SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN5_A_LLLA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 TYR A 499
GLU A 501
ASP A 479
GLU A 516
 None
 1.34A 6mn5A-1a2vA:
0.0		 6mn5A-1a2vA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bix AP ENDONUCLEASE 1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ASP A 283
TYR A 171
GLU A  96
ASP A  70
 None
None
SM  A 401 (-2.3A)
SM  A 401 (-3.3A)
 1.43A 6mn5A-1bixA:
0.0		 6mn5A-1bixA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 ASP A 346
TYR A 413
GLU A 380
ASP A 379
 None
 1.41A 6mn5A-1c7tA:
0.0		 6mn5A-1c7tA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ASP A 291
TYR A 284
GLU A 280
GLU A 574
 None
None
None
MPD  A 803 ( 4.4A)
 1.36A 6mn5A-1kwgA:
0.1		 6mn5A-1kwgA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 ASP A 394
GLU A 417
ASP A 416
GLU A 450
 None
 1.36A 6mn5A-1px8A:
0.0		 6mn5A-1px8A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Thermotoga
maritima) 		PF13393
(tRNA-synt_His) 		4 ASP C  53
TYR C  75
GLU C  96
GLU C 261
 None
 1.48A 6mn5A-1usyC:
undetectable		 6mn5A-1usyC:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		4 ASP A  92
TYR A 435
GLU A 432
ASP A 433
 None
 1.49A 6mn5A-1vg0A:
0.1		 6mn5A-1vg0A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		4 ASP A  45
GLU A  24
ASP A  70
GLU A 214
 None
None
None
ZN  A 372 ( 3.9A)
 1.12A 6mn5A-1vheA:
0.0		 6mn5A-1vheA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 ASP A 213
TYR A 141
GLU A 140
ASP A 138
 None
 1.31A 6mn5A-1wb0A:
0.0		 6mn5A-1wb0A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfx PROBABLE RNA
2'-PHOSPHOTRANSFERAS
E

(Aeropyrum
pernix) 		PF01885
(PTS_2-RNA) 		4 ASP A  59
TYR A  75
ASP A 127
GLU A 126
 None
 1.11A 6mn5A-1wfxA:
undetectable		 6mn5A-1wfxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		4 ASP A 114
TYR A  61
ASP A  47
GLU A  53
 None
 1.48A 6mn5A-1wzzA:
undetectable		 6mn5A-1wzzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Lactococcus
lactis;
Lactococcus
lactis) 		PF13393
(tRNA-synt_His)
PF01634
(HisG) 		4 ASP E  74
TYR E  81
GLU E  83
ASP A 191
 None
 1.34A 6mn5A-1z7mE:
undetectable		 6mn5A-1z7mE:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcc GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		4 TYR A 106
GLU A 108
ASP A  36
GLU A  16
 None
SO4  A4770 ( 3.7A)
SO4  A4770 ( 4.1A)
None
 1.48A 6mn5A-1zccA:
undetectable		 6mn5A-1zccA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		4 ASP A  74
TYR A  63
GLU A 236
GLU A 274
 None
 1.43A 6mn5A-2a5hA:
undetectable		 6mn5A-2a5hA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajz ANTIBODY 7A1 FAB'

(Mus musculus) 		no annotation 4 ASP L 143
TYR L 173
GLU L 105
GLU L   8
 None
 1.30A 6mn5A-2ajzL:
undetectable		 6mn5A-2ajzL:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be4 HYPOTHETICAL PROTEIN
LOC449832

(Danio rerio) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 ASP A 162
TYR A 120
ASP A 169
GLU A  87
 None
 1.47A 6mn5A-2be4A:
undetectable		 6mn5A-2be4A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ASP A 187
TYR A 157
ASP A 646
GLU A 461
 FMN  A 752 (-3.1A)
FMN  A 751 (-3.5A)
NAP  A 753 (-2.7A)
NAP  A 753 ( 3.0A)
 1.26A 6mn5A-2bf4A:
undetectable		 6mn5A-2bf4A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ASP A 214
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.41A 6mn5A-2dh4A:
undetectable		 6mn5A-2dh4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwu SODIUM/CALCIUM
EXCHANGER 1

(Canis lupus) 		PF03160
(Calx-beta) 		4 GLU A 543
ASP A 555
CYH A 557
GLU A 554
 None
 1.31A 6mn5A-2fwuA:
undetectable		 6mn5A-2fwuA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hkl L,D-TRANSPEPTIDASE

(Enterococcus
faecium) 		PF03734
(YkuD)
PF12229
(PG_binding_4) 		4 TYR A 357
GLU A 346
ASP A 348
GLU A 350
 None
 1.50A 6mn5A-2hklA:
undetectable		 6mn5A-2hklA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		4 ASP A 275
TYR A 164
GLU A  89
ASP A  63
 None
None
None
PB  A 402 (-3.3A)
 1.36A 6mn5A-2o3cA:
undetectable		 6mn5A-2o3cA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 TYR A 211
GLU A 289
ASP A 293
GLU A 297
 None
 1.46A 6mn5A-2qagA:
undetectable		 6mn5A-2qagA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 ASP A 321
TYR A 326
GLU A 327
ASP A 316
 None
 1.49A 6mn5A-2qneA:
undetectable		 6mn5A-2qneA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqy SIGMA B OPERON

(Bacillus
anthracis) 		PF00210
(Ferritin) 		4 ASP A  51
TYR A  26
GLU A  94
GLU A 132
 None
 1.30A 6mn5A-2qqyA:
undetectable		 6mn5A-2qqyA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		4 ASP A 596
TYR A 650
GLU A 648
GLU A 605
 None
 1.24A 6mn5A-2rfoA:
undetectable		 6mn5A-2rfoA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am3 ENOYL-ACP REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 ASP A 176
TYR A 251
GLU A 196
ASP A 197
 None
 1.50A 6mn5A-3am3A:
undetectable		 6mn5A-3am3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo sapiens) 		PF02373
(JmjC) 		4 TYR A1330
GLU A1337
CYH A1295
GLU A1257
 None
None
EDO  A1508 (-2.3A)
EDO  A1508 (-2.9A)
 1.44A 6mn5A-3avsA:
undetectable		 6mn5A-3avsA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 198
GLU A 195
ASP A 192
GLU A 344
 None
 1.23A 6mn5A-3cgdA:
undetectable		 6mn5A-3cgdA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqo FBP32

(Morone
saxatilis) 		PF00754
(F5_F8_type_C) 		4 ASP A 293
TYR A  61
GLU A  59
GLU A 152
 None
 0.98A 6mn5A-3cqoA:
undetectable		 6mn5A-3cqoA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 4 ASP A 194
GLU A 230
ASP A 223
GLU A 225
 None
 1.47A 6mn5A-3dsmA:
undetectable		 6mn5A-3dsmA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 ASP A  61
TYR A 136
GLU A 203
ASP A 128
 None
 1.07A 6mn5A-3f41A:
undetectable		 6mn5A-3f41A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		4 ASP A 393
GLU A 369
CYH A 246
GLU A 244
 None
 1.38A 6mn5A-3gueA:
undetectable		 6mn5A-3gueA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		4 ASP A 288
TYR A 226
ASP A 199
GLU A 100
 EDO  A 463 ( 4.9A)
EPE  A 462 (-4.5A)
None
None
 1.06A 6mn5A-3gzaA:
undetectable		 6mn5A-3gzaA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 408
GLU A 337
ASP A 343
GLU A  58
 None
 1.40A 6mn5A-3ho8A:
undetectable		 6mn5A-3ho8A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 249
TYR A 298
GLU A 327
ASP A 301
 MG  A 386 (-3.1A)
None
None
None
 1.24A 6mn5A-3i6eA:
undetectable		 6mn5A-3i6eA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 301
TYR A 298
GLU A 224
ASP A 198
 None
None
MG  A 386 (-2.7A)
MG  A 386 (-2.5A)
 1.47A 6mn5A-3i6eA:
undetectable		 6mn5A-3i6eA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 247
TYR A 294
GLU A 323
ASP A 297
 MG  A 381 (-3.1A)
None
None
None
 1.24A 6mn5A-3i6tA:
undetectable		 6mn5A-3i6tA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 297
TYR A 294
GLU A 222
ASP A 196
 None
None
MG  A 381 (-3.0A)
MG  A 381 (-2.8A)
 1.48A 6mn5A-3i6tA:
undetectable		 6mn5A-3i6tA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 ASP A 212
TYR A 180
GLU A 245
ASP A 171
 None
UNL  A 277 (-3.9A)
ZN  A 276 ( 4.4A)
None
 1.06A 6mn5A-3iehA:
undetectable		 6mn5A-3iehA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv5 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Mus musculus) 		PF16179
(RHD_dimer) 		4 TYR A 294
GLU A 264
ASP A 266
GLU A 267
 None
 1.17A 6mn5A-3jv5A:
undetectable		 6mn5A-3jv5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 ASP A  42
GLU A  21
ASP A  68
GLU A 213
 None
None
None
ZN  A 355 (-3.6A)
 1.18A 6mn5A-3kl9A:
undetectable		 6mn5A-3kl9A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 ASP A 479
GLU A  18
ASP A  15
GLU A  13
 None
 1.37A 6mn5A-3kveA:
undetectable		 6mn5A-3kveA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		4 TYR A 266
GLU A  28
CYH A  46
GLU A  43
 None
 0.92A 6mn5A-3lmaA:
undetectable		 6mn5A-3lmaA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE

(Selenomonas
ruminantium) 		PF14566
(PTPlike_phytase) 		4 ASP A  59
TYR A 140
GLU A 205
ASP A 132
 None
 1.12A 6mn5A-3mozA:
undetectable		 6mn5A-3mozA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 ASP A 200
TYR A 116
GLU A 114
GLU A 134
 None
 1.21A 6mn5A-3oajA:
undetectable		 6mn5A-3oajA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ois CYSTEINE PROTEASE

(Xylella
fastidiosa) 		PF00112
(Peptidase_C1) 		4 ASP A  44
TYR A 184
ASP A 128
GLU A 115
 UDP  A 292 (-3.7A)
UDP  A 292 (-3.2A)
None
None
 1.22A 6mn5A-3oisA:
undetectable		 6mn5A-3oisA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p02 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		4 TYR A  58
GLU A 329
ASP A 328
GLU A 177
 None
 1.45A 6mn5A-3p02A:
undetectable		 6mn5A-3p02A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 TYR A 795
GLU A 803
ASP A 906
GLU A  28
 None
 1.07A 6mn5A-3pieA:
undetectable		 6mn5A-3pieA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		4 ASP A 139
TYR A  84
ASP A 128
GLU A 117
 None
 1.46A 6mn5A-3pjaA:
undetectable		 6mn5A-3pjaA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		4 ASP A 433
TYR A 452
GLU A 474
ASP A 460
 None
 1.47A 6mn5A-3sggA:
undetectable		 6mn5A-3sggA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 ASP A 218
TYR A 149
GLU A 148
ASP A 146
 NAG  A 501 ( 3.2A)
None
NAG  A 501 (-2.7A)
NAG  A 501 (-3.0A)
 1.41A 6mn5A-3wl1A:
undetectable		 6mn5A-3wl1A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 150
GLU A 157
ASP A 198
GLU A 236
 None
 1.50A 6mn5A-4a3tA:
undetectable		 6mn5A-4a3tA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		4 ASP A 267
TYR A 271
GLU A 342
CYH A 225
 None
 1.36A 6mn5A-4dkjA:
undetectable		 6mn5A-4dkjA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B

(Mus musculus) 		PF02373
(JmjC) 		4 TYR A1574
GLU A1581
CYH A1539
GLU A1501
 None
 1.25A 6mn5A-4eyuA:
undetectable		 6mn5A-4eyuA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1

(Homo sapiens) 		PF07686
(V-set) 		4 ASP A 124
TYR A 128
ASP A  94
GLU A  95
 None
 1.45A 6mn5A-4gosA:
undetectable		 6mn5A-4gosA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ASP A 322
TYR A  32
ASP A  89
GLU A  85
 None
 1.18A 6mn5A-4i3uA:
undetectable		 6mn5A-4i3uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 368
GLU A 301
ASP A 307
GLU A  23
 None
 1.41A 6mn5A-4mv3A:
undetectable		 6mn5A-4mv3A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 TYR A 518
GLU A  58
CYH A  48
GLU A 137
 None
 1.37A 6mn5A-4mz0A:
2.1		 6mn5A-4mz0A:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4f INOSITOL
HEXAKISPHOSPHATE
KINASE

(Entamoeba
histolytica) 		PF03770
(IPK) 		4 ASP A 231
ASP A 108
CYH A 243
GLU A 110
 MG  A 402 ( 2.8A)
None
None
None
 1.29A 6mn5A-4o4fA:
undetectable		 6mn5A-4o4fA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5b THYMIDYLATE SYNTHASE
THYX

(Streptomyces
cacaoi) 		PF02511
(Thy1) 		4 ASP A 110
TYR A 107
GLU A 208
GLU A 214
 None
 0.95A 6mn5A-4p5bA:
undetectable		 6mn5A-4p5bA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		4 ASP A 223
TYR A 154
GLU A 153
ASP A 151
 GOL  A 504 (-2.7A)
None
ACT  A 502 (-3.8A)
ACT  A 502 (-3.0A)
 1.33A 6mn5A-4q22A:
undetectable		 6mn5A-4q22A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 4 ASP H 392
GLU H  14
CYH H 399
GLU H 243
 None
 1.32A 6mn5A-4qslH:
undetectable		 6mn5A-4qslH:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 385
GLU A 301
ASP A 307
GLU A  23
 None
 1.41A 6mn5A-4rcnA:
undetectable		 6mn5A-4rcnA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		4 ASP A 705
TYR A 728
GLU A 748
GLU A 754
 None
 1.33A 6mn5A-4sliA:
undetectable		 6mn5A-4sliA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 ASP A1725
GLU A1697
ASP A1779
GLU A1848
 None
None
None
SO4  A2409 ( 4.7A)
 1.14A 6mn5A-4uclA:
undetectable		 6mn5A-4uclA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ASP A 559
TYR A 504
GLU A 444
ASP A 447
 None
 1.14A 6mn5A-4uozA:
undetectable		 6mn5A-4uozA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ASP A 555
TYR A 500
GLU A 440
ASP A 443
 None
 1.18A 6mn5A-4uzsA:
undetectable		 6mn5A-4uzsA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 4 ASP B 251
TYR B 184
GLU B 183
ASP B 181
 MLI  B 501 ( 4.7A)
None
None
None
 1.35A 6mn5A-4w5uB:
undetectable		 6mn5A-4w5uB:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 4 TYR D 154
ASP D  40
CYH D  24
GLU D  42
 None
 1.36A 6mn5A-4x28D:
undetectable		 6mn5A-4x28D:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ASP A 264
TYR A 308
GLU A 236
GLU A 230
 None
 1.01A 6mn5A-4z2aA:
undetectable		 6mn5A-4z2aA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 ASP B  27
TYR B 153
GLU B 167
GLU B  49
 None
 1.35A 6mn5A-4zktB:
undetectable		 6mn5A-4zktB:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 ASP A 467
GLU A 321
ASP A 320
GLU A 257
 LOG  A 702 (-2.9A)
LOG  A 702 (-3.1A)
GAL  A 701 (-3.0A)
None
 1.23A 6mn5A-5bxpA:
undetectable		 6mn5A-5bxpA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		4 ASP A 361
GLU A 368
ASP A 369
GLU A 334
 None
 1.15A 6mn5A-5cb2A:
undetectable		 6mn5A-5cb2A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coz UNCHARACTERIZED
PROTEIN

([Eubacterium]
rectale) 		no annotation 4 ASP A 175
TYR A 349
GLU A 320
ASP A  69
 None
 1.05A 6mn5A-5cozA:
undetectable		 6mn5A-5cozA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfk PROBABLE FIMBRIAL
CHAPERONE ECPB

(Escherichia
coli) 		no annotation 4 ASP A  82
TYR A  77
GLU A  55
ASP A  51
 None
 1.07A 6mn5A-5dfkA:
undetectable		 6mn5A-5dfkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds0 PEPTIDASE M42

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF05343
(Peptidase_M42) 		4 ASP A  44
GLU A  23
ASP A  68
GLU A 214
 None
None
None
CO  A 402 (-3.4A)
 1.06A 6mn5A-5ds0A:
undetectable		 6mn5A-5ds0A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		4 ASP A 265
TYR A 329
ASP A 322
GLU A 311
 None
 1.29A 6mn5A-5es6A:
undetectable		 6mn5A-5es6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		4 ASP A 265
TYR A 329
ASP A 322
GLU A 311
 None
 1.35A 6mn5A-5es9A:
undetectable		 6mn5A-5es9A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA

(Moorella
thermoacetica;
Moorella
thermoacetica) 		PF01855
(POR_N)
PF17147
(PFOR_II)
PF00037
(Fer4)
PF01558
(POR) 		4 ASP B  54
TYR B  66
GLU B  81
GLU A 361
 None
 1.46A 6mn5A-5exeB:
undetectable		 6mn5A-5exeB:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		4 ASP A 343
TYR A  76
GLU A  78
GLU A 109
 None
 1.46A 6mn5A-5gqtA:
undetectable		 6mn5A-5gqtA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmm EXODEOXYRIBONUCLEASE

(Escherichia
virus T5) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		4 ASP A 201
TYR A  82
GLU A 128
ASP A 130
 MG  A 304 (-2.8A)
None
None
MG  A 302 ( 2.7A)
 1.14A 6mn5A-5hmmA:
undetectable		 6mn5A-5hmmA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		4 ASP A 123
TYR A 152
GLU A 153
CYH A   9
 None
None
None
ALA  A 501 (-3.3A)
 1.24A 6mn5A-5inrA:
undetectable		 6mn5A-5inrA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Paraburkholderia
xenovorans) 		PF00483
(NTP_transferase) 		4 ASP A 134
TYR A 249
GLU A 161
GLU A 167
 None
 1.27A 6mn5A-5j49A:
undetectable		 6mn5A-5j49A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 4 ASP C 265
TYR C 329
ASP C 322
GLU C 311
 None
 1.31A 6mn5A-5jnfC:
undetectable		 6mn5A-5jnfC:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 368
GLU A 300
ASP A 306
GLU A  23
 None
 1.32A 6mn5A-5ks8A:
undetectable		 6mn5A-5ks8A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 4 ASP A  50
GLU A 258
ASP A 254
GLU A  44
 None
 1.27A 6mn5A-5mlhA:
undetectable		 6mn5A-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		4 ASP N 500
TYR N 471
GLU N 468
GLU N 461
 None
 1.40A 6mn5A-5mpdN:
undetectable		 6mn5A-5mpdN:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n11 HEMAGGLUTININ-ESTERA
SE

(Betacoronavirus
1) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 ASP A 281
TYR A 367
ASP A  33
GLU A  93
 None
 1.36A 6mn5A-5n11A:
undetectable		 6mn5A-5n11A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 4 ASP A 308
GLU A 233
ASP A 297
CYH A 100
 FE2  A 502 (-3.2A)
FE2  A 501 (-2.2A)
FE2  A 501 (-3.0A)
None
 1.41A 6mn5A-5nhbA:
undetectable		 6mn5A-5nhbA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 4 TYR A 244
GLU A 292
ASP A 291
CYH A 169
 None
AHR  A 600 (-2.8A)
None
None
 1.49A 6mn5A-5o82A:
undetectable		 6mn5A-5o82A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		4 ASP A 159
GLU A 125
CYH A 133
GLU A 407
 None
 1.19A 6mn5A-5uj6A:
undetectable		 6mn5A-5uj6A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 387
GLU A  11
CYH A 394
GLU A 239
 None
 1.46A 6mn5A-5vywA:
undetectable		 6mn5A-5vywA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila) 		no annotation 4 TYR A  25
GLU A 126
CYH A 196
GLU A 242
 None
 1.08A 6mn5A-6b7pA:
undetectable		 6mn5A-6b7pA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA

(Naegleria
fowleri) 		no annotation 4 ASP A 419
GLU A  16
ASP A 286
GLU A  42
 None
 1.31A 6mn5A-6c87A:
undetectable		 6mn5A-6c87A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gii CYTOCHROME P450

(Tepidiphilus
thermophilus) 		no annotation 4 ASP A  79
TYR A 351
GLU A 397
GLU A  89
 None
 1.38A 6mn5A-6giiA:
undetectable		 6mn5A-6giiA:
20.69