SIMILAR PATTERNS OF AMINO ACIDS FOR 6MB9_D_NMYD302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 ASP A 318
THR A 232
GLY A 240
ASP A 242
GLU A 238
 GLU  A 701 (-3.0A)
None
None
None
None
 1.41A 6mb9D-1ewkA:
0.0		 6mb9D-1ewkA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 ASP A 189
THR A  39
HIS A  70
GLY A  35
GLU A  34
 None
 1.19A 6mb9D-1h3eA:
undetectable		 6mb9D-1h3eA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 TYR A 404
ASP A 547
THR A 504
HIS A 501
THR A 538
 None
 1.47A 6mb9D-1i2dA:
0.3		 6mb9D-1i2dA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pkr PLASMINOGEN

(Homo sapiens) 		PF00051
(Kringle) 		5 TYR A   9
ASP A  73
THR A  16
GLY A  60
ASP A  57
 None
 1.45A 6mb9D-1pkrA:
undetectable		 6mb9D-1pkrA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM

(Canis lupus) 		PF01216
(Calsequestrin) 		5 ASP A  90
TYR A  96
ASP A  76
GLY A  93
GLU A  39
 None
 1.29A 6mb9D-1sjiA:
0.0		 6mb9D-1sjiA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ASP B 341
TYR B  21
ASP B 188
THR B 330
GLY B 331
 None
 1.01A 6mb9D-1tqyB:
0.4		 6mb9D-1tqyB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 ASP A 622
ASP A 574
THR A 572
THR A 428
GLY A 427
 None
 1.35A 6mb9D-2b8eA:
undetectable		 6mb9D-2b8eA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.46A 6mb9D-2cgjA:
0.0		 6mb9D-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2doi ANGIOSTATIN

(Homo sapiens) 		no annotation 5 TYR X  92
ASP X 155
THR X  99
GLY X 142
ASP X 139
 None
 1.50A 6mb9D-2doiX:
undetectable		 6mb9D-2doiX:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2feb APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		5 ASP A  17
THR A   9
HIS A   5
GLY A  36
ASP A  82
 None
 1.42A 6mb9D-2febA:
undetectable		 6mb9D-2febA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		5 TYR A 295
ASP A 316
THR A 322
GLY A  87
GLU A 317
 None
 1.23A 6mb9D-2glfA:
0.0		 6mb9D-2glfA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jay PROTEASOME

(Mycobacterium
tuberculosis) 		PF00227
(Proteasome) 		5 TYR A 211
ASP A 216
THR A 215
GLY A  68
ASP A 255
 None
 1.44A 6mb9D-2jayA:
0.0		 6mb9D-2jayA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgo FKBP

(Giardia
intestinalis) 		PF00254
(FKBP_C) 		5 TYR A 106
THR A  99
GLY A  52
ASP A  51
GLU A 124
 None
 1.07A 6mb9D-2lgoA:
undetectable		 6mb9D-2lgoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ls5 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF08534
(Redoxin) 		5 ASP A  15
TYR A 108
GLY A 125
ASP A 122
GLU A 124
 None
 1.44A 6mb9D-2ls5A:
undetectable		 6mb9D-2ls5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 THR A 277
THR A  74
GLY A  73
ASP A  72
GLU A  71
 None
 1.47A 6mb9D-2p2mA:
undetectable		 6mb9D-2p2mA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 ASP I 622
ASP I 574
THR I 572
THR I 428
GLY I 427
 None
 1.35A 6mb9D-2voyI:
1.7		 6mb9D-2voyI:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF06920
(DHR-2) 		5 TYR A1438
TYR A1242
THR A1238
GLY A1291
GLU A1367
 None
 1.27A 6mb9D-3b13A:
undetectable		 6mb9D-3b13A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5o UPF0311 PROTEIN
RPA1785

(Rhodopseudomonas
palustris) 		PF11578
(DUF3237) 		5 TYR A 126
THR A  12
THR A  76
GLY A  48
GLU A  40
 None
 1.16A 6mb9D-3c5oA:
undetectable		 6mb9D-3c5oA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc7 PUTATIVE
UNCHARACTERIZED
PROTEIN LP_3323

(Lactobacillus
plantarum) 		PF13472
(Lipase_GDSL_2) 		5 TYR A  42
ASP A  56
HIS A  43
THR A  32
GLY A  59
 None
 1.49A 6mb9D-3dc7A:
undetectable		 6mb9D-3dc7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I

(Cytophaga
hutchinsonii) 		PF00425
(Chorismate_bind) 		5 TYR A 368
ASP A 370
THR A 236
GLY A 237
ASP A 238
 None
 1.17A 6mb9D-3h9mA:
undetectable		 6mb9D-3h9mA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		5 ASP A 241
THR A 215
GLY A 216
ASP A 161
GLU A 220
 PHE  A 400 (-2.7A)
None
None
None
None
 1.32A 6mb9D-3td9A:
undetectable		 6mb9D-3td9A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		5 TYR A 213
THR A 215
GLY A 216
ASP A 161
GLU A 220
 None
 1.15A 6mb9D-3td9A:
undetectable		 6mb9D-3td9A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 TYR A 563
ASP A 229
THR A 383
GLY A 540
ASP A 541
 None
MG  A 701 ( 4.0A)
None
None
None
 1.49A 6mb9D-3tw0A:
undetectable		 6mb9D-3tw0A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvv APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		5 TYR A   9
ASP A  73
THR A  16
GLY A  60
ASP A  57
 SO4  A1082 (-4.7A)
None
None
None
CPF  A1081 (-3.9A)
 1.40A 6mb9D-4bvvA:
undetectable		 6mb9D-4bvvA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 TYR A  92
ASP A 155
THR A  99
GLY A 142
ASP A 139
 None
 1.49A 6mb9D-4duuA:
undetectable		 6mb9D-4duuA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 TYR A 470
ASP A 534
THR A 477
GLY A 521
ASP A 518
 None
 1.40A 6mb9D-4duuA:
undetectable		 6mb9D-4duuA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ASP A  91
TYR A 136
HIS A  64
ASP A 457
GLU A 466
 None
None
None
CA  A 603 (-2.9A)
CA  A 603 (-2.2A)
 1.15A 6mb9D-4mvfA:
undetectable		 6mb9D-4mvfA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.04A 6mb9D-4nfuA:
undetectable		 6mb9D-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG

(Homo sapiens) 		PF04049
(ANAPC8)
PF13181
(TPR_8)
PF13414
(TPR_11) 		5 TYR C 364
ASP C 301
THR C 369
GLY C 338
GLU C 374
 None
 1.45A 6mb9D-4ui9C:
undetectable		 6mb9D-4ui9C:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1h SPINDLIN-3

(Homo sapiens) 		PF02513
(Spin-Ssty) 		5 TYR A 175
ASP A  91
TYR A 166
ASP A 183
HIS A 135
 None
 1.38A 6mb9D-5a1hA:
undetectable		 6mb9D-5a1hA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpg PLASMINOGEN

(Homo sapiens) 		PF00051
(Kringle) 		5 TYR A   9
ASP A  73
THR A  16
GLY A  60
ASP A  57
 None
 1.48A 6mb9D-5hpgA:
undetectable		 6mb9D-5hpgA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		8 TYR A  62
ASP A  64
TYR A 138
ASP A 162
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
None
COA  A 301 (-3.9A)
None
None
None
 0.58A 6mb9D-5ht0A:
39.6		 6mb9D-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
fabrum) 		PF00497
(SBP_bac_3) 		5 TYR A  39
ASP A 187
THR A 188
THR A 168
GLY A 167
 6DB  A 304 (-3.9A)
None
None
6DB  A 304 ( 4.1A)
1PE  A 303 (-3.9A)
 1.35A 6mb9D-5itoA:
undetectable		 6mb9D-5itoA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 TYR A  98
ASP A 464
THR A 441
HIS A 171
ASP A 467
 None
 1.39A 6mb9D-5t81A:
undetectable		 6mb9D-5t81A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vp3 MNEMIOPSIN 1

(Mnemiopsis
leidyi) 		no annotation 5 ASP A  48
ASP A 100
THR A  52
GLY A  95
ASP A  91
 CD  A 201 (-2.7A)
None
CD  A 201 ( 4.9A)
None
None
 1.42A 6mb9D-5vp3A:
undetectable		 6mb9D-5vp3A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 ASP A 235
TYR A 403
THR A  18
THR A 241
GLY A 240
 None
 1.33A 6mb9D-5wi5A:
undetectable		 6mb9D-5wi5A:
13.43