SIMILAR PATTERNS OF AMINO ACIDS FOR 6MKE_D_FK5D201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		4 ASP A 250
ILE A 146
PRO A 147
LEU A 149
 None
 1.29A 6mkeA-1cbfA:
0.0		 6mkeA-1cbfA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 ASP A 277
ILE A  71
PRO A  77
LEU A  75
 None
 1.43A 6mkeA-1cpyA:
0.0		 6mkeA-1cpyA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 ASP A 148
ILE A 174
PRO A 173
LEU A 177
 None
 1.05A 6mkeA-1e1cA:
0.0		 6mkeA-1e1cA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 ASP A 151
ILE A 191
PRO A 193
LEU A 195
 None
 1.32A 6mkeA-1fw8A:
0.0		 6mkeA-1fw8A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv6 ALGINATE LYASE

(Sphingomonas
sp.) 		PF05426
(Alginate_lyase) 		4 ASP A 230
ILE A 295
PRO A 292
LEU A 294
 None
 1.27A 6mkeA-1hv6A:
undetectable		 6mkeA-1hv6A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lhu SEX HORMONE-BINDING
GLOBULIN

(Homo sapiens) 		PF00054
(Laminin_G_1) 		4 ASP A 168
ILE A  27
PRO A  26
LEU A 143
 None
 1.40A 6mkeA-1lhuA:
0.0		 6mkeA-1lhuA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN
POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B;
Enterovirus B) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 ASP C 157
ILE A  28
PRO A  29
LEU A  31
 None
 1.17A 6mkeA-1mqtC:
0.0		 6mkeA-1mqtC:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		4 ASP A   6
ILE A  11
PRO A  18
LEU A   7
 None
 1.44A 6mkeA-1ocmA:
0.0		 6mkeA-1ocmA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ASP A  26
ILE A  18
PRO A 102
LEU A  25
 None
 1.34A 6mkeA-1serA:
0.0		 6mkeA-1serA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te2 2-DEOXYGLUCOSE-6-P
PHOSPHATASE

(Escherichia
coli) 		PF13419
(HAD_2) 		4 ASP A 173
ILE A  19
PRO A  92
LEU A  94
 CA  A 702 (-2.9A)
None
None
None
 1.10A 6mkeA-1te2A:
undetectable		 6mkeA-1te2A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u83 PHOSPHOSULFOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF02679
(ComA) 		4 ASP A  45
ILE A 230
PRO A 231
LEU A  23
 None
 1.12A 6mkeA-1u83A:
undetectable		 6mkeA-1u83A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 ASP A 363
ILE A 306
PRO A 337
LEU A 335
 None
 1.26A 6mkeA-1vliA:
undetectable		 6mkeA-1vliA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl7 ARABINANASE-TS

(Geobacillus
thermodenitrificans) 		PF04616
(Glyco_hydro_43) 		4 ASP A  81
ILE A  46
PRO A  86
LEU A  83
 None
 1.33A 6mkeA-1wl7A:
undetectable		 6mkeA-1wl7A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfk FORMIMIDOYLGLUTAMASE

(Vibrio cholerae) 		PF00491
(Arginase) 		4 ASP A 306
ILE A  72
PRO A  69
LEU A  71
 None
 1.33A 6mkeA-1xfkA:
undetectable		 6mkeA-1xfkA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		4 ASP A 172
ILE A 132
PRO A 133
LEU A 135
 None
 1.24A 6mkeA-1yp1A:
undetectable		 6mkeA-1yp1A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr7 ATP(GTP)BINDING
PROTEIN

(Pyrococcus
abyssi) 		PF03029
(ATP_bind_1) 		4 ASP A 232
ILE A 161
PRO A 162
LEU A 220
 None
 1.34A 6mkeA-1yr7A:
undetectable		 6mkeA-1yr7A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		4 ASP A 322
ILE A 327
PRO A 328
LEU A 326
 None
 1.29A 6mkeA-2an2A:
undetectable		 6mkeA-2an2A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ASP A 827
ILE A 887
PRO A 888
LEU A 859
 None
 1.32A 6mkeA-2b39A:
undetectable		 6mkeA-2b39A:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		4 ASP A 250
ILE A 146
PRO A 147
LEU A 149
 None
 1.28A 6mkeA-2cbfA:
undetectable		 6mkeA-2cbfA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flq NITRIC OXIDE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF02898
(NO_synthase) 		4 ASP A 331
ILE A 336
PRO A 337
LEU A 335
 None
 1.23A 6mkeA-2flqA:
undetectable		 6mkeA-2flqA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkd CALC

(Micromonospora
echinospora) 		no annotation 4 ASP A  47
ILE A  56
PRO A  43
LEU A  44
 None
 1.34A 6mkeA-2gkdA:
undetectable		 6mkeA-2gkdA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		4 ASP A  61
ILE A  46
PRO A  47
LEU A  62
 None
 1.39A 6mkeA-2go4A:
undetectable		 6mkeA-2go4A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 ASP A  12
ILE A   9
PRO A  77
LEU A  10
 None
 0.97A 6mkeA-2j3hA:
undetectable		 6mkeA-2j3hA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 ASP A  22
ILE A  78
PRO A  77
LEU A  10
 None
 1.28A 6mkeA-2j3hA:
undetectable		 6mkeA-2j3hA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgd UBIQUITIN-LIKE
DOMAIN-CONTAINING
CTD PHOSPHATASE 1

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ASP A  27
ILE A   5
PRO A  68
LEU A  61
 None
 1.43A 6mkeA-2lgdA:
undetectable		 6mkeA-2lgdA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os1 PEPTIDE DEFORMYLASE

(Enterococcus
faecalis) 		PF01327
(Pep_deformylase) 		4 ASP A  36
ILE A  68
PRO A  64
LEU A  66
 None
 1.20A 6mkeA-2os1A:
undetectable		 6mkeA-2os1A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ASP B 151
ILE B  36
PRO B  35
LEU B  54
 None
 1.34A 6mkeA-2po2B:
undetectable		 6mkeA-2po2B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE

(Chlorobaculum
tepidum) 		PF00800
(PDT) 		4 ASP A  45
ILE A   6
PRO A  26
LEU A   5
 None
 1.40A 6mkeA-2qmxA:
undetectable		 6mkeA-2qmxA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		4 ASP A 165
ILE A  37
PRO A  68
LEU A  66
 None
 1.36A 6mkeA-2qruA:
undetectable		 6mkeA-2qruA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Sphingomonas
elodea) 		PF00483
(NTP_transferase) 		4 ASP A 133
ILE A  40
PRO A  38
LEU A  39
 None
 1.21A 6mkeA-2ux8A:
undetectable		 6mkeA-2ux8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6e PROTELEMORASE

(Klebsiella
phage phiKO2) 		PF16684
(Telomere_res) 		4 ASP A 381
ILE A 531
PRO A 529
LEU A 372
 None
 1.39A 6mkeA-2v6eA:
undetectable		 6mkeA-2v6eA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfk AKAP18 DELTA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		4 ASP A 118
ILE A 244
PRO A 246
LEU A 248
 None
 1.27A 6mkeA-2vfkA:
undetectable		 6mkeA-2vfkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 ASP A1231
ILE A1258
PRO A1259
LEU A1262
 None
 1.44A 6mkeA-2vz9A:
undetectable		 6mkeA-2vz9A:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE

(Lactococcus
lactis) 		PF13419
(HAD_2) 		4 ASP A 170
ILE A 200
PRO A 191
LEU A 194
 MG  A1220 (-2.5A)
None
None
None
 1.21A 6mkeA-2wf7A:
undetectable		 6mkeA-2wf7A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 ASP A 706
ILE A 713
PRO A 731
LEU A 710
 X6K  A1951 (-3.4A)
None
None
None
 1.40A 6mkeA-2x6kA:
undetectable		 6mkeA-2x6kA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		4 ASP A 213
ILE A 535
PRO A 530
LEU A 533
 None
 1.29A 6mkeA-3biwA:
undetectable		 6mkeA-3biwA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ASP A 890
ILE A 579
PRO A 580
LEU A 582
 None
 1.32A 6mkeA-3cmmA:
undetectable		 6mkeA-3cmmA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ASP A 474
ILE A 478
PRO A 479
LEU A 477
 FAD  A 510 (-4.4A)
None
None
None
 1.34A 6mkeA-3cnjA:
undetectable		 6mkeA-3cnjA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 4 ASP B1053
ILE B1032
PRO B1029
LEU B1054
 None
 1.40A 6mkeA-3cqcB:
undetectable		 6mkeA-3cqcB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5b ISOCITRATE LYASE

(Brucella
abortus) 		PF00463
(ICL) 		4 ASP A 224
ILE A 194
PRO A 195
LEU A 193
 None
 1.03A 6mkeA-3e5bA:
undetectable		 6mkeA-3e5bA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ASP A 156
ILE A 503
PRO A 504
LEU A 506
 None
 1.18A 6mkeA-3ehmA:
undetectable		 6mkeA-3ehmA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR

(Shewanella
oneidensis) 		PF02661
(Fic)
PF13784
(Fic_N) 		4 ASP A 182
ILE A  30
PRO A  29
LEU A  31
 None
 1.30A 6mkeA-3eqxA:
undetectable		 6mkeA-3eqxA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Thermus
thermophilus;
Mus musculus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		4 ASP A  26
ILE A  18
PRO A 102
LEU A  25
 None
 1.30A 6mkeA-3errA:
undetectable		 6mkeA-3errA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN

(Agrobacterium
fabrum) 		PF03466
(LysR_substrate) 		4 ASP A 122
ILE A 286
PRO A 287
LEU A 184
 EDO  A 322 (-2.9A)
None
None
None
 1.23A 6mkeA-3fd3A:
undetectable		 6mkeA-3fd3A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE

(Oenococcus oeni) 		PF12697
(Abhydrolase_6) 		4 ASP A 152
ILE A 173
PRO A 174
LEU A 176
 None
 1.17A 6mkeA-3fsgA:
undetectable		 6mkeA-3fsgA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdl ROYAL PALM TREE
PEROXIDASE

(Roystonea regia) 		PF00141
(peroxidase) 		4 ASP A 107
ILE A  37
PRO A  34
LEU A  36
 None
HEM  A 305 ( 4.4A)
HEM  A 305 (-4.4A)
None
 1.45A 6mkeA-3hdlA:
undetectable		 6mkeA-3hdlA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1l HEMAGGLUTININ-ESTERA
SE PROTEIN

(Porcine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 ASP A  49
ILE A  61
PRO A  62
LEU A  59
 None
 0.85A 6mkeA-3i1lA:
undetectable		 6mkeA-3i1lA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i27 HEMAGGLUTININ-ESTERA
SE

(Bovine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 ASP A  40
ILE A  52
PRO A  53
LEU A  50
 None
 0.83A 6mkeA-3i27A:
undetectable		 6mkeA-3i27A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		PF03177
(Nucleoporin_C) 		4 ASP B1053
ILE B1032
PRO B1029
LEU B1054
 None
 1.26A 6mkeA-3i4rB:
undetectable		 6mkeA-3i4rB:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		4 ASP A 125
ILE A 150
PRO A 151
LEU A 149
 MG  A 201 (-4.0A)
None
None
None
 1.12A 6mkeA-3i6bA:
undetectable		 6mkeA-3i6bA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		4 ASP A 126
ILE A 150
PRO A 151
LEU A 149
 None
 1.16A 6mkeA-3i6bA:
undetectable		 6mkeA-3i6bA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		4 ASP A 109
ILE A 125
PRO A  29
LEU A  26
 None
 1.20A 6mkeA-3ipoA:
undetectable		 6mkeA-3ipoA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtf MAGNESIUM AND COBALT
EFFLUX PROTEIN

(Bordetella
parapertussis) 		PF00571
(CBS) 		4 ASP A 130
ILE A 125
PRO A 113
LEU A 126
 None
None
AMP  A   1 (-4.7A)
None
 1.09A 6mkeA-3jtfA:
undetectable		 6mkeA-3jtfA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		4 ASP A 130
ILE A  36
PRO A  34
LEU A  35
 None
 1.18A 6mkeA-3jujA:
undetectable		 6mkeA-3jujA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ASP F 152
ILE F   6
PRO F 156
LEU F 153
 None
 1.35A 6mkeA-3kfuF:
undetectable		 6mkeA-3kfuF:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxf FERREDOXIN

(Novosphingobium
aromaticivorans) 		PF00111
(Fer2) 		4 ASP A  30
ILE A  90
PRO A  20
LEU A  22
 None
 1.38A 6mkeA-3lxfA:
undetectable		 6mkeA-3lxfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myv SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASP A  51
ILE A 108
PRO A 105
LEU A  52
 None
 1.41A 6mkeA-3myvA:
undetectable		 6mkeA-3myvA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqr MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC

(Salmonella
enterica) 		PF00571
(CBS) 		4 ASP A 121
ILE A 116
PRO A 104
LEU A 117
 None
 1.10A 6mkeA-3nqrA:
undetectable		 6mkeA-3nqrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oi8 UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		PF00571
(CBS) 		4 ASP A 112
ILE A 107
PRO A  95
LEU A 108
 None
None
ADN  A   2 (-4.9A)
None
 1.10A 6mkeA-3oi8A:
undetectable		 6mkeA-3oi8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 217
ILE A 102
PRO A 103
LEU A 105
 None
 1.12A 6mkeA-3ov3A:
undetectable		 6mkeA-3ov3A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
gammaherpesvirus
4;
Human
gammaherpesvirus
4) 		no annotation
no annotation 		4 ASP A 206
ILE B  92
PRO A  52
LEU A  55
 None
 1.13A 6mkeA-3phfA:
undetectable		 6mkeA-3phfA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 ASP A 115
ILE A  95
PRO A  96
LEU A  98
 None
None
GOL  A 578 ( 4.4A)
None
 1.28A 6mkeA-3pquA:
undetectable		 6mkeA-3pquA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sft CHEMOTAXIS RESPONSE
REGULATOR
PROTEIN-GLUTAMATE
METHYLESTERASE

(Thermotoga
maritima) 		PF01339
(CheB_methylest) 		4 ASP A 308
ILE A 336
PRO A 337
LEU A 331
 None
 1.35A 6mkeA-3sftA:
undetectable		 6mkeA-3sftA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 ASP A  35
ILE A  75
PRO A  86
LEU A  89
 None
 1.31A 6mkeA-3tqoA:
undetectable		 6mkeA-3tqoA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		4 ASP A 149
ILE A 143
PRO A 142
LEU A 146
 None
 0.95A 6mkeA-3twkA:
undetectable		 6mkeA-3twkA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A 640
ILE A 828
PRO A 827
LEU A 610
 None
 1.35A 6mkeA-3zyvA:
undetectable		 6mkeA-3zyvA:
4.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8w GDP-L-FUCOSE
SYNTHASE

(Homo sapiens) 		PF01370
(Epimerase) 		4 ASP A 151
ILE A 169
PRO A 170
LEU A 113
 None
None
NAP  A 900 ( 4.4A)
None
 1.29A 6mkeA-4b8wA:
undetectable		 6mkeA-4b8wA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A  41
ILE A  49
PRO A  50
LEU A  44
 None
 1.21A 6mkeA-4cpdA:
undetectable		 6mkeA-4cpdA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF00004
(AAA) 		4 ASP K 148
ILE L 128
PRO K  93
LEU K  94
 None
 1.35A 6mkeA-4cr4K:
undetectable		 6mkeA-4cr4K:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3t OXIDOREDUCTASE DPRE1

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 ASP A 426
ILE A 399
PRO A 398
LEU A 340
 None
 1.44A 6mkeA-4g3tA:
undetectable		 6mkeA-4g3tA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC

(Escherichia
coli) 		PF00571
(CBS)
PF03471
(CorC_HlyC) 		4 ASP A 121
ILE A 116
PRO A 104
LEU A 117
 None
None
AMP  A 301 (-4.7A)
None
 1.06A 6mkeA-4hg0A:
undetectable		 6mkeA-4hg0A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE

([Clostridium]
scindens) 		PF00106
(adh_short) 		4 ASP A 244
ILE A 221
PRO A 218
LEU A 216
 None
 1.29A 6mkeA-4is2A:
undetectable		 6mkeA-4is2A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN

(Pasteurella
multocida) 		PF03480
(DctP) 		4 ASP A 215
ILE A  89
PRO A  90
LEU A 213
 None
 0.99A 6mkeA-4mmpA:
undetectable		 6mkeA-4mmpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME

(Saccharomyces
cerevisiae;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF11951
(Fungal_trans_2) 		4 ASP A 696
ILE A 639
PRO A 640
LEU A 642
 None
 0.77A 6mkeA-4n9nA:
undetectable		 6mkeA-4n9nA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		4 ASP A  16
ILE A 160
PRO A 159
LEU A 284
 None
 1.12A 6mkeA-4nruA:
undetectable		 6mkeA-4nruA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh8 RAS ASSOCIATION
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF16517
(Nore1-SARAH) 		4 ASP B   5
ILE B   9
PRO B  10
LEU B  12
 None
 1.14A 6mkeA-4oh8B:
undetectable		 6mkeA-4oh8B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usr MONOOXYGENASE

(Pseudomonas
stutzeri) 		PF13738
(Pyr_redox_3) 		4 ASP A 108
ILE A   4
PRO A   3
LEU A 121
 None
 1.16A 6mkeA-4usrA:
undetectable		 6mkeA-4usrA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztc AMINOTRANSFERASE
HOMOLOG

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		4 ASP A  73
ILE A  89
PRO A  88
LEU A  92
 None
 1.33A 6mkeA-4ztcA:
undetectable		 6mkeA-4ztcA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi) 		PF03702
(AnmK) 		4 ASP A 171
ILE A 356
PRO A 357
LEU A 351
 None
 0.97A 6mkeA-4zxzA:
undetectable		 6mkeA-4zxzA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 ASP A 615
ILE A 684
PRO A 685
LEU A 683
 None
 1.41A 6mkeA-5cj5A:
undetectable		 6mkeA-5cj5A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coz UNCHARACTERIZED
PROTEIN

([Eubacterium]
rectale) 		no annotation 4 ASP A 371
ILE A 302
PRO A 299
LEU A 297
 None
 1.37A 6mkeA-5cozA:
undetectable		 6mkeA-5cozA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dql ISOCITRATE LYASE 1

(Mycobacterium
tuberculosis) 		PF00463
(ICL) 		4 ASP A 230
ILE A 200
PRO A 201
LEU A 199
 None
 1.06A 6mkeA-5dqlA:
undetectable		 6mkeA-5dqlA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		4 ASP A 295
ILE A 140
PRO A 141
LEU A 242
 None
 1.15A 6mkeA-5ewqA:
undetectable		 6mkeA-5ewqA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 ASP A1109
ILE A1075
PRO A1076
LEU A1074
 None
 1.25A 6mkeA-5h64A:
undetectable		 6mkeA-5h64A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llq METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF01035
(DNA_binding_1) 		4 ASP A  50
ILE A  58
PRO A  57
LEU A  51
 None
 1.44A 6mkeA-5llqA:
undetectable		 6mkeA-5llqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltg AUTOPHAGY-RELATED
PROTEIN 18

(Ogataea angusta) 		no annotation 4 ASP A 463
ILE A 466
PRO A 467
LEU A 465
 None
 1.39A 6mkeA-5ltgA:
undetectable		 6mkeA-5ltgA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 4 ASP A 171
ILE A 168
PRO A 175
LEU A 169
 EDO  A 606 ( 4.2A)
None
None
EDO  A 606 ( 3.3A)
 1.41A 6mkeA-5nzgA:
undetectable		 6mkeA-5nzgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ASP A 611
ILE A 592
PRO A 591
LEU A 595
 None
 1.39A 6mkeA-5um6A:
undetectable		 6mkeA-5um6A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5w MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Homo sapiens) 		PF13927
(Ig_3) 		4 ASP A 130
ILE A 224
PRO A 225
LEU A 129
 None
 1.45A 6mkeA-5v5wA:
undetectable		 6mkeA-5v5wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkw ADENYLOSUCCINATE
LYASE

(Candida
albicans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ASP A 179
ILE A 129
PRO A 130
LEU A 132
 None
 1.29A 6mkeA-5vkwA:
undetectable		 6mkeA-5vkwA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqs BETA-AMYLASE

(Ipomoea batatas) 		no annotation 4 ASP A 117
ILE A 112
PRO A 109
LEU A 113
 None
 1.44A 6mkeA-5wqsA:
undetectable		 6mkeA-5wqsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Homo sapiens) 		PF13927
(Ig_3) 		4 ASP B 130
ILE B 224
PRO B 225
LEU B 129
 None
 1.33A 6mkeA-5xeqB:
undetectable		 6mkeA-5xeqB:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 4 ASP A 364
ILE A 370
PRO A 371
LEU A 369
 None
 1.41A 6mkeA-5yimA:
undetectable		 6mkeA-5yimA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ynl ARGINASE

(Glaciozyma
antarctica) 		no annotation 4 ASP A 304
ILE A 289
PRO A  35
LEU A  38
 None
 1.42A 6mkeA-5ynlA:
undetectable		 6mkeA-5ynlA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz2 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC

(Escherichia
coli) 		no annotation 4 ASP A 121
ILE A 116
PRO A 104
LEU A 117
 None
None
AMP  A 301 ( 4.6A)
None
 1.08A 6mkeA-5yz2A:
undetectable		 6mkeA-5yz2A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqy GDP-L-FUCOSE
SYNTHETASE

(Naegleria
fowleri) 		PF01370
(Epimerase) 		4 ASP A 158
ILE A 181
PRO A 182
LEU A 120
 None
 1.37A 6mkeA-6aqyA:
undetectable		 6mkeA-6aqyA:
14.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 4 ASP A  49
ILE A  99
PRO A 100
LEU A 102
 None
 1.15A 6mkeA-6b4pA:
24.7		 6mkeA-6b4pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgi ANOCTAMIN-1

(Mus musculus) 		no annotation 4 ASP A 812
ILE A 782
PRO A 783
LEU A 785
 None
 1.38A 6mkeA-6bgiA:
undetectable		 6mkeA-6bgiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 4 ASP I 327
ILE I  13
PRO I  14
LEU I 328
 None
 1.40A 6mkeA-6esqI:
undetectable		 6mkeA-6esqI:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC

(Acetobacterium
woodii) 		no annotation 4 ASP C 164
ILE C 113
PRO C  89
LEU C 120
 None
 1.36A 6mkeA-6fahC:
undetectable		 6mkeA-6fahC:
20.24