SIMILAR PATTERNS OF AMINO ACIDS FOR 6MDQ_A_TESA604

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a05 3-ISOPROPYLMALATE
DEHYDROGENASE

(Acidithiobacillus
ferrooxidans) 		PF00180
(Iso_dh) 		4 ALA A 281
GLY A  13
ALA A 290
LYS A 289
 None
 0.82A 6mdqA-1a05A:
undetectable		 6mdqA-1a05A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE

(Thermococcus
profundus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ALA A 241
GLY A 254
LEU A 255
ALA A 276
 None
 0.76A 6mdqA-1euzA:
undetectable		 6mdqA-1euzA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iw8 ACID PHOSPHATASE

(Shimwellia
blattae) 		PF01569
(PAP2) 		4 ALA A 196
LEU A  31
ALA A 114
LYS A 115
 None
None
None
SO4  A1001 (-2.5A)
 0.83A 6mdqA-1iw8A:
2.0		 6mdqA-1iw8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		4 ALA A  37
GLY A   7
ALA A  61
GLU A  59
 None
 0.70A 6mdqA-1jaxA:
undetectable		 6mdqA-1jaxA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ALA A 147
GLY A 231
LEU A 230
ALA A  58
 None
 0.77A 6mdqA-1jswA:
undetectable		 6mdqA-1jswA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 ALA A 518
GLY A 513
LEU A 514
ALA A 510
 None
 0.71A 6mdqA-1l5jA:
2.4		 6mdqA-1l5jA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 ALA A 343
GLY A 364
LEU A 365
ALA A 458
 None
 0.54A 6mdqA-1lnsA:
1.3		 6mdqA-1lnsA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6z CYTOCHROME C4

(Pseudomonas
stutzeri) 		PF00034
(Cytochrom_C) 		4 GLY A 188
ALA A 100
LYS A 101
GLU A 104
 None
 0.52A 6mdqA-1m6zA:
undetectable		 6mdqA-1m6zA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		4 ALA A 248
GLY A 215
LEU A 218
ALA A   5
 None
 0.72A 6mdqA-1nrwA:
2.0		 6mdqA-1nrwA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqw FIMBRIAL PROTEIN

(Pseudomonas
aeruginosa) 		PF00114
(Pilin)
PF07963
(N_methyl) 		5 LYS A 112
ALA A 107
GLY A  83
LEU A  82
ALA A  36
 None
 1.46A 6mdqA-1oqwA:
undetectable		 6mdqA-1oqwA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ALA A 104
GLY A  99
LEU A 100
ALA A 201
 None
 0.69A 6mdqA-1pw4A:
undetectable		 6mdqA-1pw4A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ARG A 149
GLY A 100
LEU A  99
ALA A  55
 None
 0.80A 6mdqA-1si8A:
undetectable		 6mdqA-1si8A:
11.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 LYS A 212
ALA A 213
GLY A 328
LEU A 331
ALA A 350
GLU A 354
 None
DKA  A1001 ( 4.0A)
DKA  A1001 ( 4.1A)
None
DKA  A1002 ( 3.8A)
DKA  A1002 ( 4.4A)
 0.50A 6mdqA-1tf0A:
46.5		 6mdqA-1tf0A:
87.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		4 ALA A 291
GLY A 278
LEU A 277
ALA A 255
 None
 0.65A 6mdqA-1v19A:
undetectable		 6mdqA-1v19A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		4 ALA A 282
GLY A  14
ALA A 291
LYS A 290
 None
 0.76A 6mdqA-1v5bA:
undetectable		 6mdqA-1v5bA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		5 LYS A  92
ALA A  93
LEU A  97
ALA A  70
GLU A  69
 None
 1.30A 6mdqA-1vpxA:
undetectable		 6mdqA-1vpxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 LYS A  14
ALA A  15
LEU A 465
ALA A 315
 None
 0.82A 6mdqA-1xrsA:
undetectable		 6mdqA-1xrsA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON

(Salmonella
enterica) 		PF01569
(PAP2) 		4 ALA A 204
LEU A  39
ALA A 122
LYS A 123
 None
None
None
WO4  A 501 (-2.7A)
 0.82A 6mdqA-2akcA:
undetectable		 6mdqA-2akcA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2

(Arabidopsis
thaliana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 146
GLY A 141
LEU A 142
ALA A 432
 None
 0.70A 6mdqA-2c7zA:
undetectable		 6mdqA-2c7zA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxs RAS-RELATED PROTEIN
RAB-28

(Homo sapiens) 		PF00071
(Ras) 		4 ALA A 125
GLY A  88
LEU A 123
LYS A 172
 None
 0.83A 6mdqA-2hxsA:
undetectable		 6mdqA-2hxsA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7n TALIN-1

(Mus musculus) 		no annotation 4 ALA A1121
LEU A1105
ALA A1169
LYS A1170
 None
 0.72A 6mdqA-2l7nA:
2.6		 6mdqA-2l7nA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ALA B 555
GLY B 557
LEU B 679
LYS B 676
 None
 0.81A 6mdqA-2o8eB:
undetectable		 6mdqA-2o8eB:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 ARG A  51
GLY A  93
LEU A  92
ALA A  98
 None
 0.80A 6mdqA-2qfqA:
undetectable		 6mdqA-2qfqA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 GLY A 327
LEU A 326
ALA A 558
GLU A 557
 None
 0.73A 6mdqA-2xy9A:
undetectable		 6mdqA-2xy9A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcx TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 ALA A  96
GLY A 158
LEU A 157
ALA A 221
 None
 0.78A 6mdqA-2zcxA:
4.2		 6mdqA-2zcxA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab1 FERREDOXIN--NADP
REDUCTASE

(Chlorobaculum
tepidum) 		PF07992
(Pyr_redox_2) 		4 ALA A 279
GLY A 128
ALA A 295
GLU A 315
 None
FAD  A 361 (-3.2A)
None
None
 0.81A 6mdqA-3ab1A:
undetectable		 6mdqA-3ab1A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		4 ARG B 121
ALA B 125
ALA B  78
GLU B 396
 None
 0.71A 6mdqA-3adaB:
undetectable		 6mdqA-3adaB:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at7 ALGINATE-BINDING
FLAGELLIN

(Sphingomonas
sp. A1) 		PF09375
(Peptidase_M75) 		4 LYS A 128
ALA A 127
LEU A 121
ALA A  67
 None
 0.82A 6mdqA-3at7A:
undetectable		 6mdqA-3at7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00616
(RasGAP) 		4 GLY A1188
LEU A1191
ALA A1164
LYS A1165
 None
 0.61A 6mdqA-3fayA:
undetectable		 6mdqA-3fayA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbl PUTATIVE
UNCHARACTERIZED
PROTEIN

(Acidianus
filamentous
virus 1) 		no annotation 4 ALA A 125
GLY A  79
LEU A  82
ALA A 106
 None
 0.62A 6mdqA-3fblA:
3.7		 6mdqA-3fblA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 LYS A 205
ALA A 204
GLY A 211
LEU A 212
ALA A 190
 None
 1.36A 6mdqA-3gdeA:
undetectable		 6mdqA-3gdeA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 383
LEU A 382
ALA A 334
GLU A 339
 None
 0.65A 6mdqA-3kdnA:
undetectable		 6mdqA-3kdnA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		4 ALA A 252
GLY A  70
LEU A  69
ALA A 243
 None
 0.78A 6mdqA-3kn1A:
undetectable		 6mdqA-3kn1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ALA A 142
GLY A 147
ALA A 205
GLU A 204
 None
 0.83A 6mdqA-3lewA:
undetectable		 6mdqA-3lewA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpo PREDICTED HYDROLASE
OF THE HAD
SUPERFAMILY

(Lactobacillus
brevis) 		PF08282
(Hydrolase_3) 		4 ALA A 230
GLY A 197
LEU A 200
ALA A   7
 None
 0.81A 6mdqA-3mpoA:
undetectable		 6mdqA-3mpoA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oid ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH]

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		4 LEU A 172
ALA A 125
LYS A 126
GLU A 129
 None
 0.59A 6mdqA-3oidA:
undetectable		 6mdqA-3oidA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Klebsiella
pneumoniae) 		PF08282
(Hydrolase_3) 		4 ALA A 225
GLY A 192
LEU A 195
ALA A   6
 None
 0.82A 6mdqA-3pgvA:
undetectable		 6mdqA-3pgvA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnx PUTATIVE
SULFURTRANSFERASE
DSRE

(Syntrophomonas
wolfei) 		PF13686
(DrsE_2) 		4 LYS A  17
ALA A  18
GLY A  43
LEU A  46
 None
 0.78A 6mdqA-3pnxA:
undetectable		 6mdqA-3pnxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR

(Shewanella
loihica) 		PF00440
(TetR_N) 		4 ALA A 123
GLY A 129
LEU A 128
ALA A  68
 None
None
PG4  A 216 (-4.6A)
None
 0.83A 6mdqA-3ppbA:
3.7		 6mdqA-3ppbA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 LYS A  20
GLY A  27
LEU A  26
ALA A 117
 None
 0.75A 6mdqA-3qanA:
2.2		 6mdqA-3qanA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		4 ALA A 259
LEU A 255
ALA A 246
GLU A 247
 None
 0.78A 6mdqA-3qt3A:
undetectable		 6mdqA-3qt3A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ALA A 214
GLY A 221
LEU A 222
ALA A 200
 None
 0.81A 6mdqA-3rr5A:
undetectable		 6mdqA-3rr5A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ALA A1089
GLY A1084
LEU A1085
ALA A1153
 None
 0.73A 6mdqA-3s5kA:
undetectable		 6mdqA-3s5kA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN

(Ralstonia
solanacearum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 ALA A 106
GLY A 101
LEU A 102
ALA A 165
 None
 0.74A 6mdqA-3totA:
2.3		 6mdqA-3totA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 ALA A 593
GLY A 693
LEU A 676
ALA A 678
 None
 0.81A 6mdqA-3ut2A:
undetectable		 6mdqA-3ut2A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9r UNCHARACTERIZED
PROTEIN YOL086W-A

(Saccharomyces
cerevisiae) 		PF15630
(CENP-S) 		4 ARG A   7
GLY A  50
LEU A  49
GLU A  43
 None
 0.82A 6mdqA-3v9rA:
undetectable		 6mdqA-3v9rA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		4 ARG A 185
GLY A 774
LEU A 188
ALA A 266
 None
 0.76A 6mdqA-3w9iA:
2.8		 6mdqA-3w9iA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdo MFS TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ALA A 291
GLY A 286
LEU A 287
ALA A 315
 None
 0.70A 6mdqA-3wdoA:
1.8		 6mdqA-3wdoA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiw GLYCOSYL HYDROLASE
FAMILY 88

(Pedobacter
heparinus) 		PF07470
(Glyco_hydro_88) 		4 ALA A 271
GLY A 251
LEU A 252
ALA A 315
 None
 0.49A 6mdqA-3wiwA:
1.6		 6mdqA-3wiwA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo0 ALANINE-ANTICAPSIN
LIGASE BACD

(Bacillus
subtilis) 		PF13535
(ATP-grasp_4) 		4 ALA A 135
GLY A 302
LEU A 303
ALA A 127
 None
 0.79A 6mdqA-3wo0A:
undetectable		 6mdqA-3wo0A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		4 ALA A1997
GLY A1992
LEU A1993
ALA A2047
 None
 0.71A 6mdqA-4c0eA:
undetectable		 6mdqA-4c0eA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ALA A1168
GLY A1134
LEU A1133
GLU A1092
 None
 0.78A 6mdqA-4c3hA:
2.7		 6mdqA-4c3hA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		4 ALA A 254
GLY A 207
LEU A 208
ALA A 242
 None
 0.82A 6mdqA-4cp8A:
undetectable		 6mdqA-4cp8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		4 ALA A 289
GLY A 151
ALA A 178
GLU A 176
 None
 0.74A 6mdqA-4dwqA:
undetectable		 6mdqA-4dwqA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eah FORMIN-LIKE PROTEIN
3

(Mus musculus) 		PF02181
(FH2) 		4 ALA A 752
ALA A 836
LYS A 835
GLU A 834
 None
 0.74A 6mdqA-4eahA:
2.2		 6mdqA-4eahA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ALA A 215
GLY A 222
LEU A 223
ALA A 201
 None
 0.74A 6mdqA-4eq5A:
undetectable		 6mdqA-4eq5A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00701
(DHDPS) 		4 GLY A 204
LEU A 203
ALA A 177
GLU A 181
 None
 0.81A 6mdqA-4fhaA:
undetectable		 6mdqA-4fhaA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00202
(Aminotran_3) 		4 ALA A  61
GLY A 290
ALA A 336
LYS A 335
 None
LLP  A 285 ( 4.4A)
None
None
 0.76A 6mdqA-4grxA:
undetectable		 6mdqA-4grxA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		4 GLY A  80
LEU A  79
ALA A  53
LYS A  54
 None
 0.62A 6mdqA-4h27A:
undetectable		 6mdqA-4h27A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00361
(Proton_antipo_M) 		4 ARG M 143
GLY N 377
LEU N 376
ALA N 372
 None
 0.79A 6mdqA-4heaM:
undetectable		 6mdqA-4heaM:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A 304
LEU A 117
ALA A 110
LYS A 109
 None
 0.79A 6mdqA-4koaA:
undetectable		 6mdqA-4koaA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 ALA A 111
LEU A  49
ALA A  96
GLU A  98
 None
 0.64A 6mdqA-4l4qA:
undetectable		 6mdqA-4l4qA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk3 GLUTATHIONE
S-TRANSFERASE

(Cupriavidus
metallidurans) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 ALA A 104
GLY A  99
LEU A 100
ALA A 163
 None
 0.70A 6mdqA-4mk3A:
2.8		 6mdqA-4mk3A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Anaerococcus
prevotii) 		PF03480
(DctP) 		4 ALA A 306
GLY A 190
LEU A 189
GLU A 167
 None
 0.82A 6mdqA-4n91A:
undetectable		 6mdqA-4n91A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzk UNCHARACTERIZED
PROTEIN

([Eubacterium]
siraeum) 		PF14286
(DHHW) 		4 LYS A 206
ALA A 205
GLY A 200
ALA A 324
 None
 0.82A 6mdqA-4nzkA:
undetectable		 6mdqA-4nzkA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc8 RESTRICTION
ENDONUCLEASE ASPBHI

(Azoarcus sp.
BH72) 		PF04471
(Mrr_cat) 		4 ARG A 217
ALA A 215
GLY A  78
LEU A 213
 None
 0.79A 6mdqA-4oc8A:
undetectable		 6mdqA-4oc8A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 LYS A 212
ALA A 213
GLY A 328
GLU A 354
 None
NPS  A 602 (-3.3A)
NPS  A 602 (-3.8A)
NPS  A 602 ( 4.9A)
 0.57A 6mdqA-4po0A:
49.9		 6mdqA-4po0A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 LYS A 212
ALA A 213
GLY A 328
LEU A 331
LYS A 351
 None
NPS  A 602 (-3.3A)
NPS  A 602 (-3.8A)
None
None
 0.76A 6mdqA-4po0A:
49.9		 6mdqA-4po0A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		4 GLY C 163
LEU C 162
ALA C 170
GLU C 168
 None
 0.82A 6mdqA-4xl5C:
undetectable		 6mdqA-4xl5C:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yla AROMATIC
PRENYLTRANSFERASE

(Marinactinospora
thermotolerans) 		PF11991
(Trp_DMAT) 		4 ALA A 329
GLY A  47
LEU A  46
ALA A 100
 None
 0.73A 6mdqA-4ylaA:
undetectable		 6mdqA-4ylaA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 4 ALA D 255
GLY D 158
LEU D 159
ALA D 163
 None
 0.72A 6mdqA-4zhsD:
undetectable		 6mdqA-4zhsD:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		4 GLY A  39
LEU A  38
ALA A  46
GLU A  44
 None
 0.70A 6mdqA-4zv6A:
undetectable		 6mdqA-4zv6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		4 GLY A 194
LEU A 193
ALA A 201
GLU A 199
 None
 0.80A 6mdqA-4zv6A:
undetectable		 6mdqA-4zv6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A  89
GLY A  26
LEU A  29
ALA A  69
 None
 0.78A 6mdqA-4zyjA:
2.6		 6mdqA-4zyjA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a60 INORGANIC
TRIPHOSPHATASE

(Escherichia
coli) 		PF01928
(CYTH) 		4 ALA A 264
GLY A 259
LEU A 260
ALA A 232
 None
 0.76A 6mdqA-5a60A:
3.2		 6mdqA-5a60A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b13 PHYCOERYTHRIN BETA
SUBUNIT

(Palmaria
palmata) 		PF00502
(Phycobilisome) 		4 ALA G  93
GLY G 166
LEU G 165
ALA G 138
 None
 0.69A 6mdqA-5b13G:
2.2		 6mdqA-5b13G:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bop NANOBODY
OCTARELLIN V.1

(Lama glama;
synthetic
construct) 		PF07686
(V-set)
no annotation 		4 GLY A 103
LEU A 102
ALA B  42
LYS B  41
 None
 0.81A 6mdqA-5bopA:
undetectable		 6mdqA-5bopA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		4 GLY A 361
LEU A 364
ALA A 376
LYS A 377
 None
 0.83A 6mdqA-5bptA:
undetectable		 6mdqA-5bptA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcq ARTIFICIAL REPEAT
PROTEINS (ALPHAREP3)

(synthetic
construct) 		PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		4 GLY A  69
LEU A  68
ALA A  76
GLU A  74
 None
 0.77A 6mdqA-5dcqA:
undetectable		 6mdqA-5dcqA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 LEU A 330
ALA A 349
LYS A 350
GLU A 353
 CZE  A 613 ( 4.2A)
CZE  A 613 ( 4.7A)
CZE  A 613 (-4.1A)
CZE  A 613 (-2.9A)
 0.69A 6mdqA-5dqfA:
55.4		 6mdqA-5dqfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 LYS A  20
GLY A 135
LEU A 138
ALA A 157
 None
LCR  A 612 ( 3.8A)
None
LCR  A 612 ( 3.8A)
 0.62A 6mdqA-5dqfA:
55.4		 6mdqA-5dqfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 LYS A 211
ALA A 212
GLY A 327
LEU A 330
ALA A 349
GLU A 353
 None
CZE  A 613 ( 3.7A)
CZE  A 613 (-3.5A)
CZE  A 613 ( 4.2A)
CZE  A 613 ( 4.7A)
CZE  A 613 (-2.9A)
 0.47A 6mdqA-5dqfA:
55.4		 6mdqA-5dqfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		4 ARG A  41
GLY A  36
LEU A  35
ALA A  31
 None
 0.76A 6mdqA-5dz6A:
undetectable		 6mdqA-5dz6A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		4 ALA A 276
GLY A 271
LEU A 272
ALA A 410
 None
None
HEM  A 501 ( 4.2A)
None
 0.77A 6mdqA-5e78A:
undetectable		 6mdqA-5e78A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 ALA A 213
GLY A 328
LEU A 331
ALA A 350
LYS A 351
GLU A 354
 None
 0.49A 6mdqA-5ghkA:
47.4		 6mdqA-5ghkA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 ARG A 261
ALA A 260
GLY A 255
ALA A 337
 None
 0.79A 6mdqA-5gj8A:
undetectable		 6mdqA-5gj8A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl6 RIBOSOME MATURATION
FACTOR RIMP

(Mycolicibacterium
smegmatis) 		PF02576
(DUF150)
PF17384
(DUF150_C) 		4 ALA A  52
GLY A  57
LEU A  58
ALA A  62
 None
 0.79A 6mdqA-5gl6A:
undetectable		 6mdqA-5gl6A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 LYS g 127
ALA g 128
LEU g 427
ALA g 446
 None
 0.76A 6mdqA-5gw4g:
undetectable		 6mdqA-5gw4g:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		4 ARG A 396
GLY A 480
LEU A 479
ALA A 425
 None
 0.77A 6mdqA-5k5mA:
2.4		 6mdqA-5k5mA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls2 LYSM TYPE RECEPTOR
KINASE

(Lotus japonicus) 		no annotation 4 ALA A  35
GLY A 164
LEU A 165
ALA A 211
 None
 0.76A 6mdqA-5ls2A:
undetectable		 6mdqA-5ls2A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi PLASTID RIBOSOMAL
PROTEIN UL5C

(Spinacia
oleracea) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		4 GLY F 139
LEU F 138
ALA F 123
LYS F 124
 U  A2329 ( 4.2A)
U  A2329 ( 4.4A)
U  A2329 ( 3.9A)
G  A2315 ( 3.2A)
 0.75A 6mdqA-5mmiF:
undetectable		 6mdqA-5mmiF:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 LYS A 445
GLY A 502
LEU A 503
ALA A 507
 None
 0.70A 6mdqA-5oasA:
undetectable		 6mdqA-5oasA:
8.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 ALA A 212
GLY A 327
LEU A 330
ALA A 349
GLU A 353
 None
 0.40A 6mdqA-5oriA:
50.6		 6mdqA-5oriA:
81.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 5 GLY A 487
LEU A 490
ALA A 521
LYS A 520
GLU A 517
 None
 1.22A 6mdqA-5ot1A:
undetectable		 6mdqA-5ot1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 ALA A 628
LEU A 529
ALA A 558
GLU A 554
 None
 0.69A 6mdqA-5ux5A:
undetectable		 6mdqA-5ux5A:
5.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 LYS A 212
ALA A 213
GLY A 328
LEU A 331
ALA A 350
GLU A 354
 None
 0.39A 6mdqA-5yxeA:
45.7		 6mdqA-5yxeA:
83.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 4 GLY A  61
LEU A  47
ALA A  58
GLU A  72
 None
 0.80A 6mdqA-5yy8A:
undetectable		 6mdqA-5yy8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 4 ALA A 175
GLY A 130
LEU A 131
ALA A 136
 None
 0.83A 6mdqA-6cn1A:
undetectable		 6mdqA-6cn1A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elc VARIANT SURFACE
GLYCOPROTEIN

(Trypanosoma
brucei) 		no annotation 4 ARG A 143
ALA A 142
LEU A 138
ALA A 134
 NAG  A 601 (-4.5A)
None
None
None
 0.66A 6mdqA-6elcA:
1.9		 6mdqA-6elcA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewi CENTROSOMAL PROTEIN
120

(Oreochromis
niloticus) 		no annotation 4 GLY A 228
LEU A 227
ALA A 170
LYS A 168
 None
 0.81A 6mdqA-6ewiA:
undetectable		 6mdqA-6ewiA:
25.00