SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN4_E_AM2E301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB) 		4 TRP B  43
THR B   6
ARG B 291
ASP B 259
 None
 1.30A 6mn4E-1bouB:
0.0		 6mn4E-1bouB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 HIS A 217
THR A 215
ARG A 257
ASP A 254
 None
 1.36A 6mn4E-1bwdA:
0.0		 6mn4E-1bwdA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 THR P 408
ARG P 299
HIS P 397
ASP P 411
 None
 1.32A 6mn4E-1e33P:
0.0		 6mn4E-1e33P:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens) 		PF07745
(Glyco_hydro_53) 		4 THR A 246
HIS A  91
GLU A 135
ASP A 180
 None
 1.20A 6mn4E-1hjqA:
0.0		 6mn4E-1hjqA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 THR A 246
HIS A  91
GLU A 135
ASP A 180
 None
None
TRS  A 704 (-2.5A)
None
 1.22A 6mn4E-1hjuA:
0.0		 6mn4E-1hjuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 TRP A 453
THR A 433
ARG A 602
ASP A 457
 None
 1.28A 6mn4E-1j0nA:
0.0		 6mn4E-1j0nA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 TRP A 550
THR A 597
ARG A 540
ASP A 538
 None
 1.21A 6mn4E-1j0nA:
0.0		 6mn4E-1j0nA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2x CLASS B
CARBAPENEMASE BLAB-1

(Elizabethkingia
meningoseptica) 		PF00753
(Lactamase_B) 		4 THR A 136
ARG A 121
HIS A 196
ASP A  84
 None
ZN  A 902 ( 4.8A)
ZN  A 901 ( 3.2A)
None
 1.12A 6mn4E-1m2xA:
0.4		 6mn4E-1m2xA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TRP A 230
HIS A  95
ARG A 239
ASP A 140
 None
 1.24A 6mn4E-1m53A:
0.0		 6mn4E-1m53A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mr2 ADPR PYROPHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00293
(NUDIX) 		4 THR A 113
ARG A 123
HIS A  87
ASP A 110
 None
 1.13A 6mn4E-1mr2A:
0.0		 6mn4E-1mr2A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01467
(CTP_transf_like) 		4 HIS A  16
THR A  13
ARG A  22
ASP A  18
 SO4  A1163 (-4.1A)
SO4  A1163 ( 4.5A)
SO4  A1162 ( 4.2A)
None
 1.12A 6mn4E-1od6A:
undetectable		 6mn4E-1od6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 HIS A 288
THR A 261
HIS A 346
ASP A  35
 None
None
None
CA  A 605 (-3.1A)
 1.27A 6mn4E-1p49A:
undetectable		 6mn4E-1p49A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 HIS A  18
THR A  15
ARG A  24
ASP A  20
 SO4  A1161 (-4.2A)
SO4  A1161 ( 4.8A)
SO4  A1160 ( 4.6A)
None
 1.15A 6mn4E-1qjcA:
undetectable		 6mn4E-1qjcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		4 HIS A 172
THR A 150
ARG A 380
ASP A 194
 None
 1.35A 6mn4E-1ru4A:
undetectable		 6mn4E-1ru4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cja SERYL-TRNA
SYNTHETASE

(Methanosarcina
barkeri) 		no annotation 4 HIS A 335
THR A 333
ARG A 201
ASP A 349
 None
 0.88A 6mn4E-2cjaA:
undetectable		 6mn4E-2cjaA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d40 PUTATIVE GENTISATE
1,2-DIOXYGENASE

(Escherichia
coli) 		PF07883
(Cupin_2) 		4 THR A 129
ARG A 194
HIS A 204
ASP A 190
 None
 1.23A 6mn4E-2d40A:
undetectable		 6mn4E-2d40A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		4 HIS A  62
THR A  91
ARG A 278
ASP A  72
 ZN  A 400 (-3.2A)
None
None
None
 1.36A 6mn4E-2icsA:
undetectable		 6mn4E-2icsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isj BLUB

(Sinorhizobium
meliloti) 		PF00881
(Nitroreductase) 		4 TRP A  66
ARG A 124
HIS A 183
ASP A 141
 None
 1.14A 6mn4E-2isjA:
undetectable		 6mn4E-2isjA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lj4 PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE/ROTAMASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00639
(Rotamase) 		4 HIS A 112
THR A 107
ARG A  26
ASP A  67
 None
 1.04A 6mn4E-2lj4A:
undetectable		 6mn4E-2lj4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TRP A 189
HIS A  54
ARG A 198
ASP A  99
 None
 1.28A 6mn4E-2pwhA:
undetectable		 6mn4E-2pwhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 HIS A 745
THR A 543
ARG A 737
ASP A 768
 None
None
None
MG  A1158 (-3.5A)
 1.26A 6mn4E-2qf7A:
undetectable		 6mn4E-2qf7A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		4 HIS A 168
THR A 166
HIS A 116
GLU A  77
 None
 1.29A 6mn4E-2qvpA:
undetectable		 6mn4E-2qvpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Paraburkholderia
phymatum) 		PF13377
(Peripla_BP_3) 		4 THR A 325
ARG A 112
HIS A 115
ASP A 108
 None
 1.27A 6mn4E-2rgyA:
undetectable		 6mn4E-2rgyA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TRP A  86
ARG A  31
HIS A  35
ASP A  79
 None
 1.36A 6mn4E-2wpgA:
undetectable		 6mn4E-2wpgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		4 HIS A 290
ARG A  94
HIS A 121
ASP A 128
 SO4  A1408 (-4.1A)
None
None
None
 1.25A 6mn4E-2wu0A:
undetectable		 6mn4E-2wu0A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09110
(HAND)
PF09111
(SLIDE)
PF15612
(WHIM1) 		4 TRP B 309
THR B 265
ARG A1035
ASP B 397
 None
 1.18A 6mn4E-2y9yB:
undetectable		 6mn4E-2y9yB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynt GIM-1 PROTEIN

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 THR B 136
ARG B 121
HIS B 196
ASP B  84
 None
ZN  B1298 ( 4.5A)
ZN  B1297 (-3.2A)
None
 1.25A 6mn4E-2yntB:
undetectable		 6mn4E-2yntB:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 HIS A  14
ARG A  42
HIS A  63
ASP A  40
 None
 0.84A 6mn4E-2yzmA:
undetectable		 6mn4E-2yzmA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2y METALLOPEPTIDASE
CONTAINING
CO-CATALYTIC
METALLOACTIVE SITE

(Shewanella
denitrificans) 		PF04952
(AstE_AspA) 		4 HIS A 169
THR A 167
HIS A 117
GLU A  78
 NI  A 275 (-3.3A)
None
None
NI  A 275 (-1.8A)
 1.25A 6mn4E-3b2yA:
undetectable		 6mn4E-3b2yA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF03063
(Prismane)
PF02552
(CO_dh) 		4 THR A 454
ARG G 141
HIS G 159
ASP A 432
 None
GOL  G 172 ( 4.4A)
None
None
 1.36A 6mn4E-3cf4A:
undetectable		 6mn4E-3cf4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm1 SSGA-LIKE
SPORULATION-SPECIFIC
CELL DIVISION
PROTEIN

(Thermobifida
fusca) 		PF04686
(SsgA) 		4 THR A 114
ARG A  29
HIS A  45
ASP A  31
 None
 1.30A 6mn4E-3cm1A:
undetectable		 6mn4E-3cm1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 TRP A  85
ARG A  30
HIS A  34
ASP A  78
 None
 1.36A 6mn4E-3czeA:
undetectable		 6mn4E-3czeA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Bacteroides
vulgatus) 		PF00891
(Methyltransf_2) 		4 HIS A 347
ARG A 292
HIS A 321
ASP A 341
 None
 1.07A 6mn4E-3dp7A:
undetectable		 6mn4E-3dp7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Thermus
thermophilus;
Mus musculus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		4 HIS A 136
ARG A 271
HIS A 273
ASP A 265
 None
 1.35A 6mn4E-3errA:
undetectable		 6mn4E-3errA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TRP A 203
HIS A  68
ARG A 212
ASP A 113
 None
 1.31A 6mn4E-3gbdA:
undetectable		 6mn4E-3gbdA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 HIS A 169
THR A 167
HIS A 117
GLU A  78
 ZN  A 276 (-3.5A)
None
None
ZN  A 276 (-2.0A)
 1.19A 6mn4E-3iehA:
undetectable		 6mn4E-3iehA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 HIS A 404
THR A 403
ARG A 275
ASP A 293
 None
 1.11A 6mn4E-3ikmA:
undetectable		 6mn4E-3ikmA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j81 US2
US5

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		PF00318
(Ribosomal_S2)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 HIS C  64
THR C 241
ARG A 119
ASP C 246
 None
 1.25A 6mn4E-3j81C:
undetectable		 6mn4E-3j81C:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 HIS A  20
THR A 159
GLU A  21
ASP A  68
 None
 1.36A 6mn4E-3kl9A:
undetectable		 6mn4E-3kl9A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6n METALLO-BETA-LACTAMA
SE

(Chryseobacterium
indologenes) 		PF00753
(Lactamase_B) 		4 THR A 115
ARG A 101
HIS A 159
ASP A  66
 None
ZN  A 302 (-4.4A)
ZN  A 301 (-3.2A)
None
 1.10A 6mn4E-3l6nA:
undetectable		 6mn4E-3l6nA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 HIS A 187
THR A 189
HIS A 303
ASP A 253
 None
 1.09A 6mn4E-3mczA:
undetectable		 6mn4E-3mczA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 THR A 340
ARG A 374
HIS A 373
ASP A 368
 None
 1.36A 6mn4E-3mi6A:
undetectable		 6mn4E-3mi6A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		no annotation 4 HIS D 205
HIS D 174
GLU D 212
ASP D 209
 None
 1.02A 6mn4E-3nmzD:
undetectable		 6mn4E-3nmzD:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		4 HIS A 168
THR A 191
ARG A 259
ASP A 166
 None
 1.28A 6mn4E-3nnmA:
undetectable		 6mn4E-3nnmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 HIS A  56
THR A  59
ARG A 141
ASP A 143
 None
 1.28A 6mn4E-3okyA:
undetectable		 6mn4E-3okyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		4 HIS A 284
THR A 288
ARG A  90
GLU A 281
 SAH  A 900 ( 4.6A)
None
None
None
 1.15A 6mn4E-3s1sA:
undetectable		 6mn4E-3s1sA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 HIS A1877
THR A1812
ARG A1872
GLU A1876
 None
 1.15A 6mn4E-3vkgA:
undetectable		 6mn4E-3vkgA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 THR A 528
ARG A 547
HIS A 548
ASP A 531
 None
 1.33A 6mn4E-3wkyA:
undetectable		 6mn4E-3wkyA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0t UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 4 THR A  24
ARG A  39
HIS A 111
ASP A  27
 None
 1.31A 6mn4E-3x0tA:
undetectable		 6mn4E-3x0tA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 HIS B  85
THR B  82
ARG B 123
ASP B  89
 None
 1.36A 6mn4E-3zu7B:
undetectable		 6mn4E-3zu7B:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 THR A 507
ARG A 468
HIS A 470
GLU A 557
 None
 1.36A 6mn4E-4a2wA:
undetectable		 6mn4E-4a2wA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		4 TRP A 424
HIS A 119
HIS A 300
GLU A 366
 None
 1.29A 6mn4E-4b3kA:
undetectable		 6mn4E-4b3kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 209
ARG A  70
HIS A  67
ASP A 214
 None
 0.92A 6mn4E-4bedA:
undetectable		 6mn4E-4bedA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 4 THR A  27
ARG A  67
HIS A 327
ASP A  69
 None
 1.13A 6mn4E-4bpsA:
undetectable		 6mn4E-4bpsA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		4 TRP A 747
HIS A 485
HIS A 465
ASP A 535
 None
 1.14A 6mn4E-4bs9A:
undetectable		 6mn4E-4bs9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 TRP A 708
HIS A 484
THR A 483
GLU A 564
 DGJ  A1985 (-3.7A)
DGJ  A1985 ( 3.8A)
None
EDO  A2021 ( 3.0A)
 0.94A 6mn4E-4cu8A:
undetectable		 6mn4E-4cu8A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1t METALLO-B-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 THR A 136
ARG A 121
HIS A 196
ASP A  84
 None
ZN  A1293 ( 4.7A)
ZN  A1292 (-3.2A)
None
 1.24A 6mn4E-4d1tA:
undetectable		 6mn4E-4d1tA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 TRP A 303
THR A 244
ARG A 305
HIS A 313
 None
None
SO4  A1014 (-3.0A)
None
 1.25A 6mn4E-4fysA:
undetectable		 6mn4E-4fysA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		4 THR A  85
ARG A 119
HIS A 274
ASP A  95
 None
 1.17A 6mn4E-4g8dA:
undetectable		 6mn4E-4g8dA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		4 HIS A 236
THR A 234
HIS A  94
ASP A 237
 None
 1.32A 6mn4E-4gniA:
undetectable		 6mn4E-4gniA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TRP A 230
HIS A  95
ARG A 239
ASP A 140
 None
None
GLC  A 703 (-2.9A)
None
 1.29A 6mn4E-4hozA:
undetectable		 6mn4E-4hozA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 THR A 166
ARG A 692
HIS A 688
ASP A 170
 None
 1.32A 6mn4E-4i3gA:
undetectable		 6mn4E-4i3gA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 HIS A 745
THR A 543
ARG A 737
ASP A 768
 None
None
None
MG  A1103 (-3.3A)
 1.32A 6mn4E-4jx6A:
undetectable		 6mn4E-4jx6A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k92 CLIP-ASSOCIATING
PROTEIN 1

(Homo sapiens) 		PF12348
(CLASP_N) 		4 THR A 413
ARG A 341
HIS A 336
ASP A 379
 None
 1.38A 6mn4E-4k92A:
undetectable		 6mn4E-4k92A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis) 		no annotation 4 ARG A 243
HIS A 240
GLU A 195
ASP A  89
 None
HEC  A 802 (-3.2A)
None
None
 1.32A 6mn4E-4lmhA:
undetectable		 6mn4E-4lmhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ARG D 385
HIS D 229
GLU D 386
ASP D 336
 None
 1.31A 6mn4E-4ngeD:
undetectable		 6mn4E-4ngeD:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5f TYPE III
PANTOTHENATE KINASE

(Burkholderia
thailandensis) 		PF03309
(Pan_kinase) 		4 THR A 250
ARG A 243
HIS A 241
ASP A 245
 None
None
None
GOL  A 307 (-4.6A)
 1.15A 6mn4E-4o5fA:
undetectable		 6mn4E-4o5fA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 TRP A 808
THR A 862
ARG A 817
ASP A 858
 None
 1.16A 6mn4E-4pj6A:
undetectable		 6mn4E-4pj6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Ochrobactrum
anthropi) 		PF01547
(SBP_bac_1) 		4 TRP A 272
HIS A 380
THR A 198
HIS A  37
 GLC  A 501 (-3.5A)
GLC  A 501 (-3.7A)
None
None
 1.05A 6mn4E-4r2bA:
undetectable		 6mn4E-4r2bA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg8 EXONUCLEASE I

(Methylocaldum
szegediense) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 HIS A  85
ARG A 374
GLU A 121
ASP A 118
 None
 1.31A 6mn4E-4rg8A:
undetectable		 6mn4E-4rg8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 4 TRP B  42
ARG B  40
HIS B 546
ASP B  38
 None
 1.36A 6mn4E-4tqoB:
undetectable		 6mn4E-4tqoB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		4 HIS A 111
THR A 110
ARG A 302
ASP A 303
 None
 1.33A 6mn4E-4x9tA:
undetectable		 6mn4E-4x9tA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 TRP A 593
HIS A 379
THR A 378
GLU A 447
 None
 0.93A 6mn4E-4ypjA:
undetectable		 6mn4E-4ypjA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zej METALLO-BETA-LACTAMA
SE

(Pseudomonas
stutzeri) 		no annotation 4 THR A  96
ARG A  82
HIS A 139
ASP A  48
 None
ZN  A 301 ( 4.5A)
ZN  A 302 (-3.3A)
None
 1.12A 6mn4E-4zejA:
undetectable		 6mn4E-4zejA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 HIS A 862
THR A 860
ARG A 864
ASP A 849
 None
None
AMP  A1403 (-3.4A)
AMP  A1403 (-2.4A)
 1.32A 6mn4E-4zxiA:
undetectable		 6mn4E-4zxiA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 HIS A1105
ARG A 912
HIS A1085
GLU A1108
 None
None
None
ZN  A3000 (-2.8A)
 1.19A 6mn4E-5a22A:
undetectable		 6mn4E-5a22A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 TRP A 591
HIS A 361
THR A 360
GLU A 447
 None
 0.99A 6mn4E-5dmyA:
undetectable		 6mn4E-5dmyA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER

(Pseudomonas
putida) 		PF01547
(SBP_bac_1) 		4 TRP A 270
HIS A 379
THR A 195
HIS A  34
 GAL  A 501 (-3.6A)
GAL  A 501 (-3.9A)
None
None
 1.05A 6mn4E-5dvjA:
undetectable		 6mn4E-5dvjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 217
ARG A 261
HIS A 211
ASP A 215
 None
 1.29A 6mn4E-5ehfA:
undetectable		 6mn4E-5ehfA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9p ANTHRONE
OXIDASE-LIKE PROTEIN

(Streptomyces
ambofaciens) 		PF03992
(ABM) 		4 HIS A  50
THR A  48
ARG A 157
ASP A 122
 None
 1.34A 6mn4E-5f9pA:
undetectable		 6mn4E-5f9pA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffp IMMUNITY 23 FAMILY
PROTEIN

(Burkholderia
dolosa) 		PF15593
(Imm42) 		4 HIS A  98
THR A  97
ARG A 141
GLU A 116
 None
 1.31A 6mn4E-5ffpA:
undetectable		 6mn4E-5ffpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1

(Homo sapiens) 		PF02002
(TFIIE_alpha)
PF08271
(TF_Zn_Ribbon) 		4 THR A 175
ARG A 113
HIS A 109
ASP A 117
 None
 1.03A 6mn4E-5gpyA:
undetectable		 6mn4E-5gpyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 ARG A 329
HIS A 328
GLU A 330
ASP A 336
 None
 1.37A 6mn4E-5gu6A:
undetectable		 6mn4E-5gu6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy3 GENOME POLYPROTEIN

(Zika virus) 		PF00948
(Flavi_NS1) 		4 HIS A 195
THR A 230
HIS A 216
ASP A 197
 None
 1.35A 6mn4E-5iy3A:
undetectable		 6mn4E-5iy3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 HIS A  56
THR A  59
ARG A 141
ASP A 143
 None
 1.15A 6mn4E-5l5gA:
undetectable		 6mn4E-5l5gA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Psychrobacter
arcticus) 		PF13393
(tRNA-synt_His) 		4 HIS A 158
THR A 160
ARG A 240
ASP A 236
 None
 1.05A 6mn4E-5m8hA:
undetectable		 6mn4E-5m8hA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5naq BETA-GALACTOSIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		4 TRP A 423
HIS A 119
HIS A 299
GLU A 365
 None
 1.29A 6mn4E-5naqA:
undetectable		 6mn4E-5naqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oes GLUTATHIONE
SYNTHETASE

(Solanum
tuberosum) 		no annotation 4 HIS A 136
THR A 156
ARG A 443
ASP A  89
 None
 1.34A 6mn4E-5oesA:
undetectable		 6mn4E-5oesA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ouo PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 4 THR A 958
ARG A1060
HIS A1023
ASP A 939
 None
CL  A1103 (-3.6A)
None
None
 0.92A 6mn4E-5ouoA:
undetectable		 6mn4E-5ouoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3

(Homo sapiens) 		no annotation 4 HIS A 100
ARG A  13
HIS A  19
GLU A  32
 None
 1.26A 6mn4E-5ukeA:
undetectable		 6mn4E-5ukeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 4 HIS A 404
THR A 408
ARG A 493
ASP A 461
 CA  A 601 ( 4.8A)
None
None
None
 1.34A 6mn4E-5ukhA:
undetectable		 6mn4E-5ukhA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1

(Pseudomonas
aeruginosa) 		PF09611
(Cas_Csy1) 		4 HIS A  83
THR A 163
HIS A 201
ASP A 107
 None
 1.09A 6mn4E-5uz9A:
undetectable		 6mn4E-5uz9A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgr ATLASTIN-3

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 HIS A 397
THR A 401
HIS A 387
ASP A 396
 None
 1.33A 6mn4E-5vgrA:
undetectable		 6mn4E-5vgrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 THR A 259
ARG A 331
HIS A 359
ASP A 329
 None
 1.28A 6mn4E-5xmjA:
undetectable		 6mn4E-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbi PEPTIDE ASPARAGINYL
LIGASE

(Viola
canadensis) 		no annotation 4 THR A 263
ARG A  63
HIS A 345
ASP A 258
 None
 1.28A 6mn4E-5zbiA:
undetectable		 6mn4E-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5c 3-DEHYDROQUINATE
SYNTHASE

(Candida
albicans) 		no annotation 4 THR A  87
HIS A 280
GLU A  80
ASP A 153
 None
None
NAD  A 401 (-2.7A)
None
 1.19A 6mn4E-6c5cA:
undetectable		 6mn4E-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 4 HIS A 384
ARG A 389
HIS A 450
ASP A 385
 None
 1.20A 6mn4E-6c7sA:
undetectable		 6mn4E-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7a PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 4 THR A 971
ARG A1073
HIS A1036
ASP A 952
 None
 1.11A 6mn4E-6d7aA:
undetectable		 6mn4E-6d7aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7a PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 4 THR A 971
ARG A1073
HIS A1074
ASP A 952
 None
 1.29A 6mn4E-6d7aA:
undetectable		 6mn4E-6d7aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2

(Homo sapiens) 		no annotation 4 THR j 232
HIS j 115
GLU j  62
ASP j  63
 None
 1.26A 6mn4E-6f1yj:
undetectable		 6mn4E-6f1yj:
undetectable