SIMILAR PATTERNS OF AMINO ACIDS FOR 6MVX_A_K4DA1304

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		4 THR A 277
LEU A 279
THR A  24
LEU A 127
 None
 1.22A 6mvxA-1a7jA:
undetectable
6mvxB-1a7jA:
undetectable
6mvxC-1a7jA:
undetectable		 6mvxA-1a7jA:
19.28
6mvxB-1a7jA:
19.28
6mvxC-1a7jA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhb BACTERIORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 MET A  68
THR A  67
LEU A  66
THR A  17
 None
 1.11A 6mvxA-1bhbA:
undetectable
6mvxB-1bhbA:
3.0
6mvxC-1bhbA:
2.8		 6mvxA-1bhbA:
15.07
6mvxB-1bhbA:
15.07
6mvxC-1bhbA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 THR A 578
LEU A 577
THR A 479
LEU A 572
 None
 0.92A 6mvxA-1d8cA:
2.5
6mvxB-1d8cA:
2.3
6mvxC-1d8cA:
2.4		 6mvxA-1d8cA:
18.37
6mvxB-1d8cA:
18.37
6mvxC-1d8cA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqn DNA PRIMASE

(Escherichia
coli) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2) 		4 MET A 187
LEU A 188
MET A 120
THR A 236
 None
 1.06A 6mvxA-1eqnA:
undetectable
6mvxB-1eqnA:
undetectable
6mvxC-1eqnA:
undetectable		 6mvxA-1eqnA:
20.62
6mvxB-1eqnA:
20.62
6mvxC-1eqnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 MET A 344
THR A 347
LEU A 346
THR A 398
 None
 1.23A 6mvxA-1gkrA:
undetectable
6mvxB-1gkrA:
undetectable
6mvxC-1gkrA:
undetectable		 6mvxA-1gkrA:
19.07
6mvxB-1gkrA:
19.07
6mvxC-1gkrA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 THR A 919
LEU A 920
THR A 852
LEU A 908
 None
 1.23A 6mvxA-1jx2A:
undetectable
6mvxB-1jx2A:
2.7
6mvxC-1jx2A:
1.1		 6mvxA-1jx2A:
13.84
6mvxB-1jx2A:
13.84
6mvxC-1jx2A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 THR A 335
LEU A 334
MET A 303
LEU A 293
 None
 1.21A 6mvxA-1q5nA:
undetectable
6mvxB-1q5nA:
1.4
6mvxC-1q5nA:
1.8		 6mvxA-1q5nA:
21.35
6mvxB-1q5nA:
21.35
6mvxC-1q5nA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3d ARSENATE REDUCTASE

(Escherichia
coli) 		PF03960
(ArsC) 		4 THR A  99
LEU A 101
THR A  27
LEU A 113
 None
 1.08A 6mvxA-1s3dA:
undetectable
6mvxB-1s3dA:
undetectable
6mvxC-1s3dA:
undetectable		 6mvxA-1s3dA:
21.51
6mvxB-1s3dA:
21.51
6mvxC-1s3dA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 THR A 286
LEU A 284
THR A 272
LEU A 268
 None
 1.23A 6mvxA-2dpnA:
undetectable
6mvxB-2dpnA:
undetectable
6mvxC-2dpnA:
undetectable		 6mvxA-2dpnA:
18.71
6mvxB-2dpnA:
18.71
6mvxC-2dpnA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		4 THR A  64
LEU A  63
MET A  43
LEU A 132
 None
 1.08A 6mvxA-2e67A:
undetectable
6mvxB-2e67A:
undetectable
6mvxC-2e67A:
undetectable		 6mvxA-2e67A:
20.34
6mvxB-2e67A:
20.34
6mvxC-2e67A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 MET A 475
LEU A 477
THR A 549
LEU A 511
 None
 1.22A 6mvxA-2e6kA:
undetectable
6mvxB-2e6kA:
undetectable
6mvxC-2e6kA:
undetectable		 6mvxA-2e6kA:
18.22
6mvxB-2e6kA:
18.22
6mvxC-2e6kA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea1 RIBONUCLEASE I

(Escherichia
coli) 		PF00445
(Ribonuclease_T2) 		4 MET A 116
THR A  53
MET A 148
LEU A 164
 None
 1.19A 6mvxA-2ea1A:
undetectable
6mvxB-2ea1A:
undetectable
6mvxC-2ea1A:
undetectable		 6mvxA-2ea1A:
18.31
6mvxB-2ea1A:
18.31
6mvxC-2ea1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		4 THR A 379
LEU A 380
THR A 226
LEU A 492
 None
 1.17A 6mvxA-2h1nA:
undetectable
6mvxB-2h1nA:
2.3
6mvxC-2h1nA:
3.7		 6mvxA-2h1nA:
20.21
6mvxB-2h1nA:
20.21
6mvxC-2h1nA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 399
LEU A 400
THR A 442
LEU A 407
 None
None
NH4  A1461 (-4.0A)
None
 1.18A 6mvxA-2iwzA:
undetectable
6mvxB-2iwzA:
undetectable
6mvxC-2iwzA:
undetectable		 6mvxA-2iwzA:
20.42
6mvxB-2iwzA:
20.42
6mvxC-2iwzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ko1 GTP
PYROPHOSPHOKINASE

(Chlorobaculum
tepidum) 		PF13291
(ACT_4) 		4 THR A  46
LEU A  38
THR A  74
LEU A  49
 None
 1.22A 6mvxA-2ko1A:
undetectable
6mvxB-2ko1A:
undetectable
6mvxC-2ko1A:
undetectable		 6mvxA-2ko1A:
14.04
6mvxB-2ko1A:
14.04
6mvxC-2ko1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 THR A  60
LEU A  59
THR A  17
LEU A  28
 None
 1.20A 6mvxA-2o1sA:
undetectable
6mvxB-2o1sA:
2.8
6mvxC-2o1sA:
2.9		 6mvxA-2o1sA:
18.59
6mvxB-2o1sA:
18.59
6mvxC-2o1sA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		4 THR A 111
LEU A 112
THR A  60
LEU A 105
 None
 1.13A 6mvxA-2pw6A:
undetectable
6mvxB-2pw6A:
undetectable
6mvxC-2pw6A:
undetectable		 6mvxA-2pw6A:
21.24
6mvxB-2pw6A:
21.24
6mvxC-2pw6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 THR G 266
LEU G 265
THR G 276
LEU G 285
 None
FAD  G 484 (-4.7A)
None
None
 1.03A 6mvxA-2vdcG:
undetectable
6mvxB-2vdcG:
undetectable
6mvxC-2vdcG:
undetectable		 6mvxA-2vdcG:
20.54
6mvxB-2vdcG:
20.54
6mvxC-2vdcG:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		4 THR C 102
LEU C 101
THR C  50
LEU C  96
 None
 1.00A 6mvxA-2vpwC:
3.7
6mvxB-2vpwC:
3.0
6mvxC-2vpwC:
3.3		 6mvxA-2vpwC:
20.32
6mvxB-2vpwC:
20.32
6mvxC-2vpwC:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		4 THR A 144
LEU A 146
THR A 132
LEU A 204
 GOL  A1216 (-4.3A)
None
None
None
 1.14A 6mvxA-2w1jA:
undetectable
6mvxB-2w1jA:
undetectable
6mvxC-2w1jA:
undetectable		 6mvxA-2w1jA:
19.31
6mvxB-2w1jA:
19.31
6mvxC-2w1jA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		4 THR A 351
LEU A 354
THR A 333
LEU A 327
 None
 1.10A 6mvxA-2w9mA:
undetectable
6mvxB-2w9mA:
undetectable
6mvxC-2w9mA:
undetectable		 6mvxA-2w9mA:
17.87
6mvxB-2w9mA:
17.87
6mvxC-2w9mA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 THR A 152
LEU A 155
THR A 144
LEU A  19
 None
 1.23A 6mvxA-2x3eA:
undetectable
6mvxB-2x3eA:
undetectable
6mvxC-2x3eA:
undetectable		 6mvxA-2x3eA:
19.78
6mvxB-2x3eA:
19.78
6mvxC-2x3eA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7l FAB HEAVY CHAIN

(unidentified) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR A  21
LEU A  20
THR A  73
LEU A   4
 None
 1.22A 6mvxA-2x7lA:
undetectable
6mvxB-2x7lA:
undetectable
6mvxC-2x7lA:
undetectable		 6mvxA-2x7lA:
19.58
6mvxB-2x7lA:
19.58
6mvxC-2x7lA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 MET A 641
LEU A 640
THR A 668
LEU A 530
 None
 1.16A 6mvxA-2xt6A:
undetectable
6mvxB-2xt6A:
2.7
6mvxC-2xt6A:
2.8		 6mvxA-2xt6A:
14.12
6mvxB-2xt6A:
14.12
6mvxC-2xt6A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 MET A 111
LEU A  79
MET A 103
THR A  38
 None
 0.97A 6mvxA-2z1aA:
undetectable
6mvxB-2z1aA:
undetectable
6mvxC-2z1aA:
undetectable		 6mvxA-2z1aA:
18.23
6mvxB-2z1aA:
18.23
6mvxC-2z1aA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 4 THR A 379
LEU A 380
THR A 226
LEU A 492
 None
 1.14A 6mvxA-3ahmA:
undetectable
6mvxB-3ahmA:
1.6
6mvxC-3ahmA:
3.6		 6mvxA-3ahmA:
19.33
6mvxB-3ahmA:
19.33
6mvxC-3ahmA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo sapiens) 		PF02373
(JmjC) 		4 THR A1245
LEU A1244
MET A1291
LEU A1119
 None
None
EDO  A1512 ( 3.2A)
None
 0.86A 6mvxA-3avsA:
undetectable
6mvxB-3avsA:
undetectable
6mvxC-3avsA:
undetectable		 6mvxA-3avsA:
20.63
6mvxB-3avsA:
20.63
6mvxC-3avsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		4 MET A 487
THR A 488
LEU A 489
LEU A 369
 VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
None
None
 1.17A 6mvxA-3c6gA:
undetectable
6mvxB-3c6gA:
undetectable
6mvxC-3c6gA:
undetectable		 6mvxA-3c6gA:
21.14
6mvxB-3c6gA:
21.14
6mvxC-3c6gA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 THR A 154
LEU A  46
THR A 147
LEU A 613
 None
 1.17A 6mvxA-3cf4A:
undetectable
6mvxB-3cf4A:
3.1
6mvxC-3cf4A:
3.2		 6mvxA-3cf4A:
16.13
6mvxB-3cf4A:
16.13
6mvxC-3cf4A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edl KINESIN13 MOTOR
DOMAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 THR D 171
MET D 190
THR D 142
LEU D 307
 None
 1.13A 6mvxA-3edlD:
undetectable
6mvxB-3edlD:
undetectable
6mvxC-3edlD:
undetectable		 6mvxA-3edlD:
19.94
6mvxB-3edlD:
19.94
6mvxC-3edlD:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g13 PUTATIVE CONJUGATIVE
TRANSPOSON
RECOMBINASE

(Clostridioides
difficile) 		PF00239
(Resolvase) 		4 THR A  94
LEU A  95
THR A  59
LEU A 101
 None
 1.18A 6mvxA-3g13A:
undetectable
6mvxB-3g13A:
undetectable
6mvxC-3g13A:
undetectable		 6mvxA-3g13A:
17.61
6mvxB-3g13A:
17.61
6mvxC-3g13A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		4 MET A 125
THR A  97
LEU A  96
THR A  72
 None
 1.09A 6mvxA-3gboA:
undetectable
6mvxB-3gboA:
undetectable
6mvxC-3gboA:
undetectable		 6mvxA-3gboA:
21.81
6mvxB-3gboA:
21.81
6mvxC-3gboA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		4 THR A 263
LEU A 262
THR A 318
LEU A 257
 None
 1.11A 6mvxA-3hd6A:
undetectable
6mvxB-3hd6A:
1.9
6mvxC-3hd6A:
2.2		 6mvxA-3hd6A:
20.49
6mvxB-3hd6A:
20.49
6mvxC-3hd6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus;
Thermus
thermophilus;
Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
PF00346
(Complex1_49kDa) 		4 THR 3 111
MET 4 321
THR 3 134
LEU 1 393
 None
SF4  3 784 ( 4.8A)
None
None
 0.99A 6mvxA-3i9v3:
undetectable
6mvxB-3i9v3:
undetectable
6mvxC-3i9v3:
undetectable		 6mvxA-3i9v3:
14.25
6mvxB-3i9v3:
14.25
6mvxC-3i9v3:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1u BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 LEU A 201
MET A  18
THR A 137
LEU A 225
 None
 1.15A 6mvxA-3k1uA:
undetectable
6mvxB-3k1uA:
undetectable
6mvxC-3k1uA:
undetectable		 6mvxA-3k1uA:
23.51
6mvxB-3k1uA:
23.51
6mvxC-3k1uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9h PF-32 PROTEIN

(Borreliella
burgdorferi) 		PF13614
(AAA_31) 		4 LEU A  38
MET A  42
THR A  10
LEU A  31
 None
 0.99A 6mvxA-3k9hA:
undetectable
6mvxB-3k9hA:
undetectable
6mvxC-3k9hA:
undetectable		 6mvxA-3k9hA:
22.44
6mvxB-3k9hA:
22.44
6mvxC-3k9hA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 MET A  82
THR A  84
LEU A  86
LEU A  20
 None
 1.16A 6mvxA-3mmtA:
undetectable
6mvxB-3mmtA:
undetectable
6mvxC-3mmtA:
undetectable		 6mvxA-3mmtA:
21.45
6mvxB-3mmtA:
21.45
6mvxC-3mmtA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 THR A 935
LEU A 936
THR A 946
LEU A 580
 None
 1.13A 6mvxA-3nafA:
undetectable
6mvxB-3nafA:
undetectable
6mvxC-3nafA:
undetectable		 6mvxA-3nafA:
16.20
6mvxB-3nafA:
16.20
6mvxC-3nafA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 MET A 289
THR A 290
LEU A 254
THR A 230
 None
 1.21A 6mvxA-3olzA:
undetectable
6mvxB-3olzA:
undetectable
6mvxC-3olzA:
undetectable		 6mvxA-3olzA:
21.95
6mvxB-3olzA:
21.95
6mvxC-3olzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 THR B 783
LEU B 787
THR B 717
LEU B 842
 None
 1.23A 6mvxA-3p8cB:
undetectable
6mvxB-3p8cB:
2.9
6mvxC-3p8cB:
2.6		 6mvxA-3p8cB:
13.66
6mvxB-3p8cB:
13.66
6mvxC-3p8cB:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 THR M  94
LEU M  93
THR M  39
LEU M  88
 None
 0.97A 6mvxA-3rkoM:
1.6
6mvxB-3rkoM:
4.2
6mvxC-3rkoM:
4.0		 6mvxA-3rkoM:
21.40
6mvxB-3rkoM:
21.40
6mvxC-3rkoM:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 MET A 806
THR A 760
LEU A 759
LEU A 754
 None
 1.14A 6mvxA-3s9vA:
undetectable
6mvxB-3s9vA:
3.7
6mvxC-3s9vA:
2.8		 6mvxA-3s9vA:
17.35
6mvxB-3s9vA:
17.35
6mvxC-3s9vA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		4 THR A 581
LEU A 584
THR A 311
LEU A 487
 None
 0.96A 6mvxA-3tbfA:
0.9
6mvxB-3tbfA:
undetectable
6mvxC-3tbfA:
undetectable		 6mvxA-3tbfA:
21.45
6mvxB-3tbfA:
21.45
6mvxC-3tbfA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4
H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2)
PF04410
(Gar1) 		4 THR A 147
LEU A 146
MET A 196
LEU C  85
 None
 1.21A 6mvxA-3uaiA:
undetectable
6mvxB-3uaiA:
undetectable
6mvxC-3uaiA:
undetectable		 6mvxA-3uaiA:
22.87
6mvxB-3uaiA:
22.87
6mvxC-3uaiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 THR A 398
LEU A 399
THR A 342
LEU A 379
 None
 0.90A 6mvxA-3vlaA:
undetectable
6mvxB-3vlaA:
undetectable
6mvxC-3vlaA:
undetectable		 6mvxA-3vlaA:
20.95
6mvxB-3vlaA:
20.95
6mvxC-3vlaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 MET A 361
THR A 368
LEU A 369
THR A 409
 None
 1.00A 6mvxA-3welA:
undetectable
6mvxB-3welA:
undetectable
6mvxC-3welA:
undetectable		 6mvxA-3welA:
16.87
6mvxB-3welA:
16.87
6mvxC-3welA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 MET A 641
LEU A 640
THR A 668
LEU A 530
 None
 1.15A 6mvxA-3zhrA:
1.9
6mvxB-3zhrA:
2.4
6mvxC-3zhrA:
2.3		 6mvxA-3zhrA:
16.02
6mvxB-3zhrA:
16.02
6mvxC-3zhrA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae) 		PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T) 		4 MET A  14
THR A  89
LEU A  88
THR A  84
 None
 1.11A 6mvxA-4ae0A:
undetectable
6mvxB-4ae0A:
undetectable
6mvxC-4ae0A:
undetectable		 6mvxA-4ae0A:
19.60
6mvxB-4ae0A:
19.60
6mvxC-4ae0A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b62 TSSL1

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		4 THR A 442
LEU A 370
THR A 333
LEU A 403
 EDO  A1447 (-2.9A)
None
None
None
 1.21A 6mvxA-4b62A:
undetectable
6mvxB-4b62A:
undetectable
6mvxC-4b62A:
undetectable		 6mvxA-4b62A:
20.00
6mvxB-4b62A:
20.00
6mvxC-4b62A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doh INTERLEUKIN-20

(Homo sapiens) 		PF00726
(IL10) 		4 THR A 118
LEU A 117
THR A  37
LEU A 112
 None
 1.20A 6mvxA-4dohA:
2.8
6mvxB-4dohA:
2.1
6mvxC-4dohA:
2.1		 6mvxA-4dohA:
20.49
6mvxB-4dohA:
20.49
6mvxC-4dohA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doi CHALCONE--FLAVONONE
ISOMERASE 1

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		4 THR A  81
LEU A  85
MET A 225
LEU A 214
 None
 1.22A 6mvxA-4doiA:
undetectable
6mvxB-4doiA:
undetectable
6mvxC-4doiA:
undetectable		 6mvxA-4doiA:
21.93
6mvxB-4doiA:
21.93
6mvxC-4doiA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e74 PLEXIN-A4

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 LEU A1584
MET A1563
THR A1571
LEU A1581
 None
None
UNX  A1704 ( 4.4A)
None
 1.06A 6mvxA-4e74A:
undetectable
6mvxB-4e74A:
undetectable
6mvxC-4e74A:
undetectable		 6mvxA-4e74A:
14.54
6mvxB-4e74A:
14.54
6mvxC-4e74A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ge0 UNCHARACTERIZED
PROTEIN C22E12.03C

(Schizosaccharomyces
pombe) 		PF01965
(DJ-1_PfpI) 		4 THR A 163
LEU A 166
THR A 128
LEU A 171
 None
 1.09A 6mvxA-4ge0A:
undetectable
6mvxB-4ge0A:
undetectable
6mvxC-4ge0A:
undetectable		 6mvxA-4ge0A:
23.08
6mvxB-4ge0A:
23.08
6mvxC-4ge0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 THR N  73
LEU N  76
THR N 213
LEU N 299
 None
 1.22A 6mvxA-4heaN:
4.4
6mvxB-4heaN:
undetectable
6mvxC-4heaN:
undetectable		 6mvxA-4heaN:
19.54
6mvxB-4heaN:
19.54
6mvxC-4heaN:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4y TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		4 THR A 148
LEU A 149
MET A 129
LEU A 265
 None
 1.12A 6mvxA-4l4yA:
undetectable
6mvxB-4l4yA:
undetectable
6mvxC-4l4yA:
undetectable		 6mvxA-4l4yA:
21.17
6mvxB-4l4yA:
21.17
6mvxC-4l4yA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5f LIGHT CHAIN OF E106
ANTIBODY (KAPPA)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR L  97
LEU L  96
MET L  33
THR L  25
 None
 1.19A 6mvxA-4l5fL:
undetectable
6mvxB-4l5fL:
undetectable
6mvxC-4l5fL:
undetectable		 6mvxA-4l5fL:
18.79
6mvxB-4l5fL:
18.79
6mvxC-4l5fL:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		4 THR A 148
LEU A 149
MET A 129
LEU A 265
 None
 1.16A 6mvxA-4l5iA:
undetectable
6mvxB-4l5iA:
undetectable
6mvxC-4l5iA:
undetectable		 6mvxA-4l5iA:
23.21
6mvxB-4l5iA:
23.21
6mvxC-4l5iA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mvu ION TRANSPORT
PROTEIN

(Arcobacter
butzleri) 		PF00520
(Ion_trans) 		4 MET A1174
THR A1175
LEU A1176
MET A1209
 PX4  A1304 ( 4.8A)
None
None
PX4  A1304 ( 4.6A)
 0.71A 6mvxA-4mvuA:
22.3
6mvxB-4mvuA:
22.8
6mvxC-4mvuA:
22.5		 6mvxA-4mvuA:
99.58
6mvxB-4mvuA:
99.58
6mvxC-4mvuA:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		4 LEU A  52
MET A 223
THR A  37
LEU A  33
 None
 1.06A 6mvxA-4narA:
undetectable
6mvxB-4narA:
undetectable
6mvxC-4narA:
undetectable		 6mvxA-4narA:
20.32
6mvxB-4narA:
20.32
6mvxC-4narA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pot VP1

(Human
polyomavirus 9) 		PF00718
(Polyoma_coat) 		4 THR A 145
LEU A 131
THR A 275
LEU A 128
 None
 1.15A 6mvxA-4potA:
undetectable
6mvxB-4potA:
undetectable
6mvxC-4potA:
undetectable		 6mvxA-4potA:
21.41
6mvxB-4potA:
21.41
6mvxC-4potA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q66 PROTEIN BCH1

(Saccharomyces
cerevisiae) 		no annotation 4 THR K 485
LEU K 484
MET K 400
LEU K 479
 None
 1.20A 6mvxA-4q66K:
undetectable
6mvxB-4q66K:
2.7
6mvxC-4q66K:
2.6		 6mvxA-4q66K:
17.32
6mvxB-4q66K:
17.32
6mvxC-4q66K:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qds NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 THR A 337
LEU A 336
MET A 440
THR A 340
 None
 1.04A 6mvxA-4qdsA:
undetectable
6mvxB-4qdsA:
undetectable
6mvxC-4qdsA:
undetectable		 6mvxA-4qdsA:
19.40
6mvxB-4qdsA:
19.40
6mvxC-4qdsA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		4 THR A 386
LEU A 385
THR A 432
LEU A 380
 None
 1.23A 6mvxA-4r0cA:
undetectable
6mvxB-4r0cA:
undetectable
6mvxC-4r0cA:
2.0		 6mvxA-4r0cA:
18.40
6mvxB-4r0cA:
18.40
6mvxC-4r0cA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 THR A 193
LEU A 194
THR A 136
LEU A 199
 None
 1.14A 6mvxA-4ru0A:
undetectable
6mvxB-4ru0A:
undetectable
6mvxC-4ru0A:
undetectable		 6mvxA-4ru0A:
20.89
6mvxB-4ru0A:
20.89
6mvxC-4ru0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uq9 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF17189
(Glyco_hydro_30C) 		4 THR A  34
LEU A  43
THR A  28
LEU A  48
 None
 1.22A 6mvxA-4uq9A:
undetectable
6mvxB-4uq9A:
undetectable
6mvxC-4uq9A:
undetectable		 6mvxA-4uq9A:
22.86
6mvxB-4uq9A:
22.86
6mvxC-4uq9A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		4 THR A 767
LEU A 768
THR A 701
LEU A 740
 None
 1.17A 6mvxA-4uvkA:
undetectable
6mvxB-4uvkA:
4.7
6mvxC-4uvkA:
5.4		 6mvxA-4uvkA:
15.32
6mvxB-4uvkA:
15.32
6mvxC-4uvkA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 THR A 770
LEU A 751
MET A 801
LEU A 744
 None
 1.18A 6mvxA-4wz9A:
undetectable
6mvxB-4wz9A:
undetectable
6mvxC-4wz9A:
undetectable		 6mvxA-4wz9A:
15.17
6mvxB-4wz9A:
15.17
6mvxC-4wz9A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgo ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1B

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 MET A 119
THR A 118
LEU A 141
MET A  97
 None
 1.07A 6mvxA-4xgoA:
undetectable
6mvxB-4xgoA:
undetectable
6mvxC-4xgoA:
undetectable		 6mvxA-4xgoA:
20.63
6mvxB-4xgoA:
20.63
6mvxC-4xgoA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypl LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA)
PF05362
(Lon_C) 		4 MET A 683
THR A 682
MET A 633
LEU A 735
 None
None
4KZ  A 801 (-3.6A)
None
 1.21A 6mvxA-4yplA:
undetectable
6mvxB-4yplA:
undetectable
6mvxC-4yplA:
undetectable		 6mvxA-4yplA:
20.00
6mvxB-4yplA:
20.00
6mvxC-4yplA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		4 THR A 433
LEU A 432
THR A 436
LEU A 417
 None
 1.06A 6mvxA-4yr1A:
undetectable
6mvxB-4yr1A:
undetectable
6mvxC-4yr1A:
undetectable		 6mvxA-4yr1A:
19.83
6mvxB-4yr1A:
19.83
6mvxC-4yr1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 THR A 851
LEU A 852
THR A 527
LEU A 856
 None
 1.21A 6mvxA-4zg7A:
undetectable
6mvxB-4zg7A:
undetectable
6mvxC-4zg7A:
undetectable		 6mvxA-4zg7A:
16.23
6mvxB-4zg7A:
16.23
6mvxC-4zg7A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 4 THR A 305
LEU A 308
MET A  87
LEU A 239
 None
 1.07A 6mvxA-5ah1A:
undetectable
6mvxB-5ah1A:
undetectable
6mvxC-5ah1A:
undetectable		 6mvxA-5ah1A:
20.75
6mvxB-5ah1A:
20.75
6mvxC-5ah1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L3

(Dictyostelium
discoideum) 		PF00297
(Ribosomal_L3) 		4 THR A 345
LEU A 346
THR A 167
LEU A  43
 None
 1.10A 6mvxA-5an9A:
undetectable
6mvxB-5an9A:
undetectable
6mvxC-5an9A:
undetectable		 6mvxA-5an9A:
21.45
6mvxB-5an9A:
21.45
6mvxC-5an9A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 THR A 656
LEU A 657
THR A 631
LEU A1066
 None
 1.20A 6mvxA-5cjuA:
undetectable
6mvxB-5cjuA:
undetectable
6mvxC-5cjuA:
undetectable		 6mvxA-5cjuA:
14.12
6mvxB-5cjuA:
14.12
6mvxC-5cjuA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coz UNCHARACTERIZED
PROTEIN

([Eubacterium]
rectale) 		no annotation 4 THR A 234
LEU A 215
THR A 152
LEU A 221
 None
 1.22A 6mvxA-5cozA:
undetectable
6mvxB-5cozA:
undetectable
6mvxC-5cozA:
undetectable		 6mvxA-5cozA:
18.36
6mvxB-5cozA:
18.36
6mvxC-5cozA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5de0 DEFERROCHELATASE

(Vibrio cholerae) 		PF04261
(Dyp_perox) 		4 MET A 139
THR A 140
THR A 278
LEU A 186
 None
HEM  A 401 ( 4.6A)
HEM  A 401 (-3.5A)
None
 1.15A 6mvxA-5de0A:
undetectable
6mvxB-5de0A:
undetectable
6mvxC-5de0A:
undetectable		 6mvxA-5de0A:
20.19
6mvxB-5de0A:
20.19
6mvxC-5de0A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		5 THR A  10
LEU A  44
MET A  17
THR A 100
LEU A  61
 UD1  A 502 ( 4.2A)
None
None
None
None
 1.36A 6mvxA-5dldA:
undetectable
6mvxB-5dldA:
undetectable
6mvxC-5dldA:
undetectable		 6mvxA-5dldA:
20.49
6mvxB-5dldA:
20.49
6mvxC-5dldA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7s LON PROTEASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C) 		4 MET A 683
THR A 682
MET A 633
LEU A 735
 None
 1.11A 6mvxA-5e7sA:
undetectable
6mvxB-5e7sA:
undetectable
6mvxC-5e7sA:
undetectable		 6mvxA-5e7sA:
23.69
6mvxB-5e7sA:
23.69
6mvxC-5e7sA:
23.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA

(Homo sapiens;
Arcobacter
butzleri) 		PF00520
(Ion_trans) 		4 MET A1677
THR A1678
LEU A1679
MET A1712
 PX4  A1806 ( 4.3A)
PX4  A1806 ( 4.8A)
None
PX4  A1806 ( 4.6A)
 0.66A 6mvxA-5ek0A:
18.7
6mvxB-5ek0A:
18.8
6mvxC-5ek0A:
18.9		 6mvxA-5ek0A:
82.39
6mvxB-5ek0A:
82.39
6mvxC-5ek0A:
82.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 MET A 159
THR A 160
LEU A 161
LEU A 201
 None
 1.18A 6mvxA-5f15A:
undetectable
6mvxB-5f15A:
3.0
6mvxC-5f15A:
2.9		 6mvxA-5f15A:
18.29
6mvxB-5f15A:
18.29
6mvxC-5f15A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fie CELL SURFACE PROTEIN
SPAA

(Lactobacillus
rhamnosus) 		no annotation 4 THR A 108
LEU A 115
THR A 140
LEU A  73
 None
 1.21A 6mvxA-5fieA:
undetectable
6mvxB-5fieA:
undetectable
6mvxC-5fieA:
undetectable		 6mvxA-5fieA:
18.47
6mvxB-5fieA:
18.47
6mvxC-5fieA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxv HISTONE DEMETHYLASE
UTY

(Homo sapiens) 		PF02373
(JmjC) 		4 THR A1192
LEU A1191
MET A1238
LEU A1066
 None
 1.10A 6mvxA-5fxvA:
undetectable
6mvxB-5fxvA:
2.0
6mvxC-5fxvA:
undetectable		 6mvxA-5fxvA:
21.46
6mvxB-5fxvA:
21.46
6mvxC-5fxvA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		4 MET A 405
LEU A 406
THR A 397
LEU A   8
 None
 1.21A 6mvxA-5ir6A:
undetectable
6mvxB-5ir6A:
2.9
6mvxC-5ir6A:
2.3		 6mvxA-5ir6A:
22.59
6mvxB-5ir6A:
22.59
6mvxC-5ir6A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgy ALDOSE REDUCTASE,
AKR4C13

(Zea mays) 		PF00248
(Aldo_ket_red) 		4 THR A  85
LEU A 114
THR A  30
LEU A  82
 None
 1.04A 6mvxA-5jgyA:
undetectable
6mvxB-5jgyA:
undetectable
6mvxC-5jgyA:
undetectable		 6mvxA-5jgyA:
19.77
6mvxB-5jgyA:
19.77
6mvxC-5jgyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n40 PUTATIVE INVASIN

(Yersinia
pseudotuberculosis) 		PF05689
(DUF823)
PF09134
(Invasin_D3) 		4 MET A2751
THR A2750
THR A2663
LEU A2680
 None
 1.14A 6mvxA-5n40A:
undetectable
6mvxB-5n40A:
undetectable
6mvxC-5n40A:
undetectable		 6mvxA-5n40A:
21.41
6mvxB-5n40A:
21.41
6mvxC-5n40A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npx POLYPROTEIN
POLYPROTEIN

(Broad bean
stain virus;
Broad bean
stain virus) 		no annotation
no annotation 		4 THR L 233
LEU L 237
THR S 438
LEU L 185
 None
 1.22A 6mvxA-5npxL:
undetectable
6mvxB-5npxL:
undetectable
6mvxC-5npxL:
undetectable		 6mvxA-5npxL:
undetectable
6mvxB-5npxL:
undetectable
6mvxC-5npxL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr1 FTSZ-BINDING PROTEIN
FZLA

(Caulobacter
vibrioides) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 THR A   6
LEU A   7
THR A  59
LEU A  28
 None
 1.20A 6mvxA-5nr1A:
undetectable
6mvxB-5nr1A:
2.4
6mvxC-5nr1A:
2.5		 6mvxA-5nr1A:
18.33
6mvxB-5nr1A:
18.33
6mvxC-5nr1A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 THR A2326
LEU A2324
THR A2281
LEU A2319
 None
 1.18A 6mvxA-5nugA:
undetectable
6mvxB-5nugA:
undetectable
6mvxC-5nugA:
undetectable		 6mvxA-5nugA:
4.89
6mvxB-5nugA:
4.89
6mvxC-5nugA:
4.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 THR A 525
MET A  46
THR A 564
LEU A 517
 None
 1.21A 6mvxA-5ubkA:
undetectable
6mvxB-5ubkA:
undetectable
6mvxC-5ubkA:
undetectable		 6mvxA-5ubkA:
17.16
6mvxB-5ubkA:
17.16
6mvxC-5ubkA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 THR A1309
LEU A1308
THR A1289
LEU A1274
 None
 1.19A 6mvxA-5vkqA:
7.2
6mvxB-5vkqA:
5.3
6mvxC-5vkqA:
7.7		 6mvxA-5vkqA:
9.77
6mvxB-5vkqA:
9.77
6mvxC-5vkqA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5) 		PF01801
(Cytomega_gL) 		4 THR B 108
LEU B 111
THR B 130
LEU B 122
 None
 1.19A 6mvxA-5vocB:
undetectable
6mvxB-5vocB:
undetectable
6mvxC-5vocB:
undetectable		 6mvxA-5vocB:
19.68
6mvxB-5vocB:
19.68
6mvxC-5vocB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Campylobacter
jejuni) 		no annotation 4 THR A 309
LEU A 312
THR A 327
LEU A 291
 None
 1.15A 6mvxA-5x2gA:
undetectable
6mvxB-5x2gA:
3.0
6mvxC-5x2gA:
3.0		 6mvxA-5x2gA:
14.85
6mvxB-5x2gA:
14.85
6mvxC-5x2gA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 THR A 172
LEU A 171
THR A 236
LEU A 166
 None
 1.21A 6mvxA-5xjjA:
undetectable
6mvxB-5xjjA:
2.1
6mvxC-5xjjA:
2.1		 6mvxA-5xjjA:
23.39
6mvxB-5xjjA:
23.39
6mvxC-5xjjA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 THR A  71
LEU A  70
THR A 102
LEU A 149
 None
 1.17A 6mvxA-5yfbA:
undetectable
6mvxB-5yfbA:
undetectable
6mvxC-5yfbA:
undetectable		 6mvxA-5yfbA:
undetectable
6mvxB-5yfbA:
undetectable
6mvxC-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yua ION TRANSPORT
PROTEIN

(Arcobacter
butzleri) 		no annotation 4 MET A1174
THR A1175
LEU A1176
MET A1209
 LMT  A1302 (-3.1A)
LMT  A1302 (-4.9A)
LMT  A1302 (-4.4A)
LMT  A1302 (-4.3A)
 0.41A 6mvxA-5yuaA:
21.9
6mvxB-5yuaA:
19.6
6mvxC-5yuaA:
18.2		 6mvxA-5yuaA:
undetectable
6mvxB-5yuaA:
undetectable
6mvxC-5yuaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh5 LYSINE--TRNA LIGASE

(Plasmodium
falciparum) 		no annotation 4 MET A 562
THR A 561
LEU A 564
LEU A 261
 None
 1.12A 6mvxA-5zh5A:
undetectable
6mvxB-5zh5A:
undetectable
6mvxC-5zh5A:
undetectable		 6mvxA-5zh5A:
undetectable
6mvxB-5zh5A:
undetectable
6mvxC-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S7
RIBOSOMAL PROTEIN
S25E

(Leishmania
donovani;
Leishmania
donovani) 		no annotation
no annotation 		4 THR H  82
LEU H  83
THR a  98
LEU H  88
 None
 1.05A 6mvxA-6az1H:
2.7
6mvxB-6az1H:
2.2
6mvxC-6az1H:
2.9		 6mvxA-6az1H:
21.72
6mvxB-6az1H:
21.72
6mvxC-6az1H:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 4 MET C   1
THR C   4
LEU C   5
LEU C  31
 None
 1.13A 6mvxA-6c4mC:
undetectable
6mvxB-6c4mC:
2.2
6mvxC-6c4mC:
2.4		 6mvxA-6c4mC:
undetectable
6mvxB-6c4mC:
undetectable
6mvxC-6c4mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 THR A 304
LEU A 303
THR A 314
LEU A 322
 None
 0.98A 6mvxA-6f9nA:
undetectable
6mvxB-6f9nA:
undetectable
6mvxC-6f9nA:
undetectable		 6mvxA-6f9nA:
undetectable
6mvxB-6f9nA:
undetectable
6mvxC-6f9nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 4 THR M  69
LEU M  68
MET M  76
LEU M  39
 None
3PE  M 503 ( 4.2A)
None
None
 1.05A 6mvxA-6g2jM:
undetectable
6mvxB-6g2jM:
undetectable
6mvxC-6g2jM:
undetectable		 6mvxA-6g2jM:
undetectable
6mvxB-6g2jM:
undetectable
6mvxC-6g2jM:
undetectable