SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN4_F_AM2F301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aug PYROGLUTAMYL
PEPTIDASE-1

(Bacillus
amyloliquefaciens) 		PF01470
(Peptidase_C15) 		4 HIS A 158
HIS A 146
GLU A 154
GLU A  56
 None
 1.12A 6mn4F-1augA:
0.0		 6mn4F-1augA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 HIS A 621
ARG A 577
ASP A 601
GLU A 603
 None
 1.22A 6mn4F-1fcpA:
0.0		 6mn4F-1fcpA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		4 HIS A   2
GLU A 164
ASP A 171
GLU A 172
 None
 1.40A 6mn4F-1g0vA:
0.0		 6mn4F-1g0vA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 HIS B 524
HIS B 862
GLU B 543
GLU B 807
 None
 1.33A 6mn4F-1m2vB:
0.0		 6mn4F-1m2vB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 TRP A 207
ARG A 210
HIS A 212
ASP A 198
 None
 1.37A 6mn4F-1pgsA:
0.0		 6mn4F-1pgsA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ARG A 260
HIS A 405
ASP A 256
GLU A 385
 None
SO4  A9002 (-4.3A)
None
None
 1.22A 6mn4F-1rt8A:
0.0		 6mn4F-1rt8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uai POLYGULURONATE LYASE

(Corynebacterium
sp.) 		PF08787
(Alginate_lyase2) 		4 HIS A 223
ARG A  76
HIS A 119
GLU A  77
 None
 1.31A 6mn4F-1uaiA:
0.0		 6mn4F-1uaiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167

(Pseudomonas
aeruginosa) 		PF08787
(Alginate_lyase2) 		4 HIS A 222
ARG A  63
HIS A 104
GLU A  64
 None
 1.42A 6mn4F-1vavA:
0.0		 6mn4F-1vavA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 HIS A 567
HIS A 628
GLU A 566
ASP A 624
GLU A 750
 None
None
None
MG  A2000 ( 3.7A)
MG  A2000 (-2.6A)
 1.36A 6mn4F-1vbgA:
0.0		 6mn4F-1vbgA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmf HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01894
(UPF0047) 		4 ARG A 121
GLU A 116
ASP A 118
GLU A  79
 None
 1.20A 6mn4F-1vmfA:
undetectable		 6mn4F-1vmfA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpq HYPOTHETICAL PROTEIN
TM1631

(Thermotoga
maritima) 		PF01904
(DUF72) 		4 TRP A 199
HIS A 193
ASP A 169
GLU A 216
 SO4  A 263 ( 4.9A)
SO4  A 262 (-3.9A)
None
None
 1.42A 6mn4F-1vpqA:
undetectable		 6mn4F-1vpqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ww6 GALECTIN

(Agrocybe
cylindracea) 		PF00337
(Gal-bind_lectin) 		4 TRP A  83
HIS A  62
ARG A  88
GLU A  69
 GAL  A 200 (-3.6A)
GAL  A 200 (-4.1A)
BGC  A 201 ( 4.3A)
None
 1.42A 6mn4F-1ww6A:
undetectable		 6mn4F-1ww6A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 TRP A 181
HIS A 173
GLU A 202
ASP A 163
 None
None
None
MN  A 430 (-2.6A)
 1.37A 6mn4F-1xzwA:
undetectable		 6mn4F-1xzwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TRP A 552
HIS A 369
GLU A 394
GLU A 399
 NA  A7501 (-4.7A)
None
None
None
 1.35A 6mn4F-1yq2A:
undetectable		 6mn4F-1yq2A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		4 HIS A  52
ARG A 321
HIS A 325
GLU A 318
 None
 1.04A 6mn4F-2cwfA:
undetectable		 6mn4F-2cwfA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 ARG A 156
GLU A 303
ASP A 300
GLU A 480
 None
 1.32A 6mn4F-2f6dA:
undetectable		 6mn4F-2f6dA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faz UBIQUITIN-LIKE
CONTAINING PHD AND
RING FINGER DOMAINS
PROTEIN 1

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ARG A  29
GLU A  26
ASP A  54
GLU A  53
 None
 1.42A 6mn4F-2fazA:
undetectable		 6mn4F-2fazA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		4 HIS A 329
ARG A 333
HIS A 334
ASP A 328
 None
None
SO4  A 503 (-4.0A)
None
 1.23A 6mn4F-2nnjA:
undetectable		 6mn4F-2nnjA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 HIS A 212
GLU A 289
ASP A 293
GLU A 297
 None
 1.08A 6mn4F-2qagA:
undetectable		 6mn4F-2qagA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 TRP A 182
HIS A 174
GLU A 203
ASP A 164
 None
None
None
ZN  A 434 ( 2.8A)
 1.43A 6mn4F-2qfrA:
undetectable		 6mn4F-2qfrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		4 HIS A 317
GLU A 314
ASP A 309
GLU A 305
 None
 1.40A 6mn4F-2vugA:
undetectable		 6mn4F-2vugA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ARG A 377
HIS A 376
ASP A 371
GLU A 417
 None
 1.41A 6mn4F-2xn1A:
undetectable		 6mn4F-2xn1A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymz GALECTIN 2

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		4 TRP A  65
HIS A  45
ARG A  70
GLU A  52
 None
 1.37A 6mn4F-2ymzA:
undetectable		 6mn4F-2ymzA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zab ALGINATE LYASE

(Sphingomonas
sp. A1) 		PF08787
(Alginate_lyase2) 		4 HIS A 306
ARG A 150
HIS A 191
GLU A 151
 None
LGU  A 401 (-3.8A)
LGU  A 403 (-3.7A)
None
 1.31A 6mn4F-2zabA:
undetectable		 6mn4F-2zabA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		4 HIS A 363
ARG A 404
HIS A 406
ASP A 340
 None
 1.30A 6mn4F-3ayxA:
undetectable		 6mn4F-3ayxA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		4 HIS A 382
GLU A  32
ASP A  68
GLU A 418
 None
 1.31A 6mn4F-3c2uA:
undetectable		 6mn4F-3c2uA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 HIS A 668
GLU A 666
ASP A 638
GLU A 641
 None
 1.40A 6mn4F-3decA:
undetectable		 6mn4F-3decA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		4 ARG A 377
HIS A 417
ASP A 374
GLU A 413
 HMH  A1001 (-4.6A)
ZN  A 613 (-3.4A)
None
None
 1.35A 6mn4F-3epmA:
undetectable		 6mn4F-3epmA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f11 IRON TRANSPORT
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		4 HIS A  54
ARG A 147
HIS A 274
ASP A 221
 SO4  A 402 (-3.3A)
None
None
None
 1.40A 6mn4F-3f11A:
undetectable		 6mn4F-3f11A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 HIS A 687
ARG A 180
ASP A 704
GLU A 706
 None
 1.35A 6mn4F-3fedA:
undetectable		 6mn4F-3fedA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 TRP A 715
HIS A 608
GLU A 706
ASP A 704
 None
 1.28A 6mn4F-3fedA:
undetectable		 6mn4F-3fedA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		4 HIS A 152
ARG A  78
GLU A 125
GLU A  57
 None
 0.83A 6mn4F-3h3bA:
undetectable		 6mn4F-3h3bA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4r EXODEOXYRIBONUCLEASE
8

(Escherichia
coli) 		PF12684
(DUF3799) 		4 HIS A 652
HIS A 727
GLU A 729
GLU A 659
 None
 1.31A 6mn4F-3h4rA:
undetectable		 6mn4F-3h4rA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 HIS A 244
HIS A 333
GLU A 246
GLU A 123
 None
 1.15A 6mn4F-3ho8A:
undetectable		 6mn4F-3ho8A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis) 		PF04389
(Peptidase_M28) 		4 HIS A 206
ARG A 163
HIS A 164
ASP A 422
 None
 1.19A 6mn4F-3iibA:
undetectable		 6mn4F-3iibA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF15

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF01423
(LSM) 		4 HIS A 927
ARG A1055
ASP h 265
GLU A1009
 None
 1.42A 6mn4F-3jb9A:
undetectable		 6mn4F-3jb9A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ARG A 374
HIS A 373
ASP A 368
GLU A 414
 None
 1.38A 6mn4F-3mi6A:
undetectable		 6mn4F-3mi6A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		no annotation 4 HIS D 205
HIS D 174
GLU D 212
ASP D 209
 None
 0.92A 6mn4F-3nmzD:
undetectable		 6mn4F-3nmzD:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa7 HEAD MORPHOGENESIS
PROTEIN, CHAOTIC
NUCLEAR MIGRATION
PROTEIN 67 FUSION
PROTEIN

(Saccharomyces
cerevisiae;
Bacillus virus
phi29) 		PF11418
(Scaffolding_pro)
PF11778
(SID) 		4 HIS A 562
ARG A 566
HIS A 570
ASP A 561
 None
 1.27A 6mn4F-3oa7A:
undetectable		 6mn4F-3oa7A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 TRP A 582
HIS A 389
GLU A 414
GLU A 431
 GAL  A2001 (-4.0A)
GAL  A2001 (-3.8A)
MG  A3001 (-2.8A)
None
 1.40A 6mn4F-3ob8A:
undetectable		 6mn4F-3ob8A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		4 HIS A  -2
HIS A 262
GLU A 291
GLU A 283
 None
 1.12A 6mn4F-3p8rA:
undetectable		 6mn4F-3p8rA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)

(Mycobacterium
tuberculosis) 		PF00857
(Isochorismatase) 		4 ARG A   2
HIS A  42
ASP A 129
GLU A 181
 None
 1.41A 6mn4F-3pl1A:
undetectable		 6mn4F-3pl1A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnw CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ARG B 259
HIS B 219
ASP B 231
GLU B 234
 None
 1.38A 6mn4F-3qnwB:
undetectable		 6mn4F-3qnwB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 HIS L 364
ARG L 405
HIS L 407
ASP L 341
 None
 1.35A 6mn4F-3rgwL:
undetectable		 6mn4F-3rgwL:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01261
(AP_endonuc_2) 		4 HIS A 144
ARG A 218
HIS A 250
GLU A 138
 None
EDO  A 280 (-4.1A)
None
EDO  A 280 ( 4.1A)
 1.21A 6mn4F-3u0hA:
undetectable		 6mn4F-3u0hA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucn CARBONIC ANHYDRASE

(Coccomyxa sp.
PA) 		PF00484
(Pro_CA) 		4 HIS A 142
HIS A 116
ASP A 135
GLU A 132
 None
 1.38A 6mn4F-3ucnA:
undetectable		 6mn4F-3ucnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp0 DISKS LARGE HOMOLOG
4

(Rattus
norvegicus) 		PF00625
(Guanylate_kin) 		4 ARG A 653
GLU A 660
ASP A 695
GLU A 699
 None
GOL  A 806 (-3.1A)
GOL  A 806 ( 4.6A)
None
 1.36A 6mn4F-3wp0A:
undetectable		 6mn4F-3wp0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		4 HIS A 263
ARG A 283
HIS A 343
GLU A 332
 None
 1.38A 6mn4F-3wvsA:
undetectable		 6mn4F-3wvsA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpy ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 HIS A 445
ARG A 278
HIS A 323
GLU A 279
 None
 1.40A 6mn4F-3zpyA:
undetectable		 6mn4F-3zpyA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		4 TRP A 747
HIS A 485
HIS A 465
ASP A 535
 None
 1.03A 6mn4F-4bs9A:
undetectable		 6mn4F-4bs9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnm TROPHOBLAST
GLYCOPROTEIN

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 HIS A 151
GLU A 216
ASP A 240
GLU A 266
 PEG  A1351 ( 4.2A)
CIT  A1356 (-3.8A)
None
None
 1.12A 6mn4F-4cnmA:
undetectable		 6mn4F-4cnmA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 TRP B 177
ARG B 102
GLU B  40
ASP B  41
 None
 1.41A 6mn4F-4gh4B:
undetectable		 6mn4F-4gh4B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2

(Mus musculus) 		PF03372
(Exo_endo_phos) 		4 TRP A 307
HIS A 323
ARG A 247
GLU A 242
 None
 1.32A 6mn4F-4gz2A:
undetectable		 6mn4F-4gz2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ibn RIBONUCLEASE H

(uncultured
organism) 		PF00075
(RNase_H) 		4 ARG A  80
HIS A  84
GLU A  77
GLU A 131
 None
 0.94A 6mn4F-4ibnA:
undetectable		 6mn4F-4ibnA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iua HEPATOCYTE GROWTH
FACTOR

(Mus musculus) 		PF00024
(PAN_1)
PF00051
(Kringle) 		4 HIS A 244
ARG A 235
HIS A  41
ASP A 237
 None
 1.10A 6mn4F-4iuaA:
undetectable		 6mn4F-4iuaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		4 HIS A 805
HIS A 601
GLU A 470
GLU A 463
 None
 1.37A 6mn4F-4j5tA:
undetectable		 6mn4F-4j5tA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 HIS A 329
ARG A 559
HIS A 564
ASP A 160
 None
 1.39A 6mn4F-4jklA:
undetectable		 6mn4F-4jklA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis) 		no annotation 4 ARG A 243
HIS A 240
GLU A 195
ASP A  89
 None
HEC  A 802 (-3.2A)
None
None
 1.38A 6mn4F-4lmhA:
undetectable		 6mn4F-4lmhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 HIS A 487
HIS A 530
GLU A 527
GLU A 247
 None
 1.31A 6mn4F-4lq1A:
undetectable		 6mn4F-4lq1A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi7 BACTERIOPHAGE
ENCODED VIRULENCE
FACTOR

(Salmonella
enterica) 		no annotation 4 HIS A 151
GLU A 153
ASP A 169
GLU A 176
 SO4  A 301 (-3.7A)
None
None
None
 1.24A 6mn4F-4mi7A:
undetectable		 6mn4F-4mi7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqj HEMOGLOBIN SUBUNIT
GAMMA-2

(Homo sapiens) 		PF00042
(Globin) 		4 HIS B  97
ARG B 144
HIS B 146
ASP B  94
 None
 1.30A 6mn4F-4mqjB:
undetectable		 6mn4F-4mqjB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 4 HIS A 412
GLU A 411
ASP A 407
GLU A 404
 None
 1.23A 6mn4F-4n5aA:
undetectable		 6mn4F-4n5aA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 HIS A 339
ARG A 369
ASP A 368
GLU A 393
 MLY  A 338 ( 4.2A)
None
None
None
 1.36A 6mn4F-4nk6A:
undetectable		 6mn4F-4nk6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PGT135 HEAVY CHAIN
PROTEIN M TD

(Homo sapiens;
Mycoplasma
genitalium) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		4 ARG M 457
GLU M 453
ASP H  31
GLU H  31
 None
 1.42A 6mn4F-4nzrM:
undetectable		 6mn4F-4nzrM:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 ARG A 163
HIS A 164
ASP A 192
GLU A 189
 None
 1.31A 6mn4F-4oraA:
undetectable		 6mn4F-4oraA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1

(Sicarius
terrosus) 		no annotation 4 HIS A  11
GLU A  31
ASP A  91
GLU A 134
 None
MG  A 301 (-2.6A)
MG  A 301 (-3.1A)
None
 1.19A 6mn4F-4q6xA:
undetectable		 6mn4F-4q6xA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r42 ALR3090 PROTEIN

(Nostoc sp. PCC
7120) 		PF05067
(Mn_catalase) 		4 HIS A   4
HIS A  10
GLU A  70
GLU A  77
 None
 1.20A 6mn4F-4r42A:
undetectable		 6mn4F-4r42A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 586
HIS A 587
GLU A 582
GLU A 640
 None
 1.01A 6mn4F-4rcnA:
undetectable		 6mn4F-4rcnA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 HIS A1344
GLU A1439
ASP A1436
GLU A2082
 None
 1.20A 6mn4F-4rh7A:
undetectable		 6mn4F-4rh7A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6q GLUCOSYLTRANSFERASE

(Streptococcus
agalactiae) 		no annotation 4 ARG A  54
HIS A  39
ASP A  46
GLU A  50
 None
 1.29A 6mn4F-4w6qA:
undetectable		 6mn4F-4w6qA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 ARG A 265
GLU A 269
ASP A 266
GLU A 201
 SO4  A 401 (-3.6A)
None
None
SO4  A 401 ( 4.7A)
 1.32A 6mn4F-4wy5A:
undetectable		 6mn4F-4wy5A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1

(Capnocytophaga
gingivalis) 		no annotation 4 TRP C 323
HIS C 342
ASP C 269
GLU C 274
 None
SAH  C 501 (-3.6A)
None
None
 1.23A 6mn4F-4xruC:
undetectable		 6mn4F-4xruC:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 ARG A 369
HIS A 420
GLU A 363
ASP A 364
 None
 1.11A 6mn4F-4zg7A:
undetectable		 6mn4F-4zg7A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 HIS A  89
HIS A 158
GLU A  27
GLU A 166
 None
 1.29A 6mn4F-5a1iA:
undetectable		 6mn4F-5a1iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF09440
(eIF3_N) 		4 TRP E 170
ARG E 191
ASP E 188
GLU E 149
 None
 1.32A 6mn4F-5a5tE:
undetectable		 6mn4F-5a5tE:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF01398
(JAB)
PF13012
(MitMem_reg)
PF01398
(JAB) 		4 HIS H 238
ARG F 266
HIS H 228
ASP F 263
 None
 1.32A 6mn4F-5a5tH:
undetectable		 6mn4F-5a5tH:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq9 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF12252
(SidE) 		4 HIS A 443
HIS A 366
ASP A 424
GLU A 343
 None
 1.29A 6mn4F-5bq9A:
undetectable		 6mn4F-5bq9A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		4 HIS A 443
HIS A 366
ASP A 424
GLU A 343
 None
 1.17A 6mn4F-5bu1A:
undetectable		 6mn4F-5bu1A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		4 HIS A 150
ARG A  96
GLU A 122
GLU A 160
 None
 1.42A 6mn4F-5c1iA:
2.6		 6mn4F-5c1iA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 TRP A 734
HIS A 736
HIS A 766
ASP A 738
 None
 1.40A 6mn4F-5dllA:
undetectable		 6mn4F-5dllA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 217
ARG A 261
HIS A 211
ASP A 215
 None
 1.41A 6mn4F-5ehfA:
undetectable		 6mn4F-5ehfA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		4 TRP A 314
HIS A 177
GLU A 167
GLU A 423
 DQR  A 544 (-4.1A)
DQR  A 544 (-4.7A)
DQR  A 544 (-2.8A)
DQR  A 544 (-2.8A)
 1.29A 6mn4F-5g5zA:
undetectable		 6mn4F-5g5zA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 HIS A 516
HIS A 559
GLU A 556
GLU A 255
 GOL  A 825 (-3.8A)
None
GOL  A 825 (-3.4A)
None
 1.31A 6mn4F-5gr1A:
undetectable		 6mn4F-5gr1A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 HIS A 637
HIS A 472
GLU A 642
ASP A 585
 None
 1.34A 6mn4F-5hp5A:
undetectable		 6mn4F-5hp5A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 HIS A  69
ARG A  39
HIS A  36
ASP A  73
 None
 1.30A 6mn4F-5jbgA:
undetectable		 6mn4F-5jbgA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 HIS A  90
ARG A 307
HIS A 161
ASP A 303
 None
 1.36A 6mn4F-5jodA:
undetectable		 6mn4F-5jodA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel EBOLA SURFACE
GLYCOPROTEIN, GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		4 HIS A 154
HIS A 139
GLU A 178
GLU A 103
 None
 1.34A 6mn4F-5kelA:
undetectable		 6mn4F-5kelA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		4 TRP N 362
HIS N 444
ARG N 515
GLU N 479
 None
 1.24A 6mn4F-5mpdN:
undetectable		 6mn4F-5mpdN:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 4 HIS A 510
GLU A 540
ASP A 574
GLU A 594
 None
 1.16A 6mn4F-5mqpA:
undetectable		 6mn4F-5mqpA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mv9 UNCONVENTIONAL
MYOSIN-VIIA

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		4 ARG A1967
HIS A1968
GLU A1801
ASP A1797
 None
 1.31A 6mn4F-5mv9A:
undetectable		 6mn4F-5mv9A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE

(Leishmania
major) 		PF00883
(Peptidase_M17) 		4 HIS A 432
ARG A 117
ASP A 119
GLU A 123
 None
 1.27A 6mn4F-5nthA:
undetectable		 6mn4F-5nthA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Homo sapiens) 		no annotation 4 HIS A4583
ARG A4533
GLU A4534
ASP A4531
 None
 1.29A 6mn4F-5o6cA:
undetectable		 6mn4F-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 4 HIS A 262
ARG A 360
ASP A 354
GLU A1072
 None
 1.40A 6mn4F-5u30A:
undetectable		 6mn4F-5u30A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Homo sapiens) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 ARG A 285
HIS A 451
GLU A 457
GLU A 193
 None
 1.33A 6mn4F-5ukwA:
undetectable		 6mn4F-5ukwA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 HIS A 207
HIS A 295
GLU A 209
GLU A  87
 None
 1.22A 6mn4F-5vywA:
undetectable		 6mn4F-5vywA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		4 ARG A 153
HIS A 157
ASP A 150
GLU A 251
 None
 1.34A 6mn4F-5xa5A:
undetectable		 6mn4F-5xa5A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Staphylococcus
aureus) 		no annotation 4 ARG A 256
HIS A 162
ASP A 185
GLU A 130
 FLC  A 301 (-3.6A)
None
None
FLC  A 301 (-3.6A)
 1.29A 6mn4F-5z7hA:
undetectable		 6mn4F-5z7hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 TRP A 548
HIS A 368
GLU A 393
GLU A 398
 None
 1.38A 6mn4F-6etzA:
undetectable		 6mn4F-6etzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Saccharomyces
cerevisiae) 		no annotation 4 TRP G 210
GLU G 144
ASP G 141
GLU G 125
 None
 0.93A 6mn4F-6f42G:
undetectable		 6mn4F-6f42G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Synechocystis
sp. PCC 6803;
Deinococcus
radiodurans) 		no annotation 4 HIS A  38
ARG A 100
GLU A 127
GLU A 306
 None
 1.35A 6mn4F-6fhtA:
undetectable		 6mn4F-6fhtA:
undetectable