SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN5_C_LLLC301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		4 ASP A 306
GLU A 231
ASP A 295
CYH A  98
 CO  A 492 ( 1.9A)
CO  A 491 ( 2.4A)
CO  A 491 ( 3.1A)
None
 1.40A 6mn5C-1a0cA:
0.0		 6mn5C-1a0cA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		4 ASP A 304
GLU A 229
ASP A 293
CYH A  96
 MN  A 492 ( 3.2A)
MN  A 491 ( 2.4A)
MN  A 491 ( 3.4A)
None
 1.48A 6mn5C-1a0dA:
0.0		 6mn5C-1a0dA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 TYR A 499
GLU A 501
ASP A 479
GLU A 516
 None
 1.17A 6mn5C-1a2vA:
0.0		 6mn5C-1a2vA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 ASP A 346
TYR A 413
GLU A 380
ASP A 379
 None
 1.40A 6mn5C-1c7tA:
0.0		 6mn5C-1c7tA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjl PROCATHEPSIN L

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 ASP A  84
TYR A  76
ASP A  55
GLU A  96
 None
 1.48A 6mn5C-1cjlA:
0.0		 6mn5C-1cjlA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		4 ASP A 281
TYR A 381
GLU A  78
GLU A 146
 None
 1.40A 6mn5C-1h14A:
0.0		 6mn5C-1h14A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 332
GLU A 338
ASP A 341
GLU A 344
 ZN  A1363 (-2.1A)
None
None
None
 1.34A 6mn5C-1h2bA:
2.4		 6mn5C-1h2bA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		4 ASP A 643
TYR A 526
ASP A 544
GLU A 584
 None
CO3  A 701 ( 3.9A)
None
None
 1.44A 6mn5C-1h76A:
0.0		 6mn5C-1h76A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ASP A 291
TYR A 284
GLU A 280
GLU A 574
 None
None
None
MPD  A 803 ( 4.4A)
 1.34A 6mn5C-1kwgA:
0.2		 6mn5C-1kwgA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhw ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 ASP A 176
TYR A 251
GLU A 196
ASP A 197
 None
 1.41A 6mn5C-1nhwA:
undetectable		 6mn5C-1nhwA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc2 MITOCHONDRIA FISSION
PROTEIN

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		4 ASP A  50
TYR A  38
GLU A  18
GLU A  12
 None
 1.12A 6mn5C-1pc2A:
undetectable		 6mn5C-1pc2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 ASP A 394
GLU A 417
ASP A 416
GLU A 450
 None
 1.18A 6mn5C-1px8A:
undetectable		 6mn5C-1px8A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus A;
Rhinovirus A) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 ASP 2 212
TYR 1 194
GLU 2 129
ASP 1 198
 None
 1.30A 6mn5C-1r1a2:
undetectable		 6mn5C-1r1a2:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ASP A 139
GLU A 394
ASP A 112
GLU A  50
 None
 1.35A 6mn5C-1u3dA:
undetectable		 6mn5C-1u3dA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Thermotoga
maritima) 		PF13393
(tRNA-synt_His) 		4 ASP C  53
TYR C  75
GLU C  96
GLU C 261
 None
 1.37A 6mn5C-1usyC:
undetectable		 6mn5C-1usyC:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASP A 169
TYR A  54
GLU A  25
GLU A  16
 None
 1.32A 6mn5C-1v26A:
undetectable		 6mn5C-1v26A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		4 ASP A  92
TYR A 435
GLU A 432
ASP A 433
 None
 1.37A 6mn5C-1vg0A:
undetectable		 6mn5C-1vg0A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		4 ASP A  45
GLU A  24
ASP A  70
GLU A 214
 None
None
None
ZN  A 372 ( 3.9A)
 1.24A 6mn5C-1vheA:
undetectable		 6mn5C-1vheA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E

(Aeropyrum
pernix) 		PF01885
(PTS_2-RNA) 		4 ASP A  59
TYR A  75
ASP A 127
GLU A 126
 None
 1.02A 6mn5C-1wfxA:
undetectable		 6mn5C-1wfxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		4 ASP A 114
TYR A  61
ASP A  47
GLU A  53
 None
 1.30A 6mn5C-1wzzA:
undetectable		 6mn5C-1wzzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx5 UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ASP B  39
GLU B  24
ASP B  52
GLU B  51
 None
 1.15A 6mn5C-1yx5B:
undetectable		 6mn5C-1yx5B:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Lactococcus
lactis;
Lactococcus
lactis) 		PF13393
(tRNA-synt_His)
PF01634
(HisG) 		4 ASP E  74
TYR E  81
GLU E  83
ASP A 191
 None
 1.30A 6mn5C-1z7mE:
undetectable		 6mn5C-1z7mE:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		4 ASP A  74
TYR A  63
GLU A 236
GLU A 274
 None
 1.39A 6mn5C-2a5hA:
undetectable		 6mn5C-2a5hA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajz ANTIBODY 7A1 FAB'

(Mus musculus) 		no annotation 4 ASP L 143
TYR L 173
GLU L 105
GLU L   8
 None
 1.28A 6mn5C-2ajzL:
undetectable		 6mn5C-2ajzL:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be4 HYPOTHETICAL PROTEIN
LOC449832

(Danio rerio) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 ASP A 162
TYR A 120
ASP A 169
GLU A  87
 None
 1.34A 6mn5C-2be4A:
undetectable		 6mn5C-2be4A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ASP A 187
TYR A 157
ASP A 646
GLU A 461
 FMN  A 752 (-3.1A)
FMN  A 751 (-3.5A)
NAP  A 753 (-2.7A)
NAP  A 753 ( 3.0A)
 1.35A 6mn5C-2bf4A:
undetectable		 6mn5C-2bf4A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 TYR A  16
GLU A 338
ASP A 333
GLU A 266
 None
None
GLC  A 605 (-3.5A)
None
 1.11A 6mn5C-2d3lA:
undetectable		 6mn5C-2d3lA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ASP A 214
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.33A 6mn5C-2dh4A:
undetectable		 6mn5C-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 ASP A 176
TYR A 251
GLU A 196
ASP A 197
 None
 1.35A 6mn5C-2foiA:
undetectable		 6mn5C-2foiA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwu SODIUM/CALCIUM
EXCHANGER 1

(Canis lupus) 		PF03160
(Calx-beta) 		4 GLU A 543
ASP A 555
CYH A 557
GLU A 554
 None
 1.43A 6mn5C-2fwuA:
undetectable		 6mn5C-2fwuA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		4 ASP A 101
GLU A  35
ASP A  96
GLU A 280
 None
None
None
MN  A5001 (-4.4A)
 1.35A 6mn5C-2glfA:
undetectable		 6mn5C-2glfA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hkl L,D-TRANSPEPTIDASE

(Enterococcus
faecium) 		PF03734
(YkuD)
PF12229
(PG_binding_4) 		4 TYR A 357
GLU A 346
ASP A 348
GLU A 350
 None
 1.22A 6mn5C-2hklA:
undetectable		 6mn5C-2hklA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ASP A 404
TYR A 401
GLU A 242
GLU A 208
 None
 1.42A 6mn5C-2i00A:
undetectable		 6mn5C-2i00A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jer AGMATINE DEIMINASE

(Enterococcus
faecalis) 		PF04371
(PAD_porph) 		4 ASP A 152
TYR A 197
ASP A 113
CYH A 141
 None
 1.48A 6mn5C-2jerA:
undetectable		 6mn5C-2jerA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		4 ASP A 275
TYR A 164
GLU A  89
ASP A  63
 None
None
None
PB  A 402 (-3.3A)
 1.45A 6mn5C-2o3cA:
undetectable		 6mn5C-2o3cA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 TYR X 114
GLU X 112
ASP X 111
GLU X  63
 None
 1.37A 6mn5C-2pmoX:
undetectable		 6mn5C-2pmoX:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqy SIGMA B OPERON

(Bacillus
anthracis) 		PF00210
(Ferritin) 		4 ASP A  51
TYR A  26
GLU A  94
GLU A 132
 None
 1.22A 6mn5C-2qqyA:
undetectable		 6mn5C-2qqyA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		4 ASP A 596
TYR A 650
GLU A 648
GLU A 605
 None
 1.21A 6mn5C-2rfoA:
undetectable		 6mn5C-2rfoA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am3 ENOYL-ACP REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 ASP A 176
TYR A 251
GLU A 196
ASP A 197
 None
 1.34A 6mn5C-3am3A:
undetectable		 6mn5C-3am3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 198
GLU A 195
ASP A 192
GLU A 344
 None
 1.35A 6mn5C-3cgdA:
undetectable		 6mn5C-3cgdA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 4 ASP A 194
GLU A 230
ASP A 223
GLU A 225
 None
 1.48A 6mn5C-3dsmA:
undetectable		 6mn5C-3dsmA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE

(Salmonella
enterica) 		PF00215
(OMPdecase) 		4 ASP A 138
GLU A   9
ASP A   8
GLU A  30
 None
 1.19A 6mn5C-3f4wA:
undetectable		 6mn5C-3f4wA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		4 ASP A 393
GLU A 369
CYH A 246
GLU A 244
 None
 1.37A 6mn5C-3gueA:
undetectable		 6mn5C-3gueA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		4 ASP A 288
TYR A 226
ASP A 199
GLU A 100
 EDO  A 463 ( 4.9A)
EPE  A 462 (-4.5A)
None
None
 0.84A 6mn5C-3gzaA:
undetectable		 6mn5C-3gzaA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht4 ALUMINUM RESISTANCE
PROTEIN

(Bacillus cereus) 		PF06838
(Met_gamma_lyase) 		4 ASP A 207
TYR A 245
GLU A 212
GLU A 215
 None
 1.43A 6mn5C-3ht4A:
undetectable		 6mn5C-3ht4A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 249
TYR A 298
GLU A 327
ASP A 301
 MG  A 386 (-3.1A)
None
None
None
 1.21A 6mn5C-3i6eA:
undetectable		 6mn5C-3i6eA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 247
TYR A 294
GLU A 323
ASP A 297
 MG  A 381 (-3.1A)
None
None
None
 1.21A 6mn5C-3i6tA:
undetectable		 6mn5C-3i6tA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 ASP A 212
TYR A 180
GLU A 245
ASP A 171
 None
UNL  A 277 (-3.9A)
ZN  A 276 ( 4.4A)
None
 1.01A 6mn5C-3iehA:
undetectable		 6mn5C-3iehA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASP A 325
TYR A 392
ASP A 384
GLU A 386
 None
 1.36A 6mn5C-3iplA:
undetectable		 6mn5C-3iplA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASP A 325
TYR A 392
GLU A 382
ASP A 384
 None
 1.24A 6mn5C-3iplA:
undetectable		 6mn5C-3iplA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j40 GP7

(Salmonella
virus Epsilon15) 		no annotation 4 ASP A 220
TYR A 218
GLU A 200
ASP A 201
 None
 1.30A 6mn5C-3j40A:
undetectable		 6mn5C-3j40A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv5 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Mus musculus) 		PF16179
(RHD_dimer) 		4 TYR A 294
GLU A 264
ASP A 266
GLU A 267
 None
 1.26A 6mn5C-3jv5A:
undetectable		 6mn5C-3jv5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 ASP A  42
GLU A  21
ASP A  68
GLU A 213
 None
None
None
ZN  A 355 (-3.6A)
 1.33A 6mn5C-3kl9A:
undetectable		 6mn5C-3kl9A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 ASP A 479
GLU A  18
ASP A  15
GLU A  13
 None
 1.20A 6mn5C-3kveA:
undetectable		 6mn5C-3kveA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		4 TYR A 266
GLU A  28
CYH A  46
GLU A  43
 None
 0.93A 6mn5C-3lmaA:
undetectable		 6mn5C-3lmaA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 ASP A 200
TYR A 116
GLU A 114
GLU A 134
 None
 1.25A 6mn5C-3oajA:
undetectable		 6mn5C-3oajA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ois CYSTEINE PROTEASE

(Xylella
fastidiosa) 		PF00112
(Peptidase_C1) 		4 ASP A  44
TYR A 184
ASP A 128
GLU A 115
 UDP  A 292 (-3.7A)
UDP  A 292 (-3.2A)
None
None
 1.03A 6mn5C-3oisA:
undetectable		 6mn5C-3oisA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 TYR A 795
GLU A 803
ASP A 906
GLU A  28
 None
 1.00A 6mn5C-3pieA:
undetectable		 6mn5C-3pieA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 TYR A 277
GLU A 307
ASP A  14
CYH A  77
 None
 1.33A 6mn5C-3ttsA:
undetectable		 6mn5C-3ttsA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu9 CHROMOSOME
SEGREGATION IN
MEIOSIS PROTEIN 2

(Saccharomyces
cerevisiae) 		PF16834
(CSM2) 		4 ASP B  41
TYR B 115
GLU B 164
GLU B 168
 None
 1.49A 6mn5C-3vu9B:
undetectable		 6mn5C-3vu9B:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 ASP A 218
TYR A 149
GLU A 148
ASP A 146
 NAG  A 501 ( 3.2A)
None
NAG  A 501 (-2.7A)
NAG  A 501 (-3.0A)
 1.43A 6mn5C-3wl1A:
undetectable		 6mn5C-3wl1A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 150
GLU A 157
ASP A 198
GLU A 236
 None
 1.40A 6mn5C-4a3tA:
undetectable		 6mn5C-4a3tA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		4 ASP A 267
TYR A 271
GLU A 342
CYH A 225
 None
 1.40A 6mn5C-4dkjA:
undetectable		 6mn5C-4dkjA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1

(Homo sapiens) 		PF07686
(V-set) 		4 ASP A 124
TYR A 128
ASP A  94
GLU A  95
 None
 1.47A 6mn5C-4gosA:
undetectable		 6mn5C-4gosA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ASP A 322
TYR A  32
ASP A  89
GLU A  85
 None
 1.19A 6mn5C-4i3uA:
undetectable		 6mn5C-4i3uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		4 ASP A 173
TYR A 300
GLU A 306
GLU A 312
 None
 1.40A 6mn5C-4nguA:
undetectable		 6mn5C-4nguA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4f INOSITOL
HEXAKISPHOSPHATE
KINASE

(Entamoeba
histolytica) 		PF03770
(IPK) 		4 ASP A 231
ASP A 108
CYH A 243
GLU A 110
 MG  A 402 ( 2.8A)
None
None
None
 1.15A 6mn5C-4o4fA:
undetectable		 6mn5C-4o4fA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		4 ASP A 223
TYR A 154
GLU A 153
ASP A 151
 GOL  A 504 (-2.7A)
None
ACT  A 502 (-3.8A)
ACT  A 502 (-3.0A)
 1.32A 6mn5C-4q22A:
undetectable		 6mn5C-4q22A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 4 ASP H 392
GLU H  14
CYH H 399
GLU H 243
 None
 1.37A 6mn5C-4qslH:
undetectable		 6mn5C-4qslH:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 ASP A1725
GLU A1697
ASP A1779
GLU A1848
 None
None
None
SO4  A2409 ( 4.7A)
 0.91A 6mn5C-4uclA:
undetectable		 6mn5C-4uclA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ASP A 559
TYR A 504
GLU A 444
ASP A 447
 None
 1.17A 6mn5C-4uozA:
undetectable		 6mn5C-4uozA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 4 ASP B 251
TYR B 184
GLU B 183
ASP B 181
 MLI  B 501 ( 4.7A)
None
None
None
 1.32A 6mn5C-4w5uB:
undetectable		 6mn5C-4w5uB:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
ALPHA
STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida;
Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY)
PF00622
(SPRY)
PF13765
(PRY) 		4 ASP B 650
TYR B 522
GLU B 466
GLU A 587
 None
 1.41A 6mn5C-4wvmB:
undetectable		 6mn5C-4wvmB:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 4 TYR D 154
ASP D  40
CYH D  24
GLU D  42
 None
 1.29A 6mn5C-4x28D:
undetectable		 6mn5C-4x28D:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ASP A 264
TYR A 308
GLU A 236
GLU A 230
 None
 0.98A 6mn5C-4z2aA:
undetectable		 6mn5C-4z2aA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 ASP B  27
TYR B 153
GLU B 167
GLU B  49
 None
 1.35A 6mn5C-4zktB:
undetectable		 6mn5C-4zktB:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 ASP A 467
GLU A 321
ASP A 320
GLU A 257
 LOG  A 702 (-2.9A)
LOG  A 702 (-3.1A)
GAL  A 701 (-3.0A)
None
 1.32A 6mn5C-5bxpA:
undetectable		 6mn5C-5bxpA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		4 ASP A 361
GLU A 368
ASP A 369
GLU A 334
 None
 1.17A 6mn5C-5cb2A:
undetectable		 6mn5C-5cb2A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwm DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ASP A   2
GLU A  57
ASP A  59
GLU A  61
 None
 1.29A 6mn5C-5cwmA:
undetectable		 6mn5C-5cwmA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwn DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ASP A  52
GLU A 100
ASP A 102
GLU A 104
 None
 1.28A 6mn5C-5cwnA:
undetectable		 6mn5C-5cwnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfk PROBABLE FIMBRIAL
CHAPERONE ECPB

(Escherichia
coli) 		no annotation 4 ASP A  82
TYR A  77
GLU A  55
ASP A  51
 None
 1.09A 6mn5C-5dfkA:
undetectable		 6mn5C-5dfkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds0 PEPTIDASE M42

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF05343
(Peptidase_M42) 		4 ASP A  44
GLU A  23
ASP A  68
GLU A 214
 None
None
None
CO  A 402 (-3.4A)
 1.19A 6mn5C-5ds0A:
undetectable		 6mn5C-5ds0A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		4 ASP A 265
TYR A 329
ASP A 322
GLU A 311
 None
 1.26A 6mn5C-5es6A:
undetectable		 6mn5C-5es6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		4 ASP A 265
TYR A 329
ASP A 322
GLU A 311
 None
 1.29A 6mn5C-5es9A:
undetectable		 6mn5C-5es9A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASP A 186
GLU A 221
ASP A 172
GLU A 170
 None
 1.47A 6mn5C-5f7sA:
undetectable		 6mn5C-5f7sA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		4 ASP A 343
TYR A  76
GLU A  78
GLU A 109
 None
 1.46A 6mn5C-5gqtA:
undetectable		 6mn5C-5gqtA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmm EXODEOXYRIBONUCLEASE

(Escherichia
virus T5) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		4 ASP A 201
TYR A  82
GLU A 128
ASP A 130
 MG  A 304 (-2.8A)
None
None
MG  A 302 ( 2.7A)
 1.21A 6mn5C-5hmmA:
undetectable		 6mn5C-5hmmA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		4 ASP A 643
TYR A 640
GLU A 615
ASP A 614
 None
 1.41A 6mn5C-5iv8A:
undetectable		 6mn5C-5iv8A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Paraburkholderia
xenovorans) 		PF00483
(NTP_transferase) 		4 ASP A 134
TYR A 249
GLU A 161
GLU A 167
 None
 1.25A 6mn5C-5j49A:
undetectable		 6mn5C-5j49A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 4 ASP C 265
TYR C 329
ASP C 322
GLU C 311
 None
 1.29A 6mn5C-5jnfC:
undetectable		 6mn5C-5jnfC:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Rhinovirus C;
Rhinovirus C) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 ASP C 215
TYR A 179
GLU C 129
ASP A 183
 None
 1.03A 6mn5C-5k0uC:
undetectable		 6mn5C-5k0uC:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		4 ASP N 500
TYR N 471
GLU N 468
GLU N 461
 None
 1.41A 6mn5C-5mpdN:
undetectable		 6mn5C-5mpdN:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 4 ASP A 308
GLU A 233
ASP A 297
CYH A 100
 FE2  A 502 (-3.2A)
FE2  A 501 (-2.2A)
FE2  A 501 (-3.0A)
None
 1.43A 6mn5C-5nhbA:
undetectable		 6mn5C-5nhbA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 4 TYR A 244
GLU A 292
ASP A 291
CYH A 169
 None
AHR  A 600 (-2.8A)
None
None
 1.44A 6mn5C-5o82A:
undetectable		 6mn5C-5o82A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		4 ASP A 159
GLU A 125
CYH A 133
GLU A 407
 None
 1.20A 6mn5C-5uj6A:
undetectable		 6mn5C-5uj6A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veg FLAVODOXIN

(Lactobacillus
reuteri) 		no annotation 4 TYR A  95
GLU A  61
ASP A  60
GLU A  66
 FMN  A 201 (-3.4A)
None
FMN  A 201 ( 4.7A)
None
 1.46A 6mn5C-5vegA:
undetectable		 6mn5C-5vegA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 387
GLU A  11
CYH A 394
GLU A 239
 None
 1.48A 6mn5C-5vywA:
undetectable		 6mn5C-5vywA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA

(Naegleria
fowleri) 		no annotation 4 ASP A 419
GLU A  16
ASP A 286
GLU A  42
 None
 1.50A 6mn5C-6c87A:
undetectable		 6mn5C-6c87A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gii CYTOCHROME P450

(Tepidiphilus
thermophilus) 		no annotation 4 ASP A  79
TYR A 351
GLU A 397
GLU A  89
 None
 1.37A 6mn5C-6giiA:
undetectable		 6mn5C-6giiA:
20.69