SIMILAR PATTERNS OF AMINO ACIDS FOR 6MN1_A_LLLA302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		5 GLY A 202
TYR A 237
THR A 250
THR A 245
SER A 135
 None
 1.29A 6mn1A-1eg1A:
0.0		 6mn1A-1eg1A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Haemophilus
influenzae) 		PF08282
(Hydrolase_3) 		5 ASP A 111
ASP A  16
GLY A 106
ASP A  90
THR A  86
 CO  A 201 ( 4.3A)
None
None
GOL  A2502 (-4.2A)
None
 1.44A 6mn1A-1k1eA:
1.0		 6mn1A-1k1eA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 ASP A 354
TRP A 405
GLY A 353
ASP A 317
THR A 295
 IFG  A 557 (-3.6A)
IFG  A 557 (-3.3A)
None
None
None
 1.33A 6mn1A-1nowA:
0.0		 6mn1A-1nowA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 ASP A 142
ASP A  52
ASP A  79
THR A 171
THR A  58
 None
None
KJ2  A1214 (-2.8A)
KJ2  A1214 (-4.0A)
None
 1.17A 6mn1A-2breA:
0.0		 6mn1A-2breA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA

(Human
mastadenovirus
C) 		PF01686
(Adeno_Penton_B) 		5 GLY A 173
ASP A 366
THR A 368
THR A 180
SER A 176
 None
 1.40A 6mn1A-2c6sA:
0.0		 6mn1A-2c6sA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 ASP A 411
GLY A 669
TYR A 474
ASP A 354
THR A 355
 None
None
None
GOL  A 804 (-3.2A)
GOL  A 805 (-3.5A)
 1.19A 6mn1A-2ww2A:
0.0		 6mn1A-2ww2A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 ASP A 405
GLY A 665
TYR A 469
ASP A 348
THR A 349
 None
None
None
MVL  A 801 (-2.9A)
None
 1.47A 6mn1A-2wzsA:
0.0		 6mn1A-2wzsA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		5 ASP A 532
ASP A 538
GLY A 648
ASP A 576
THR A 572
 CA  A1934 (-3.1A)
CA  A1934 ( 4.7A)
CA  A1934 ( 4.4A)
None
None
 1.47A 6mn1A-2yhgA:
0.8		 6mn1A-2yhgA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		5 ASP A 251
GLY A 288
ASP A 319
THR A 323
SER A 281
 None
 1.45A 6mn1A-3wh9A:
0.0		 6mn1A-3wh9A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		5 ASP A 353
GLY A 349
ASP A 281
THR A 324
SER A 318
 None
 1.31A 6mn1A-4gwnA:
undetectable		 6mn1A-4gwnA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 TYR A 215
ASP A 179
THR A 242
THR A  47
SER A  37
 None
 1.49A 6mn1A-4mivA:
undetectable		 6mn1A-4mivA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5h CLAUDIN-2
HEAT-LABILE
ENTEROTOXIN B CHAIN

(Mus musculus;
Clostridium
perfringens) 		no annotation
PF03505
(Clenterotox) 		5 TYR A 139
ASP A  45
ASP 1 154
GLY A  47
THR A 107
 None
 1.29A 6mn1A-4p5hA:
undetectable		 6mn1A-4p5hA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 GLY A 670
TYR A 634
ASP A 503
THR A 567
SER A 665
 None
 1.31A 6mn1A-4qnlA:
undetectable		 6mn1A-4qnlA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yga VHH-1B7

(Vicugna pacos) 		PF07686
(V-set) 		5 TRP B  37
GLY B  36
TYR B 111
THR B 100
SER B  33
 None
 1.41A 6mn1A-4ygaB:
undetectable		 6mn1A-4ygaB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ASP A 215
GLY A 212
ASP A  50
THR A 240
THR A  19
 None
 0.83A 6mn1A-5a6dA:
undetectable		 6mn1A-5a6dA:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		6 ASP A  64
TRP A  65
GLY A 115
TYR A 138
ASP A 213
THR A 204
 None
 1.47A 6mn1A-5ht0A:
43.8		 6mn1A-5ht0A:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		8 TRP A  65
ASP A  69
GLY A 115
TYR A 138
ASP A 162
THR A 163
THR A 204
SER A 205
 None
None
None
None
None
COA  A 301 (-3.9A)
None
None
 0.76A 6mn1A-5ht0A:
43.8		 6mn1A-5ht0A:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		9 TYR A  62
ASP A  64
TRP A  65
ASP A  69
GLY A 115
TYR A 138
ASP A 162
THR A 163
THR A 204
 COA  A 301 (-4.7A)
None
None
None
None
None
None
COA  A 301 (-3.9A)
None
 0.53A 6mn1A-5ht0A:
43.8		 6mn1A-5ht0A:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7k FN3CON-A-LYS

(synthetic
construct) 		PF00041
(fn3) 		5 TYR A  66
ASP A  12
THR A  19
THR A  92
SER A  15
 None
 1.16A 6mn1A-5j7kA:
undetectable		 6mn1A-5j7kA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 5 TYR A 468
ASP A 481
GLY A 483
TYR A  79
ASP A 475
 9UB  A 803 (-4.7A)
None
9UB  A 803 ( 3.8A)
9UB  A 803 (-4.4A)
MN  A 802 (-2.9A)
 1.44A 6mn1A-5oglA:
undetectable		 6mn1A-5oglA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1

(Norwalk virus;
Mus musculus) 		no annotation
no annotation 		5 TYR C  34
ASP C  98
ASP A 410
ASP C  51
THR C  50
 None
NA  C 401 (-2.9A)
None
None
NA  C 402 (-3.0A)
 1.48A 6mn1A-5or7C:
undetectable		 6mn1A-5or7C:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szw ELAV-LIKE PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		5 TYR A  70
ASP A  75
GLY A  46
ASP A   9
THR A  82
 None
 1.39A 6mn1A-5szwA:
undetectable		 6mn1A-5szwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN

(Squalimorphii) 		PF00566
(RabGAP-TBC) 		5 TYR A 472
ASP A 434
GLY A 475
ASP A 458
SER A 481
 None
 1.30A 6mn1A-5tubA:
undetectable		 6mn1A-5tubA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuc SUS TBC1D15 GAP
DOMAIN

(Sus scrofa) 		PF00566
(RabGAP-TBC) 		5 TYR A 435
ASP A 397
GLY A 438
ASP A 421
SER A 444
 None
 1.29A 6mn1A-5tucA:
undetectable		 6mn1A-5tucA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		5 ASP A 185
GLY A 316
ASP A 304
THR A 303
SER A 313
 None
 1.21A 6mn1A-5uibA:
undetectable		 6mn1A-5uibA:
14.02