SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN4_B_AM2B301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aug PYROGLUTAMYL
PEPTIDASE-1

(Bacillus
amyloliquefaciens) 		PF01470
(Peptidase_C15) 		4 HIS A 158
HIS A 146
GLU A 154
GLU A  56
 None
 1.11A 6mn4B-1augA:
0.0		 6mn4B-1augA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		4 TRP A  20
ASP A  57
ASP A 292
GLU A 181
 None
 1.27A 6mn4B-1bhwA:
0.0		 6mn4B-1bhwA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 TRP A 405
ARG A 143
ASP A 129
GLU A 133
 None
 1.07A 6mn4B-1crzA:
0.0		 6mn4B-1crzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
MOLECULAR CHAPERONE
DNAK

(Escherichia
coli;
Escherichia
coli) 		PF01025
(GrpE)
PF00012
(HSP70) 		4 ASP A 150
ARG D  56
HIS A 154
GLU D  31
 None
 1.24A 6mn4B-1dkgA:
0.0		 6mn4B-1dkgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7y STEM/LEAF LECTIN
DB58

(Vigna
unguiculata) 		PF00139
(Lectin_legB) 		4 ASP A 125
HIS A 181
ARG A 137
HIS A 138
 CA  A 254 ( 2.2A)
None
None
MN  A 257 (-3.4A)
 1.06A 6mn4B-1g7yA:
0.0		 6mn4B-1g7yA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ASP A 497
HIS A 398
ARG A 494
GLU A 351
 None
BEZ  A1501 ( 4.2A)
None
None
 1.26A 6mn4B-1i7qA:
0.0		 6mn4B-1i7qA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 HIS A 510
GLU A 517
ASP A 394
GLU A 393
 None
MLY  A 390 ( 3.7A)
MLY  A 390 ( 3.8A)
None
 1.14A 6mn4B-1iv8A:
0.0		 6mn4B-1iv8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ASP A  30
HIS A 591
HIS A 158
ASP A 327
 None
 1.25A 6mn4B-1lf9A:
0.0		 6mn4B-1lf9A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 198
HIS A 322
ASP A 386
GLU A 388
 None
 1.13A 6mn4B-1lnlA:
undetectable		 6mn4B-1lnlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ASP A 761
HIS A 760
ASP A 764
GLU A 765
 None
 1.17A 6mn4B-1pd1A:
undetectable		 6mn4B-1pd1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TRP A 552
ASP A 582
HIS A 369
GLU A 399
 NA  A7501 (-4.7A)
None
None
None
 1.13A 6mn4B-1yq2A:
undetectable		 6mn4B-1yq2A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TRP A 552
HIS A 369
GLU A 394
GLU A 399
 NA  A7501 (-4.7A)
None
None
None
 1.25A 6mn4B-1yq2A:
undetectable		 6mn4B-1yq2A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 ASP A 253
HIS A 130
ASP A 222
GLU A 248
 None
 1.20A 6mn4B-1yrgA:
undetectable		 6mn4B-1yrgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ASP B 166
HIS B 449
ASP B 458
GLU B 461
 None
None
MG  A 901 ( 4.9A)
MG  A 901 (-3.1A)
 1.26A 6mn4B-2amcB:
undetectable		 6mn4B-2amcB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5u COLICIN E3

(Escherichia
coli) 		PF03515
(Cloacin)
PF09000
(Cytotoxic)
PF11570
(E2R135) 		4 ASP A 531
HIS A 526
GLU A 517
ASP A 510
 None
 1.28A 6mn4B-2b5uA:
undetectable		 6mn4B-2b5uA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		4 HIS A  52
ARG A 321
HIS A 325
GLU A 318
 None
 0.89A 6mn4B-2cwfA:
undetectable		 6mn4B-2cwfA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ARG A 154
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 0.95A 6mn4B-2dh4A:
undetectable		 6mn4B-2dh4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE

(Rhizobium sp.
MTP-10005) 		PF04909
(Amidohydro_2) 		4 ASP A  38
HIS A  10
ARG A  35
HIS A  34
 None
ZN  A1501 ( 3.3A)
None
None
 1.24A 6mn4B-2dvuA:
undetectable		 6mn4B-2dvuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 TRP A 234
ASP A 268
ARG A 224
GLU A 391
 FAD  A1000 ( 4.4A)
None
None
None
 1.25A 6mn4B-2fjaA:
undetectable		 6mn4B-2fjaA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkz BACTERIOFERRITIN

(Azotobacter
vinelandii) 		PF00210
(Ferritin) 		4 ASP A  90
HIS A  46
HIS A  28
GLU A  18
 None
None
None
FE2  A1600 (-2.4A)
 1.27A 6mn4B-2fkzA:
undetectable		 6mn4B-2fkzA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 HIS A 553
ARG A 593
HIS A 591
ASP A 184
 None
 1.28A 6mn4B-2ivfA:
undetectable		 6mn4B-2ivfA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mnz LYSINE-SPECIFIC
DEMETHYLASE 5B

(Homo sapiens) 		PF00628
(PHD) 		4 ASP A 320
ARG A 323
HIS A 335
ASP A 345
 None
None
ZN  A 401 (-3.1A)
None
 1.23A 6mn4B-2mnzA:
undetectable		 6mn4B-2mnzA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1t ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90) 		4 ASP A 520
HIS A 517
GLU A 564
GLU A 529
 None
 1.17A 6mn4B-2o1tA:
undetectable		 6mn4B-2o1tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 ASP A 166
HIS A 116
HIS A 242
GLU A 160
 None
 1.14A 6mn4B-2pbgA:
undetectable		 6mn4B-2pbgA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		4 ARG A 133
GLU A 210
ASP A  68
GLU A  67
 None
MG  A 401 ( 3.9A)
MG  A 400 (-2.6A)
None
 0.98A 6mn4B-2q80A:
undetectable		 6mn4B-2q80A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 TRP A 234
ASP A 171
HIS A 152
GLU A 198
 None
FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.4A)
None
 1.25A 6mn4B-2q9uA:
undetectable		 6mn4B-2q9uA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 HIS A 212
GLU A 289
ASP A 293
GLU A 297
 None
 1.10A 6mn4B-2qagA:
undetectable		 6mn4B-2qagA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbu PRECORRIN-2
METHYLTRANSFERASE

(Methanothermobacter
thermautotrophicus) 		PF00590
(TP_methylase) 		4 ASP A 120
ARG A 117
ASP A  81
GLU A  77
 None
 0.95A 6mn4B-2qbuA:
undetectable		 6mn4B-2qbuA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1
SNURPORTIN-1

(Homo sapiens;
Homo sapiens) 		PF13513
(HEAT_EZ)
PF11538
(Snurportin1) 		4 ASP A 579
ARG B  43
ASP A 627
GLU A 626
 None
 1.27A 6mn4B-2qnaA:
undetectable		 6mn4B-2qnaA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vug PAB1020

(Pyrococcus
abyssi) 		PF09414
(RNA_ligase) 		4 HIS A 317
GLU A 314
ASP A 309
GLU A 305
 None
 1.26A 6mn4B-2vugA:
undetectable		 6mn4B-2vugA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x56 COAGULASE/FIBRINOLYS
IN

(Yersinia pestis) 		PF01278
(Omptin) 		4 ASP A  44
HIS A 208
HIS A  28
ASP A  86
 None
C8E  A1308 ( 4.4A)
None
None
 1.20A 6mn4B-2x56A:
undetectable		 6mn4B-2x56A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 ASP A 175
HIS A 441
GLU A 322
GLU A 107
 None
 1.00A 6mn4B-2yk0A:
undetectable		 6mn4B-2yk0A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 HIS A  14
ARG A  42
HIS A  63
ASP A  40
 None
 1.20A 6mn4B-2yzmA:
undetectable		 6mn4B-2yzmA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ago RIBONUCLEASE U2

(Ustilago
sphaerogena) 		PF00545
(Ribonuclease) 		4 ASP A  84
HIS A  41
GLU A  62
GLU A  49
 None
3AM  A 115 (-3.8A)
3AM  A 115 (-2.9A)
3AM  A 115 (-2.8A)
 1.11A 6mn4B-3agoA:
undetectable		 6mn4B-3agoA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ASP A 483
ARG A 520
GLU A 334
GLU A 319
 None
 1.20A 6mn4B-3fahA:
undetectable		 6mn4B-3fahA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		4 HIS A 152
ARG A  78
GLU A 125
GLU A  57
 None
 1.11A 6mn4B-3h3bA:
undetectable		 6mn4B-3h3bA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 ASP A 161
ARG A  68
HIS A 158
GLU A  61
 None
 1.09A 6mn4B-3hhgA:
undetectable		 6mn4B-3hhgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 ALPHA-SOLUBLE NSF
ATTACHMENT PROTEIN

(Rattus
norvegicus) 		no annotation 4 ASP H  80
HIS H 123
HIS H  72
ASP H  87
 None
 1.11A 6mn4B-3j97H:
undetectable		 6mn4B-3j97H:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llc PUTATIVE HYDROLASE

(Agrobacterium
vitis) 		PF12697
(Abhydrolase_6) 		4 ASP A 255
ARG A 258
GLU A  56
ASP A  59
 None
None
EDO  A 275 (-3.5A)
EDO  A 275 ( 4.0A)
 1.19A 6mn4B-3llcA:
undetectable		 6mn4B-3llcA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn1 PROBABLE YRBI FAMILY
PHOSPHATASE

(Pseudomonas
savastanoi) 		PF08282
(Hydrolase_3) 		4 ASP A  49
HIS A 175
GLU A 162
GLU A   2
 None
 1.26A 6mn4B-3mn1A:
undetectable		 6mn4B-3mn1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(marine
actinobacterium
PHSC20C1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 291
HIS A 317
GLU A 241
ASP A 215
 None
 1.14A 6mn4B-3msyA:
undetectable		 6mn4B-3msyA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		4 ASP A 578
HIS A 491
ASP A 500
GLU A 497
 None
None
None
TRS  A 702 ( 3.9A)
 1.15A 6mn4B-3nxpA:
undetectable		 6mn4B-3nxpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2h BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		4 ASP A  89
HIS A  46
HIS A  28
GLU A  18
 None
None
None
NA  A 156 (-2.8A)
 1.27A 6mn4B-3r2hA:
undetectable		 6mn4B-3r2hA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		4 ASP A 172
HIS A  99
ASP A  16
GLU A 236
 None
GOL  A 367 ( 4.8A)
MN  A 365 (-2.6A)
None
 0.87A 6mn4B-3rmjA:
undetectable		 6mn4B-3rmjA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 HIS A  50
GLU A  24
ASP A  81
GLU A 143
 None
None
None
ZN  A 401 ( 3.8A)
 1.25A 6mn4B-3rzaA:
undetectable		 6mn4B-3rzaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 HIS A 381
ARG A 471
HIS A 426
ASP A 400
 None
 1.02A 6mn4B-3u1kA:
undetectable		 6mn4B-3u1kA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		4 ASP A 243
ARG A 242
ASP A  84
GLU A  87
 None
 1.08A 6mn4B-3uqzA:
undetectable		 6mn4B-3uqzA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
None
None
SO4  A 601 ( 4.4A)
 0.99A 6mn4B-3wfoA:
undetectable		 6mn4B-3wfoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
 1.03A 6mn4B-3wfpA:
undetectable		 6mn4B-3wfpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP

(Salmonella
enterica) 		PF00814
(Peptidase_M22) 		4 HIS B  51
HIS B 110
GLU B   7
ASP B 300
 None
None
None
ZN  B1339 ( 2.5A)
 1.05A 6mn4B-3zeuB:
undetectable		 6mn4B-3zeuB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpm LATHERIN

(Equus caballus) 		PF01273
(LBP_BPI_CETP) 		4 ASP A  80
HIS A 132
ASP A  85
GLU A  76
 None
 0.81A 6mn4B-3zpmA:
undetectable		 6mn4B-3zpmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abx DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		no annotation 4 ASP A 252
GLU A 304
ASP A 301
GLU A 298
 None
 1.25A 6mn4B-4abxA:
undetectable		 6mn4B-4abxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 178
HIS A 235
HIS A 176
GLU A 255
 None
 1.09A 6mn4B-4btmA:
undetectable		 6mn4B-4btmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 396
ARG A 395
HIS A 381
GLU A 384
 None
 0.94A 6mn4B-4f7kA:
undetectable		 6mn4B-4f7kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		4 HIS A  15
ARG A   7
GLU A  11
GLU A  28
 GOL  A 505 (-3.4A)
None
None
None
 1.14A 6mn4B-4ijaA:
undetectable		 6mn4B-4ijaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens) 		PF00888
(Cullin) 		4 ASP D  20
ARG D  23
ASP D  68
GLU D  67
 None
 1.14A 6mn4B-4jghD:
undetectable		 6mn4B-4jghD:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keq 4-PYRIDOXOLACTONASE

(Mesorhizobium
japonicum) 		PF00753
(Lactamase_B) 		4 ASP A 207
HIS A 116
HIS A 101
GLU A 119
 ZN  A 301 ( 2.1A)
None
ZN  A 301 (-3.2A)
None
 1.18A 6mn4B-4keqA:
undetectable		 6mn4B-4keqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keq 4-PYRIDOXOLACTONASE

(Mesorhizobium
japonicum) 		PF00753
(Lactamase_B) 		4 ASP A 207
HIS A 116
HIS A 101
GLU A 130
 ZN  A 301 ( 2.1A)
None
ZN  A 301 (-3.2A)
None
 1.28A 6mn4B-4keqA:
undetectable		 6mn4B-4keqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis) 		no annotation 4 ARG A 243
HIS A 240
GLU A 195
ASP A  89
 None
HEC  A 802 (-3.2A)
None
None
 1.08A 6mn4B-4lmhA:
undetectable		 6mn4B-4lmhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2x DIHYDROFOLATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF00186
(DHFR_1) 		4 HIS A  30
HIS A 157
GLU A 111
GLU A  90
 None
 1.17A 6mn4B-4m2xA:
undetectable		 6mn4B-4m2xA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi7 BACTERIOPHAGE
ENCODED VIRULENCE
FACTOR

(Salmonella
enterica) 		no annotation 4 ASP A 182
HIS A 151
GLU A 153
ASP A 169
 None
SO4  A 301 (-3.7A)
None
None
 1.14A 6mn4B-4mi7A:
undetectable		 6mn4B-4mi7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi7 BACTERIOPHAGE
ENCODED VIRULENCE
FACTOR

(Salmonella
enterica) 		no annotation 4 HIS A 151
GLU A 153
ASP A 169
GLU A 176
 SO4  A 301 (-3.7A)
None
None
None
 1.08A 6mn4B-4mi7A:
undetectable		 6mn4B-4mi7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 4 HIS A 412
GLU A 411
ASP A 407
GLU A 404
 None
 1.15A 6mn4B-4n5aA:
undetectable		 6mn4B-4n5aA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1

(Sicarius
terrosus) 		no annotation 4 HIS A  11
GLU A  31
ASP A  91
GLU A 134
 None
MG  A 301 (-2.6A)
MG  A 301 (-3.1A)
None
 1.01A 6mn4B-4q6xA:
undetectable		 6mn4B-4q6xA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ASP A 230
ARG A 231
HIS A 226
ASP A 272
 None
 1.28A 6mn4B-4q73A:
undetectable		 6mn4B-4q73A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qei GLYCINE--TRNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ASP A  66
HIS A 537
ARG A  67
GLU A 536
 None
None
C  C  70 ( 4.5A)
None
 1.24A 6mn4B-4qeiA:
undetectable		 6mn4B-4qeiA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ASP B  34
HIS B 205
GLU B 204
ASP B  53
 None
 1.28A 6mn4B-4r1dB:
undetectable		 6mn4B-4r1dB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 HIS A1344
GLU A1439
ASP A1436
GLU A2082
 None
 1.18A 6mn4B-4rh7A:
undetectable		 6mn4B-4rh7A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 217
HIS A 147
ASP A 173
GLU A  79
 None
 1.21A 6mn4B-4usfA:
undetectable		 6mn4B-4usfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B

(Corynebacterium
sp.) 		PF13561
(adh_short_C2) 		4 HIS A 162
ARG A 186
ASP A 183
GLU A 179
 None
 1.17A 6mn4B-4zd6A:
undetectable		 6mn4B-4zd6A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyl RPHYB PROTEIN

(Rhodopseudomonas
palustris) 		PF00072
(Response_reg) 		4 ASP A  77
HIS A 107
ARG A  79
GLU A 110
 None
 1.16A 6mn4B-4zylA:
undetectable		 6mn4B-4zylA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 HIS A 365
ARG A 438
HIS A 338
GLU A 383
 FLC  A1893 ( 4.5A)
FLC  A1893 ( 4.9A)
None
None
 1.24A 6mn4B-5agaA:
undetectable		 6mn4B-5agaA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		4 ASP A 129
ARG A 130
GLU A 132
ASP A  93
 None
 1.14A 6mn4B-5allA:
undetectable		 6mn4B-5allA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		4 ASP A 438
ARG A 151
GLU A 479
ASP A 141
 None
 1.16A 6mn4B-5axhA:
undetectable		 6mn4B-5axhA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 TRP A 177
HIS A 602
GLU A 557
ASP A 137
 None
 1.27A 6mn4B-5by3A:
undetectable		 6mn4B-5by3A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 HIS A 291
HIS A 367
ASP A 238
GLU A 240
 None
 1.22A 6mn4B-5c0yA:
undetectable		 6mn4B-5c0yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		4 HIS A 150
ARG A  96
GLU A 122
GLU A 160
 None
 1.28A 6mn4B-5c1iA:
undetectable		 6mn4B-5c1iA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens;
Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3)
PF00169
(PH)
PF16746
(BAR_3) 		4 ASP A  49
HIS B 100
ARG A  46
HIS A  45
 None
 1.22A 6mn4B-5c5bA:
undetectable		 6mn4B-5c5bA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dji 3'-PHOSPHOADENOSINE
5'-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		4 ASP A  94
HIS A 110
GLU A  74
ASP A  50
 MG  A 302 (-3.1A)
None
None
PO4  A 304 ( 3.9A)
 1.21A 6mn4B-5djiA:
undetectable		 6mn4B-5djiA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ASP A 397
ARG A 165
GLU A  81
GLU A 450
 None
None
NI  A 904 (-3.6A)
None
 1.15A 6mn4B-5dmyA:
undetectable		 6mn4B-5dmyA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ASP B 662
HIS B 827
ARG B 693
GLU B 685
 None
 1.23A 6mn4B-5eduB:
undetectable		 6mn4B-5eduB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezo C12 FAB

(Plasmodium
falciparum) 		no annotation 4 ASP A 121
ARG A 102
HIS A 104
ASP A  67
 None
 0.97A 6mn4B-5ezoA:
undetectable		 6mn4B-5ezoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		4 ASP A  65
HIS A 135
GLU A  27
GLU A 177
 PO4  A 601 ( 2.7A)
ZN  A 402 ( 3.2A)
None
BTB  A1002 (-2.8A)
 0.90A 6mn4B-5fbbA:
undetectable		 6mn4B-5fbbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		4 ASP A 641
HIS A 532
ARG A 535
ASP A 564
 None
 1.26A 6mn4B-5fswA:
undetectable		 6mn4B-5fswA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		4 TRP A 314
HIS A 177
GLU A 167
GLU A 423
 DQR  A 544 (-4.1A)
DQR  A 544 (-4.7A)
DQR  A 544 (-2.8A)
DQR  A 544 (-2.8A)
 1.14A 6mn4B-5g5zA:
undetectable		 6mn4B-5g5zA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gte LACHRYMATORY-FACTOR
SYNTHASE

(Allium cepa) 		PF10604
(Polyketide_cyc2) 		4 HIS A  78
HIS A  48
GLU A 158
GLU A 165
 None
 1.21A 6mn4B-5gteA:
undetectable		 6mn4B-5gteA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 HIS A 554
ARG A 124
HIS A 120
GLU A 568
 None
 1.08A 6mn4B-5hrmA:
undetectable		 6mn4B-5hrmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 ASP A  83
ARG A  79
GLU A  97
ASP A 146
 None
 1.25A 6mn4B-5husA:
undetectable		 6mn4B-5husA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 HIS A 362
ARG A 419
GLU A 423
GLU A 416
 None
 1.21A 6mn4B-5i1wA:
undetectable		 6mn4B-5i1wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		4 ARG A 147
HIS A 150
GLU A 144
GLU A 115
 None
 1.06A 6mn4B-5lc8A:
undetectable		 6mn4B-5lc8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 HIS A4100
HIS A4054
ASP A2030
GLU A4206
 None
 1.26A 6mn4B-5nugA:
undetectable		 6mn4B-5nugA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulu CADHERIN-23

(Mus musculus) 		no annotation 4 ASP A2196
ARG A2225
GLU A2162
ASP A2262
 None
 1.17A 6mn4B-5uluA:
undetectable		 6mn4B-5uluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usc PREPHENATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF02153
(PDH) 		4 ASP A 191
HIS A 161
HIS A 190
GLU A 117
 None
 1.26A 6mn4B-5uscA:
undetectable		 6mn4B-5uscA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1d PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 ARG A 450
GLU A 385
ASP A 480
GLU A 517
 None
CA  A1007 (-2.9A)
CA  A1007 (-2.7A)
K  A1006 (-2.8A)
 1.03A 6mn4B-5w1dA:
undetectable		 6mn4B-5w1dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Homo sapiens) 		PF01370
(Epimerase) 		4 TRP J 313
ASP J 133
ARG J 132
GLU J 311
 None
None
NDP  J 401 (-3.2A)
None
 1.23A 6mn4B-5xtdJ:
undetectable		 6mn4B-5xtdJ:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		4 TRP A  20
ASP A  57
ASP A 287
GLU A 181
 None
None
XYL  A 402 ( 2.9A)
XYL  A 402 ( 2.4A)
 1.23A 6mn4B-5y4jA:
undetectable		 6mn4B-5y4jA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypz COFB

(Escherichia
coli) 		no annotation 4 ASP A 132
HIS A 199
ASP A  49
GLU A  53
 None
 1.22A 6mn4B-5ypzA:
undetectable		 6mn4B-5ypzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 4 ASP A 692
HIS A 623
HIS A 691
GLU A 659
 None
 1.25A 6mn4B-5ze3A:
undetectable		 6mn4B-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 4 ASP A 672
GLU A 605
ASP A1162
GLU A1159
 None
 1.12A 6mn4B-6co7A:
undetectable		 6mn4B-6co7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		4 ASP A 427
HIS C 235
HIS A 433
GLU A 585
 None
 1.22A 6mn4B-6f5oA:
undetectable		 6mn4B-6f5oA:
undetectable