SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN4_D_AM2D301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ap8 TRANSLATION
INITIATION FACTOR
EIF4E

(Saccharomyces
cerevisiae) 		PF01652
(IF4E) 		4 ASP A  92
HIS A  94
GLU A  83
ASP A 127
 M7G  A 214 (-3.6A)
M7G  A 214 ( 4.1A)
None
None
 1.10A 6mn4D-1ap8A:
undetectable		 6mn4D-1ap8A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aug PYROGLUTAMYL
PEPTIDASE-1

(Bacillus
amyloliquefaciens) 		PF01470
(Peptidase_C15) 		4 HIS A 158
HIS A 146
GLU A 154
GLU A  56
 None
 1.11A 6mn4D-1augA:
0.0		 6mn4D-1augA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		4 ARG B  42
HIS B 333
GLU B  30
GLU B  32
 None
 1.15A 6mn4D-1e3dB:
0.0		 6mn4D-1e3dB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		4 ASP B 357
ARG B  42
GLU B  30
GLU B  40
 None
 1.15A 6mn4D-1e3dB:
0.0		 6mn4D-1e3dB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi) 		PF00150
(Cellulase) 		4 HIS A  98
HIS A 198
GLU A 220
GLU A 261
 None
 1.19A 6mn4D-1egzA:
0.3		 6mn4D-1egzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 HIS A 621
ARG A 577
ASP A 601
GLU A 603
 None
 1.12A 6mn4D-1fcpA:
0.0		 6mn4D-1fcpA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g01 ENDOGLUCANASE

(Bacillus sp.
KSM-635) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		4 HIS A 331
HIS A 448
GLU A 485
GLU A 526
 None
None
CD  A 591 (-2.8A)
None
 1.16A 6mn4D-1g01A:
0.0		 6mn4D-1g01A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 ASP A 436
HIS A 226
ARG A 207
GLU A 124
 None
 1.09A 6mn4D-1h39A:
undetectable		 6mn4D-1h39A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		4 ASP A 269
HIS A 175
HIS A 294
GLU A 334
 None
GOL  A1450 (-4.4A)
None
GOL  A1450 ( 4.1A)
 1.20A 6mn4D-1h4pA:
0.1		 6mn4D-1h4pA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 HIS A 510
GLU A 517
ASP A 394
GLU A 393
 None
MLY  A 390 ( 3.7A)
MLY  A 390 ( 3.8A)
None
 1.19A 6mn4D-1iv8A:
0.0		 6mn4D-1iv8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ASP A  30
HIS A 591
HIS A 158
ASP A 327
 None
 1.23A 6mn4D-1lf9A:
undetectable		 6mn4D-1lf9A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 HIS A 393
ARG A 296
HIS A 295
ASP A 338
 None
 1.20A 6mn4D-1mb9A:
undetectable		 6mn4D-1mb9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdm C-ETS-1 PROTEIN

(Mus musculus) 		PF00178
(Ets) 		4 ARG B 413
HIS B 403
GLU B 362
ASP B 359
 None
 1.02A 6mn4D-1mdmB:
undetectable		 6mn4D-1mdmB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyq THREONYL-TRNA
SYNTHETASE 1

(Staphylococcus
aureus) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		4 ASP A 385
ARG A 518
HIS A 387
GLU A 285
 TSB  A1002 (-3.1A)
None
ZN  A1001 ( 3.3A)
None
 1.18A 6mn4D-1nyqA:
undetectable		 6mn4D-1nyqA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 HIS A 555
GLU A 632
ASP A 636
GLU A 635
 None
 1.22A 6mn4D-1r5nA:
undetectable		 6mn4D-1r5nA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		4 ARG A 311
HIS A 303
GLU A 314
GLU A 258
 None
 0.73A 6mn4D-1xvtA:
undetectable		 6mn4D-1xvtA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 ASP A 253
HIS A 130
ASP A 222
GLU A 248
 None
 1.16A 6mn4D-1yrgA:
undetectable		 6mn4D-1yrgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxu AT5G01750 PROTEIN

(Arabidopsis
thaliana) 		PF04525
(LOR) 		4 ASP A  51
ARG A  78
ASP A 209
GLU A  93
 None
 1.20A 6mn4D-1zxuA:
undetectable		 6mn4D-1zxuA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 ASP A 121
HIS A 296
GLU A 230
ASP A 232
 CA  A 485 (-3.2A)
None
CA  A 486 (-2.5A)
None
 1.09A 6mn4D-2aaaA:
undetectable		 6mn4D-2aaaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 228
HIS A 134
ARG A 226
ASP A 141
 None
 1.18A 6mn4D-2atcA:
2.3		 6mn4D-2atcA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		4 HIS A  52
ARG A 321
HIS A 325
GLU A 318
 None
 1.17A 6mn4D-2cwfA:
undetectable		 6mn4D-2cwfA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		4 TRP A 423
HIS A 123
HIS A 231
GLU A 365
 None
 1.22A 6mn4D-2e3zA:
undetectable		 6mn4D-2e3zA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz2 ARGININOSUCCINATE
SYNTHASE

(Homo sapiens) 		PF00764
(Arginosuc_synth) 		4 TRP A 145
ASP A 124
ARG A 272
GLU A 196
 None
ASP  A 501 ( 3.6A)
ASP  A 501 ( 4.6A)
None
 1.21A 6mn4D-2nz2A:
undetectable		 6mn4D-2nz2A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT

(Bacillus sp. D6) 		PF09491
(RE_AlwI) 		4 HIS A  93
GLU A  73
ASP A  60
GLU A  22
 SO4  A 194 (-3.9A)
None
None
None
 1.12A 6mn4D-2p14A:
undetectable		 6mn4D-2p14A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psp PORCINE PANCREATIC
SPASMOLYTIC
POLYPEPTIDE

(Sus scrofa) 		PF00088
(Trefoil) 		4 ASP A  12
HIS A 105
ARG A  16
ASP A  37
 None
 0.76A 6mn4D-2pspA:
undetectable		 6mn4D-2pspA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 TRP A 234
ASP A 171
HIS A 152
GLU A 198
 None
FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.4A)
None
 1.19A 6mn4D-2q9uA:
undetectable		 6mn4D-2q9uA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhh CG3027-PA

(Drosophila
melanogaster) 		PF00795
(CN_hydrolase) 		4 ARG A 196
HIS A 195
GLU A 169
ASP A 171
 None
 0.99A 6mn4D-2vhhA:
undetectable		 6mn4D-2vhhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ASP A 192
HIS A 396
GLU A 418
GLU A 431
 None
 1.10A 6mn4D-2x05A:
undetectable		 6mn4D-2x05A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 TRP A 284
ASP A 217
HIS A 316
ASP A 320
 None
 1.22A 6mn4D-2yikA:
undetectable		 6mn4D-2yikA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 ASP A 175
HIS A 441
GLU A 322
GLU A 107
 None
 1.11A 6mn4D-2yk0A:
undetectable		 6mn4D-2yk0A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymz GALECTIN 2

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		4 TRP A  65
HIS A  45
ARG A  70
GLU A  52
 None
 1.22A 6mn4D-2ymzA:
undetectable		 6mn4D-2ymzA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ago RIBONUCLEASE U2

(Ustilago
sphaerogena) 		PF00545
(Ribonuclease) 		4 ASP A  84
HIS A  41
GLU A  62
GLU A  49
 None
3AM  A 115 (-3.8A)
3AM  A 115 (-2.9A)
3AM  A 115 (-2.8A)
 1.06A 6mn4D-3agoA:
undetectable		 6mn4D-3agoA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 HIS A 454
ARG A 366
HIS A 365
GLU A 394
 None
 1.19A 6mn4D-3apoA:
undetectable		 6mn4D-3apoA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 ASP A  46
HIS A 136
ARG A 118
GLU A 115
 None
 1.02A 6mn4D-3be5A:
undetectable		 6mn4D-3be5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gu0 TRIGGER FACTOR

(Thermotoga
maritima) 		PF05697
(Trigger_N)
PF05698
(Trigger_C) 		4 ASP A 289
ARG A  12
GLU A 104
GLU A   7
 None
 1.19A 6mn4D-3gu0A:
undetectable		 6mn4D-3gu0A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 ASP A 161
ARG A  68
HIS A 158
GLU A  61
 None
 1.17A 6mn4D-3hhgA:
undetectable		 6mn4D-3hhgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		4 ASP A 100
HIS A 101
GLU A 432
ASP A 201
 None
 1.20A 6mn4D-3i3lA:
undetectable		 6mn4D-3i3lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		4 ASP A 180
ARG A 374
ASP A 233
GLU A 369
 None
 1.19A 6mn4D-3i3lA:
undetectable		 6mn4D-3i3lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 ASP A  63
HIS A  64
GLU A  11
GLU A 402
 ZN  A 452 (-2.5A)
ZN  A 452 (-3.5A)
None
None
 1.13A 6mn4D-3ie1A:
undetectable		 6mn4D-3ie1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxv 70 KDA
PEPTIDYL-PROLYL
ISOMERASE

(Triticum
aestivum) 		PF00254
(FKBP_C) 		4 ASP A 272
ARG A 336
GLU A 332
GLU A 292
 None
 1.17A 6mn4D-3jxvA:
undetectable		 6mn4D-3jxvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on9 TUMOUR NECROSIS
FACTOR RECEPTOR

(Ectromelia
virus) 		PF07190
(DUF1406) 		4 ASP A 297
HIS A 266
ASP A 167
GLU A 169
 None
 1.15A 6mn4D-3on9A:
undetectable		 6mn4D-3on9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)

(Mycobacterium
tuberculosis) 		PF00857
(Isochorismatase) 		4 ASP A  40
ARG A   2
GLU A 127
GLU A 181
 None
 1.14A 6mn4D-3pl1A:
undetectable		 6mn4D-3pl1A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		4 ASP A 172
HIS A  99
ASP A  16
GLU A 236
 None
GOL  A 367 ( 4.8A)
MN  A 365 (-2.6A)
None
 1.01A 6mn4D-3rmjA:
undetectable		 6mn4D-3rmjA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 ASP A  31
ARG A  77
ASP A  80
GLU A  15
 None
 1.14A 6mn4D-3rv2A:
undetectable		 6mn4D-3rv2A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 HIS A  50
GLU A  24
ASP A  81
GLU A 143
 None
None
None
ZN  A 401 ( 3.8A)
 1.17A 6mn4D-3rzaA:
undetectable		 6mn4D-3rzaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 ASP A 129
HIS A 134
HIS A 180
ASP A 136
 None
 1.20A 6mn4D-3t57A:
undetectable		 6mn4D-3t57A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		4 TRP A 432
HIS A 125
HIS A 301
GLU A 377
 TRS  A 501 (-4.9A)
None
None
TRS  A 501 (-3.0A)
 1.18A 6mn4D-3w53A:
undetectable		 6mn4D-3w53A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
None
None
SO4  A 601 ( 4.4A)
 0.92A 6mn4D-3wfoA:
undetectable		 6mn4D-3wfoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
 0.98A 6mn4D-3wfpA:
undetectable		 6mn4D-3wfpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wu1 PROTEIN C-ETS-1

(Homo sapiens) 		PF00178
(Ets) 		4 ARG B 413
HIS B 403
GLU B 362
ASP B 359
 None
 0.92A 6mn4D-3wu1B:
undetectable		 6mn4D-3wu1B:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP

(Salmonella
enterica) 		PF00814
(Peptidase_M22) 		4 HIS B  51
HIS B 110
GLU B   7
ASP B 300
 None
None
None
ZN  B1339 ( 2.5A)
 1.03A 6mn4D-3zeuB:
undetectable		 6mn4D-3zeuB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpm LATHERIN

(Equus caballus) 		PF01273
(LBP_BPI_CETP) 		4 ASP A  80
HIS A 132
ASP A  85
GLU A  76
 None
 0.99A 6mn4D-3zpmA:
undetectable		 6mn4D-3zpmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awd BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 ASP A 236
ARG A 136
HIS A 238
ASP A 309
 None
None
None
CA  A1321 (-3.4A)
 1.12A 6mn4D-4awdA:
undetectable		 6mn4D-4awdA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		4 TRP A 424
HIS A 119
HIS A 300
GLU A 366
 None
 1.22A 6mn4D-4b3kA:
undetectable		 6mn4D-4b3kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		4 ASP A  71
GLU A 361
ASP A  63
GLU A  67
 None
 1.22A 6mn4D-4bokA:
undetectable		 6mn4D-4bokA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 178
HIS A 235
HIS A 176
GLU A 255
 None
 1.06A 6mn4D-4btmA:
undetectable		 6mn4D-4btmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		4 ASP A1989
ARG A2051
GLU A2054
GLU A2004
 None
 1.05A 6mn4D-4c0eA:
undetectable		 6mn4D-4c0eA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASP A 228
ARG A  45
HIS A  46
ASP A   6
 None
 1.21A 6mn4D-4c7vA:
undetectable		 6mn4D-4c7vA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ASP A 179
ARG A 219
ASP A 216
GLU A 215
 None
 1.04A 6mn4D-4dzaA:
undetectable		 6mn4D-4dzaA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk8 FERREDOXIN--NADP
REDUCTASE

(Burkholderia
thailandensis) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 TRP A  30
ARG A 142
ASP A 174
GLU A  76
 None
 1.19A 6mn4D-4fk8A:
undetectable		 6mn4D-4fk8A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ibn RIBONUCLEASE H

(uncultured
organism) 		PF00075
(RNase_H) 		4 ARG A  80
HIS A  84
GLU A  77
GLU A 131
 None
 0.81A 6mn4D-4ibnA:
undetectable		 6mn4D-4ibnA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 ARG A  43
HIS A  42
GLU A 617
GLU A  33
 None
 1.12A 6mn4D-4jzaA:
undetectable		 6mn4D-4jzaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00814
(Peptidase_M22) 		4 HIS A  86
HIS A 144
GLU A  39
ASP A 361
 None
None
None
ZN  A 601 (-2.1A)
 0.87A 6mn4D-4k25A:
undetectable		 6mn4D-4k25A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2x DIHYDROFOLATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF00186
(DHFR_1) 		5 HIS A  30
ARG A 109
HIS A 157
GLU A 111
GLU A  90
 None
 1.29A 6mn4D-4m2xA:
undetectable		 6mn4D-4m2xA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi7 BACTERIOPHAGE
ENCODED VIRULENCE
FACTOR

(Salmonella
enterica) 		no annotation 4 ASP A 182
HIS A 151
GLU A 153
ASP A 169
 None
SO4  A 301 (-3.7A)
None
None
 1.12A 6mn4D-4mi7A:
undetectable		 6mn4D-4mi7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ASP A  32
ARG A 182
HIS A 181
ASP A 235
 FGP  A  70 (-3.0A)
None
FGP  A  70 ( 4.5A)
None
 1.23A 6mn4D-4mivA:
undetectable		 6mn4D-4mivA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		4 HIS A  73
ARG A 313
GLU A 281
ASP A 280
 SO4  A 501 (-4.6A)
None
None
None
 1.19A 6mn4D-4narA:
2.2		 6mn4D-4narA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		4 ASP A  40
ARG A 304
HIS A 295
GLU A 300
 CD  A 502 ( 2.6A)
NDG  A 504 (-3.9A)
ACT  A 503 (-4.5A)
None
 1.11A 6mn4D-4nz5A:
undetectable		 6mn4D-4nz5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 HIS A 102
ARG A 174
ASP A 171
GLU A 170
 None
 1.08A 6mn4D-4p22A:
undetectable		 6mn4D-4p22A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 ASP A 262
HIS A 306
ARG A 265
ASP A 311
 None
 0.98A 6mn4D-4p4sA:
undetectable		 6mn4D-4p4sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 ASP B 262
HIS B 306
ARG B 265
ASP B 311
 None
 0.97A 6mn4D-4p4sB:
undetectable		 6mn4D-4p4sB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1

(Sicarius
terrosus) 		no annotation 4 HIS A  11
GLU A  31
ASP A  91
GLU A 134
 None
MG  A 301 (-2.6A)
MG  A 301 (-3.1A)
None
 1.03A 6mn4D-4q6xA:
undetectable		 6mn4D-4q6xA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ASP A3239
ARG A3241
GLU A3266
ASP A3262
 None
 1.06A 6mn4D-4rh7A:
undetectable		 6mn4D-4rh7A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 HIS A1344
GLU A1439
ASP A1436
GLU A2082
 None
 1.11A 6mn4D-4rh7A:
undetectable		 6mn4D-4rh7A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		4 ASP A 310
ARG A 309
HIS A 127
GLU A 265
 None
 1.21A 6mn4D-4s13A:
undetectable		 6mn4D-4s13A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		4 ASP A 170
ARG A 171
GLU A 125
ASP A 217
 None
 1.17A 6mn4D-4twbA:
undetectable		 6mn4D-4twbA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhv YFIB

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		4 ASP A  52
HIS A 100
ARG A  51
GLU A  56
 None
 1.23A 6mn4D-4zhvA:
undetectable		 6mn4D-4zhvA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF01398
(JAB)
PF13012
(MitMem_reg)
PF01398
(JAB) 		4 HIS H 238
ARG F 266
HIS H 228
ASP F 263
 None
 1.17A 6mn4D-5a5tH:
undetectable		 6mn4D-5a5tH:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3v BILIVERDIN REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 4 HIS B 129
ARG B  25
GLU B 128
ASP B 287
 None
None
NAP  B 401 (-3.4A)
None
 1.15A 6mn4D-5b3vB:
undetectable		 6mn4D-5b3vB:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb6 PROBABLE
ADENYLYL-SULFATE
KINASE

(Synechocystis
sp. PCC 6803) 		PF01583
(APS_kinase) 		4 HIS A  23
ARG A  30
GLU A  26
GLU A  37
 None
 1.05A 6mn4D-5cb6A:
undetectable		 6mn4D-5cb6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzv PROTEIN PCDHA7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 ARG A  60
GLU A   9
ASP A  62
GLU A  65
 None
CA  A 603 (-3.1A)
CA  A 603 (-3.5A)
None
 1.18A 6mn4D-5dzvA:
undetectable		 6mn4D-5dzvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezo C12 FAB

(Plasmodium
falciparum) 		no annotation 4 ASP A 121
ARG A 102
HIS A 104
ASP A  67
 None
 1.17A 6mn4D-5ezoA:
undetectable		 6mn4D-5ezoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 ASP A 179
ARG A 184
GLU A  43
GLU A  50
 None
 1.06A 6mn4D-5f56A:
undetectable		 6mn4D-5f56A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		4 ASP A  65
HIS A 135
GLU A  27
GLU A 177
 PO4  A 601 ( 2.7A)
ZN  A 402 ( 3.2A)
None
BTB  A1002 (-2.8A)
 1.05A 6mn4D-5fbbA:
undetectable		 6mn4D-5fbbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 TRP A 300
ARG A1318
GLU A1323
GLU A1327
 None
 1.15A 6mn4D-5gjvA:
undetectable		 6mn4D-5gjvA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 HIS A  90
ARG A 307
HIS A 161
ASP A 303
 None
 1.21A 6mn4D-5jodA:
undetectable		 6mn4D-5jodA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		4 ARG A 147
HIS A 150
GLU A 144
GLU A 115
 None
 0.96A 6mn4D-5lc8A:
undetectable		 6mn4D-5lc8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		4 TRP N 362
HIS N 444
ARG N 515
GLU N 479
 None
 1.12A 6mn4D-5mpdN:
undetectable		 6mn4D-5mpdN:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15

(Thermobia
domestica) 		no annotation 4 ASP A  35
HIS A   1
ARG A 165
GLU A 182
 None
CU1  A 303 (-3.0A)
None
CU1  A 303 ( 4.4A)
 1.15A 6mn4D-5mszA:
undetectable		 6mn4D-5mszA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5naq BETA-GALACTOSIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		4 TRP A 423
HIS A 119
HIS A 299
GLU A 365
 None
 1.22A 6mn4D-5naqA:
undetectable		 6mn4D-5naqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 HIS B 686
ARG B 290
HIS B 302
GLU B 285
 None
 1.11A 6mn4D-5nd1B:
undetectable		 6mn4D-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 HIS A4100
HIS A4054
ASP A2030
GLU A4206
 None
 1.19A 6mn4D-5nugA:
undetectable		 6mn4D-5nugA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2

(Homo sapiens) 		no annotation 4 HIS H  63
ARG H  91
HIS H  88
GLU H  66
 None
 1.09A 6mn4D-5vfrH:
undetectable		 6mn4D-5vfrH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3w ARYLDIALKYLPHOSPHATA
SE

(Sulfolobus
solfataricus) 		no annotation 4 ASP A 256
HIS A 174
HIS A  22
ASP A 141
 FE  A 401 (-2.4A)
EDO  A 403 (-4.5A)
FE  A 401 (-3.3A)
None
 1.16A 6mn4D-5w3wA:
undetectable		 6mn4D-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 ARG A  76
GLU A 247
ASP A  78
GLU A  66
 None
 0.99A 6mn4D-5x7sA:
undetectable		 6mn4D-5x7sA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION

(Mycolicibacterium
smegmatis) 		PF00383
(dCMP_cyt_deam_1) 		4 ASP A  44
ARG A  45
GLU A  20
ASP A  24
 None
 1.17A 6mn4D-5xkoA:
undetectable		 6mn4D-5xkoA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 4 ASP A 692
HIS A 623
HIS A 691
GLU A 659
 None
 1.09A 6mn4D-5ze3A:
undetectable		 6mn4D-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 4 TRP A 300
ARG A1318
GLU A1323
GLU A1327
 None
 1.11A 6mn4D-6byoA:
undetectable		 6mn4D-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation
no annotation 		4 ASP A2213
HIS B  52
GLU I 717
GLU I 724
 None
 1.12A 6mn4D-6emkA:
undetectable		 6mn4D-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		4 ASP A 427
HIS C 235
HIS A 433
GLU A 585
 None
 1.21A 6mn4D-6f5oA:
undetectable		 6mn4D-6f5oA:
undetectable