SIMILAR PATTERNS OF AMINO ACIDS FOR 6MXT_A_K5YA1401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		5 VAL A 228
VAL A 229
ASP A 143
PHE A 145
PHE A 202
 None
 1.39A 6mxtA-1a88A:
undetectable		 6mxtA-1a88A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL B 755
ASP B 739
PHE B 480
TYR B 656
ILE B 655
 PCD  B1920 (-4.1A)
None
None
None
None
 1.35A 6mxtA-1ffvB:
0.0		 6mxtA-1ffvB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 VAL A 500
VAL A 499
PHE A 422
PHE A 396
TYR A 428
 None
 1.46A 6mxtA-1jedA:
0.0		 6mxtA-1jedA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN

(Schizosaccharomyces
pombe) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 VAL A  63
VAL A  89
PHE A  36
ILE A 263
TYR A 120
 None
 1.14A 6mxtA-1ni3A:
0.0		 6mxtA-1ni3A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9v HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DQ(3) ALPHA
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		5 PHE A  58
HIS A  24
TYR A  22
ILE A  63
ASN A  62
 EDO  A 501 (-4.6A)
EDO  A 504 (-4.3A)
None
None
None
 1.29A 6mxtA-1s9vA:
0.0		 6mxtA-1s9vA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		5 VAL A 321
VAL A 324
ASP A  19
ASN A 292
ILE A 345
 None
 1.24A 6mxtA-1v5bA:
0.6		 6mxtA-1v5bA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		5 VAL A 269
VAL A 272
ASP A 259
ASN A  40
ILE A  47
 None
 1.40A 6mxtA-1w6fA:
0.0		 6mxtA-1w6fA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 VAL A 462
VAL A 477
ASP A 707
PHE A 269
TYR A 574
 None
 1.30A 6mxtA-1we5A:
0.0		 6mxtA-1we5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL

(Bos taurus) 		PF00889
(EF_TS) 		5 VAL B 151
VAL B 154
PHE B 147
ASN B 135
ILE B 203
 None
 1.37A 6mxtA-1xb2B:
undetectable		 6mxtA-1xb2B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE

(Bos taurus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 VAL A  69
VAL A  71
ASP A 129
ILE A 134
TYR A 111
 None
 1.41A 6mxtA-1zyeA:
undetectable		 6mxtA-1zyeA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 5 VAL A  80
VAL A  47
HIS A 150
ILE A  87
ASN A  88
 LAQ  A2001 ( 3.6A)
LAQ  A2001 ( 4.8A)
None
None
LAQ  A2001 ( 4.4A)
 1.38A 6mxtA-2e5aA:
undetectable		 6mxtA-2e5aA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ex5 DNA ENDONUCLEASE
I-CEUI

(Chlamydomonas
moewusii) 		PF00961
(LAGLIDADG_1) 		5 VAL A 107
PHE A 140
PHE A  89
TYR A 141
ILE A 138
 None
 1.44A 6mxtA-2ex5A:
0.9		 6mxtA-2ex5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 VAL A 330
VAL A 153
PHE A 314
HIS A 340
ILE A 168
 None
 1.43A 6mxtA-2f7vA:
undetectable		 6mxtA-2f7vA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		5 VAL A 154
ASP A 150
PHE A 152
PHE A 140
ILE A  90
 None
 1.17A 6mxtA-2w1jA:
undetectable		 6mxtA-2w1jA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 VAL A 443
HIS A 200
ILE A 483
ASN A 484
TYR A 486
 None
 1.42A 6mxtA-2wghA:
undetectable		 6mxtA-2wghA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 VAL A 352
PHE A 326
TYR A 205
ILE A 169
ASN A 174
 None
None
PGU  A 500 (-4.5A)
PGU  A 500 ( 4.3A)
PGU  A 500 (-3.5A)
 1.09A 6mxtA-2zyjA:
undetectable		 6mxtA-2zyjA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF03063
(Prismane)
PF02552
(CO_dh) 		5 VAL A 653
HIS A 734
TYR G  84
ILE G  85
ASN G  86
 None
ACY  A 818 (-3.8A)
ACY  A 818 ( 4.9A)
None
None
 1.49A 6mxtA-3cf4A:
undetectable		 6mxtA-3cf4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 VAL A 116
PHE A  55
PHE A 161
HIS A  84
TYR A  66
 None
 1.33A 6mxtA-3kf3A:
undetectable		 6mxtA-3kf3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khy PROPIONATE KINASE

(Francisella
tularensis) 		PF00871
(Acetate_kinase) 		5 VAL A 304
VAL A 300
PHE A 343
PHE A 319
ILE A 345
 None
 1.32A 6mxtA-3khyA:
undetectable		 6mxtA-3khyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf2 SHORT CHAIN
OXIDOREDUCTASE
Q9HYA2

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 VAL A  74
VAL A  68
PHE A 129
ILE A 141
ASN A  93
 None
NDP  A 301 (-3.6A)
None
None
None
 1.41A 6mxtA-3lf2A:
undetectable		 6mxtA-3lf2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		5 VAL A 121
ASP A 106
ASN A  73
ILE A 196
TYR A  88
 None
 1.22A 6mxtA-3lnbA:
undetectable		 6mxtA-3lnbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		5 VAL A 328
ASP A 312
PHE A 244
ILE A 209
TYR A  26
 None
 1.48A 6mxtA-3ob8A:
undetectable		 6mxtA-3ob8A:
17.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A 109
VAL A 114
ASP A 192
PHE A 193
PHE A 289
ASN A 293
TYR A 308
ILE A 309
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.8A)
ERC  A1201 (-4.2A)
ERC  A1201 (-4.4A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
None
ERC  A1201 (-4.1A)
ERC  A1201 (-3.0A)
None
 0.67A 6mxtA-3pdsA:
33.8		 6mxtA-3pdsA:
57.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A 109
VAL A 114
PHE A 289
ASN A 293
TYR A 308
 None
ERC  A1201 (-3.8A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
None
 1.39A 6mxtA-3pdsA:
33.8		 6mxtA-3pdsA:
57.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A 109
VAL A 114
VAL A 117
ASP A 192
PHE A 193
PHE A 289
ASN A 293
TYR A 308
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.2A)
ERC  A1201 (-4.4A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
None
ERC  A1201 (-3.0A)
None
 0.71A 6mxtA-3pdsA:
33.8		 6mxtA-3pdsA:
57.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 VAL A 355
VAL A 379
ASP A 441
PHE A 443
ILE A 436
 None
 1.27A 6mxtA-3wbkA:
undetectable		 6mxtA-3wbkA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		5 VAL A 199
VAL A 221
PHE A  48
HIS A   9
ILE A  24
 None
 1.23A 6mxtA-3wp5A:
undetectable		 6mxtA-3wp5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		5 VAL A 240
VAL A 237
PHE A  88
HIS A 115
ILE A  94
 None
 1.40A 6mxtA-4cp8A:
undetectable		 6mxtA-4cp8A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 PHE A 197
ASN A 201
HIS A 243
TYR A 247
ILE A 251
 None
 1.08A 6mxtA-4d8mA:
2.5		 6mxtA-4d8mA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 192
HIS A 268
TYR A 280
ILE A 281
ASN A 284
TYR A 288
 None
None
None
None
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 1.33A 6mxtA-4gbrA:
34.3		 6mxtA-4gbrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		7 TRP A 109
ASP A 192
PHE A 261
ASN A 265
TYR A 280
ILE A 281
TYR A 288
 None
None
CAU  A 500 (-4.2A)
CAU  A 500 (-3.4A)
None
None
CAU  A 500 (-4.6A)
 0.87A 6mxtA-4gbrA:
34.3		 6mxtA-4gbrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		7 TRP A 109
ASP A 192
PHE A 261
TYR A 280
ILE A 281
ASN A 284
TYR A 288
 None
None
CAU  A 500 (-4.2A)
None
None
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.79A 6mxtA-4gbrA:
34.3		 6mxtA-4gbrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		8 TRP A 109
VAL A 114
ASP A 192
PHE A 193
PHE A 261
TYR A 280
ASN A 284
TYR A 288
 None
CAU  A 500 (-3.5A)
None
CAU  A 500 (-4.5A)
CAU  A 500 (-4.2A)
None
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.74A 6mxtA-4gbrA:
34.3		 6mxtA-4gbrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		9 TRP A 109
VAL A 114
VAL A 117
ASP A 192
PHE A 193
PHE A 261
ASN A 265
TYR A 280
TYR A 288
 None
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
None
CAU  A 500 (-4.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.4A)
None
CAU  A 500 (-4.6A)
 0.78A 6mxtA-4gbrA:
34.3		 6mxtA-4gbrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 TRP A 131
VAL A 136
PHE A 340
ASN A 344
TYR A 370
 None
ERM  A2001 (-3.8A)
ERM  A2001 (-4.3A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
 0.59A 6mxtA-4ib4A:
28.4		 6mxtA-4ib4A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idi ORYZA SATIVA
RURM1-RELATED

(Plasmodium
yoelii) 		PF09138
(Urm1) 		5 VAL A  71
VAL A  25
ASP A  83
PHE A  42
ILE A  40
 None
 1.44A 6mxtA-4idiA:
undetectable		 6mxtA-4idiA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu2 CELL-WALL ANCHORING
PROTEIN

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		5 ASP A  14
ASN A 107
HIS A  72
TYR A  74
ASN A 109
 None
 1.33A 6mxtA-4iu2A:
undetectable		 6mxtA-4iu2A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix8 TYROSINE
AMINOTRANSFERASE

(Leishmania
infantum) 		PF00155
(Aminotran_1_2) 		5 VAL A 407
VAL A 409
PHE A 397
HIS A 446
ILE A 366
 None
 1.31A 6mxtA-4ix8A:
undetectable		 6mxtA-4ix8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Drosophila
melanogaster) 		PF01144
(CoA_trans) 		5 ASP A 380
PHE A 382
PHE A  58
ASN A  84
ASN A 341
 None
 1.34A 6mxtA-4kgbA:
undetectable		 6mxtA-4kgbA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 TRP A1109
ASP A1192
HIS A1296
TYR A1308
ILE A1309
 None
None
None
None
P0G  A1401 (-4.1A)
 1.06A 6mxtA-4ldeA:
48.9		 6mxtA-4ldeA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 TRP A1109
VAL A1114
VAL A1117
ASP A1192
PHE A1193
PHE A1289
ASN A1293
TYR A1308
ILE A1309
ASN A1312
TYR A1316
 None
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
None
P0G  A1401 (-3.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 (-3.0A)
None
P0G  A1401 (-4.1A)
P0G  A1401 (-2.9A)
None
 0.48A 6mxtA-4ldeA:
48.9		 6mxtA-4ldeA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 VAL A 177
VAL A 181
ASP A 105
ASN A 101
TYR A  67
 None
 1.26A 6mxtA-4m8uA:
undetectable		 6mxtA-4m8uA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5q TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 3

(Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 ASP A 156
PHE A 157
PHE A 193
ILE A 199
ASN A 197
 None
 1.07A 6mxtA-4n5qA:
undetectable		 6mxtA-4n5qA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per ANGIOGENIN

(Gallus gallus) 		PF00074
(RnaseA) 		5 VAL B 102
ASP B   7
PHE B   8
ASN B  57
TYR B   5
 None
 1.38A 6mxtA-4perB:
undetectable		 6mxtA-4perB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 VAL A 306
VAL A 314
ASP A 368
PHE A 358
TYR A 329
 None
 1.49A 6mxtA-4raeA:
undetectable		 6mxtA-4raeA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 5 TRP B 117
VAL B 122
ASP B 200
PHE B 201
PHE B 307
 P32  B 400 (-4.8A)
P32  B 400 (-3.5A)
None
P32  B 400 (-4.0A)
P32  B 400 (-4.9A)
 1.35A 6mxtA-5f8uB:
35.0		 6mxtA-5f8uB:
41.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 5 TRP B 117
VAL B 122
VAL B 125
ASP B 200
PHE B 201
 P32  B 400 (-4.8A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.7A)
None
P32  B 400 (-4.0A)
 0.90A 6mxtA-5f8uB:
35.0		 6mxtA-5f8uB:
41.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 8 TRP B 117
VAL B 122
VAL B 125
PHE B 201
PHE B 306
ASN B 310
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.7A)
P32  B 400 (-4.0A)
P32  B 400 (-4.1A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 0.75A 6mxtA-5f8uB:
35.0		 6mxtA-5f8uB:
41.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 5 VAL B 125
PHE B 306
ASN B 310
ASN B 329
TYR B 333
 P32  B 400 ( 4.7A)
P32  B 400 (-4.1A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 1.46A 6mxtA-5f8uB:
35.0		 6mxtA-5f8uB:
41.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 VAL A  69
VAL A  71
ASP A 129
ILE A 134
TYR A 111
 None
 1.35A 6mxtA-5jcgA:
undetectable		 6mxtA-5jcgA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 VAL A  68
VAL A  62
PHE A 124
ILE A 136
ASN A  87
 None
NAD  A 401 (-3.6A)
None
None
None
 1.47A 6mxtA-5jlaA:
undetectable		 6mxtA-5jlaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5d PTS SYSTEM, IIB
COMPONENT

(Streptococcus
pneumoniae) 		PF03830
(PTSIIB_sorb) 		5 VAL A 144
ASP A  10
PHE A   5
ILE A   8
ASN A 102
 None
 1.20A 6mxtA-5t5dA:
undetectable		 6mxtA-5t5dA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 VAL A 443
HIS A 200
ILE A 483
ASN A 484
TYR A 486
 None
 1.34A 6mxtA-5tusA:
0.0		 6mxtA-5tusA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wde KINESIN-LIKE PROTEIN
KIFC3

(Homo sapiens) 		PF00225
(Kinesin) 		5 VAL A 452
VAL A 745
ASP A 472
PHE A 471
ASN A 467
 None
None
UNX  A 909 ( 3.7A)
None
None
 1.42A 6mxtA-5wdeA:
undetectable		 6mxtA-5wdeA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6da0 GLUCOKINASE

(Naegleria
fowleri) 		no annotation 5 VAL A  53
VAL A  55
ASP A 143
PHE A 146
PHE A 136
 None
 1.46A 6mxtA-6da0A:
undetectable		 6mxtA-6da0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adv ADENOVIRUS
SINGLE-STRANDED
DNA-BINDING PROTEIN

(Human
mastadenovirus
C) 		PF02236
(Viral_DNA_bi)
PF03728
(Viral_DNA_Zn_bi) 		3 ASP A 475
SER A 435
SER A 439
 None
 0.76A 6mxtA-1advA:
0.0		 6mxtA-1advA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		3 ASP A  36
SER A 117
SER A 121
 None
 0.68A 6mxtA-1bgpA:
0.0		 6mxtA-1bgpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		3 ASP A 172
SER A 144
SER A 318
 None
 0.81A 6mxtA-1eg1A:
undetectable		 6mxtA-1eg1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flz URACIL-DNA
GLYCOSYLASE

(Escherichia
coli) 		PF03167
(UDG) 		3 ASP A  64
SER A 189
SER A  88
 None
None
URA  A 230 ( 4.9A)
 0.69A 6mxtA-1flzA:
0.0		 6mxtA-1flzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR 2

(Homo sapiens) 		PF00167
(FGF) 		3 ASP A  90
SER A  87
SER A  85
 None
 0.63A 6mxtA-1fq9A:
undetectable		 6mxtA-1fq9A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwu CYSTEINE-RICH DOMAIN
OF MANNOSE RECEPTOR

(Mus musculus) 		PF00652
(Ricin_B_lectin) 		3 ASP A  73
SER A  45
SER A  43
 None
 0.71A 6mxtA-1fwuA:
0.0		 6mxtA-1fwuA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		3 ASP A 178
SER A 201
SER A  14
 SO4  A1224 ( 4.9A)
SO4  A1224 (-3.1A)
SO4  A1224 ( 4.1A)
 0.75A 6mxtA-1h1yA:
undetectable		 6mxtA-1h1yA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6h NEUTROPHIL CYTOSOL
FACTOR 4

(Homo sapiens) 		PF00787
(PX) 		3 ASP A 126
SER A  79
SER A  77
 None
 0.83A 6mxtA-1h6hA:
0.0		 6mxtA-1h6hA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbj CD3 EPSILON AND
GAMMA ECTODOMAIN
FRAGMENT COMPLEX

(Mus musculus) 		PF16680
(Ig_4)
PF16681
(Ig_5) 		3 ASP A  88
SER A  11
SER A  13
 None
 0.80A 6mxtA-1jbjA:
0.0		 6mxtA-1jbjA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A  72
SER A  45
SER A  48
 None
SO4  A 501 (-3.1A)
None
 0.81A 6mxtA-1odfA:
undetectable		 6mxtA-1odfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASP A 205
SER A 178
SER A 181
 None
 0.81A 6mxtA-1rcqA:
undetectable		 6mxtA-1rcqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		3 ASP A 185
SER A 208
SER A  19
 None
SO4  A 231 (-3.2A)
SO4  A 231 ( 4.2A)
 0.69A 6mxtA-1rpxA:
undetectable		 6mxtA-1rpxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqj RIBULOSE-PHOSPHATE
3-EPIMERASE

(Synechocystis
sp.) 		PF00834
(Ribul_P_3_epim) 		3 ASP A 179
SER A 202
SER A  13
 None
 0.78A 6mxtA-1tqjA:
undetectable		 6mxtA-1tqjA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa4 PCZA361.16

(Amycolatopsis
orientalis) 		PF00908
(dTDP_sugar_isom) 		3 ASP A  84
SER A  54
SER A  52
 None
 0.83A 6mxtA-1wa4A:
undetectable		 6mxtA-1wa4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ASP A 135
SER A 262
SER A 266
 None
 0.83A 6mxtA-1x8vA:
undetectable		 6mxtA-1x8vA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ASP A 138
SER A 262
SER A 266
 None
 0.68A 6mxtA-1x8vA:
undetectable		 6mxtA-1x8vA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		3 ASP A 281
SER A 212
SER A 214
 None
 0.80A 6mxtA-2gzsA:
undetectable		 6mxtA-2gzsA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		3 ASP A 329
SER A  44
SER A  42
 None
SO4  A 383 ( 4.8A)
SO4  A 383 (-2.5A)
 0.80A 6mxtA-2hkeA:
undetectable		 6mxtA-2hkeA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		3 ASP A  42
SER A 296
SER A 294
 None
 0.78A 6mxtA-2i9kA:
undetectable		 6mxtA-2i9kA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		3 ASP A 213
SER A 183
SER A 173
 None
NHE  A   1 ( 4.3A)
None
 0.76A 6mxtA-2ichA:
undetectable		 6mxtA-2ichA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n04 DNAJ HOMOLOG
SUBFAMILY C MEMBER 5

(Homo sapiens) 		PF00226
(DnaJ) 		3 ASP A  55
SER A  15
SER A  12
 SEP  A  10 ( 3.7A)
None
SEP  A  10 ( 3.4A)
 0.65A 6mxtA-2n04A:
undetectable		 6mxtA-2n04A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n62 GELATION FACTOR,
SECRETION MONITOR
CHIMERA

(Escherichia
coli;
Dictyostelium
discoideum) 		PF00630
(Filamin) 		3 ASP L 165
SER L 120
SER L 123
 None
 0.82A 6mxtA-2n62L:
undetectable		 6mxtA-2n62L:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		3 ASP X 295
SER X 214
SER X 236
 None
 0.84A 6mxtA-2odtX:
undetectable		 6mxtA-2odtX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		3 ASP A 353
SER A 336
SER A 359
 None
 0.70A 6mxtA-2omvA:
undetectable		 6mxtA-2omvA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		3 ASP A 169
SER A 175
SER A 307
 None
 0.73A 6mxtA-2pg6A:
undetectable		 6mxtA-2pg6A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
halodurans) 		PF00268
(Ribonuc_red_sm) 		3 ASP A 139
SER A 126
SER A 130
 None
 0.60A 6mxtA-2rccA:
1.4		 6mxtA-2rccA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus) 		PF00423
(HN) 		3 ASP A 347
SER A 429
SER A 409
 None
 0.80A 6mxtA-2rkcA:
undetectable		 6mxtA-2rkcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		3 ASP A  14
SER A  74
SER A  77
 None
 0.54A 6mxtA-2v8jA:
undetectable		 6mxtA-2v8jA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		3 ASP A 749
SER A 772
SER A 770
 None
 0.79A 6mxtA-2w92A:
undetectable		 6mxtA-2w92A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 ASP A 168
SER A  25
SER A  19
 None
None
POP  A 500 ( 3.9A)
 0.83A 6mxtA-2x4dA:
undetectable		 6mxtA-2x4dA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9m PEROXISOME ASSEMBLY
PROTEIN 22

(Saccharomyces
cerevisiae) 		PF12827
(Peroxin-22) 		3 ASP B 167
SER B  69
SER B  67
 None
 0.69A 6mxtA-2y9mB:
undetectable		 6mxtA-2y9mB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN

(Barmah Forest
virus;
Barmah Forest
virus) 		PF01589
(Alpha_E1_glycop)
PF00943
(Alpha_E2_glycop) 		3 ASP C 171
SER C 238
SER B  57
 None
 0.75A 6mxtA-2yewC:
undetectable		 6mxtA-2yewC:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		3 ASP A 212
SER A 279
SER A 283
 None
 0.67A 6mxtA-3a1nA:
undetectable		 6mxtA-3a1nA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		3 ASP A  99
SER A 202
SER A 205
 None
 0.82A 6mxtA-3c9bA:
undetectable		 6mxtA-3c9bA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE

(Histophilus
somni) 		PF00834
(Ribul_P_3_epim) 		3 ASP A 192
SER A 217
SER A  21
 NI  A 238 (-2.6A)
None
None
 0.80A 6mxtA-3cu2A:
undetectable		 6mxtA-3cu2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		3 ASP A 749
SER A 772
SER A 770
 None
 0.68A 6mxtA-3gdbA:
undetectable		 6mxtA-3gdbA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gku PROBABLE RNA-BINDING
PROTEIN

([Clostridium]
symbiosum) 		PF01424
(R3H)
PF13083
(KH_4)
PF14804
(Jag_N) 		3 ASP A 193
SER A 204
SER A 164
 None
 0.67A 6mxtA-3gkuA:
undetectable		 6mxtA-3gkuA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 183
SER A 190
SER A  98
 None
 0.76A 6mxtA-3ip1A:
undetectable		 6mxtA-3ip1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx8 PUTATIVE LIPOPROTEIN

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		3 ASP A 102
SER A  50
SER A 125
 None
SO4  A   8 (-4.1A)
SO4  A   8 (-2.7A)
 0.66A 6mxtA-3jx8A:
undetectable		 6mxtA-3jx8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		3 ASP A 569
SER A 282
SER A 441
 None
 0.81A 6mxtA-3loyA:
undetectable		 6mxtA-3loyA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		3 ASP A 200
SER A  48
SER A  52
 None
 0.82A 6mxtA-3m8uA:
undetectable		 6mxtA-3m8uA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otm CARBONIC ANHYDRASE

(Methanosarcina
thermophila) 		PF00132
(Hexapep)
PF14602
(Hexapep_2) 		3 ASP A  61
SER A  39
SER A  57
 None
 0.83A 6mxtA-3otmA:
undetectable		 6mxtA-3otmA:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ASP A 113
SER A 203
SER A 207
 ERC  A1201 (-3.7A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
 0.48A 6mxtA-3pdsA:
34.0		 6mxtA-3pdsA:
57.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		3 ASP A  82
SER A  73
SER A  71
 None
 0.76A 6mxtA-3tc2A:
undetectable		 6mxtA-3tc2A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ASP A   4
SER A  90
SER A  94
 None
 0.66A 6mxtA-3txxA:
undetectable		 6mxtA-3txxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus) 		PF00141
(peroxidase) 		3 ASP A  31
SER A 110
SER A 114
 None
 0.69A 6mxtA-4a5gA:
undetectable		 6mxtA-4a5gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aez WD REPEAT-CONTAINING
PROTEIN SLP1

(Schizosaccharomyces
pombe) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 ASP A 388
SER A 417
SER A 407
 None
 0.74A 6mxtA-4aezA:
undetectable		 6mxtA-4aezA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b50 2H10 LLAMA VHH

(Lama glama) 		PF07686
(V-set) 		3 ASP A  53
SER A 100
SER A  99
 None
 0.74A 6mxtA-4b50A:
undetectable		 6mxtA-4b50A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ASP C  69
SER C 296
SER C 238
 None
 0.82A 6mxtA-4bujC:
undetectable		 6mxtA-4bujC:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0w FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Pseudomonas
putida) 		PF02525
(Flavodoxin_2) 		3 ASP A  41
SER A  17
SER A  15
 None
FMN  A1201 (-2.6A)
FMN  A1201 (-2.6A)
 0.83A 6mxtA-4c0wA:
undetectable		 6mxtA-4c0wA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuo BANYAN PEROXIDASE

(Ficus
benghalensis) 		PF00141
(peroxidase) 		3 ASP A  29
SER A 108
SER A 112
 None
 0.66A 6mxtA-4cuoA:
undetectable		 6mxtA-4cuoA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d86 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		3 ASP A1038
SER A1034
SER A1047
 None
ADP  A1202 (-2.6A)
None
 0.82A 6mxtA-4d86A:
undetectable		 6mxtA-4d86A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE

(Streptococcus
mutans) 		PF01063
(Aminotran_4) 		3 ASP A 142
SER A  46
SER A  44
 None
 0.68A 6mxtA-4dqnA:
undetectable		 6mxtA-4dqnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		3 ASP A  50
SER A 194
SER A 192
 None
 0.56A 6mxtA-4eiuA:
undetectable		 6mxtA-4eiuA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN ALPHA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		3 ASP A  95
SER A 134
SER A 138
 None
HEM  A 202 ( 4.3A)
None
 0.79A 6mxtA-4esaA:
undetectable		 6mxtA-4esaA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		3 ASP A  11
SER A  61
SER A  59
 None
NAP  A 401 (-4.4A)
NAP  A 401 (-2.7A)
 0.61A 6mxtA-4fc7A:
undetectable		 6mxtA-4fc7A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gou EHRGS-RHOGEF

(Entamoeba
histolytica) 		PF00615
(RGS)
PF00621
(RhoGEF) 		3 ASP A 232
SER A 210
SER A 213
 None
 0.81A 6mxtA-4gouA:
2.2		 6mxtA-4gouA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		3 ASP A  74
SER A 140
SER A 131
 None
 0.54A 6mxtA-4h7nA:
undetectable		 6mxtA-4h7nA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht4 NICKING ENZYME

(Staphylococcus
aureus) 		PF03389
(MobA_MobL) 		3 ASP A  64
SER A  23
SER A  27
 None
 0.57A 6mxtA-4ht4A:
undetectable		 6mxtA-4ht4A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		3 ASP A 122
SER A 314
SER A 324
 None
 0.68A 6mxtA-4kg7A:
undetectable		 6mxtA-4kg7A:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ASP A1113
SER A1203
SER A1207
 P0G  A1401 (-2.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
 0.57A 6mxtA-4ldeA:
48.9		 6mxtA-4ldeA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		3 ASP A 293
SER A 322
SER A 320
 None
 0.84A 6mxtA-4llfA:
undetectable		 6mxtA-4llfA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		3 ASP A 405
SER A 373
SER A 475
 None
 0.70A 6mxtA-4mt1A:
0.0		 6mxtA-4mt1A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		3 ASP A 118
SER A 105
SER A 109
 None
 0.81A 6mxtA-4n83A:
undetectable		 6mxtA-4n83A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		3 ASP A 489
SER A 441
SER A 437
 None
SO4  A 701 (-3.7A)
SO4  A 701 (-2.9A)
 0.83A 6mxtA-4nbqA:
undetectable		 6mxtA-4nbqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ASP A  52
SER A  98
SER A 102
 None
 0.82A 6mxtA-4p52A:
undetectable		 6mxtA-4p52A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio
vulnificus) 		PF05134
(T2SSL) 		3 ASP X  61
SER X 168
SER X 139
 None
 0.78A 6mxtA-4phtX:
undetectable		 6mxtA-4phtX:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ASP A  30
SER A  49
SER A  52
 None
 0.60A 6mxtA-4plhA:
undetectable		 6mxtA-4plhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		3 ASP A 516
SER A 222
SER A 226
 None
 0.73A 6mxtA-4q0cA:
undetectable		 6mxtA-4q0cA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		3 ASP 3 182
SER 3  85
SER 3  87
 None
 0.63A 6mxtA-4q4y3:
undetectable		 6mxtA-4q4y3:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		3 ASP A  12
SER A 124
SER A 117
 None
 0.75A 6mxtA-4qi6A:
undetectable		 6mxtA-4qi6A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38

(Homo sapiens) 		no annotation 3 ASP A 259
SER A 225
SER A 266
 None
 0.80A 6mxtA-4rxxA:
undetectable		 6mxtA-4rxxA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ASP A 937
SER A 808
SER A 811
 None
SO4  A1986 ( 3.7A)
None
 0.80A 6mxtA-4udbA:
undetectable		 6mxtA-4udbA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		3 ASP A 314
SER A 369
SER A 391
 None
 0.77A 6mxtA-4uqgA:
undetectable		 6mxtA-4uqgA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		3 ASP A 100
SER A 281
SER A 285
 None
 0.69A 6mxtA-4w7gA:
undetectable		 6mxtA-4w7gA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2h PUTATIVE MRNA EXPORT
PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 ASP A 419
SER A 427
SER A 430
 None
 0.82A 6mxtA-4x2hA:
undetectable		 6mxtA-4x2hA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aog CATIONIC PEROXIDASE
SPC4

(Sorghum bicolor) 		PF00141
(peroxidase) 		3 ASP A  68
SER A 149
SER A 153
 None
 0.74A 6mxtA-5aogA:
undetectable		 6mxtA-5aogA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		3 ASP A 459
SER A 448
SER A 451
 None
 0.66A 6mxtA-5cb2A:
undetectable		 6mxtA-5cb2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		3 ASP A 373
SER A 340
SER A 324
 HMC  A 606 ( 3.0A)
None
None
 0.65A 6mxtA-5csuA:
undetectable		 6mxtA-5csuA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		3 ASP A 232
SER A 465
SER A 393
 None
 0.78A 6mxtA-5cykA:
undetectable		 6mxtA-5cykA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 ASP A 578
SER A 550
SER A 543
 None
 0.75A 6mxtA-5dfaA:
undetectable		 6mxtA-5dfaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 249
SER A 211
SER A 231
 None
PO4  A 403 ( 4.2A)
None
 0.80A 6mxtA-5fi5A:
undetectable		 6mxtA-5fi5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A  97
SER A 293
SER A 254
 None
 0.79A 6mxtA-5fr8A:
undetectable		 6mxtA-5fr8A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 ASP A 377
SER A 617
SER A 620
 None
 0.67A 6mxtA-5gtmA:
3.0		 6mxtA-5gtmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 ASP a  91
SER a 523
SER a 527
 None
 0.67A 6mxtA-5gw5a:
undetectable		 6mxtA-5gw5a:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz1 FRUCTOSE-1,6-BISPHOS
PHATASE

(Physcomitrella
patens) 		PF00316
(FBPase) 		3 ASP A 106
SER A 167
SER A 187
 None
 0.67A 6mxtA-5iz1A:
undetectable		 6mxtA-5iz1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j56 VHH SINGLE CHAIN
ANTIBODY V1C7

(Vicugna pacos) 		PF07686
(V-set) 		3 ASP B 116
SER B 111
SER B 109
 None
 0.58A 6mxtA-5j56B:
undetectable		 6mxtA-5j56B:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ASP A 354
SER A 361
SER A 366
 None
 0.83A 6mxtA-5jo7A:
undetectable		 6mxtA-5jo7A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 3 ASP A 152
SER A  94
SER A  89
 ZN  A 808 ( 2.3A)
None
None
 0.69A 6mxtA-5m11A:
undetectable		 6mxtA-5m11A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 ASP A 185
SER A 162
SER A 160
 None
 0.78A 6mxtA-5mvhA:
undetectable		 6mxtA-5mvhA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 3 ASP A 875
SER A 884
SER A 882
 None
 0.75A 6mxtA-5n2gA:
undetectable		 6mxtA-5n2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		3 ASP J 334
SER J 457
SER J 460
 None
 0.83A 6mxtA-5nilJ:
3.0		 6mxtA-5nilJ:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ASP A4050
SER A1969
SER A1972
 None
 0.78A 6mxtA-5nugA:
undetectable		 6mxtA-5nugA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		3 ASP A 246
SER A 107
SER A 105
 None
 0.58A 6mxtA-5u47A:
undetectable		 6mxtA-5u47A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)

(Sorghum bicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 252
SER A 214
SER A 234
 None
NAP  A 405 (-2.6A)
NAP  A 405 ( 4.7A)
 0.65A 6mxtA-5vktA:
undetectable		 6mxtA-5vktA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 3 ASP A 261
SER A 301
SER A 535
 None
 0.82A 6mxtA-5w7dA:
undetectable		 6mxtA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi8 BETA-BARREL
ASSEMBLY-ENHANCING
PROTEASE

(Escherichia
coli) 		no annotation 3 ASP A 472
SER A 451
SER A 454
 None
 0.83A 6mxtA-5xi8A:
2.1		 6mxtA-5xi8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		3 ASP A1093
SER A 847
SER A 849
 None
 0.62A 6mxtA-5xvmA:
undetectable		 6mxtA-5xvmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 3 ASP A 404
SER A 335
SER A 365
 None
 0.45A 6mxtA-6bfnA:
1.3		 6mxtA-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbh HOPQ

(Helicobacter
pylori) 		no annotation 3 ASP C 236
SER C 276
SER C 279
 None
 0.82A 6mxtA-6gbhC:
3.3		 6mxtA-6gbhC:
undetectable