SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN5_F_LLLF301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 TYR A 467
GLU A 462
ASP A 313
CYH A 317
 None
 1.34A 6mn5F-3ilvA:
0.0		 6mn5F-3ilvA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  60
GLU A 261
ASP A 260
CYH A 258
 None
MG  A 400 ( 4.0A)
MG  A 400 (-3.1A)
None
 1.37A 6mn5F-3mwcA:
0.0		 6mn5F-3mwcA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 4 ASP A 225
TYR A 174
ASP A 181
CYH A  86
 None
 1.39A 6mn5F-4okmA:
0.0		 6mn5F-4okmA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q69 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 ASP A 292
TYR A 298
ASP A 420
CYH A 345
 None
 1.43A 6mn5F-4q69A:
0.0		 6mn5F-4q69A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkm XYLOSE ISOMERASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASP A 309
GLU A 234
ASP A 298
CYH A 101
 MN  A 502 (-3.3A)
MN  A 501 (-2.5A)
MN  A 501 (-3.2A)
None
 1.33A 6mn5F-4xkmA:
0.0		 6mn5F-4xkmA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdk HOLLIDAY JUNCTION
RESOLVASE RECU

(Bacillus
subtilis) 		PF03838
(RecU) 		4 ASP A 131
TYR A 197
GLU A 148
ASP A 150
 None
 1.21A 6mn5F-5fdkA:
0.0		 6mn5F-5fdkA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		4 ASP A 123
TYR A 152
GLU A 153
CYH A   9
 None
None
None
ALA  A 501 (-3.3A)
 1.27A 6mn5F-5inrA:
0.0		 6mn5F-5inrA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 4 ASP A 308
GLU A 233
ASP A 297
CYH A 100
 FE2  A 502 (-3.2A)
FE2  A 501 (-2.2A)
FE2  A 501 (-3.0A)
None
 1.28A 6mn5F-5nhbA:
0.0		 6mn5F-5nhbA:
12.37