SIMILAR PATTERNS OF AMINO ACIDS FOR 6MDQ_A_TESA605

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 HIS A 107
GLY A 330
LEU A 151
GLY A 152
 None
NAP  A 802 ( 3.8A)
None
NAP  A 802 (-3.6A)
 0.81A 6mdqA-1e1kA:
undetectable		 6mdqA-1e1kA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 GLY A  11
LEU A  72
GLY A  67
LEU A  62
 None
 0.73A 6mdqA-1iovA:
0.4		 6mdqA-1iovA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 257
LEU A 168
GLY A 169
LEU A 172
 None
 0.76A 6mdqA-1j3nA:
undetectable		 6mdqA-1j3nA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 HIS A   3
GLY A 165
LEU A 173
GLU A 169
 None
 0.86A 6mdqA-1oypA:
undetectable		 6mdqA-1oypA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr0 4'-PHOSPHOPANTETHEIN
YL TRANSFERASE SFP

(Bacillus
subtilis) 		PF01648
(ACPS) 		4 GLY A  97
LEU A  46
GLY A  47
LEU A  50
 None
 0.86A 6mdqA-1qr0A:
undetectable		 6mdqA-1qr0A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 LYS A 228
GLY A 229
LEU A  70
GLY A  69
 None
 0.81A 6mdqA-1r30A:
undetectable		 6mdqA-1r30A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzn ANTHRAX TOXIN
RECEPTOR 2

(Homo sapiens) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 LYS a1150
GLY a1149
GLY a1177
GLU a1187
 None
 0.72A 6mdqA-1tzna:
1.6		 6mdqA-1tzna:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		4 LYS A 128
GLY A 127
LEU A  84
GLY A  24
 None
 0.83A 6mdqA-1u79A:
undetectable		 6mdqA-1u79A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		4 LYS A  28
LEU A 245
GLY A 246
LEU A 249
 None
 0.79A 6mdqA-1wcxA:
undetectable		 6mdqA-1wcxA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdy 2-5A-DEPENDENT
RIBONUCLEASE

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LYS A 137
LYS A 139
LEU A 108
GLU A 131
 None
None
None
25A  A1001 (-2.7A)
 0.76A 6mdqA-1wdyA:
0.5		 6mdqA-1wdyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		4 HIS A 296
GLY A 292
GLY A  51
LEU A 232
 None
 0.67A 6mdqA-2a8iA:
0.4		 6mdqA-2a8iA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		4 GLY A  54
LEU A 309
GLY A 310
LEU A 314
 None
 0.79A 6mdqA-2b81A:
undetectable		 6mdqA-2b81A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF01255
(Prenyltransf) 		4 HIS A  30
LYS A  32
GLY A  33
LEU A 206
 None
 0.61A 6mdqA-2d2rA:
undetectable		 6mdqA-2d2rA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ick ISOPENTENYL-DIPHOSPH
ATE DELTA ISOMERASE

(Homo sapiens) 		PF00293
(NUDIX) 		4 HIS A  41
LEU A  51
GLY A  49
GLU A 149
 MN  A 229 (-3.4A)
None
None
DMA  A 301 ( 2.5A)
 0.85A 6mdqA-2ickA:
undetectable		 6mdqA-2ickA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		4 HIS A 107
GLY A  77
LEU A  80
GLY A  81
 FE2  A1326 ( 3.4A)
None
None
None
 0.87A 6mdqA-2ivpA:
undetectable		 6mdqA-2ivpA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		4 LYS A 314
LEU A  80
GLY A  81
LEU A  84
 None
 0.79A 6mdqA-2ivpA:
undetectable		 6mdqA-2ivpA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcr PROBABLE ZINC
METALLOPROTEINASE,
PUTATIVE

(Brugia malayi) 		PF01549
(ShK) 		4 LYS A  23
GLY A  26
GLY A  34
LEU A  35
 None
 0.77A 6mdqA-2mcrA:
undetectable		 6mdqA-2mcrA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263

(Thermus
thermophilus) 		PF13429
(TPR_15)
PF14559
(TPR_19) 		4 LEU A 150
GLY A 149
LEU A 165
GLU A 183
 None
 0.82A 6mdqA-2pl2A:
1.8		 6mdqA-2pl2A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 GLY A 377
GLY A 361
LEU A 262
GLU A 259
 None
 0.70A 6mdqA-2qpsA:
undetectable		 6mdqA-2qpsA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qul D-TAGATOSE
3-EPIMERASE

(Pseudomonas
cichorii) 		PF01261
(AP_endonuc_2) 		4 HIS A  42
GLY A  39
LEU A  69
GLY A  68
 None
 0.84A 6mdqA-2qulA:
undetectable		 6mdqA-2qulA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		4 HIS A  65
GLY A  62
GLY A  29
GLU A 237
 None
 0.87A 6mdqA-2r98A:
undetectable		 6mdqA-2r98A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 HIS A 158
GLY A 156
LEU A 143
GLY A 144
 None
 0.63A 6mdqA-2rcbA:
undetectable		 6mdqA-2rcbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlb ELECTRON TRANSFER
PROTEIN 1,
MITOCHONDRIAL

(Schizosaccharomyces
pombe) 		PF00111
(Fer2) 		4 GLY A 558
GLY A 601
LEU A 542
GLU A 553
 FES  A 619 (-4.1A)
None
None
None
 0.84A 6mdqA-2wlbA:
undetectable		 6mdqA-2wlbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ah7 [2FE-2S]FERREDOXIN

(Pseudomonas
putida) 		PF00111
(Fer2) 		4 GLY A  43
GLY A  85
LEU A  27
GLU A  38
 FES  A 201 (-3.5A)
None
None
NA  A 202 (-3.6A)
 0.77A 6mdqA-3ah7A:
undetectable		 6mdqA-3ah7A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		4 HIS A 446
GLY A 145
GLY A 168
GLU A 165
 None
 0.87A 6mdqA-3bwsA:
undetectable		 6mdqA-3bwsA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		4 GLY A 520
LEU A  90
GLY A  91
LEU A 521
 None
 0.87A 6mdqA-3do6A:
undetectable		 6mdqA-3do6A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0o 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 GLY A  34
LEU A  70
GLY A  13
LEU A  14
 None
 0.82A 6mdqA-3g0oA:
undetectable		 6mdqA-3g0oA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 GLY A 344
LEU A  68
GLY A  69
LEU A 348
 None
 0.73A 6mdqA-3hjrA:
undetectable		 6mdqA-3hjrA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 GLY A 617
GLY A 632
LEU A 626
GLU A 644
 None
 0.88A 6mdqA-3j08A:
2.2		 6mdqA-3j08A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 GLY A 111
LEU A 675
GLY A 676
LEU A 679
 None
 0.66A 6mdqA-3jb9A:
undetectable		 6mdqA-3jb9A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7t MACROPHAGE BINDING
PROTEIN

(Coccidioides
immitis) 		PF01965
(DJ-1_PfpI) 		4 GLY A 134
LEU A 104
GLY A 103
LEU A   4
 None
 0.82A 6mdqA-3n7tA:
1.2		 6mdqA-3n7tA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3x GP41-5

(synthetic
construct) 		no annotation 4 GLY A  80
LEU A  76
GLY A  77
GLU A  72
 None
 0.88A 6mdqA-3o3xA:
undetectable		 6mdqA-3o3xA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 LYS A 181
GLY A 180
GLY A 170
GLU A 117
 None
 0.88A 6mdqA-3ojlA:
undetectable		 6mdqA-3ojlA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 LYS A 181
GLY A 180
GLY A 171
GLU A 117
 None
 0.87A 6mdqA-3ojlA:
undetectable		 6mdqA-3ojlA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovz CATHEPSIN K

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LYS A  10
GLY A  11
GLY A  43
GLU A  35
 None
 0.71A 6mdqA-3ovzA:
undetectable		 6mdqA-3ovzA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY

(Staphylococcus
aureus) 		PF00795
(CN_hydrolase) 		4 HIS A   0
GLY A  -2
LEU A 135
GLY A 138
 GOL  A 268 (-4.2A)
None
CL  A 269 (-4.1A)
None
 0.87A 6mdqA-3p8kA:
undetectable		 6mdqA-3p8kA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 LEU A  49
GLY A  50
LEU A 163
GLU A  90
 None
None
None
GOL  A 579 (-2.8A)
 0.73A 6mdqA-3pquA:
undetectable		 6mdqA-3pquA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		4 GLY A 215
LEU A 202
GLY A 203
LEU A 197
 None
 0.70A 6mdqA-3qt3A:
undetectable		 6mdqA-3qt3A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		4 HIS A 171
LYS A 173
GLY A 174
LEU A 147
 None
 0.82A 6mdqA-3ri6A:
undetectable		 6mdqA-3ri6A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to9 HISTONE
ACETYLTRANSFERASE
ESA1

(Saccharomyces
cerevisiae) 		PF01853
(MOZ_SAS) 		4 GLY A 288
LEU A 319
GLY A 317
LEU A 320
 None
None
COA  A 500 (-3.3A)
None
 0.85A 6mdqA-3to9A:
undetectable		 6mdqA-3to9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE

(Sphaerobacter
thermophilus) 		PF00583
(Acetyltransf_1) 		4 GLY A  86
LEU A  97
GLY A  98
LEU A 101
 MES  A 344 (-3.6A)
None
SO4  A 338 ( 3.3A)
MES  A 344 ( 4.7A)
 0.67A 6mdqA-3tt2A:
undetectable		 6mdqA-3tt2A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		4 GLY A 218
LEU A 253
GLY A 254
LEU A 257
 None
 0.70A 6mdqA-3w7bA:
undetectable		 6mdqA-3w7bA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 HIS A 154
GLY A 152
LEU A 102
GLY A 106
 None
 0.86A 6mdqA-3zh4A:
undetectable		 6mdqA-3zh4A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 HIS A 358
GLY A 356
LEU A 306
GLY A 307
 FAD  A3005 (-3.8A)
FAD  A3005 ( 4.8A)
None
None
 0.77A 6mdqA-3zyvA:
1.4		 6mdqA-3zyvA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k CULLIN-4A

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 GLY A 331
LEU A 295
GLY A 296
LEU A 299
 None
 0.78A 6mdqA-4a0kA:
undetectable		 6mdqA-4a0kA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 HIS A 298
GLY A 333
LEU A 305
GLY A 306
 None
 0.78A 6mdqA-4a3rA:
2.1		 6mdqA-4a3rA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a64 CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin) 		4 GLY A 467
LEU A 431
GLY A 432
LEU A 435
 None
 0.73A 6mdqA-4a64A:
undetectable		 6mdqA-4a64A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar9 COLLAGENASE COLT

(Clostridium
tetani) 		PF01752
(Peptidase_M9) 		4 HIS A 351
GLY A 348
LEU A 427
GLU A 420
 None
 0.88A 6mdqA-4ar9A:
undetectable		 6mdqA-4ar9A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 GLY D 423
LEU D 399
GLY D 400
LEU D 425
 None
 0.81A 6mdqA-4b8cD:
undetectable		 6mdqA-4b8cD:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		4 LYS A 424
GLY A 425
LEU A 389
GLY A 390
 None
 0.62A 6mdqA-4c1tA:
undetectable		 6mdqA-4c1tA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0c PHOSPHOLIPASE/CARBOX
YLESTERASE

(Dyadobacter
fermentans) 		PF02230
(Abhydrolase_2) 		4 GLY A 130
LEU A 110
GLY A 107
GLU A 113
 CIT  A 301 (-3.4A)
None
None
None
 0.81A 6mdqA-4h0cA:
undetectable		 6mdqA-4h0cA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		4 GLY A 791
LEU A 537
GLY A 538
LEU A 795
 None
 0.74A 6mdqA-4h6xA:
undetectable		 6mdqA-4h6xA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR

(Homo sapiens) 		PF00415
(RCC1) 		4 GLY C 267
LEU C 222
GLY C 223
GLU C 216
 None
 0.63A 6mdqA-4jhpC:
undetectable		 6mdqA-4jhpC:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 HIS A 160
GLY A 158
LEU A 145
GLY A 146
 None
 0.69A 6mdqA-4kcdA:
undetectable		 6mdqA-4kcdA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis) 		no annotation 4 HIS A 158
GLY A 159
LEU A  84
GLY A  83
 None
 0.82A 6mdqA-4lmhA:
undetectable		 6mdqA-4lmhA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus) 		PF00156
(Pribosyltran) 		4 HIS A 172
LEU A  68
GLY A  69
LEU A  72
 None
 0.56A 6mdqA-4m0kA:
undetectable		 6mdqA-4m0kA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 HIS A  41
GLY A  15
GLY A   8
GLU A 220
 MLI  A 502 (-4.2A)
MLI  A 502 (-3.3A)
None
None
 0.75A 6mdqA-4m9dA:
undetectable		 6mdqA-4m9dA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc0 PUTATIVE
SESQUITERPENE
CYCLASE

(Kitasatospora
setae) 		no annotation 4 GLY A 124
LEU A 111
GLY A 110
GLU A 103
 None
 0.87A 6mdqA-4mc0A:
2.5		 6mdqA-4mc0A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1

(Homo sapiens) 		PF00415
(RCC1) 		4 GLY A4107
LEU A4059
GLY A4060
GLU A4053
 None
UNX  A4409 ( 3.9A)
UNX  A4409 ( 4.5A)
None
 0.51A 6mdqA-4o2wA:
undetectable		 6mdqA-4o2wA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcb TRWC

(Escherichia
coli) 		PF08751
(TrwC) 		4 HIS A 163
LEU A  84
GLY A  83
LEU A   7
 PO4  A 301 (-3.7A)
None
None
None
 0.79A 6mdqA-4pcbA:
undetectable		 6mdqA-4pcbA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 HIS A  18
GLY A  21
GLY A 136
LEU A 139
 None
 0.38A 6mdqA-4po0A:
49.9		 6mdqA-4po0A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 LYS A 132
GLY A 136
GLY A  21
LEU A  24
 None
 0.76A 6mdqA-4po0A:
49.9		 6mdqA-4po0A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 LYS A 212
LEU A 327
GLY A 328
LEU A 331
 None
NPS  A 602 ( 4.7A)
NPS  A 602 (-3.8A)
None
 0.65A 6mdqA-4po0A:
49.9		 6mdqA-4po0A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqu ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A  35
GLY A  97
LEU A 116
GLU A 101
 None
 0.70A 6mdqA-4rquA:
undetectable		 6mdqA-4rquA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 LYS A 245
GLY A 250
LEU A 251
GLU A 176
 None
 0.72A 6mdqA-4wy5A:
undetectable		 6mdqA-4wy5A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 HIS A  69
LEU A  14
GLY A  15
LEU A  18
 None
 0.72A 6mdqA-4zfhA:
undetectable		 6mdqA-4zfhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LYS A 480
LYS A 482
GLY A 483
GLY A 544
 None
 0.75A 6mdqA-4zlgA:
undetectable		 6mdqA-4zlgA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 GLY B 191
LEU B 188
GLY B 187
LEU B 185
 None
 0.88A 6mdqA-5a8rB:
undetectable		 6mdqA-5a8rB:
10.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		7 HIS A  18
LYS A  20
GLY A  21
LEU A 134
GLY A 135
LEU A 138
GLU A 158
 None
None
LCR  A 612 ( 4.0A)
LCR  A 612 ( 4.5A)
LCR  A 612 ( 3.8A)
None
None
 0.35A 6mdqA-5dqfA:
55.4		 6mdqA-5dqfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		4 LYS A 217
GLY A 218
GLY A 185
LEU A 188
 None
 0.86A 6mdqA-5e9jA:
undetectable		 6mdqA-5e9jA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		4 GLY B 609
LEU B 625
GLY B 626
LEU B 527
 None
 0.76A 6mdqA-5ej1B:
undetectable		 6mdqA-5ej1B:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 GLY C 112
LEU C 154
GLY C 151
LEU C 150
 None
 0.85A 6mdqA-5flzC:
undetectable		 6mdqA-5flzC:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		4 GLY I   5
LEU I 100
GLY I 101
LEU I 110
 None
 0.86A 6mdqA-5fmgI:
undetectable		 6mdqA-5fmgI:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 HIS A  18
GLY A  21
LEU A 135
GLY A 136
LEU A 139
 None
 0.27A 6mdqA-5ghkA:
47.4		 6mdqA-5ghkA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj3 PERIPLASMIC BINDING
PROTEIN

(Roseiflexus sp.
RS-1) 		PF01497
(Peripla_BP_2) 		4 GLY A 242
LEU A 299
GLY A 298
LEU A 240
 None
 0.86A 6mdqA-5gj3A:
undetectable		 6mdqA-5gj3A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 LYS A 175
GLY A 176
LEU A 198
GLY A 197
 None
 0.55A 6mdqA-5gjaA:
undetectable		 6mdqA-5gjaA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw9 GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Homo sapiens) 		PF16647
(GCSF) 		4 GLY A  52
GLY A 150
LEU A 153
GLU A  47
 None
 0.84A 6mdqA-5gw9A:
undetectable		 6mdqA-5gw9A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		4 GLY A 279
LEU A 234
GLY A 235
GLU A 228
 None
 0.55A 6mdqA-5gwnA:
undetectable		 6mdqA-5gwnA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf2 PREDICTED
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00583
(Acetyltransf_1) 		4 GLY A 254
LEU A 264
GLY A 265
LEU A 268
 COA  A 401 (-3.3A)
None
COA  A 401 (-3.4A)
None
 0.85A 6mdqA-5kf2A:
undetectable		 6mdqA-5kf2A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 GLY A 111
LEU A  84
GLY A  83
LEU A 116
 None
 0.70A 6mdqA-5ktkA:
undetectable		 6mdqA-5ktkA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 LEU B  94
GLY B  93
LEU B 168
GLU B 101
 None
 0.78A 6mdqA-5l9wB:
undetectable		 6mdqA-5l9wB:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 GLY A1303
LEU A1376
GLY A1308
LEU A1307
 None
 0.83A 6mdqA-5lcwA:
undetectable		 6mdqA-5lcwA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 HIS A  69
LEU A  14
GLY A  15
LEU A  18
 None
 0.74A 6mdqA-5le9A:
undetectable		 6mdqA-5le9A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT

(Xanthobacter
autotrophicus) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 LEU B  96
GLY B  95
LEU B 170
GLU B 103
 None
 0.78A 6mdqA-5m45B:
undetectable		 6mdqA-5m45B:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A2056
GLY A2057
LEU A2058
GLU A2021
 None
 0.87A 6mdqA-5m59A:
2.8		 6mdqA-5m59A:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6b ATP-DEPENDENT DNA
HELICASE PIF1

(Saccharomyces
cerevisiae) 		no annotation 4 LYS A 725
GLY A 726
LEU A 433
GLY A 434
 None
 0.60A 6mdqA-5o6bA:
undetectable		 6mdqA-5o6bA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twb FERREDOXIN--NADP
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		4 HIS A 186
GLY A 185
GLY A 156
LEU A 161
 None
 0.88A 6mdqA-5twbA:
undetectable		 6mdqA-5twbA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 GLY A 309
GLY A  63
LEU A 311
GLU A 132
 None
 0.86A 6mdqA-5uhkA:
undetectable		 6mdqA-5uhkA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN

(Zea mays) 		PF07714
(Pkinase_Tyr) 		4 GLY A 822
LEU A 809
GLY A 810
LEU A 820
 None
 0.84A 6mdqA-5uv4A:
undetectable		 6mdqA-5uv4A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz7 CALCITONIN RECEPTOR

(Homo sapiens) 		PF00002
(7tm_2) 		4 HIS R 245
GLY R 241
GLY R 353
LEU R 352
 None
 0.83A 6mdqA-5uz7R:
undetectable		 6mdqA-5uz7R:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 GLY A 112
GLY A 149
LEU A 150
GLU A 157
 None
 0.80A 6mdqA-5w3fA:
undetectable		 6mdqA-5w3fA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8q BIS3 BIPHENYL
SYNTHASE

(Malus domestica) 		no annotation 4 LYS A 177
GLY A 178
GLY A 220
GLU A 224
 None
 0.86A 6mdqA-5w8qA:
undetectable		 6mdqA-5w8qA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 LYS B 276
GLY B 273
GLY B 251
LEU B 252
 None
 0.84A 6mdqA-5wwpB:
undetectable		 6mdqA-5wwpB:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 4 GLY A 222
GLY A 201
LEU A 223
GLU A 195
 None
 0.88A 6mdqA-5x3hA:
undetectable		 6mdqA-5x3hA:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 GLY A  21
LEU A 135
GLY A 136
LEU A 139
 None
 0.29A 6mdqA-5yxeA:
45.7		 6mdqA-5yxeA:
83.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji 16KDA MEMBRANE
PROTEIN

(Zea mays) 		no annotation 4 HIS O 103
LEU O  53
GLY O  52
LEU O 110
 CLA  O2001 (-3.3A)
None
CLA  O2002 ( 4.1A)
None
 0.85A 6mdqA-5zjiO:
undetectable		 6mdqA-5zjiO:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 4 GLY A 129
LEU A 139
GLY A 140
LEU A 143
 None
 0.82A 6mdqA-6brmA:
undetectable		 6mdqA-6brmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 4 HIS C 361
GLY C 502
LEU C 354
GLY C 352
 None
 0.80A 6mdqA-6c08C:
2.7		 6mdqA-6c08C:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emg G0S4M2

(Chaetomium
thermophilum) 		no annotation 4 LYS A 125
GLY A 209
LEU A 210
GLU A 217
 None
 0.84A 6mdqA-6emgA:
undetectable		 6mdqA-6emgA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 LYS a 163
GLY a 162
GLY a 152
GLU a 244
 None
 0.85A 6mdqA-6fkha:
undetectable		 6mdqA-6fkha:
23.26