SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN4_C_AM2C301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		4 TRP A  20
ASP A  57
ASP A 292
GLU A 181
 None
 1.06A 6mn4C-1bhwA:
0.0		 6mn4C-1bhwA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		4 ASP A  56
HIS A 288
ASP A 286
GLU A 180
 None
 1.19A 6mn4C-1bxcA:
0.0		 6mn4C-1bxcA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1d L-PHENYLALANINE
DEHYDROGENASE

(Rhodococcus sp.) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ASP A 127
HIS A 294
ARG A 139
GLU A 299
 None
None
K  A 853 (-4.4A)
K  A 853 (-2.7A)
 1.12A 6mn4C-1c1dA:
2.4		 6mn4C-1c1dA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 TRP A 405
ARG A 143
ASP A 129
GLU A 133
 None
 1.22A 6mn4C-1crzA:
0.0		 6mn4C-1crzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 TRP A 610
HIS A 713
ARG A 636
GLU A 427
 None
None
None
MG  A3001 ( 2.6A)
 1.11A 6mn4C-1d8cA:
0.0		 6mn4C-1d8cA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ASP A 272
HIS A 219
HIS A 242
ASP A 280
 None
 1.26A 6mn4C-1dgjA:
0.0		 6mn4C-1dgjA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
MOLECULAR CHAPERONE
DNAK

(Escherichia
coli;
Escherichia
coli) 		PF01025
(GrpE)
PF00012
(HSP70) 		4 ASP A 150
ARG D  56
HIS A 154
GLU D  31
 None
 1.32A 6mn4C-1dkgA:
undetectable		 6mn4C-1dkgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 HIS P 125
HIS P 227
ASP P 281
GLU P 312
 DDZ  P  69 ( 3.9A)
None
MG  P 603 (-2.2A)
None
 1.18A 6mn4C-1e33P:
0.0		 6mn4C-1e33P:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 HIS A  60
ARG A 285
HIS A 288
ASP A 282
 None
 1.24A 6mn4C-1e4oA:
undetectable		 6mn4C-1e4oA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		4 HIS A 497
HIS A 405
GLU A 493
GLU A 509
 None
 1.19A 6mn4C-1h79A:
undetectable		 6mn4C-1h79A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ASP A 596
GLU A 517
ASP A 394
GLU A 393
 MLZ  A 513 ( 4.9A)
MLY  A 390 ( 3.7A)
MLY  A 390 ( 3.8A)
None
 1.17A 6mn4C-1iv8A:
undetectable		 6mn4C-1iv8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 HIS A 510
GLU A 517
ASP A 394
GLU A 393
 None
MLY  A 390 ( 3.7A)
MLY  A 390 ( 3.8A)
None
 1.24A 6mn4C-1iv8A:
undetectable		 6mn4C-1iv8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		4 ASP A 177
HIS A 384
GLU A 489
GLU A 316
 SO4  A 601 (-4.0A)
None
None
None
 1.26A 6mn4C-1kzhA:
undetectable		 6mn4C-1kzhA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 TRP A 131
HIS A 190
GLU A 216
ASP A 186
 None
 1.22A 6mn4C-1lwhA:
undetectable		 6mn4C-1lwhA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi4 HYPOTHETICAL PROTEIN
YHBO

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		4 ASP A 178
HIS A 126
GLU A  38
GLU A  70
 None
 1.31A 6mn4C-1oi4A:
undetectable		 6mn4C-1oi4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		4 ASP A  68
ARG A  67
GLU A  64
GLU A 408
 None
None
None
CD  A 813 (-3.2A)
 1.29A 6mn4C-1rq1A:
undetectable		 6mn4C-1rq1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TRP A 552
ASP A 582
HIS A 369
GLU A 399
 NA  A7501 (-4.7A)
None
None
None
 1.32A 6mn4C-1yq2A:
undetectable		 6mn4C-1yq2A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1z MINOR TAIL PROTEIN U

(Escherichia
virus Lambda) 		PF06141
(Phage_tail_U) 		4 ASP A 122
ARG A  27
HIS A  63
GLU A  33
 None
 1.00A 6mn4C-1z1zA:
undetectable		 6mn4C-1z1zA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ARG B 276
HIS B 294
ASP B 206
GLU B 208
 None
 1.15A 6mn4C-2amcB:
undetectable		 6mn4C-2amcB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjr MFP2B

(Ascaris suum) 		PF12150
(MFP2b) 		4 HIS A  46
ARG A 165
ASP A   9
GLU A   8
 None
 1.15A 6mn4C-2bjrA:
undetectable		 6mn4C-2bjrA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8j FERROCHELATASE 1

(Bacillus
anthracis) 		PF00762
(Ferrochelatase) 		4 ASP A  41
GLU A 271
ASP A 267
GLU A 263
 None
 1.17A 6mn4C-2c8jA:
undetectable		 6mn4C-2c8jA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ARG A 154
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 0.95A 6mn4C-2dh4A:
undetectable		 6mn4C-2dh4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 ASP A 339
HIS A 443
HIS A 341
GLU A 382
 None
 1.15A 6mn4C-2gj4A:
undetectable		 6mn4C-2gj4A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 TRP A 612
HIS A 715
ARG A 638
GLU A 434
 None
None
None
MG  A1000 ( 2.7A)
 1.07A 6mn4C-2gq3A:
undetectable		 6mn4C-2gq3A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igi OLIGORIBONUCLEASE

(Escherichia
coli) 		PF00929
(RNase_T) 		4 ASP A 111
HIS A  65
ASP A 162
GLU A 165
 CD  A1002 ( 3.9A)
None
ZN  A1001 ( 3.0A)
None
 1.24A 6mn4C-2igiA:
undetectable		 6mn4C-2igiA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igi OLIGORIBONUCLEASE

(Escherichia
coli) 		PF00929
(RNase_T) 		4 ASP A 111
HIS A  65
GLU A  13
GLU A 165
 CD  A1002 ( 3.9A)
None
ZN  A1001 ( 2.5A)
None
 1.27A 6mn4C-2igiA:
undetectable		 6mn4C-2igiA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASP A 107
HIS A 192
ARG A 105
ASP A 194
 None
 1.20A 6mn4C-2ldxA:
undetectable		 6mn4C-2ldxA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 HIS A 212
GLU A 289
ASP A 293
GLU A 297
 None
 1.21A 6mn4C-2qagA:
undetectable		 6mn4C-2qagA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbu PRECORRIN-2
METHYLTRANSFERASE

(Methanothermobacter
thermautotrophicus) 		PF00590
(TP_methylase) 		4 ASP A 120
ARG A 117
ASP A  81
GLU A  77
 None
 1.12A 6mn4C-2qbuA:
undetectable		 6mn4C-2qbuA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 ASP A 259
GLU A 287
ASP A 291
GLU A 295
 None
 1.22A 6mn4C-2v1uA:
undetectable		 6mn4C-2v1uA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ASP A 568
HIS A 555
ARG A 572
ASP A 422
 None
 1.21A 6mn4C-2vdaA:
undetectable		 6mn4C-2vdaA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG

(Methanothermobacter
thermautotrophicus) 		PF01172
(SBDS)
PF09377
(SBDS_C) 		4 ASP A  99
HIS A   0
ASP A   6
GLU A   5
 None
 1.30A 6mn4C-2wbmA:
undetectable		 6mn4C-2wbmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wz9 GLUTAREDOXIN-3

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 ASP A  98
HIS A 104
HIS A 115
GLU A 107
 None
 1.20A 6mn4C-2wz9A:
undetectable		 6mn4C-2wz9A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xeh NI3C MUT6

(synthetic
construct) 		PF12796
(Ank_2) 		4 ASP A 143
ARG A 122
HIS A 118
GLU A 156
 None
SO4  A1171 (-3.0A)
None
None
 1.14A 6mn4C-2xehA:
undetectable		 6mn4C-2xehA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		4 HIS A 988
HIS A 594
ASP A 895
GLU A 807
 None
None
GLC  A2150 ( 4.3A)
GLC  A2150 ( 4.5A)
 1.12A 6mn4C-2ya1A:
undetectable		 6mn4C-2ya1A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 HIS A 533
HIS A 139
ASP A 440
GLU A 352
 None
None
NOJ  A1689 (-2.9A)
NOJ  A1689 (-3.0A)
 1.05A 6mn4C-2ya2A:
undetectable		 6mn4C-2ya2A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 HIS A  14
ARG A  42
HIS A  63
ASP A  40
 None
 0.88A 6mn4C-2yzmA:
undetectable		 6mn4C-2yzmA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 ASP A 385
HIS A 203
GLU A 201
GLU A  72
 None
None
CBI  A 459 ( 4.0A)
None
 1.27A 6mn4C-3axxA:
undetectable		 6mn4C-3axxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 ASP B 305
HIS B  42
ARG B 307
HIS B 306
 None
 1.23A 6mn4C-3bxwB:
undetectable		 6mn4C-3bxwB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8z CYSTEINYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF01406
(tRNA-synt_1e) 		4 HIS A  55
ARG A 304
ASP A 114
GLU A 113
 5CA  A 418 (-4.3A)
None
None
None
 1.20A 6mn4C-3c8zA:
undetectable		 6mn4C-3c8zA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chi P-AMINOBENZOATE
N-OXYGENASE

(Streptomyces
thioluteus) 		PF11583
(AurF) 		4 ASP A 148
ARG A 151
GLU A  95
GLU A 158
 None
 1.29A 6mn4C-3chiA:
undetectable		 6mn4C-3chiA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		4 HIS A 250
GLU A 247
ASP A 275
GLU A 448
 None
MG  A   1 (-2.6A)
MG  A   1 (-3.3A)
None
 1.22A 6mn4C-3cuxA:
undetectable		 6mn4C-3cuxA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 ASP A  42
ARG A  38
HIS A  41
ASP A  35
 None
 1.24A 6mn4C-3dlaA:
undetectable		 6mn4C-3dlaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		4 ASP A 200
ARG A 202
GLU A 145
GLU A 178
 None
 0.98A 6mn4C-3flbA:
undetectable		 6mn4C-3flbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN

(Bacteroides
vulgatus) 		PF03372
(Exo_endo_phos) 		4 ASP A 250
HIS A 141
HIS A 210
ASP A 172
 None
 1.18A 6mn4C-3g6sA:
undetectable		 6mn4C-3g6sA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwi MAGNESIUM-TRANSPORTI
NG ATPASE, P-TYPE 1

(Escherichia
coli) 		PF13246
(Cation_ATPase) 		4 HIS A 388
HIS A 408
ASP A 426
GLU A 428
 None
 1.27A 6mn4C-3gwiA:
undetectable		 6mn4C-3gwiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 ALPHA-SOLUBLE NSF
ATTACHMENT PROTEIN

(Rattus
norvegicus) 		no annotation 4 ASP H  80
HIS H 123
HIS H  72
ASP H  87
 None
 1.07A 6mn4C-3j97H:
undetectable		 6mn4C-3j97H:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 ASP A 812
HIS A 350
GLU A 354
GLU A 386
 None
 1.31A 6mn4C-3nafA:
undetectable		 6mn4C-3nafA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 ASP A 578
HIS A 491
ASP A 500
GLU A 497
 None
None
None
TRS  A 702 ( 3.9A)
 0.89A 6mn4C-3nxpA:
undetectable		 6mn4C-3nxpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		4 TRP A 336
ASP A 261
ARG A 262
HIS A 260
 None
 1.32A 6mn4C-3oh8A:
undetectable		 6mn4C-3oh8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ASP A 465
HIS A  44
GLU A 518
GLU A 364
 None
 1.08A 6mn4C-3pigA:
undetectable		 6mn4C-3pigA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		4 ASP A  60
HIS A  51
GLU A 499
GLU A 302
 MN  A 930 (-2.5A)
None
None
None
 1.20A 6mn4C-3s1sA:
undetectable		 6mn4C-3s1sA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		4 TRP A 185
ASP A  33
HIS A 209
ASP A 247
 ADE  A 400 ( 3.5A)
None
ADE  A 400 (-4.5A)
None
 1.23A 6mn4C-3s99A:
undetectable		 6mn4C-3s99A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 ASP X2055
HIS X1974
ARG X2051
GLU X2050
 None
 1.32A 6mn4C-3su8X:
undetectable		 6mn4C-3su8X:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ASP A  49
ARG A  35
GLU A 101
GLU A  28
 None
 1.22A 6mn4C-3thzA:
undetectable		 6mn4C-3thzA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 ASP A 200
ARG A 140
HIS A 133
ASP A 161
 None
 1.20A 6mn4C-3uc3A:
undetectable		 6mn4C-3uc3A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP

(Salmonella
enterica) 		PF00814
(Peptidase_M22) 		4 HIS B  51
HIS B 110
GLU B   7
ASP B 300
 None
None
None
ZN  B1339 ( 2.5A)
 0.95A 6mn4C-3zeuB:
undetectable		 6mn4C-3zeuB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		4 TRP A 617
HIS A 720
ARG A 643
GLU A 439
 None
None
None
MG  A 801 (-2.6A)
 1.12A 6mn4C-4ex4A:
undetectable		 6mn4C-4ex4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ARG A  87
HIS A 380
ASP A 117
GLU A 304
 None
 1.30A 6mn4C-4f7kA:
undetectable		 6mn4C-4f7kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 396
ARG A 395
HIS A 381
GLU A 384
 None
 1.10A 6mn4C-4f7kA:
undetectable		 6mn4C-4f7kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ge0 UNCHARACTERIZED
PROTEIN C22E12.03C

(Schizosaccharomyces
pombe) 		PF01965
(DJ-1_PfpI) 		4 HIS A 130
GLU A  16
ASP A  13
GLU A  14
 None
 1.17A 6mn4C-4ge0A:
undetectable		 6mn4C-4ge0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ioy FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 HIS X 743
GLU X 826
ASP X 850
GLU X 866
 PO4  X1001 (-3.8A)
None
None
None
 1.27A 6mn4C-4ioyX:
undetectable		 6mn4C-4ioyX:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 ASP A 108
HIS A  14
GLU A  17
GLU A 167
 None
 1.04A 6mn4C-4js5A:
undetectable		 6mn4C-4js5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 TRP A 386
HIS A 394
ARG A 381
GLU A 655
 None
 1.32A 6mn4C-4jzaA:
undetectable		 6mn4C-4jzaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		4 ASP A 363
HIS A 369
ASP A 347
GLU A 344
 None
 1.17A 6mn4C-4l22A:
undetectable		 6mn4C-4l22A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis) 		no annotation 4 ARG A 243
HIS A 240
GLU A 195
ASP A  89
 None
HEC  A 802 (-3.2A)
None
None
 1.30A 6mn4C-4lmhA:
undetectable		 6mn4C-4lmhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		4 ASP A 237
HIS A 307
GLU A 166
GLU A 434
 None
None
GOL  A 507 (-3.2A)
GOL  A 507 (-2.9A)
 1.19A 6mn4C-4mdpA:
undetectable		 6mn4C-4mdpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		4 ASP A 137
ARG A 133
GLU A 117
GLU A 129
 None
None
None
UD1  A 400 (-3.6A)
 1.30A 6mn4C-4nesA:
1.9		 6mn4C-4nesA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ASP B 428
HIS B 438
GLU B 470
GLU B 473
 None
 1.18A 6mn4C-4qiwB:
undetectable		 6mn4C-4qiwB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9z UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		4 TRP A 175
ARG A 159
GLU A 157
GLU A 130
 None
 1.25A 6mn4C-4r9zA:
undetectable		 6mn4C-4r9zA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ARG A 111
HIS A 115
ASP A 134
GLU A  64
 None
FAD  A 601 (-2.5A)
None
None
 1.21A 6mn4C-4ud8A:
undetectable		 6mn4C-4ud8A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 217
HIS A 147
ASP A 173
GLU A  79
 None
 1.00A 6mn4C-4usfA:
undetectable		 6mn4C-4usfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		4 TRP A  19
ASP A  56
ASP A 292
GLU A 180
 None
None
SOR  A 400 ( 2.7A)
MG  A 399 ( 2.5A)
 1.07A 6mn4C-4xiaA:
undetectable		 6mn4C-4xiaA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 HIS A1105
ARG A 912
HIS A1085
GLU A1108
 None
None
None
ZN  A3000 (-2.8A)
 1.25A 6mn4C-5a22A:
undetectable		 6mn4C-5a22A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 ASP A 487
HIS A1591
ARG A 484
ASP A1338
 None
 1.05A 6mn4C-5amqA:
undetectable		 6mn4C-5amqA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 ASP A 299
HIS A 403
ASP A 169
GLU A 170
 None
 1.17A 6mn4C-5by3A:
undetectable		 6mn4C-5by3A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dji 3'-PHOSPHOADENOSINE
5'-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		4 ASP A 212
HIS A 110
GLU A  74
ASP A  50
 MG  A 302 ( 2.7A)
None
None
PO4  A 304 ( 3.9A)
 1.26A 6mn4C-5djiA:
undetectable		 6mn4C-5djiA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ASP A 397
ARG A 165
GLU A  81
GLU A 450
 None
None
NI  A 904 (-3.6A)
None
 1.01A 6mn4C-5dmyA:
undetectable		 6mn4C-5dmyA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 HIS A 270
GLU A 591
ASP A 589
GLU A 588
 None
 1.25A 6mn4C-5gjvA:
undetectable		 6mn4C-5gjvA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gte LACHRYMATORY-FACTOR
SYNTHASE

(Allium cepa) 		PF10604
(Polyketide_cyc2) 		4 HIS A  78
HIS A  48
GLU A 158
GLU A 165
 None
 1.22A 6mn4C-5gteA:
undetectable		 6mn4C-5gteA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 4 TRP B  93
HIS B 179
GLU B 693
GLU B 700
 None
 1.16A 6mn4C-5hzgB:
undetectable		 6mn4C-5hzgB:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1u GERMACRADIEN-4-OL
SYNTHASE

(Streptomyces
citricolor) 		no annotation 4 TRP A 124
ASP A 122
HIS A  33
GLU A  64
 None
 1.27A 6mn4C-5i1uA:
undetectable		 6mn4C-5i1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 ASP A 162
HIS A  90
HIS A 161
ASP A 303
 GOL  A 402 (-2.9A)
None
None
None
 1.21A 6mn4C-5jodA:
undetectable		 6mn4C-5jodA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A
COMPLEMENT C4-A

(Homo sapiens;
Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
PF01759
(NTR)
PF07677
(A2M_recep) 		4 ASP B1304
ARG B1300
GLU C1563
GLU B 943
 None
 1.02A 6mn4C-5jpnB:
undetectable		 6mn4C-5jpnB:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb3 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		4 ARG B 148
HIS B 149
GLU B 119
GLU B 117
 None
 1.27A 6mn4C-5lb3B:
undetectable		 6mn4C-5lb3B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		4 ARG A 147
HIS A 150
GLU A 144
GLU A 115
 None
 1.15A 6mn4C-5lc8A:
undetectable		 6mn4C-5lc8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgg ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ASP A  88
ARG A 594
HIS A 592
ASP A  16
 None
 1.23A 6mn4C-5lggA:
undetectable		 6mn4C-5lggA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx0 DIPEPTIDASE

(Aspergillus
fumigatus) 		PF01244
(Peptidase_M19) 		4 HIS A 164
ARG A 235
HIS A 233
GLU A 134
 None
None
None
FE  A 401 ( 2.4A)
 1.31A 6mn4C-5lx0A:
undetectable		 6mn4C-5lx0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		4 ASP A  65
HIS A 518
ASP A 290
GLU A 291
 None
 1.15A 6mn4C-5mtzA:
undetectable		 6mn4C-5mtzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9c OSMOPORIN OMP36

(Klebsiella
aerogenes) 		no annotation 4 ASP C 225
HIS C 226
ASP C 202
GLU C 160
 None
 1.22A 6mn4C-5o9cC:
undetectable		 6mn4C-5o9cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 TRP A 610
HIS A 713
ARG A 636
GLU A 432
 None
GOL  A 801 (-3.6A)
None
MG  A 820 ( 2.7A)
 1.09A 6mn4C-5oasA:
undetectable		 6mn4C-5oasA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL

(Homo sapiens) 		PF01161
(PBP) 		4 ASP 6 302
ARG 6 299
GLU 6 231
GLU 6 227
 None
 1.26A 6mn4C-5ool6:
undetectable		 6mn4C-5ool6:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3w ARYLDIALKYLPHOSPHATA
SE

(Sulfolobus
solfataricus) 		no annotation 4 ASP A 256
HIS A 174
HIS A  22
ASP A 141
 FE  A 401 (-2.4A)
EDO  A 403 (-4.5A)
FE  A 401 (-3.3A)
None
 1.19A 6mn4C-5w3wA:
undetectable		 6mn4C-5w3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9g MAGNESIUM
TRANSPORTER MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF03448
(MgtE_N) 		4 ASP A 250
HIS A  29
GLU A  59
GLU A 166
 None
None
None
MG  A 302 ( 3.5A)
 1.31A 6mn4C-5x9gA:
undetectable		 6mn4C-5x9gA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		4 TRP A  20
ASP A  57
ASP A 287
GLU A 181
 None
None
XYL  A 402 ( 2.9A)
XYL  A 402 ( 2.4A)
 1.03A 6mn4C-5y4jA:
undetectable		 6mn4C-5y4jA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT

(Thermococcus
kodakarensis) 		no annotation 4 ASP A 416
HIS A  72
ASP A 103
GLU A 106
 None
 1.28A 6mn4C-5yy0A:
undetectable		 6mn4C-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 4 TRP A 179
HIS A 208
ARG A 214
GLU A 499
 None
 1.26A 6mn4C-5yy3A:
undetectable		 6mn4C-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		4 TRP A 616
HIS A 719
ARG A 642
GLU A 438
 None
None
None
MG  A 802 (-2.7A)
 1.13A 6mn4C-6axeA:
undetectable		 6mn4C-6axeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 4 HIS A 270
GLU A 591
ASP A 589
GLU A 588
 None
 1.27A 6mn4C-6byoA:
undetectable		 6mn4C-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		4 ASP A 427
HIS C 235
HIS A 433
GLU A 585
 None
 1.30A 6mn4C-6f5oA:
undetectable		 6mn4C-6f5oA:
undetectable