SIMILAR PATTERNS OF AMINO ACIDS FOR 6MXT_A_K5YA1401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adv ADENOVIRUS
SINGLE-STRANDED
DNA-BINDING PROTEIN

(Human
mastadenovirus
C) 		PF02236
(Viral_DNA_bi)
PF03728
(Viral_DNA_Zn_bi) 		3 ASP A 475
SER A 435
SER A 439
 None
 0.76A 6mxtA-1advA:
0.0		 6mxtA-1advA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		3 ASP A  36
SER A 117
SER A 121
 None
 0.68A 6mxtA-1bgpA:
0.0		 6mxtA-1bgpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		3 ASP A 172
SER A 144
SER A 318
 None
 0.81A 6mxtA-1eg1A:
undetectable		 6mxtA-1eg1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flz URACIL-DNA
GLYCOSYLASE

(Escherichia
coli) 		PF03167
(UDG) 		3 ASP A  64
SER A 189
SER A  88
 None
None
URA  A 230 ( 4.9A)
 0.69A 6mxtA-1flzA:
0.0		 6mxtA-1flzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR 2

(Homo sapiens) 		PF00167
(FGF) 		3 ASP A  90
SER A  87
SER A  85
 None
 0.63A 6mxtA-1fq9A:
undetectable		 6mxtA-1fq9A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwu CYSTEINE-RICH DOMAIN
OF MANNOSE RECEPTOR

(Mus musculus) 		PF00652
(Ricin_B_lectin) 		3 ASP A  73
SER A  45
SER A  43
 None
 0.71A 6mxtA-1fwuA:
0.0		 6mxtA-1fwuA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		3 ASP A 178
SER A 201
SER A  14
 SO4  A1224 ( 4.9A)
SO4  A1224 (-3.1A)
SO4  A1224 ( 4.1A)
 0.75A 6mxtA-1h1yA:
undetectable		 6mxtA-1h1yA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6h NEUTROPHIL CYTOSOL
FACTOR 4

(Homo sapiens) 		PF00787
(PX) 		3 ASP A 126
SER A  79
SER A  77
 None
 0.83A 6mxtA-1h6hA:
0.0		 6mxtA-1h6hA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbj CD3 EPSILON AND
GAMMA ECTODOMAIN
FRAGMENT COMPLEX

(Mus musculus) 		PF16680
(Ig_4)
PF16681
(Ig_5) 		3 ASP A  88
SER A  11
SER A  13
 None
 0.80A 6mxtA-1jbjA:
0.0		 6mxtA-1jbjA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A  72
SER A  45
SER A  48
 None
SO4  A 501 (-3.1A)
None
 0.81A 6mxtA-1odfA:
undetectable		 6mxtA-1odfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASP A 205
SER A 178
SER A 181
 None
 0.81A 6mxtA-1rcqA:
undetectable		 6mxtA-1rcqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		3 ASP A 185
SER A 208
SER A  19
 None
SO4  A 231 (-3.2A)
SO4  A 231 ( 4.2A)
 0.69A 6mxtA-1rpxA:
undetectable		 6mxtA-1rpxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqj RIBULOSE-PHOSPHATE
3-EPIMERASE

(Synechocystis
sp.) 		PF00834
(Ribul_P_3_epim) 		3 ASP A 179
SER A 202
SER A  13
 None
 0.78A 6mxtA-1tqjA:
undetectable		 6mxtA-1tqjA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa4 PCZA361.16

(Amycolatopsis
orientalis) 		PF00908
(dTDP_sugar_isom) 		3 ASP A  84
SER A  54
SER A  52
 None
 0.83A 6mxtA-1wa4A:
undetectable		 6mxtA-1wa4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ASP A 135
SER A 262
SER A 266
 None
 0.83A 6mxtA-1x8vA:
undetectable		 6mxtA-1x8vA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ASP A 138
SER A 262
SER A 266
 None
 0.68A 6mxtA-1x8vA:
undetectable		 6mxtA-1x8vA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		3 ASP A 281
SER A 212
SER A 214
 None
 0.80A 6mxtA-2gzsA:
undetectable		 6mxtA-2gzsA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		3 ASP A 329
SER A  44
SER A  42
 None
SO4  A 383 ( 4.8A)
SO4  A 383 (-2.5A)
 0.80A 6mxtA-2hkeA:
undetectable		 6mxtA-2hkeA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		3 ASP A  42
SER A 296
SER A 294
 None
 0.78A 6mxtA-2i9kA:
undetectable		 6mxtA-2i9kA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		3 ASP A 213
SER A 183
SER A 173
 None
NHE  A   1 ( 4.3A)
None
 0.76A 6mxtA-2ichA:
undetectable		 6mxtA-2ichA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n04 DNAJ HOMOLOG
SUBFAMILY C MEMBER 5

(Homo sapiens) 		PF00226
(DnaJ) 		3 ASP A  55
SER A  15
SER A  12
 SEP  A  10 ( 3.7A)
None
SEP  A  10 ( 3.4A)
 0.65A 6mxtA-2n04A:
undetectable		 6mxtA-2n04A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n62 GELATION FACTOR,
SECRETION MONITOR
CHIMERA

(Escherichia
coli;
Dictyostelium
discoideum) 		PF00630
(Filamin) 		3 ASP L 165
SER L 120
SER L 123
 None
 0.82A 6mxtA-2n62L:
undetectable		 6mxtA-2n62L:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		3 ASP X 295
SER X 214
SER X 236
 None
 0.84A 6mxtA-2odtX:
undetectable		 6mxtA-2odtX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		3 ASP A 353
SER A 336
SER A 359
 None
 0.70A 6mxtA-2omvA:
undetectable		 6mxtA-2omvA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		3 ASP A 169
SER A 175
SER A 307
 None
 0.73A 6mxtA-2pg6A:
undetectable		 6mxtA-2pg6A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
halodurans) 		PF00268
(Ribonuc_red_sm) 		3 ASP A 139
SER A 126
SER A 130
 None
 0.60A 6mxtA-2rccA:
1.4		 6mxtA-2rccA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus) 		PF00423
(HN) 		3 ASP A 347
SER A 429
SER A 409
 None
 0.80A 6mxtA-2rkcA:
undetectable		 6mxtA-2rkcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		3 ASP A  14
SER A  74
SER A  77
 None
 0.54A 6mxtA-2v8jA:
undetectable		 6mxtA-2v8jA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		3 ASP A 749
SER A 772
SER A 770
 None
 0.79A 6mxtA-2w92A:
undetectable		 6mxtA-2w92A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 ASP A 168
SER A  25
SER A  19
 None
None
POP  A 500 ( 3.9A)
 0.83A 6mxtA-2x4dA:
undetectable		 6mxtA-2x4dA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9m PEROXISOME ASSEMBLY
PROTEIN 22

(Saccharomyces
cerevisiae) 		PF12827
(Peroxin-22) 		3 ASP B 167
SER B  69
SER B  67
 None
 0.69A 6mxtA-2y9mB:
undetectable		 6mxtA-2y9mB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN

(Barmah Forest
virus;
Barmah Forest
virus) 		PF01589
(Alpha_E1_glycop)
PF00943
(Alpha_E2_glycop) 		3 ASP C 171
SER C 238
SER B  57
 None
 0.75A 6mxtA-2yewC:
undetectable		 6mxtA-2yewC:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		3 ASP A 212
SER A 279
SER A 283
 None
 0.67A 6mxtA-3a1nA:
undetectable		 6mxtA-3a1nA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		3 ASP A  99
SER A 202
SER A 205
 None
 0.82A 6mxtA-3c9bA:
undetectable		 6mxtA-3c9bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE

(Histophilus
somni) 		PF00834
(Ribul_P_3_epim) 		3 ASP A 192
SER A 217
SER A  21
 NI  A 238 (-2.6A)
None
None
 0.80A 6mxtA-3cu2A:
undetectable		 6mxtA-3cu2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		3 ASP A 749
SER A 772
SER A 770
 None
 0.68A 6mxtA-3gdbA:
undetectable		 6mxtA-3gdbA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gku PROBABLE RNA-BINDING
PROTEIN

([Clostridium]
symbiosum) 		PF01424
(R3H)
PF13083
(KH_4)
PF14804
(Jag_N) 		3 ASP A 193
SER A 204
SER A 164
 None
 0.67A 6mxtA-3gkuA:
undetectable		 6mxtA-3gkuA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 183
SER A 190
SER A  98
 None
 0.76A 6mxtA-3ip1A:
undetectable		 6mxtA-3ip1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx8 PUTATIVE LIPOPROTEIN

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		3 ASP A 102
SER A  50
SER A 125
 None
SO4  A   8 (-4.1A)
SO4  A   8 (-2.7A)
 0.66A 6mxtA-3jx8A:
undetectable		 6mxtA-3jx8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		3 ASP A 569
SER A 282
SER A 441
 None
 0.81A 6mxtA-3loyA:
undetectable		 6mxtA-3loyA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		3 ASP A 200
SER A  48
SER A  52
 None
 0.82A 6mxtA-3m8uA:
undetectable		 6mxtA-3m8uA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otm CARBONIC ANHYDRASE

(Methanosarcina
thermophila) 		PF00132
(Hexapep)
PF14602
(Hexapep_2) 		3 ASP A  61
SER A  39
SER A  57
 None
 0.83A 6mxtA-3otmA:
undetectable		 6mxtA-3otmA:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ASP A 113
SER A 203
SER A 207
 ERC  A1201 (-3.7A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
 0.48A 6mxtA-3pdsA:
34.0		 6mxtA-3pdsA:
57.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		3 ASP A  82
SER A  73
SER A  71
 None
 0.76A 6mxtA-3tc2A:
undetectable		 6mxtA-3tc2A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ASP A   4
SER A  90
SER A  94
 None
 0.66A 6mxtA-3txxA:
undetectable		 6mxtA-3txxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus) 		PF00141
(peroxidase) 		3 ASP A  31
SER A 110
SER A 114
 None
 0.69A 6mxtA-4a5gA:
undetectable		 6mxtA-4a5gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aez WD REPEAT-CONTAINING
PROTEIN SLP1

(Schizosaccharomyces
pombe) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 ASP A 388
SER A 417
SER A 407
 None
 0.74A 6mxtA-4aezA:
undetectable		 6mxtA-4aezA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b50 2H10 LLAMA VHH

(Lama glama) 		PF07686
(V-set) 		3 ASP A  53
SER A 100
SER A  99
 None
 0.74A 6mxtA-4b50A:
undetectable		 6mxtA-4b50A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ASP C  69
SER C 296
SER C 238
 None
 0.82A 6mxtA-4bujC:
undetectable		 6mxtA-4bujC:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0w FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Pseudomonas
putida) 		PF02525
(Flavodoxin_2) 		3 ASP A  41
SER A  17
SER A  15
 None
FMN  A1201 (-2.6A)
FMN  A1201 (-2.6A)
 0.83A 6mxtA-4c0wA:
undetectable		 6mxtA-4c0wA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuo BANYAN PEROXIDASE

(Ficus
benghalensis) 		PF00141
(peroxidase) 		3 ASP A  29
SER A 108
SER A 112
 None
 0.66A 6mxtA-4cuoA:
undetectable		 6mxtA-4cuoA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d86 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		3 ASP A1038
SER A1034
SER A1047
 None
ADP  A1202 (-2.6A)
None
 0.82A 6mxtA-4d86A:
undetectable		 6mxtA-4d86A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE

(Streptococcus
mutans) 		PF01063
(Aminotran_4) 		3 ASP A 142
SER A  46
SER A  44
 None
 0.68A 6mxtA-4dqnA:
undetectable		 6mxtA-4dqnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		3 ASP A  50
SER A 194
SER A 192
 None
 0.56A 6mxtA-4eiuA:
undetectable		 6mxtA-4eiuA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN ALPHA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		3 ASP A  95
SER A 134
SER A 138
 None
HEM  A 202 ( 4.3A)
None
 0.79A 6mxtA-4esaA:
undetectable		 6mxtA-4esaA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		3 ASP A  11
SER A  61
SER A  59
 None
NAP  A 401 (-4.4A)
NAP  A 401 (-2.7A)
 0.61A 6mxtA-4fc7A:
undetectable		 6mxtA-4fc7A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gou EHRGS-RHOGEF

(Entamoeba
histolytica) 		PF00615
(RGS)
PF00621
(RhoGEF) 		3 ASP A 232
SER A 210
SER A 213
 None
 0.81A 6mxtA-4gouA:
2.2		 6mxtA-4gouA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		3 ASP A  74
SER A 140
SER A 131
 None
 0.54A 6mxtA-4h7nA:
undetectable		 6mxtA-4h7nA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht4 NICKING ENZYME

(Staphylococcus
aureus) 		PF03389
(MobA_MobL) 		3 ASP A  64
SER A  23
SER A  27
 None
 0.57A 6mxtA-4ht4A:
undetectable		 6mxtA-4ht4A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		3 ASP A 122
SER A 314
SER A 324
 None
 0.68A 6mxtA-4kg7A:
undetectable		 6mxtA-4kg7A:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ASP A1113
SER A1203
SER A1207
 P0G  A1401 (-2.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
 0.57A 6mxtA-4ldeA:
48.9		 6mxtA-4ldeA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		3 ASP A 293
SER A 322
SER A 320
 None
 0.84A 6mxtA-4llfA:
undetectable		 6mxtA-4llfA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		3 ASP A 405
SER A 373
SER A 475
 None
 0.70A 6mxtA-4mt1A:
0.0		 6mxtA-4mt1A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		3 ASP A 118
SER A 105
SER A 109
 None
 0.81A 6mxtA-4n83A:
undetectable		 6mxtA-4n83A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		3 ASP A 489
SER A 441
SER A 437
 None
SO4  A 701 (-3.7A)
SO4  A 701 (-2.9A)
 0.83A 6mxtA-4nbqA:
undetectable		 6mxtA-4nbqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ASP A  52
SER A  98
SER A 102
 None
 0.82A 6mxtA-4p52A:
undetectable		 6mxtA-4p52A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio
vulnificus) 		PF05134
(T2SSL) 		3 ASP X  61
SER X 168
SER X 139
 None
 0.78A 6mxtA-4phtX:
undetectable		 6mxtA-4phtX:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ASP A  30
SER A  49
SER A  52
 None
 0.60A 6mxtA-4plhA:
undetectable		 6mxtA-4plhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		3 ASP A 516
SER A 222
SER A 226
 None
 0.73A 6mxtA-4q0cA:
undetectable		 6mxtA-4q0cA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		3 ASP 3 182
SER 3  85
SER 3  87
 None
 0.63A 6mxtA-4q4y3:
undetectable		 6mxtA-4q4y3:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		3 ASP A  12
SER A 124
SER A 117
 None
 0.75A 6mxtA-4qi6A:
undetectable		 6mxtA-4qi6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38

(Homo sapiens) 		no annotation 3 ASP A 259
SER A 225
SER A 266
 None
 0.80A 6mxtA-4rxxA:
undetectable		 6mxtA-4rxxA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ASP A 937
SER A 808
SER A 811
 None
SO4  A1986 ( 3.7A)
None
 0.80A 6mxtA-4udbA:
undetectable		 6mxtA-4udbA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		3 ASP A 314
SER A 369
SER A 391
 None
 0.77A 6mxtA-4uqgA:
undetectable		 6mxtA-4uqgA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		3 ASP A 100
SER A 281
SER A 285
 None
 0.69A 6mxtA-4w7gA:
undetectable		 6mxtA-4w7gA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2h PUTATIVE MRNA EXPORT
PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 ASP A 419
SER A 427
SER A 430
 None
 0.82A 6mxtA-4x2hA:
undetectable		 6mxtA-4x2hA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aog CATIONIC PEROXIDASE
SPC4

(Sorghum bicolor) 		PF00141
(peroxidase) 		3 ASP A  68
SER A 149
SER A 153
 None
 0.74A 6mxtA-5aogA:
undetectable		 6mxtA-5aogA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		3 ASP A 459
SER A 448
SER A 451
 None
 0.66A 6mxtA-5cb2A:
undetectable		 6mxtA-5cb2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		3 ASP A 373
SER A 340
SER A 324
 HMC  A 606 ( 3.0A)
None
None
 0.65A 6mxtA-5csuA:
undetectable		 6mxtA-5csuA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		3 ASP A 232
SER A 465
SER A 393
 None
 0.78A 6mxtA-5cykA:
undetectable		 6mxtA-5cykA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 ASP A 578
SER A 550
SER A 543
 None
 0.75A 6mxtA-5dfaA:
undetectable		 6mxtA-5dfaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 249
SER A 211
SER A 231
 None
PO4  A 403 ( 4.2A)
None
 0.80A 6mxtA-5fi5A:
undetectable		 6mxtA-5fi5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A  97
SER A 293
SER A 254
 None
 0.79A 6mxtA-5fr8A:
undetectable		 6mxtA-5fr8A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 ASP A 377
SER A 617
SER A 620
 None
 0.67A 6mxtA-5gtmA:
3.0		 6mxtA-5gtmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 ASP a  91
SER a 523
SER a 527
 None
 0.67A 6mxtA-5gw5a:
undetectable		 6mxtA-5gw5a:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz1 FRUCTOSE-1,6-BISPHOS
PHATASE

(Physcomitrella
patens) 		PF00316
(FBPase) 		3 ASP A 106
SER A 167
SER A 187
 None
 0.67A 6mxtA-5iz1A:
undetectable		 6mxtA-5iz1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j56 VHH SINGLE CHAIN
ANTIBODY V1C7

(Vicugna pacos) 		PF07686
(V-set) 		3 ASP B 116
SER B 111
SER B 109
 None
 0.58A 6mxtA-5j56B:
undetectable		 6mxtA-5j56B:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ASP A 354
SER A 361
SER A 366
 None
 0.83A 6mxtA-5jo7A:
undetectable		 6mxtA-5jo7A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 3 ASP A 152
SER A  94
SER A  89
 ZN  A 808 ( 2.3A)
None
None
 0.69A 6mxtA-5m11A:
undetectable		 6mxtA-5m11A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 ASP A 185
SER A 162
SER A 160
 None
 0.78A 6mxtA-5mvhA:
undetectable		 6mxtA-5mvhA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 3 ASP A 875
SER A 884
SER A 882
 None
 0.75A 6mxtA-5n2gA:
undetectable		 6mxtA-5n2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		3 ASP J 334
SER J 457
SER J 460
 None
 0.83A 6mxtA-5nilJ:
3.0		 6mxtA-5nilJ:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ASP A4050
SER A1969
SER A1972
 None
 0.78A 6mxtA-5nugA:
undetectable		 6mxtA-5nugA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		3 ASP A 246
SER A 107
SER A 105
 None
 0.58A 6mxtA-5u47A:
undetectable		 6mxtA-5u47A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)

(Sorghum bicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 252
SER A 214
SER A 234
 None
NAP  A 405 (-2.6A)
NAP  A 405 ( 4.7A)
 0.65A 6mxtA-5vktA:
undetectable		 6mxtA-5vktA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 3 ASP A 261
SER A 301
SER A 535
 None
 0.82A 6mxtA-5w7dA:
undetectable		 6mxtA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi8 BETA-BARREL
ASSEMBLY-ENHANCING
PROTEASE

(Escherichia
coli) 		no annotation 3 ASP A 472
SER A 451
SER A 454
 None
 0.83A 6mxtA-5xi8A:
2.1		 6mxtA-5xi8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		3 ASP A1093
SER A 847
SER A 849
 None
 0.62A 6mxtA-5xvmA:
undetectable		 6mxtA-5xvmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 3 ASP A 404
SER A 335
SER A 365
 None
 0.45A 6mxtA-6bfnA:
1.3		 6mxtA-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbh HOPQ

(Helicobacter
pylori) 		no annotation 3 ASP C 236
SER C 276
SER C 279
 None
 0.82A 6mxtA-6gbhC:
3.3		 6mxtA-6gbhC:
undetectable