SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN5_D_LLLD301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ARG A 165
GLU A 314
ASP A 279
GLU A 255
 OXL  A1583 ( 2.8A)
NAP  A1581 (-3.3A)
MN  A1584 ( 3.1A)
MN  A1584 ( 3.3A)
 1.44A 6mn5D-1gq2A:
1.3		 6mn5D-1gq2A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ARG A 165
GLU A 314
ASP A 279
GLU A 255
 ATP  A 601 ( 3.2A)
ATP  A 601 (-4.1A)
MN  A 604 ( 2.6A)
MN  A 604 ( 3.3A)
 1.48A 6mn5D-1gz4A:
1.7		 6mn5D-1gz4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 332
GLU A 338
ASP A 341
GLU A 344
 ZN  A1363 (-2.1A)
None
None
None
 1.32A 6mn5D-1h2bA:
2.8		 6mn5D-1h2bA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ASP A 344
ARG A 302
ASP A 306
CYH A 290
 None
 1.48A 6mn5D-1mroA:
0.0		 6mn5D-1mroA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		4 ARG A 308
GLU A 309
ASP A 305
GLU A 301
 None
 1.50A 6mn5D-1phpA:
0.0		 6mn5D-1phpA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 ASP A 394
GLU A 417
ASP A 416
GLU A 450
 None
 1.33A 6mn5D-1px8A:
0.0		 6mn5D-1px8A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51

(Pyrococcus
furiosus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 ASP A 267
ARG A 270
GLU A  60
GLU A  38
 None
 1.48A 6mn5D-1pznA:
undetectable		 6mn5D-1pznA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ASP A 139
GLU A 394
ASP A 112
GLU A  50
 None
 1.45A 6mn5D-1u3dA:
undetectable		 6mn5D-1u3dA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 ASP A  68
ARG A 127
GLU A 128
ASP A 134
 None
ZN  A1405 ( 4.8A)
None
None
 1.34A 6mn5D-1uwyA:
undetectable		 6mn5D-1uwyA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx5 UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ASP B  39
GLU B  24
ASP B  52
GLU B  51
 None
 1.14A 6mn5D-1yx5B:
undetectable		 6mn5D-1yx5B:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ARG A 154
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.06A 6mn5D-2dh4A:
undetectable		 6mn5D-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ASP A 214
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.33A 6mn5D-2dh4A:
undetectable		 6mn5D-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		4 ASP A  88
ARG A  90
ASP A 119
GLU A 144
 None
GDP  A 501 (-3.4A)
GDP  A 501 (-2.8A)
None
 1.18A 6mn5D-2dykA:
undetectable		 6mn5D-2dykA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 ASP A 160
GLU A 303
ASP A 300
GLU A 480
 None
 1.15A 6mn5D-2f6dA:
undetectable		 6mn5D-2f6dA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 ASP A 303
ARG A 299
GLU A 295
GLU A 271
 None
 1.12A 6mn5D-2hcbA:
undetectable		 6mn5D-2hcbA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jer AGMATINE DEIMINASE

(Enterococcus
faecalis) 		PF04371
(PAD_porph) 		4 ASP A 152
ARG A 150
ASP A 113
CYH A 141
 None
 1.20A 6mn5D-2jerA:
undetectable		 6mn5D-2jerA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 ASP A 819
ARG A 826
ASP A 796
GLU A 795
 None
 1.46A 6mn5D-2o2qA:
undetectable		 6mn5D-2o2qA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF12708
(Pectate_lyase_3) 		4 ARG A 144
GLU A 145
ASP A 108
GLU A  43
 None
CA  A 379 ( 4.5A)
None
None
 1.33A 6mn5D-2pyhA:
undetectable		 6mn5D-2pyhA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtk PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ASP A 289
ARG A 324
GLU A 343
GLU A 347
 None
 1.45A 6mn5D-2qtkA:
undetectable		 6mn5D-2qtkA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA
NITROGEN REGULATORY
PROTEIN AREA

(Aspergillus
nidulans;
Aspergillus
nidulans) 		PF05368
(NmrA)
PF00320
(GATA) 		4 ASP A 195
ARG A 329
GLU A 333
CYH I 673
 None
None
None
ZN  I1713 (-2.4A)
 1.31A 6mn5D-2vutA:
undetectable		 6mn5D-2vutA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 ASP H 105
ARG H  85
ASP H 380
GLU H 382
 None
 1.44A 6mn5D-3c75H:
undetectable		 6mn5D-3c75H:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		4 ASP A  64
ARG A 104
ASP A 112
CYH A 116
 None
CA  A 401 ( 4.2A)
None
None
 0.89A 6mn5D-3cdxA:
undetectable		 6mn5D-3cdxA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		4 ASP A  89
GLU A  60
ASP A  71
GLU A  73
 None
 1.46A 6mn5D-3dc8A:
undetectable		 6mn5D-3dc8A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 4 ASP A 194
GLU A 230
ASP A 223
GLU A 225
 None
 1.40A 6mn5D-3dsmA:
undetectable		 6mn5D-3dsmA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		4 ASP A 365
ARG A 551
GLU A 549
CYH A 554
 None
None
MLZ  A  20 ( 4.2A)
MLZ  A  20 ( 4.1A)
 1.45A 6mn5D-3f70A:
undetectable		 6mn5D-3f70A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		4 ASP A 200
ARG A 202
GLU A 145
GLU A 178
 None
 1.07A 6mn5D-3flbA:
undetectable		 6mn5D-3flbA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASP A 325
GLU A 382
ASP A 384
GLU A 386
 None
 1.24A 6mn5D-3iplA:
undetectable		 6mn5D-3iplA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 ASP A  42
GLU A  21
ASP A  68
GLU A 213
 None
None
None
ZN  A 355 (-3.6A)
 1.18A 6mn5D-3kl9A:
undetectable		 6mn5D-3kl9A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 ASP A 479
GLU A  18
ASP A  15
GLU A  13
 None
 1.30A 6mn5D-3kveA:
undetectable		 6mn5D-3kveA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Salmonella
enterica) 		PF00926
(DHBP_synthase) 		4 ARG A  24
GLU A  25
ASP A  21
GLU A  17
 None
 1.34A 6mn5D-3lquA:
undetectable		 6mn5D-3lquA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo) 		4 ASP W 464
ARG W 463
GLU W 501
ASP W 498
 None
 1.33A 6mn5D-3mwyW:
undetectable		 6mn5D-3mwyW:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 ASP A 277
ARG A 164
ASP A 318
GLU A 160
 GOL  A 496 ( 3.4A)
GOL  A 491 (-4.2A)
GOL  A 491 ( 3.3A)
GOL  A 491 (-3.3A)
 1.35A 6mn5D-3n6xA:
undetectable		 6mn5D-3n6xA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE
DIHEME CYTOCHROME C
NAPB

(Cupriavidus
necator;
Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF03892
(NapB) 		4 ASP B  84
ARG B  83
GLU A 177
CYH A 172
 None
 1.38A 6mn5D-3o5aB:
undetectable		 6mn5D-3o5aB:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 ASP A 145
ARG A 170
GLU A 152
CYH A 136
 None
 1.50A 6mn5D-3othA:
1.6		 6mn5D-3othA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrc DUFFY RECEPTOR

(Plasmodium
vivax) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		4 ARG A 224
GLU A 403
ASP A 399
GLU A 395
 None
 1.18A 6mn5D-3rrcA:
undetectable		 6mn5D-3rrcA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 150
GLU A 157
ASP A 198
GLU A 236
 None
 1.44A 6mn5D-4a3tA:
undetectable		 6mn5D-4a3tA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ASP A 150
ARG A 364
GLU A 352
GLU A 540
 MG  A1640 ( 4.2A)
None
MG  A1640 ( 4.3A)
None
 1.44A 6mn5D-4cgyA:
undetectable		 6mn5D-4cgyA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxb PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ASP A 267
ARG A 390
GLU A 389
ASP A 391
 None
 1.45A 6mn5D-4fxbA:
undetectable		 6mn5D-4fxbA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens) 		PF00888
(Cullin) 		4 ASP D  20
ARG D  23
ASP D  68
GLU D  67
 None
 1.35A 6mn5D-4jghD:
undetectable		 6mn5D-4jghD:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASP A 412
ARG A 288
GLU A 434
ASP A 370
 None
 1.44A 6mn5D-4mrqA:
undetectable		 6mn5D-4mrqA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4f INOSITOL
HEXAKISPHOSPHATE
KINASE

(Entamoeba
histolytica) 		PF03770
(IPK) 		4 ASP A 231
ASP A 108
CYH A 243
GLU A 110
 MG  A 402 ( 2.8A)
None
None
None
 1.13A 6mn5D-4o4fA:
undetectable		 6mn5D-4o4fA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3

(Homo sapiens) 		PF10189
(Ints3) 		4 ASP A 348
ARG A 304
CYH A 236
GLU A 232
 None
 1.32A 6mn5D-4owtA:
undetectable		 6mn5D-4owtA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 4 ASP H 392
GLU H  14
CYH H 399
GLU H 243
 None
 1.30A 6mn5D-4qslH:
undetectable		 6mn5D-4qslH:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 ASP A1725
GLU A1697
ASP A1779
GLU A1848
 None
None
None
SO4  A2409 ( 4.7A)
 1.03A 6mn5D-4uclA:
undetectable		 6mn5D-4uclA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 ARG A 265
GLU A 269
ASP A 266
GLU A 201
 SO4  A 401 (-3.6A)
None
None
SO4  A 401 ( 4.7A)
 1.29A 6mn5D-4wy5A:
undetectable		 6mn5D-4wy5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycz FUSION PROTEIN OF
SEC13 AND NUP145C
NUP120

(Thermothelomyces
thermophila;
Thermothelomyces
thermophila) 		PF00400
(WD40)
PF12110
(Nup96)
no annotation 		4 ASP C1126
ARG C1202
ASP A1754
GLU A1757
 None
 1.21A 6mn5D-4yczC:
undetectable		 6mn5D-4yczC:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 ASP A 162
ARG A 158
ASP A  88
GLU A  56
 None
 1.41A 6mn5D-5a5tA:
undetectable		 6mn5D-5a5tA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC

(Escherichia
coli;
Escherichia
coli) 		PF01458
(UPF0051)
PF00005
(ABC_tran) 		4 ASP A 443
GLU C  51
ASP C  52
GLU C  12
 None
 1.22A 6mn5D-5awfA:
undetectable		 6mn5D-5awfA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 ASP A 467
GLU A 321
ASP A 320
GLU A 257
 LOG  A 702 (-2.9A)
LOG  A 702 (-3.1A)
GAL  A 701 (-3.0A)
None
 1.36A 6mn5D-5bxpA:
undetectable		 6mn5D-5bxpA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		4 ASP A 361
GLU A 368
ASP A 369
GLU A 334
 None
 1.23A 6mn5D-5cb2A:
undetectable		 6mn5D-5cb2A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASP A 186
GLU A 221
ASP A 172
GLU A 170
 None
 1.42A 6mn5D-5f7sA:
undetectable		 6mn5D-5f7sA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		4 ASP A 239
ARG A 240
GLU A 241
ASP A 263
 SO4  A 303 (-2.7A)
SO4  A 303 (-4.0A)
None
None
 1.48A 6mn5D-5hw3A:
undetectable		 6mn5D-5hw3A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 ASP A  56
ARG A  52
GLU A  36
GLU A  69
 None
 1.45A 6mn5D-5infA:
undetectable		 6mn5D-5infA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A
COMPLEMENT C4-A

(Homo sapiens;
Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
PF01759
(NTR)
PF07677
(A2M_recep) 		4 ASP B1304
ARG B1300
GLU C1563
GLU B 943
 None
 1.19A 6mn5D-5jpnB:
undetectable		 6mn5D-5jpnB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 368
GLU A 300
ASP A 306
GLU A  23
 None
 1.43A 6mn5D-5ks8A:
undetectable		 6mn5D-5ks8A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 4 ARG A 144
GLU A 145
ASP A 108
GLU A  43
 None
 1.42A 6mn5D-5lw3A:
undetectable		 6mn5D-5lw3A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 4 ASP A  50
GLU A 258
ASP A 254
GLU A  44
 None
 1.34A 6mn5D-5mlhA:
undetectable		 6mn5D-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 4 ASP A 308
GLU A 233
ASP A 297
CYH A 100
 FE2  A 502 (-3.2A)
FE2  A 501 (-2.2A)
FE2  A 501 (-3.0A)
None
 1.41A 6mn5D-5nhbA:
undetectable		 6mn5D-5nhbA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 387
GLU A  11
CYH A 394
GLU A 239
 None
 1.40A 6mn5D-5vywA:
undetectable		 6mn5D-5vywA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1d PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 ASP A 449
ARG A 450
ASP A 480
GLU A 517
 None
None
CA  A1007 (-2.7A)
K  A1006 (-2.8A)
 1.30A 6mn5D-5w1dA:
undetectable		 6mn5D-5w1dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		4 ASP G  47
ARG G 132
GLU G  35
GLU G 125
 None
 1.36A 6mn5D-5x5yG:
undetectable		 6mn5D-5x5yG:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA

(Naegleria
fowleri) 		no annotation 4 ASP A 419
GLU A  16
ASP A 286
GLU A  42
 None
 1.39A 6mn5D-6c87A:
undetectable		 6mn5D-6c87A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN
FACTOR VIII INTRON
22 PROTEIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ARG A1998
GLU B 331
ASP B 333
GLU B 335
 None
 1.43A 6mn5D-6ez8A:
undetectable		 6mn5D-6ez8A:
15.00