 		PF04203
(Sortase) 		4 GLY A 218
TYR A 175
GLU A 131
GLY A 130
 None
 0.86A 6n7fA-4tqxA:
undetectable		 6n7fA-4tqxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7p ALKALINE D-PEPTIDASE

(Bacillus cereus) 		PF00144
(Beta-lactamase) 		4 GLY A 175
TYR A 176
ASN A 124
GLY A 297
 None
 0.94A 6n7fA-4y7pA:
undetectable		 6n7fA-4y7pA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT BETA

(Yersinia
enterocolitica) 		PF00699
(Urease_beta) 		4 GLY B  92
LYS B  93
ASN B 142
GLY B 138
 None
 0.88A 6n7fA-4z42B:
undetectable		 6n7fA-4z42B:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 GLY A 133
HIS A 326
GLU A 128
GLY A 358
 None
 0.98A 6n7fA-5a1iA:
undetectable		 6n7fA-5a1iA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 319
ASN A 279
GLU A 254
GLY A 253
 None
 0.94A 6n7fA-5brqA:
undetectable		 6n7fA-5brqA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MINOR STRUCTURAL
PROTEIN 4

(Lactococcus
phage Tuc2009) 		no annotation 4 GLY A 225
ASN A 217
GLU A 279
GLY A 277
 None
 0.89A 6n7fA-5e7tA:
undetectable		 6n7fA-5e7tA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		4 GLY A 193
HIS A 336
GLU A  83
GLY A  84
 None
 0.90A 6n7fA-5evjA:
2.2		 6n7fA-5evjA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella ovis) 		PF13561
(adh_short_C2) 		4 GLY A  21
ASN A 123
GLU A 125
GLY A 126
 None
 0.91A 6n7fA-5ha5A:
4.1		 6n7fA-5ha5A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 GLY A 305
HIS A 422
GLU A  73
GLY A  69
 None
AHR  A 718 ( 4.3A)
AHR  A 718 ( 3.0A)
None
 0.98A 6n7fA-5ho9A:
undetectable		 6n7fA-5ho9A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		4 HIS A 518
ASN A 437
GLU A 468
GLY A 466
 None
CA  A 611 (-3.2A)
None
None
 0.87A 6n7fA-5iryA:
undetectable		 6n7fA-5iryA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it6 GALECTIN-RELATED
PROTEIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		4 GLY A  10
HIS A 113
GLU A  95
GLY A  15
 None
 0.97A 6n7fA-5it6A:
undetectable		 6n7fA-5it6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38

(Enterococcus
faecalis) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 GLY A 184
ASN A 129
GLU A 281
GLY A 280
 None
 0.92A 6n7fA-5kbpA:
undetectable		 6n7fA-5kbpA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 GLY A1006
ASN A 547
GLU A 539
GLY A 542
 None
 0.83A 6n7fA-5kf7A:
undetectable		 6n7fA-5kf7A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lvy ADHESIN PROTEIN

(Escherichia
coli) 		no annotation 4 GLY A  81
TYR A  79
HIS A  95
GLY A  92
 None
 0.73A 6n7fA-5lvyA:
undetectable		 6n7fA-5lvyA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 4 GLY A 182
ASN A 118
GLU A 153
GLY A 152
 None
NAG  A 401 (-1.9A)
None
None
 0.95A 6n7fA-5mktA:
undetectable		 6n7fA-5mktA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 4 GLY A 182
ASN A 118
GLU A 153
GLY A 152
 None
NAG  A 401 (-1.9A)
None
None
 0.97A 6n7fA-5mlgA:
undetectable		 6n7fA-5mlgA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		4 GLY A 295
TYR A 296
GLU A  42
GLY A  69
 None
 0.84A 6n7fA-5ti8A:
undetectable		 6n7fA-5ti8A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN

(Squalimorphii) 		PF00566
(RabGAP-TBC) 		4 TYR A 536
ASN A 600
GLU A 606
GLY A 603
 None
 0.90A 6n7fA-5tubA:
undetectable		 6n7fA-5tubA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 GLY A  35
LYS A  36
TYR A 114
HIS A 142
ASN A 266
GLY A 269
 FAD  A 501 (-4.1A)
None
FAD  A 501 (-3.4A)
GOL  A 524 (-3.8A)
None
GOL  A 523 (-3.3A)
 0.62A 6n7fA-5v36A:
57.4		 6n7fA-5v36A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 4 GLY A 266
HIS A 409
ASN A 416
GLY A 285
 None
 0.96A 6n7fA-5ykdA:
undetectable		 6n7fA-5ykdA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY

(Thermobifida
fusca) 		no annotation 4 GLY G 640
HIS G 695
GLU G 309
GLY G 308
 None
 0.91A 6n7fA-6c66G:
undetectable		 6n7fA-6c66G:
17.28