SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN5_B_LLLB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 TYR A 499
GLU A 501
ASP A 479
GLU A 516
 None
 1.31A 6mn5B-1a2vA:
0.0		 6mn5B-1a2vA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brl BACTERIAL LUCIFERASE

(Vibrio harveyi) 		PF00296
(Bac_luciferase) 		4 ASP A 293
TYR A 296
GLU A 297
GLU A 200
 None
 1.33A 6mn5B-1brlA:
0.0		 6mn5B-1brlA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ASP A 282
ARG A 284
TYR A 269
ASP A 313
 None
 1.31A 6mn5B-1dedA:
0.0		 6mn5B-1dedA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 332
GLU A 338
ASP A 341
GLU A 344
 ZN  A1363 (-2.1A)
None
None
None
 1.33A 6mn5B-1h2bA:
2.6		 6mn5B-1h2bA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		4 ARG A 227
TYR A 284
GLU A 317
ASP A 318
 None
 1.19A 6mn5B-1h7zA:
undetectable		 6mn5B-1h7zA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		4 ASP A 625
ARG A 629
GLU A 410
GLU A 413
 None
 1.24A 6mn5B-1jnfA:
0.0		 6mn5B-1jnfA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		4 ASP A 348
GLU A 203
ASP A 259
GLU A 256
 None
 1.20A 6mn5B-1k9xA:
0.0		 6mn5B-1k9xA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 ASP A 541
GLU A 563
ASP A 620
GLU A 745
 None
None
NH4  A 901 (-3.2A)
NH4  A 901 (-2.8A)
 1.34A 6mn5B-1kblA:
0.0		 6mn5B-1kblA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 ARG A 205
TYR A 473
GLU A 458
GLU A 180
 None
 1.17A 6mn5B-1nj1A:
1.2		 6mn5B-1nj1A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc2 MITOCHONDRIA FISSION
PROTEIN

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		4 ASP A  50
TYR A  38
GLU A  18
GLU A  12
 None
 1.15A 6mn5B-1pc2A:
undetectable		 6mn5B-1pc2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 ASP A 394
GLU A 417
ASP A 416
GLU A 450
 None
 1.20A 6mn5B-1px8A:
undetectable		 6mn5B-1px8A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus A;
Rhinovirus A) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 ASP 2 212
TYR 1 194
GLU 2 129
ASP 1 198
 None
 1.31A 6mn5B-1r1a2:
undetectable		 6mn5B-1r1a2:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASP A 142
ARG A 138
GLU A 135
GLU A  41
 None
 1.21A 6mn5B-1r3nA:
undetectable		 6mn5B-1r3nA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ARG A 238
GLU A 241
CYH A 313
GLU A  70
 None
 1.30A 6mn5B-1r8wA:
undetectable		 6mn5B-1r8wA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASP A 235
ARG A 238
GLU A 241
CYH A 313
 None
 1.28A 6mn5B-1r8wA:
undetectable		 6mn5B-1r8wA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3

(Homo sapiens) 		PF02214
(BTB_2) 		4 ARG A 141
GLU A 142
ASP A 138
GLU A 134
 None
 1.03A 6mn5B-1s1gA:
undetectable		 6mn5B-1s1gA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		4 ASP A 357
ARG A 307
TYR A 305
ASP A 270
 None
 1.35A 6mn5B-1slqA:
undetectable		 6mn5B-1slqA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv SEROTRANSFERRIN,
C-LOBE

(Homo sapiens) 		PF00405
(Transferrin) 		4 ASP E 625
ARG E 629
GLU E 410
GLU E 413
 None
 1.24A 6mn5B-1suvE:
undetectable		 6mn5B-1suvE:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		4 TYR B  87
GLU B 176
CYH B  42
GLU B 179
 None
None
None
EDO  B 207 (-4.9A)
 1.16A 6mn5B-1te1B:
undetectable		 6mn5B-1te1B:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASP A 169
TYR A  54
GLU A  25
GLU A  16
 None
 1.28A 6mn5B-1v26A:
undetectable		 6mn5B-1v26A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmf HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01894
(UPF0047) 		4 ARG A 121
GLU A 116
ASP A 118
GLU A  79
 None
 1.28A 6mn5B-1vmfA:
undetectable		 6mn5B-1vmfA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E

(Aeropyrum
pernix) 		PF01885
(PTS_2-RNA) 		4 ASP A  59
TYR A  75
ASP A 127
GLU A 126
 None
 1.07A 6mn5B-1wfxA:
undetectable		 6mn5B-1wfxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ARG X 536
TYR X 534
GLU X 524
ASP X 521
 None
 1.26A 6mn5B-1z3iX:
undetectable		 6mn5B-1z3iX:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ASP X 538
ARG X 536
GLU X 524
ASP X 521
 None
 1.33A 6mn5B-1z3iX:
undetectable		 6mn5B-1z3iX:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajz ANTIBODY 7A1 FAB'

(Mus musculus) 		no annotation 4 ASP L 143
TYR L 173
GLU L 105
GLU L   8
 None
 1.19A 6mn5B-2ajzL:
undetectable		 6mn5B-2ajzL:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 TYR A  16
GLU A 338
ASP A 333
GLU A 266
 None
None
GLC  A 605 (-3.5A)
None
 1.12A 6mn5B-2d3lA:
undetectable		 6mn5B-2d3lA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d40 PUTATIVE GENTISATE
1,2-DIOXYGENASE

(Escherichia
coli) 		PF07883
(Cupin_2) 		4 ASP A 237
TYR A 280
ASP A 276
GLU A 332
 None
 1.33A 6mn5B-2d40A:
undetectable		 6mn5B-2d40A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ARG A 154
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.01A 6mn5B-2dh4A:
undetectable		 6mn5B-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ASP A 214
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.25A 6mn5B-2dh4A:
undetectable		 6mn5B-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbq PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 ARG A  59
GLU A  15
ASP A  12
GLU A   5
 None
 1.21A 6mn5B-2fbqA:
undetectable		 6mn5B-2fbqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzk SEX-DETERMINING
REGION ON Y / HMGB1

(Homo sapiens;
Rattus rattus) 		PF00505
(HMG_box) 		4 ASP A 134
TYR A 138
GLU A 102
GLU A 110
 None
 1.28A 6mn5B-2gzkA:
undetectable		 6mn5B-2gzkA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 ASP A 303
ARG A 299
GLU A 295
GLU A 271
 None
 1.22A 6mn5B-2hcbA:
undetectable		 6mn5B-2hcbA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF12708
(Pectate_lyase_3) 		4 ARG A 144
GLU A 145
ASP A 108
GLU A  43
 None
CA  A 379 ( 4.5A)
None
None
 1.30A 6mn5B-2pyhA:
undetectable		 6mn5B-2pyhA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE

(Escherichia
coli) 		PF02618
(YceG) 		4 ASP A 122
ARG A 119
TYR A 142
GLU A 158
 None
 1.33A 6mn5B-2r1fA:
undetectable		 6mn5B-2r1fA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		4 ASP A  57
TYR A 211
GLU A 172
ASP A 207
 None
 1.22A 6mn5B-2r3aA:
undetectable		 6mn5B-2r3aA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		4 ASP A 596
TYR A 650
GLU A 648
GLU A 605
 None
 1.17A 6mn5B-2rfoA:
undetectable		 6mn5B-2rfoA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 ASP A  89
ARG A  58
TYR A 403
GLU A 401
 None
 1.22A 6mn5B-2yr5A:
undetectable		 6mn5B-2yr5A:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 198
GLU A 195
ASP A 192
GLU A 344
 None
 1.34A 6mn5B-3cgdA:
undetectable		 6mn5B-3cgdA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00535
(Glycos_transf_2) 		4 TYR A 170
GLU A 217
ASP A 139
GLU A  59
 None
None
UDP  A 332 (-3.5A)
UDP  A 332 (-2.4A)
 1.34A 6mn5B-3cknA:
undetectable		 6mn5B-3cknA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)

(Escherichia
coli;
Homo sapiens) 		PF00085
(Thioredoxin) 		4 ASP A 553
TYR A 496
GLU A 498
GLU A 429
 None
 1.19A 6mn5B-3dxbA:
undetectable		 6mn5B-3dxbA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		4 ASP A 118
ARG A 117
TYR A 155
GLU A 147
 None
SO4  A 225 (-3.0A)
None
None
 1.34A 6mn5B-3e23A:
undetectable		 6mn5B-3e23A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 ASP A  61
TYR A 136
GLU A 203
ASP A 128
 None
 1.16A 6mn5B-3f41A:
undetectable		 6mn5B-3f41A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		4 ASP A 200
ARG A 202
GLU A 145
GLU A 178
 None
 1.13A 6mn5B-3flbA:
undetectable		 6mn5B-3flbA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyw NUCLEOSOME ASSEMBLY
PROTEIN 1, PUTATIVE

(Plasmodium
falciparum) 		PF00956
(NAP) 		4 ASP A 134
ARG A 132
TYR A 151
ASP A  80
 None
 1.17A 6mn5B-3gywA:
undetectable		 6mn5B-3gywA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		4 ASP A 288
TYR A 226
ASP A 199
GLU A 100
 EDO  A 463 ( 4.9A)
EPE  A 462 (-4.5A)
None
None
 0.92A 6mn5B-3gzaA:
undetectable		 6mn5B-3gzaA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm7 ALLANTOINASE

(Bacillus
halodurans) 		PF01979
(Amidohydro_1) 		4 ARG A 125
ASP A 123
CYH A 429
GLU A 387
 None
 1.31A 6mn5B-3hm7A:
undetectable		 6mn5B-3hm7A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		4 ASP A 217
TYR A 255
GLU A 222
GLU A 225
 LLP  A 243 ( 2.9A)
None
None
None
 1.32A 6mn5B-3hvyA:
undetectable		 6mn5B-3hvyA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 247
TYR A 294
GLU A 323
ASP A 297
 MG  A 381 (-3.1A)
None
None
None
 1.21A 6mn5B-3i6tA:
undetectable		 6mn5B-3i6tA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 ASP A 212
TYR A 180
GLU A 245
ASP A 171
 None
UNL  A 277 (-3.9A)
ZN  A 276 ( 4.4A)
None
 1.03A 6mn5B-3iehA:
undetectable		 6mn5B-3iehA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASP A 325
TYR A 392
GLU A 382
ASP A 384
 None
 1.24A 6mn5B-3iplA:
undetectable		 6mn5B-3iplA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j40 GP7

(Salmonella
virus Epsilon15) 		no annotation 5 ASP A 220
ARG A 219
TYR A 218
GLU A 200
ASP A 201
 None
 1.42A 6mn5B-3j40A:
undetectable		 6mn5B-3j40A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv5 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Mus musculus) 		PF16179
(RHD_dimer) 		4 TYR A 294
GLU A 264
ASP A 266
GLU A 267
 None
 1.08A 6mn5B-3jv5A:
undetectable		 6mn5B-3jv5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 ASP A 479
GLU A  18
ASP A  15
GLU A  13
 None
 1.29A 6mn5B-3kveA:
undetectable		 6mn5B-3kveA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		4 TYR A 266
GLU A  28
CYH A  46
GLU A  43
 None
 0.77A 6mn5B-3lmaA:
undetectable		 6mn5B-3lmaA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Salmonella
enterica) 		PF00926
(DHBP_synthase) 		4 ARG A  24
GLU A  25
ASP A  21
GLU A  17
 None
 1.24A 6mn5B-3lquA:
undetectable		 6mn5B-3lquA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE

(Selenomonas
ruminantium) 		PF14566
(PTPlike_phytase) 		4 ASP A  59
TYR A 140
GLU A 205
ASP A 132
 None
 1.19A 6mn5B-3mozA:
undetectable		 6mn5B-3mozA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 ASP A 200
TYR A 116
GLU A 114
GLU A 134
 None
 1.11A 6mn5B-3oajA:
undetectable		 6mn5B-3oajA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ois CYSTEINE PROTEASE

(Xylella
fastidiosa) 		PF00112
(Peptidase_C1) 		4 ASP A  44
TYR A 184
ASP A 128
GLU A 115
 UDP  A 292 (-3.7A)
UDP  A 292 (-3.2A)
None
None
 1.10A 6mn5B-3oisA:
undetectable		 6mn5B-3oisA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 TYR A 795
GLU A 803
ASP A 906
GLU A  28
 None
 1.01A 6mn5B-3pieA:
undetectable		 6mn5B-3pieA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1

(Homo sapiens) 		PF00071
(Ras) 		4 ARG C  68
TYR C  72
ASP C  65
GLU C  62
 None
 1.27A 6mn5B-3rytC:
undetectable		 6mn5B-3rytC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 TYR A 641
GLU A 644
CYH A 733
GLU A 732
 None
 1.31A 6mn5B-3sdqA:
undetectable		 6mn5B-3sdqA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 ASP A 551
ARG A 547
GLU A 544
GLU A 183
 None
 1.24A 6mn5B-4a2wA:
undetectable		 6mn5B-4a2wA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4art STRUCTURAL PROTEIN
ORF273

(Acidianus
two-tailed
virus) 		no annotation 4 TYR A 140
GLU A  92
ASP A  94
GLU A 101
 None
 1.22A 6mn5B-4artA:
undetectable		 6mn5B-4artA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgu MALATE DEHYDROGENASE

(Haloferax
volcanii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASP A 137
ARG A 138
TYR A 131
ASP A 252
 CL  A1324 (-3.9A)
None
PGE  A1341 ( 3.9A)
None
 0.90A 6mn5B-4bguA:
undetectable		 6mn5B-4bguA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		4 ASP A 230
ARG A 261
TYR A 257
ASP A 264
 None
 1.26A 6mn5B-4d1iA:
undetectable		 6mn5B-4d1iA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg RHO-LIKE SMALL
GTPASE

(Entamoeba
histolytica) 		PF00071
(Ras) 		4 ARG A  85
TYR A  89
GLU A 117
GLU A  79
 None
 1.25A 6mn5B-4dvgA:
undetectable		 6mn5B-4dvgA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE

(Streptococcus
mutans) 		PF00232
(Glyco_hydro_1) 		4 ARG A 263
TYR A 330
GLU A 332
GLU A 176
 None
None
None
6GB  A 501 (-3.0A)
 1.23A 6mn5B-4gpnA:
undetectable		 6mn5B-4gpnA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ASP A 322
TYR A  32
ASP A  89
GLU A  85
 None
 1.04A 6mn5B-4i3uA:
undetectable		 6mn5B-4i3uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A 315
TYR A 319
GLU A 173
ASP A 312
 None
 1.16A 6mn5B-4j6fA:
3.1		 6mn5B-4j6fA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ASP A 272
ARG A 274
TYR A 259
ASP A 303
 None
 1.14A 6mn5B-4jcmA:
undetectable		 6mn5B-4jcmA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3b OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Neisseria
gonorrhoeae) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 ARG A 298
TYR A 296
ASP A 227
GLU A 223
 None
 1.26A 6mn5B-4k3bA:
undetectable		 6mn5B-4k3bA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrq PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Vibrio cholerae) 		PF01451
(LMWPc) 		4 ARG A  60
TYR A  62
GLU A 139
ASP A 136
 None
 1.28A 6mn5B-4lrqA:
undetectable		 6mn5B-4lrqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 ASP A 638
GLU A 678
ASP A 674
GLU A 667
 None
 1.27A 6mn5B-4m0mA:
undetectable		 6mn5B-4m0mA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		4 TYR A  27
GLU A  25
ASP A 224
GLU A 335
 None
 1.27A 6mn5B-4mh1A:
undetectable		 6mn5B-4mh1A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mit RHO FAMILY GTPASE

(Entamoeba
histolytica) 		PF00071
(Ras) 		4 ARG A  75
TYR A  79
ASP A  72
GLU A  69
 None
None
MG  A 203 (-3.1A)
None
 1.15A 6mn5B-4mitA:
undetectable		 6mn5B-4mitA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4f INOSITOL
HEXAKISPHOSPHATE
KINASE

(Entamoeba
histolytica) 		PF03770
(IPK) 		4 ASP A 231
ASP A 108
CYH A 243
GLU A 110
 MG  A 402 ( 2.8A)
None
None
None
 1.32A 6mn5B-4o4fA:
undetectable		 6mn5B-4o4fA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3

(Homo sapiens) 		PF10189
(Ints3) 		4 ASP A 348
ARG A 304
CYH A 236
GLU A 232
 None
 1.29A 6mn5B-4owtA:
undetectable		 6mn5B-4owtA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		4 ASP A 130
TYR A 133
GLU A 535
GLU A 542
 None
 1.27A 6mn5B-4p05A:
undetectable		 6mn5B-4p05A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 ASP A1725
GLU A1697
ASP A1779
GLU A1848
 None
None
None
SO4  A2409 ( 4.7A)
 1.06A 6mn5B-4uclA:
undetectable		 6mn5B-4uclA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 ASP A 162
ARG A 158
ASP A  88
GLU A  56
 None
 1.34A 6mn5B-5a5tA:
undetectable		 6mn5B-5a5tA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aip TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Neisseria
meningitidis) 		PF01047
(MarR) 		4 ASP A 112
ARG A  43
TYR A 104
GLU A  47
 None
 1.12A 6mn5B-5aipA:
undetectable		 6mn5B-5aipA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		4 ASP A 361
GLU A 368
ASP A 369
GLU A 334
 None
 1.28A 6mn5B-5cb2A:
undetectable		 6mn5B-5cb2A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cq9 SECRETED EFFECTOR
PROTEIN SOPD2

(Salmonella
enterica) 		PF11047
(SopD) 		4 ASP A 195
ARG A 196
ASP A 180
GLU A 178
 None
 1.32A 6mn5B-5cq9A:
undetectable		 6mn5B-5cq9A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfk PROBABLE FIMBRIAL
CHAPERONE ECPB

(Escherichia
coli) 		no annotation 4 ASP A  82
TYR A  77
GLU A  55
ASP A  51
 None
 1.04A 6mn5B-5dfkA:
undetectable		 6mn5B-5dfkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 4 ASP C  78
ARG C 460
TYR C 590
ASP C 459
 None
 1.13A 6mn5B-5elpC:
undetectable		 6mn5B-5elpC:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ARG A 291
GLU A 294
CYH A 369
GLU A 119
 None
 1.26A 6mn5B-5favA:
undetectable		 6mn5B-5favA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASP A 288
ARG A 291
GLU A 294
CYH A 369
 None
 1.24A 6mn5B-5favA:
undetectable		 6mn5B-5favA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fft PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN A

(Rattus
norvegicus) 		PF00059
(Lectin_C) 		4 TYR A 208
GLU A 195
ASP A 215
GLU A 171
 None
CA  A 300 (-2.8A)
CA  A 300 (-3.1A)
None
 1.20A 6mn5B-5fftA:
undetectable		 6mn5B-5fftA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 ARG A 918
TYR A 916
GLU A 906
ASP A 903
 None
 1.22A 6mn5B-5hzrA:
undetectable		 6mn5B-5hzrA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		4 ASP A 123
TYR A 152
GLU A 153
CYH A   9
 None
None
None
ALA  A 501 (-3.3A)
 1.20A 6mn5B-5inrA:
undetectable		 6mn5B-5inrA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ARG A 535
TYR A 533
GLU A 523
ASP A 520
 None
 1.25A 6mn5B-5jxrA:
undetectable		 6mn5B-5jxrA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		4 ARG A 126
TYR A 130
GLU A  94
GLU A  86
 None
 1.27A 6mn5B-5k04A:
undetectable		 6mn5B-5k04A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 ASP B 335
ARG B 267
GLU B 271
GLU B 221
 None
 1.24A 6mn5B-5l3xB:
undetectable		 6mn5B-5l3xB:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngh ODORANT BINDING
PROTEIN 3

(Ailuropoda
melanoleuca) 		no annotation 4 ARG A 135
TYR A 139
GLU A  96
ASP A   6
 None
 1.35A 6mn5B-5nghA:
undetectable		 6mn5B-5nghA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ASP A 475
ARG A  21
GLU A  25
CYH A  30
 None
 1.34A 6mn5B-5tw7A:
undetectable		 6mn5B-5tw7A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		4 ASP A 159
GLU A 125
CYH A 133
GLU A 407
 None
 1.24A 6mn5B-5uj6A:
undetectable		 6mn5B-5uj6A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veg FLAVODOXIN

(Lactobacillus
reuteri) 		no annotation 4 TYR A  95
GLU A  61
ASP A  60
GLU A  66
 FMN  A 201 (-3.4A)
None
FMN  A 201 ( 4.7A)
None
 1.27A 6mn5B-5vegA:
undetectable		 6mn5B-5vegA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		4 ASP A 149
TYR A 326
GLU A 333
GLU A 160
 None
 1.21A 6mn5B-5wayA:
undetectable		 6mn5B-5wayA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA

(Naegleria
fowleri) 		no annotation 4 ASP A 419
GLU A  16
ASP A 286
GLU A  42
 None
 1.30A 6mn5B-6c87A:
undetectable		 6mn5B-6c87A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml INO80

(Chaetomium
thermophilum) 		no annotation 4 ARG G1598
TYR G1596
GLU G1586
ASP G1583
 None
 1.19A 6mn5B-6fmlG:
undetectable		 6mn5B-6fmlG:
24.14