SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN5_E_LLLE301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 ASP A 674
ARG A 649
ASP A 646
GLU A 705
 None
 1.32A 6mn5E-1bf5A:
0.0		 6mn5E-1bf5A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ASP A  69
ARG A 147
ASP A 174
GLU A 175
 None
 1.26A 6mn5E-1iovA:
0.0		 6mn5E-1iovA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn1 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Haemophilus
influenzae) 		PF02542
(YgbB) 		4 ASP A  73
ARG A  79
ASP A 120
GLU A 119
 None
 1.31A 6mn5E-1jn1A:
0.0		 6mn5E-1jn1A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs2 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 ASP A 267
ARG A 405
TYR A 348
ASP A 456
 None
 1.30A 6mn5E-1qs2A:
0.0		 6mn5E-1qs2A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rro RAT ONCOMODULIN

(Rattus rattus) 		PF13499
(EF-hand_7) 		4 ASP A  94
TYR A  57
ASP A 100
GLU A 104
 CA  A 109 (-2.9A)
None
None
None
 1.34A 6mn5E-1rroA:
undetectable		 6mn5E-1rroA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C)
PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 ARG D 155
GLU C 118
ASP C 117
GLU C  81
 None
AGS  C 803 ( 4.9A)
MG  C 813 (-3.9A)
None
 1.33A 6mn5E-1sxjD:
0.0		 6mn5E-1sxjD:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)

(Salmonella
enterica) 		PF00440
(TetR_N)
PF09209
(DUF1956) 		4 ASP A  93
ARG A  96
TYR A 155
ASP A 212
 None
 1.10A 6mn5E-1t33A:
0.0		 6mn5E-1t33A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx7 OXETANOCIN-LIKE
PROTEIN

(Pyrococcus
furiosus) 		PF13023
(HD_3) 		4 ASP A 124
ARG A  16
GLU A  71
ASP A  76
 NI  A 201 ( 2.6A)
UNX  A2019 (-3.1A)
None
None
 1.20A 6mn5E-1xx7A:
0.0		 6mn5E-1xx7A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		4 GLU A 217
ASP A 218
CYH A 253
GLU A 221
 None
K  A1417 ( 3.3A)
None
K  A1417 (-3.5A)
 1.08A 6mn5E-1zl0A:
0.1		 6mn5E-1zl0A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqz 177AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13023
(HD_3) 		4 ASP A 124
ARG A  16
GLU A  71
ASP A  76
 NI  A 601 (-2.7A)
NI  A 601 ( 4.3A)
None
None
 1.29A 6mn5E-2cqzA:
undetectable		 6mn5E-2cqzA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		4 ASP A  88
ARG A  90
ASP A 119
GLU A 144
 None
GDP  A 501 (-3.4A)
GDP  A 501 (-2.8A)
None
 1.35A 6mn5E-2dykA:
undetectable		 6mn5E-2dykA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f15 5'-AMP-ACTIVATED
PROTEIN KINASE,
BETA-2 SUBUNIT

(Homo sapiens) 		PF16561
(AMPK1_CBM) 		4 ASP A 111
GLU A  85
ASP A 136
GLU A 139
 None
 1.30A 6mn5E-2f15A:
undetectable		 6mn5E-2f15A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz4 HYPOTHETICAL PROTEIN
ATU1052

(Agrobacterium
fabrum) 		no annotation 4 ASP A 140
ARG A  43
GLU A  89
ASP A  94
 None
 1.24A 6mn5E-2gz4A:
undetectable		 6mn5E-2gz4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 ASP A 303
ARG A 299
GLU A 295
GLU A 271
 None
 0.76A 6mn5E-2hcbA:
undetectable		 6mn5E-2hcbA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 368
ARG A 379
TYR A 185
ASP A 378
 None
 1.18A 6mn5E-2hneA:
undetectable		 6mn5E-2hneA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASP A 253
ARG A 393
GLU A 234
GLU A 351
 None
 1.06A 6mn5E-2ibuA:
undetectable		 6mn5E-2ibuA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASP A 246
ARG A 386
GLU A 223
GLU A 344
 None
 1.20A 6mn5E-2iikA:
undetectable		 6mn5E-2iikA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		4 ASP A 300
TYR A 247
GLU A 251
GLU A 148
 None
 1.23A 6mn5E-2jbwA:
undetectable		 6mn5E-2jbwA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jer AGMATINE DEIMINASE

(Enterococcus
faecalis) 		PF04371
(PAD_porph) 		4 ASP A 152
ARG A 150
ASP A 113
CYH A 141
 None
 1.26A 6mn5E-2jerA:
undetectable		 6mn5E-2jerA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jll NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 ASP A 374
ARG A 336
TYR A 378
ASP A 339
 None
 1.24A 6mn5E-2jllA:
undetectable		 6mn5E-2jllA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ARG A  67
TYR A  69
GLU A  83
GLU A  63
 None
 1.06A 6mn5E-2pmiA:
undetectable		 6mn5E-2pmiA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 268
TYR A  57
GLU A 242
CYH A 227
 None
 1.36A 6mn5E-2qddA:
undetectable		 6mn5E-2qddA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rau PUTATIVE ESTERASE

(Sulfolobus
solfataricus) 		PF12146
(Hydrolase_4) 		4 ARG A  81
TYR A  80
GLU A 338
GLU A 335
 None
 1.28A 6mn5E-2rauA:
undetectable		 6mn5E-2rauA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 ARG A 719
TYR A 717
GLU A 668
ASP A 667
 None
 1.18A 6mn5E-2wzsA:
undetectable		 6mn5E-2wzsA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy1 NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		4 ASP A 374
ARG A 336
TYR A 378
ASP A 339
 None
 1.24A 6mn5E-2xy1A:
undetectable		 6mn5E-2xy1A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 ASP A 374
ARG A 336
TYR A 378
ASP A 339
 None
 1.22A 6mn5E-2xycA:
undetectable		 6mn5E-2xycA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA

(Homo sapiens) 		PF01504
(PIP5K) 		4 ASP A 223
GLU A 220
ASP A 237
GLU A 241
 None
 1.28A 6mn5E-2ybxA:
undetectable		 6mn5E-2ybxA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		4 ASP A  92
TYR A  78
GLU A  79
GLU A 177
 None
 0.98A 6mn5E-3at7A:
undetectable		 6mn5E-3at7A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		4 ASP A  64
ARG A 104
ASP A 112
CYH A 116
 None
CA  A 401 ( 4.2A)
None
None
 1.10A 6mn5E-3cdxA:
undetectable		 6mn5E-3cdxA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00814
(Peptidase_M22) 		4 ARG A 274
TYR A 276
GLU A 247
ASP A 246
 None
 1.19A 6mn5E-3enoA:
undetectable		 6mn5E-3enoA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew7 LMO0794 PROTEIN

(Listeria
monocytogenes) 		PF13460
(NAD_binding_10) 		4 ASP A  74
ARG A  32
TYR A  69
ASP A  50
 None
 1.27A 6mn5E-3ew7A:
undetectable		 6mn5E-3ew7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 ASP A 159
ARG A 154
GLU A 155
GLU A 404
 None
 1.31A 6mn5E-3fddA:
undetectable		 6mn5E-3fddA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		4 ASP A 200
ARG A 202
GLU A 145
GLU A 178
 None
 1.27A 6mn5E-3flbA:
undetectable		 6mn5E-3flbA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		4 ASP A 669
GLU A 643
ASP A 582
GLU A 581
 None
 1.12A 6mn5E-3g06A:
undetectable		 6mn5E-3g06A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gby UNCHARACTERIZED
PROTEIN CT1051

(Chlorobaculum
tepidum) 		PF00571
(CBS) 		4 ARG A 107
GLU A 109
ASP A 103
GLU A 104
 None
 1.10A 6mn5E-3gbyA:
undetectable		 6mn5E-3gbyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i10 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacteroides
thetaiotaomicron) 		PF03009
(GDPD)
PF16387
(DUF4996) 		4 ASP A 285
ARG A  47
GLU A  73
ASP A  75
 None
EDO  A  10 (-4.3A)
None
None
 1.36A 6mn5E-3i10A:
undetectable		 6mn5E-3i10A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 ASP A 212
TYR A 180
GLU A 245
ASP A 171
 None
UNL  A 277 (-3.9A)
ZN  A 276 ( 4.4A)
None
 1.05A 6mn5E-3iehA:
undetectable		 6mn5E-3iehA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		4 ASP A 166
ARG A 414
TYR A 361
ASP A 364
 None
 1.28A 6mn5E-3iibA:
undetectable		 6mn5E-3iibA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxv 70 KDA
PEPTIDYL-PROLYL
ISOMERASE

(Triticum
aestivum) 		PF00254
(FKBP_C) 		4 ARG A 336
TYR A 355
GLU A 332
GLU A 292
 None
 1.22A 6mn5E-3jxvA:
undetectable		 6mn5E-3jxvA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		4 ASP A  45
ARG A  16
TYR A  85
ASP A  13
 None
 1.07A 6mn5E-3kxwA:
undetectable		 6mn5E-3kxwA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		4 ASP B  21
ARG B   8
TYR B  63
ASP B   9
 None
 1.35A 6mn5E-3l4gB:
undetectable		 6mn5E-3l4gB:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 ASP A 277
ARG A 164
ASP A 318
GLU A 160
 GOL  A 496 ( 3.4A)
GOL  A 491 (-4.2A)
GOL  A 491 ( 3.3A)
GOL  A 491 (-3.3A)
 1.37A 6mn5E-3n6xA:
undetectable		 6mn5E-3n6xA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocm PUTATIVE MEMBRANE
PROTEIN

(Bordetella
parapertussis) 		PF00571
(CBS) 		4 ASP A 433
ASP A 376
CYH A 371
GLU A 377
 None
 1.35A 6mn5E-3ocmA:
undetectable		 6mn5E-3ocmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr0 GUANYLATE KINASE

(Coxiella
burnetii) 		PF00625
(Guanylate_kin) 		4 ARG A  78
TYR A  76
GLU A  77
GLU A  57
 None
 1.35A 6mn5E-3tr0A:
undetectable		 6mn5E-3tr0A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3x EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 ASP A 257
ARG A 182
TYR A 148
GLU A  64
 None
 1.36A 6mn5E-4a3xA:
undetectable		 6mn5E-4a3xA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 ASP A 480
TYR A 189
GLU A 415
GLU A 343
 None
 1.37A 6mn5E-4b9yA:
undetectable		 6mn5E-4b9yA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASP A 220
ARG A 360
GLU A 202
GLU A 318
 None
 1.04A 6mn5E-4c2kA:
undetectable		 6mn5E-4c2kA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4coy EPITHELIAL ADHESIN 6

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 ASP A 257
ARG A 182
TYR A 148
GLU A  64
 None
 1.26A 6mn5E-4coyA:
undetectable		 6mn5E-4coyA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii) 		PF00267
(Porin_1) 		4 ASP A 117
ARG A 126
TYR A  95
GLU A  60
 None
 1.33A 6mn5E-4d65A:
undetectable		 6mn5E-4d65A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		4 ASP A 455
ARG A 472
TYR A 386
ASP A 211
 None
 1.27A 6mn5E-4dwqA:
undetectable		 6mn5E-4dwqA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		4 ASP A 474
ARG A 397
ASP A 396
CYH A 345
 None
 1.31A 6mn5E-4ix3A:
undetectable		 6mn5E-4ix3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Mus musculus) 		PF00106
(adh_short) 		4 ARG A  48
TYR A  52
GLU A  49
GLU A 221
 SO4  A 303 ( 3.2A)
None
None
SO4  A 302 (-4.0A)
 1.30A 6mn5E-4k26A:
undetectable		 6mn5E-4k26A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7w HD DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF13023
(HD_3) 		4 ASP A 143
ARG A  32
GLU A  81
ASP A  86
 None
MG  A 302 ( 4.0A)
MG  A 303 ( 2.4A)
MG  A 301 ( 2.8A)
 1.17A 6mn5E-4l7wA:
undetectable		 6mn5E-4l7wA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A 411
ASP A 407
CYH A 362
GLU A 404
 None
 1.07A 6mn5E-4n5aA:
undetectable		 6mn5E-4n5aA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 GLU D 634
ASP D 631
CYH D 692
GLU D 695
 None
 0.98A 6mn5E-4ngeD:
undetectable		 6mn5E-4ngeD:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5b THYMIDYLATE SYNTHASE
THYX

(Streptomyces
cacaoi) 		PF02511
(Thy1) 		4 ASP A 110
TYR A 107
GLU A 208
GLU A 210
 None
 1.02A 6mn5E-4p5bA:
undetectable		 6mn5E-4p5bA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5b THYMIDYLATE SYNTHASE
THYX

(Streptomyces
cacaoi) 		PF02511
(Thy1) 		4 ASP A 110
TYR A 107
GLU A 208
GLU A 214
 None
 0.96A 6mn5E-4p5bA:
undetectable		 6mn5E-4p5bA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1

(Homo sapiens) 		PF05014
(Nuc_deoxyrib_tr) 		4 TYR A 145
GLU A  93
ASP A  35
GLU A  34
 None
 1.37A 6mn5E-4p5eA:
undetectable		 6mn5E-4p5eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 4 ARG H  18
GLU H  14
ASP H 377
CYH H 399
 None
 1.09A 6mn5E-4qslH:
undetectable		 6mn5E-4qslH:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tma DNA GYRASE SUBUNIT B
DNA GYRASE INHIBITOR
YACG

(Escherichia
coli;
Escherichia
coli) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF03884
(YacG) 		4 ARG B 516
TYR B 515
ASP I  36
GLU I  39
 None
 1.12A 6mn5E-4tmaB:
undetectable		 6mn5E-4tmaB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tma DNA GYRASE SUBUNIT B
DNA GYRASE INHIBITOR
YACG

(Escherichia
coli;
Escherichia
coli) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF03884
(YacG) 		4 ASP B 774
ARG B 516
ASP I  36
GLU I  39
 None
 1.27A 6mn5E-4tmaB:
undetectable		 6mn5E-4tmaB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		4 ASP A 733
ARG A 449
TYR A 445
GLU A 124
 None
 1.17A 6mn5E-4txgA:
undetectable		 6mn5E-4txgA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASP A 217
ARG A 355
GLU A 192
GLU A 313
 None
 1.09A 6mn5E-4ubtA:
undetectable		 6mn5E-4ubtA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		4 ASP A 136
ARG A  83
TYR A  79
ASP A  84
 None
 1.18A 6mn5E-4uirA:
undetectable		 6mn5E-4uirA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 ARG A 265
GLU A 269
ASP A 266
GLU A 201
 SO4  A 401 (-3.6A)
None
None
SO4  A 401 ( 4.7A)
 1.33A 6mn5E-4wy5A:
undetectable		 6mn5E-4wy5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ASP A 191
TYR A 180
ASP A 135
GLU A 134
 None
 1.06A 6mn5E-4y9lA:
undetectable		 6mn5E-4y9lA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6s ENDOLYSIN

(Clostridium
phage phiCTP1) 		PF01183
(Glyco_hydro_25) 		4 ASP A 177
TYR A 121
GLU A  94
GLU A  33
 SO4  A1274 (-3.4A)
SO4  A1274 (-4.4A)
SO4  A1274 (-3.0A)
None
 1.16A 6mn5E-5a6sA:
undetectable		 6mn5E-5a6sA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aip TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Neisseria
meningitidis) 		PF01047
(MarR) 		4 ASP A 112
ARG A  43
TYR A 104
GLU A  47
 None
 1.08A 6mn5E-5aipA:
undetectable		 6mn5E-5aipA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Francisella
tularensis) 		PF00005
(ABC_tran) 		4 ARG A 436
GLU A 437
ASP A 434
GLU A 427
 None
 1.34A 6mn5E-5dgxA:
undetectable		 6mn5E-5dgxA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl8 BENZOATE TRANSPORT
PORIN BENP

(Acinetobacter
baumannii) 		no annotation 4 ASP B 121
TYR B 289
GLU B 201
ASP B 189
 None
 1.36A 6mn5E-5dl8B:
undetectable		 6mn5E-5dl8B:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl8 BENZOATE TRANSPORT
PORIN BENP

(Acinetobacter
baumannii) 		no annotation 4 TYR B 215
GLU B 201
ASP B 189
GLU B 153
 None
 1.31A 6mn5E-5dl8B:
undetectable		 6mn5E-5dl8B:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		4 ASP A 249
ARG A 245
TYR A 341
ASP A 240
 None
 1.28A 6mn5E-5dt5A:
undetectable		 6mn5E-5dt5A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo9 DPR6, ISOFORM C

(Drosophila
melanogaster) 		PF07679
(I-set) 		4 ASP A 151
ARG A 109
TYR A 155
ASP A 112
 None
 1.23A 6mn5E-5eo9A:
undetectable		 6mn5E-5eo9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		4 ASP E 237
ARG E 243
ASP E 284
GLU E 283
 None
 1.37A 6mn5E-5esvE:
undetectable		 6mn5E-5esvE:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esz 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		4 ASP C 231
ARG C 237
ASP C 278
GLU C 277
 None
 1.37A 6mn5E-5eszC:
undetectable		 6mn5E-5eszC:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASP B 217
ARG B 357
GLU B 199
GLU B 315
 None
 1.23A 6mn5E-5f38B:
undetectable		 6mn5E-5f38B:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdk HOLLIDAY JUNCTION
RESOLVASE RECU

(Bacillus
subtilis) 		PF03838
(RecU) 		4 ASP A 131
TYR A 197
GLU A 148
ASP A 150
 None
 1.37A 6mn5E-5fdkA:
undetectable		 6mn5E-5fdkA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		4 ASP A  96
ARG A  92
TYR A 301
ASP A  88
 None
 1.18A 6mn5E-5hlbA:
undetectable		 6mn5E-5hlbA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 4 ASP B 330
TYR B 218
GLU B 214
CYH B 169
 None
 1.12A 6mn5E-5i61B:
undetectable		 6mn5E-5i61B:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		4 ASP A 123
TYR A 152
GLU A 153
CYH A   9
 None
None
None
ALA  A 501 (-3.3A)
 1.30A 6mn5E-5inrA:
undetectable		 6mn5E-5inrA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A
COMPLEMENT C4-A

(Homo sapiens;
Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
PF01759
(NTR)
PF07677
(A2M_recep) 		4 ASP B1304
ARG B1300
GLU C1563
GLU B 943
 None
 1.13A 6mn5E-5jpnB:
undetectable		 6mn5E-5jpnB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		4 ASP A 333
ARG A   8
TYR A  10
GLU A  52
 None
 1.14A 6mn5E-5kh0A:
undetectable		 6mn5E-5kh0A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrg TAR DNA-BINDING
PROTEIN 43

(Homo sapiens) 		no annotation 4 ARG A  18
TYR A  16
GLU A  29
GLU A  26
 None
 1.36A 6mn5E-5mrgA:
undetectable		 6mn5E-5mrgA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 ASP W 755
ARG W 313
GLU W 283
GLU W 288
 None
 1.13A 6mn5E-5o9gW:
undetectable		 6mn5E-5o9gW:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL

(Homo sapiens) 		PF01161
(PBP) 		4 ASP 6 302
ARG 6 299
GLU 6 231
GLU 6 227
 None
 1.01A 6mn5E-5ool6:
undetectable		 6mn5E-5ool6:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL

(Aplysia
californica) 		PF00520
(Ion_trans)
PF03493
(BK_channel_a) 		4 ASP A 517
ARG A1026
TYR A1042
ASP A1057
 None
 1.30A 6mn5E-5tj6A:
undetectable		 6mn5E-5tj6A:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ASP A 475
ARG A  21
GLU A  25
CYH A  30
 None
 1.17A 6mn5E-5tw7A:
undetectable		 6mn5E-5tw7A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		4 ASP A 159
GLU A 125
CYH A 133
GLU A 407
 None
 1.33A 6mn5E-5uj6A:
undetectable		 6mn5E-5uj6A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ASP A 201
ARG A 199
ASP A 197
GLU A 335
 EDO  A 609 (-4.1A)
None
None
EDO  A 604 (-2.8A)
 1.24A 6mn5E-5vpuA:
undetectable		 6mn5E-5vpuA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A  15
GLU A  11
ASP A 372
CYH A 394
 None
 1.19A 6mn5E-5vywA:
undetectable		 6mn5E-5vywA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1d PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 ARG A 450
GLU A 385
ASP A 480
GLU A 517
 None
CA  A1007 (-2.9A)
CA  A1007 (-2.7A)
K  A1006 (-2.8A)
 1.28A 6mn5E-5w1dA:
undetectable		 6mn5E-5w1dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		4 ASP A  69
GLU A 148
ASP A  91
GLU A 330
 None
 1.30A 6mn5E-5xoyA:
undetectable		 6mn5E-5xoyA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyj ACETYL-COA
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		no annotation 4 ASP B 221
ARG B 362
GLU B 201
GLU B 320
 None
 1.14A 6mn5E-5xyjB:
undetectable		 6mn5E-5xyjB:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z8l -

(-) 		no annotation 4 ASP A 158
TYR A 128
GLU A  89
GLU A  75
 None
 1.32A 6mn5E-5z8lA:
undetectable		 6mn5E-5z8lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arr ACETYL-COA
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		no annotation 4 ASP A 222
ARG A 362
GLU A 202
GLU A 320
 None
 1.18A 6mn5E-6arrA:
undetectable		 6mn5E-6arrA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 4 ASP A 217
ARG A 356
GLU A 199
GLU A 314
 None
 1.14A 6mn5E-6bj9A:
undetectable		 6mn5E-6bj9A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 4 ASP A 219
ARG A 360
GLU A 200
GLU A 318
 None
 1.15A 6mn5E-6bjaA:
undetectable		 6mn5E-6bjaA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bn2 ACETYL-COA
ACETYLTRANSFERASE

(Elizabethkingia
anophelis) 		no annotation 4 ASP A 216
ARG A 356
GLU A 197
GLU A 314
 None
 1.15A 6mn5E-6bn2A:
undetectable		 6mn5E-6bn2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 4 ASP A 672
GLU A 605
ASP A1162
GLU A1159
 None
 1.21A 6mn5E-6co7A:
undetectable		 6mn5E-6co7A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehe OMPT PROTEIN

(Vibrio cholerae) 		no annotation 4 ASP A  98
TYR A 270
GLU A 286
GLU A 274
 None
None
None
ACT  A 410 ( 4.6A)
 1.29A 6mn5E-6eheA:
undetectable		 6mn5E-6eheA:
18.82