SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN4_A_AM2A301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aug PYROGLUTAMYL
PEPTIDASE-1

(Bacillus
amyloliquefaciens) 		PF01470
(Peptidase_C15) 		4 HIS A 158
HIS A 146
GLU A 154
GLU A  56
 None
 1.20A 6mn4A-1augA:
0.0		 6mn4A-1augA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 ASP A  86
ARG A  85
ASP A 103
GLU A 130
 None
 1.22A 6mn4A-1bwdA:
0.0		 6mn4A-1bwdA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7y STEM/LEAF LECTIN
DB58

(Vigna
unguiculata) 		PF00139
(Lectin_legB) 		4 ASP A 125
HIS A 181
ARG A 137
HIS A 138
 CA  A 254 ( 2.2A)
None
None
MN  A 257 (-3.4A)
 1.10A 6mn4A-1g7yA:
0.0		 6mn4A-1g7yA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg3 ERYTHROID MEMBRANE
PROTEIN 4.1R

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 ASP A  25
ARG A  29
GLU A  32
ASP A  40
 None
 1.12A 6mn4A-1gg3A:
0.0		 6mn4A-1gg3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 ASP A 436
HIS A 226
ARG A 207
GLU A 124
 None
 0.90A 6mn4A-1h39A:
undetectable		 6mn4A-1h39A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ASP A 497
HIS A 398
ARG A 494
GLU A 351
 None
BEZ  A1501 ( 4.2A)
None
None
 1.24A 6mn4A-1i7qA:
0.0		 6mn4A-1i7qA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvt CROTONOBETAINYL-COA:
CARNITINE
COA-TRANSFERASE

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		4 ARG A 311
HIS A 303
GLU A 314
GLU A 258
 None
 1.20A 6mn4A-1xvtA:
0.5		 6mn4A-1xvtA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 TRP A 632
ARG A 541
ASP A 539
GLU A 640
 None
 0.98A 6mn4A-1z7eA:
1.3		 6mn4A-1z7eA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		4 ASP A 116
GLU A 217
ASP A 218
GLU A 221
 None
None
K  A1417 ( 3.3A)
K  A1417 (-3.5A)
 1.14A 6mn4A-1zl0A:
0.1		 6mn4A-1zl0A:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 TRP A 279
ARG A 264
HIS A 260
ASP A 273
 None
 1.17A 6mn4A-2atcA:
2.4		 6mn4A-2atcA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5i INTERLEUKIN-2
RECEPTOR BETA CHAIN
CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
PF00041
(fn3)
PF09240
(IL6Ra-bind) 		4 HIS C 141
HIS C 184
GLU C 149
GLU B 140
 None
 1.19A 6mn4A-2b5iC:
undetectable		 6mn4A-2b5iC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ARG A 154
GLU A 236
ASP A  84
GLU A  83
 None
MG  A 341 ( 4.8A)
MG  A 341 (-3.0A)
None
 1.19A 6mn4A-2dh4A:
undetectable		 6mn4A-2dh4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36

(Canis lupus) 		PF03388
(Lectin_leg-like) 		4 ASP A 131
HIS A 121
ASP A  93
GLU A  94
 GOL  A   7 (-3.3A)
None
None
None
 1.21A 6mn4A-2dupA:
undetectable		 6mn4A-2dupA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 TRP A 234
ASP A 268
ARG A 224
GLU A 391
 FAD  A1000 ( 4.4A)
None
None
None
 1.15A 6mn4A-2fjaA:
undetectable		 6mn4A-2fjaA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjd SODIUM/HYDROGEN
EXCHANGE REGULATORY
COFACTOR NHE-RF1

(Homo sapiens) 		PF00595
(PDZ)
PF09007
(EBP50_C) 		4 ASP A  29
HIS A  27
ASP A  94
GLU A  95
 None
 1.21A 6mn4A-2kjdA:
undetectable		 6mn4A-2kjdA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1t ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90) 		4 ASP A 520
HIS A 517
GLU A 564
GLU A 529
 None
 1.19A 6mn4A-2o1tA:
undetectable		 6mn4A-2o1tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB

(Escherichia
coli) 		PF03888
(MucB_RseB)
PF17188
(MucB_RseB_C) 		4 ASP A 138
ARG A 139
ASP A 161
GLU A 163
 None
 1.21A 6mn4A-2p4bA:
undetectable		 6mn4A-2p4bA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 HIS A 212
GLU A 289
ASP A 293
GLU A 297
 None
 1.16A 6mn4A-2qagA:
undetectable		 6mn4A-2qagA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbu PRECORRIN-2
METHYLTRANSFERASE

(Methanothermobacter
thermautotrophicus) 		PF00590
(TP_methylase) 		4 ASP A 120
ARG A 117
ASP A  81
GLU A  77
 None
 0.93A 6mn4A-2qbuA:
undetectable		 6mn4A-2qbuA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ASP A 192
HIS A 396
GLU A 418
GLU A 431
 None
 1.01A 6mn4A-2x05A:
undetectable		 6mn4A-2x05A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B) 		4 ASP A 151
HIS A 168
HIS A  56
ASP A 162
 ZN  A1211 (-2.4A)
None
None
None
 1.06A 6mn4A-2xf4A:
undetectable		 6mn4A-2xf4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 ASP A 175
HIS A 441
GLU A 322
GLU A 107
 None
 1.18A 6mn4A-2xu0A:
undetectable		 6mn4A-2xu0A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 ASP A 175
HIS A 441
GLU A 322
GLU A 107
 None
 1.00A 6mn4A-2yk0A:
undetectable		 6mn4A-2yk0A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 HIS A  14
ARG A  42
HIS A  63
ASP A  40
 None
 1.00A 6mn4A-2yzmA:
undetectable		 6mn4A-2yzmA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ago RIBONUCLEASE U2

(Ustilago
sphaerogena) 		PF00545
(Ribonuclease) 		4 ASP A  84
HIS A  41
GLU A  62
GLU A  49
 None
3AM  A 115 (-3.8A)
3AM  A 115 (-2.9A)
3AM  A 115 (-2.8A)
 1.03A 6mn4A-3agoA:
undetectable		 6mn4A-3agoA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		4 ASP A 108
HIS A 298
ARG A 107
ASP A 296
 None
 1.24A 6mn4A-3bw2A:
undetectable		 6mn4A-3bw2A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 ASP H 105
ARG H  85
ASP H 380
GLU H 382
 None
 1.17A 6mn4A-3c75H:
undetectable		 6mn4A-3c75H:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ASP A 582
HIS A 325
ARG A 572
ASP A 166
 None
 1.17A 6mn4A-3cmgA:
undetectable		 6mn4A-3cmgA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ASP A 221
ARG A 198
HIS A 224
ASP A 168
 RDF  A2001 ( 4.7A)
RDF  A2001 (-2.6A)
None
None
 0.98A 6mn4A-3dbkA:
undetectable		 6mn4A-3dbkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		4 HIS A 152
ARG A  78
GLU A 125
GLU A  57
 None
 0.94A 6mn4A-3h3bA:
undetectable		 6mn4A-3h3bA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhg TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 ASP A 161
ARG A  68
HIS A 158
GLU A  61
 None
 1.06A 6mn4A-3hhgA:
undetectable		 6mn4A-3hhgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 ASP A 183
ARG A 180
ASP A 197
GLU A 196
 None
 1.11A 6mn4A-3hlmA:
undetectable		 6mn4A-3hlmA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ASP A 236
HIS A 220
ARG A 239
ASP A 268
 None
 1.17A 6mn4A-3m07A:
undetectable		 6mn4A-3m07A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		no annotation 4 HIS D 205
HIS D 174
GLU D 212
ASP D 209
 None
 0.89A 6mn4A-3nmzD:
undetectable		 6mn4A-3nmzD:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		4 HIS A  -2
HIS A 262
GLU A 291
GLU A 283
 None
 1.18A 6mn4A-3p8rA:
undetectable		 6mn4A-3p8rA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		4 ASP A 172
HIS A  99
ASP A  16
GLU A 236
 None
GOL  A 367 ( 4.8A)
MN  A 365 (-2.6A)
None
 0.87A 6mn4A-3rmjA:
undetectable		 6mn4A-3rmjA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpk BACKBONE PILUS
SUBUNIT

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 TRP A 239
ASP A 319
ARG A 242
ASP A 278
 None
 1.20A 6mn4A-3rpkA:
undetectable		 6mn4A-3rpkA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 HIS A  50
GLU A  24
ASP A  81
GLU A 143
 None
None
None
ZN  A 401 ( 3.8A)
 1.12A 6mn4A-3rzaA:
undetectable		 6mn4A-3rzaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 HIS A  50
GLU A  24
ASP A  81
GLU A 144
 None
None
None
CA  A 402 (-2.2A)
 1.06A 6mn4A-3rzaA:
undetectable		 6mn4A-3rzaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujq LEGUME LECTIN

(Lablab
purpureus) 		PF00139
(Lectin_legB) 		4 ASP A 148
HIS A 204
ARG A 160
HIS A 161
 CA  A 303 ( 3.0A)
None
None
MN  A 304 (-4.0A)
 1.19A 6mn4A-3ujqA:
undetectable		 6mn4A-3ujqA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 ASP A 270
HIS A 174
ARG A 266
ASP A 313
 None
 1.22A 6mn4A-3v1vA:
undetectable		 6mn4A-3v1vA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE

(Paecilomyces
sp.
'thermophila') 		no annotation 4 ASP A 252
HIS A 127
GLU A 118
ASP A 115
 CBI  A 301 (-4.5A)
None
CBI  A 301 (-3.0A)
CBI  A 301 (-3.7A)
 1.00A 6mn4A-3wdyA:
undetectable		 6mn4A-3wdyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
None
None
SO4  A 601 ( 4.4A)
 1.08A 6mn4A-3wfoA:
undetectable		 6mn4A-3wfoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
 1.14A 6mn4A-3wfpA:
undetectable		 6mn4A-3wfpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ARG A 193
HIS A 192
GLU A 237
GLU A 244
 None
None
CA  A1589 (-2.9A)
None
 1.17A 6mn4A-3zo9A:
undetectable		 6mn4A-3zo9A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpm LATHERIN

(Equus caballus) 		PF01273
(LBP_BPI_CETP) 		4 ASP A  80
HIS A 132
ASP A  85
GLU A  76
 None
 1.00A 6mn4A-3zpmA:
undetectable		 6mn4A-3zpmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		4 TRP A 747
HIS A 485
HIS A 465
ASP A 535
 None
 1.06A 6mn4A-4bs9A:
undetectable		 6mn4A-4bs9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du5 PFKB

(Polaromonas sp.
JS666) 		PF00294
(PfkB) 		4 ASP A 178
HIS A 155
ARG A 181
ASP A 216
 None
 1.06A 6mn4A-4du5A:
undetectable		 6mn4A-4du5A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 ASP W 728
ARG W 729
ASP W 770
GLU W 769
 None
 1.06A 6mn4A-4f5xW:
undetectable		 6mn4A-4f5xW:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 396
ARG A 395
HIS A 381
GLU A 384
 None
 1.09A 6mn4A-4f7kA:
undetectable		 6mn4A-4f7kA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		4 ASP A  90
ARG A 102
HIS A  92
ASP A 107
 UNX  A 302 ( 3.2A)
None
UNX  A 302 ( 3.3A)
None
 1.13A 6mn4A-4fp4A:
undetectable		 6mn4A-4fp4A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 750
HIS A 647
GLU A 533
ASP A 520
 None
 1.17A 6mn4A-4hq6A:
undetectable		 6mn4A-4hq6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ibn RIBONUCLEASE H

(uncultured
organism) 		PF00075
(RNase_H) 		4 ARG A  80
HIS A  84
GLU A  77
GLU A 131
 None
 0.96A 6mn4A-4ibnA:
undetectable		 6mn4A-4ibnA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		4 HIS A  15
ARG A   7
GLU A  11
GLU A  28
 GOL  A 505 (-3.4A)
None
None
None
 1.11A 6mn4A-4ijaA:
undetectable		 6mn4A-4ijaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iua HEPATOCYTE GROWTH
FACTOR

(Mus musculus) 		PF00024
(PAN_1)
PF00051
(Kringle) 		4 HIS A 244
ARG A 235
HIS A  41
ASP A 237
 None
 1.12A 6mn4A-4iuaA:
undetectable		 6mn4A-4iuaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 ASP A 343
HIS A 282
ARG A 303
ASP A 284
 None
 1.09A 6mn4A-4j0wA:
undetectable		 6mn4A-4j0wA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens) 		PF00888
(Cullin) 		4 ASP D  20
ARG D  23
ASP D  68
GLU D  67
 None
 1.05A 6mn4A-4jghD:
undetectable		 6mn4A-4jghD:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ARG A 201
HIS A 200
GLU A 245
GLU A 252
 None
None
CA  A 701 (-2.8A)
None
 1.21A 6mn4A-4lxfA:
undetectable		 6mn4A-4lxfA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2x DIHYDROFOLATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF00186
(DHFR_1) 		4 HIS A  30
HIS A 157
GLU A 111
GLU A  90
 None
 1.11A 6mn4A-4m2xA:
undetectable		 6mn4A-4m2xA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi7 BACTERIOPHAGE
ENCODED VIRULENCE
FACTOR

(Salmonella
enterica) 		no annotation 4 ASP A 182
HIS A 151
GLU A 153
ASP A 169
 None
SO4  A 301 (-3.7A)
None
None
 1.01A 6mn4A-4mi7A:
undetectable		 6mn4A-4mi7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi7 BACTERIOPHAGE
ENCODED VIRULENCE
FACTOR

(Salmonella
enterica) 		no annotation 4 HIS A 151
GLU A 153
ASP A 169
GLU A 176
 SO4  A 301 (-3.7A)
None
None
None
 1.08A 6mn4A-4mi7A:
undetectable		 6mn4A-4mi7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ASP A  32
ARG A 182
HIS A 181
ASP A 235
 FGP  A  70 (-3.0A)
None
FGP  A  70 ( 4.5A)
None
 1.12A 6mn4A-4mivA:
undetectable		 6mn4A-4mivA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 4 HIS A 412
GLU A 411
ASP A 407
GLU A 404
 None
 1.04A 6mn4A-4n5aA:
undetectable		 6mn4A-4n5aA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PGT135 HEAVY CHAIN
PROTEIN M TD

(Homo sapiens;
Mycoplasma
genitalium) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		5 ASP M 408
ARG M 457
GLU M 453
ASP H  31
GLU H  31
 None
 1.41A 6mn4A-4nzrM:
undetectable		 6mn4A-4nzrM:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ASP A  80
ARG A  77
GLU A  55
GLU A  30
 None
 1.18A 6mn4A-4pv4A:
undetectable		 6mn4A-4pv4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 ASP L 388
HIS L 444
ASP L 516
GLU L 515
 K  L 707 (-3.0A)
TCK  L 720 ( 3.6A)
TCK  L 720 (-3.0A)
None
 1.17A 6mn4A-4tkxL:
undetectable		 6mn4A-4tkxL:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3A
EIF3C

(Lachancea
kluyveri;
Lachancea
kluyveri) 		no annotation
PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 TRP a 154
ASP c 388
ARG a 156
GLU a 198
 None
 1.22A 6mn4A-4uera:
undetectable		 6mn4A-4uera:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf4 CARBOXYPEPTIDASE A1

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 HIS A  23
ARG A 181
ASP A  51
GLU A 273
 None
 1.13A 6mn4A-4uf4A:
undetectable		 6mn4A-4uf4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		4 ASP A 124
ARG A 385
ASP A 129
GLU A 128
 None
 1.17A 6mn4A-4uhiA:
undetectable		 6mn4A-4uhiA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1

(Capnocytophaga
gingivalis) 		no annotation 4 TRP C 323
HIS C 342
ASP C 269
GLU C 274
 None
SAH  C 501 (-3.6A)
None
None
 1.17A 6mn4A-4xruC:
undetectable		 6mn4A-4xruC:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(uncultured
bacterium;
Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		4 ASP A 293
HIS A 290
ARG A 296
ASP A 288
 None
 1.20A 6mn4A-4xzwA:
undetectable		 6mn4A-4xzwA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE

(Caldicellulosiruptor
saccharolyticus) 		PF07221
(GlcNAc_2-epim) 		4 TRP A 236
HIS A 186
ARG A 152
GLU A 166
 None
 1.19A 6mn4A-4z4lA:
undetectable		 6mn4A-4z4lA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyl RPHYB PROTEIN

(Rhodopseudomonas
palustris) 		PF00072
(Response_reg) 		4 ASP A  77
HIS A 107
ARG A  79
GLU A 110
 None
 1.22A 6mn4A-4zylA:
undetectable		 6mn4A-4zylA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 HIS A 365
ARG A 438
HIS A 338
GLU A 383
 FLC  A1893 ( 4.5A)
FLC  A1893 ( 4.9A)
None
None
 1.18A 6mn4A-5agaA:
undetectable		 6mn4A-5agaA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		4 HIS A 443
HIS A 366
ASP A 424
GLU A 343
 None
 1.19A 6mn4A-5bu1A:
undetectable		 6mn4A-5bu1A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens;
Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3)
PF00169
(PH)
PF16746
(BAR_3) 		4 ASP A  49
HIS B 100
ARG A  46
HIS A  45
 None
 1.13A 6mn4A-5c5bA:
undetectable		 6mn4A-5c5bA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 HIS A  83
HIS A  78
ASP A 130
GLU A 131
 None
 1.19A 6mn4A-5cerA:
undetectable		 6mn4A-5cerA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo WD REPEAT-CONTAINING
PROTEIN 48
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46

(Homo sapiens;
Homo sapiens) 		PF00400
(WD40)
PF00443
(UCH) 		4 ASP A  76
HIS A 116
ASP A 118
GLU B 237
 None
 1.15A 6mn4A-5cvoA:
undetectable		 6mn4A-5cvoA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcf TYROSINE RECOMBINASE
XERD,DNA TRANSLOCASE
FTSK

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF09397
(Ftsk_gamma) 		4 ARG A 117
HIS A 116
ASP A  26
GLU A  23
 None
 1.11A 6mn4A-5dcfA:
undetectable		 6mn4A-5dcfA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxd PUTATIVE
BETA-GLUCANASE

(Mycobacteroides
abscessus) 		PF00722
(Glyco_hydro_16) 		4 TRP A 129
ASP A 196
ARG A 115
ASP A 252
 None
None
None
NA  A 300 (-3.2A)
 1.22A 6mn4A-5dxdA:
undetectable		 6mn4A-5dxdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ASP B 662
HIS B 827
ARG B 693
GLU B 685
 None
 1.22A 6mn4A-5eduB:
undetectable		 6mn4A-5eduB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		4 ASP A  65
HIS A 135
GLU A  27
GLU A 177
 PO4  A 601 ( 2.7A)
ZN  A 402 ( 3.2A)
None
BTB  A1002 (-2.8A)
 0.99A 6mn4A-5fbbA:
undetectable		 6mn4A-5fbbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 ASP A  38
ARG A 200
HIS A 199
ASP A 250
 CA  A1521 ( 2.8A)
SGN  A1522 (-3.6A)
SGN  A1522 (-4.3A)
None
 1.19A 6mn4A-5g2vA:
undetectable		 6mn4A-5g2vA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ARG B1259
GLU B1263
ASP B 803
GLU B 802
 None
 1.19A 6mn4A-5hb4B:
undetectable		 6mn4A-5hb4B:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 HIS A 554
ARG A 124
HIS A 120
GLU A 568
 None
 1.19A 6mn4A-5hrmA:
undetectable		 6mn4A-5hrmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		4 ASP B1545
HIS B1543
GLU B1541
GLU B1537
 None
 1.23A 6mn4A-5hzkB:
undetectable		 6mn4A-5hzkB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 HIS A 362
ARG A 419
GLU A 423
GLU A 416
 None
 1.21A 6mn4A-5i1wA:
undetectable		 6mn4A-5i1wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens;
Homo sapiens) 		PF00443
(UCH)
PF00400
(WD40) 		4 ASP B  76
HIS B 116
ASP B 118
GLU A 241
 None
 1.23A 6mn4A-5k1cB:
undetectable		 6mn4A-5k1cB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 172
HIS A 144
ASP A 168
GLU A 216
 None
 1.24A 6mn4A-5lxdA:
undetectable		 6mn4A-5lxdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 HIS B 686
ARG B 290
HIS B 302
GLU B 285
 None
 1.14A 6mn4A-5nd1B:
undetectable		 6mn4A-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 4 ASP A 118
ARG A 130
ASP A 170
GLU A 169
 None
 1.22A 6mn4A-5o25A:
undetectable		 6mn4A-5o25A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9c OSMOPORIN OMP36

(Klebsiella
aerogenes) 		no annotation 4 ASP C 225
HIS C 226
ASP C 161
GLU C 160
 None
 1.21A 6mn4A-5o9cC:
undetectable		 6mn4A-5o9cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oec GTGE

(Salmonella
enterica) 		no annotation 4 ASP A 185
HIS A 151
GLU A 153
GLU A 176
 None
 1.15A 6mn4A-5oecA:
undetectable		 6mn4A-5oecA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ASP A 587
HIS A 858
GLU A 836
GLU A 768
 None
 1.21A 6mn4A-5okoA:
undetectable		 6mn4A-5okoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 FIBROBLAST GROWTH
FACTOR 23

(Homo sapiens) 		no annotation 4 ASP B 109
ARG B 114
GLU B  78
ASP B  79
 None
 1.18A 6mn4A-5w21B:
undetectable		 6mn4A-5w21B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi8 BETA-BARREL
ASSEMBLY-ENHANCING
PROTEASE

(Escherichia
coli) 		no annotation 4 ASP A 326
ARG A 329
ASP A 353
GLU A 361
 None
 1.22A 6mn4A-5xi8A:
undetectable		 6mn4A-5xi8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 4 ASP A 692
HIS A 623
HIS A 691
GLU A 659
 None
 1.24A 6mn4A-5ze3A:
undetectable		 6mn4A-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 4 ASP A 672
GLU A 605
ASP A1162
GLU A1159
 None
 1.21A 6mn4A-6co7A:
undetectable		 6mn4A-6co7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation
no annotation 		4 ASP A2213
HIS B  52
GLU I 717
GLU I 724
 None
 1.13A 6mn4A-6emkA:
undetectable		 6mn4A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		4 ASP A 427
HIS C 235
HIS A 433
GLU A 585
 None
 1.14A 6mn4A-6f5oA:
undetectable		 6mn4A-6f5oA:
undetectable