SIMILAR PATTERNS OF AMINO ACIDS FOR 6MB9_C_NMYC302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		5 TYR A 235
ASP A 149
THR A 151
HIS A 142
GLY A 230
 None
 1.27A 6mb9C-1eb3A:
1.0		 6mb9C-1eb3A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 TYR A 404
ASP A 547
THR A 504
HIS A 501
THR A 538
 None
 1.48A 6mb9C-1i2dA:
0.4		 6mb9C-1i2dA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		5 ASP A 351
THR A 361
HIS A 251
THR A 265
GLU A 270
 None
 1.43A 6mb9C-1m7jA:
0.0		 6mb9C-1m7jA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ASP B 341
TYR B  21
ASP B 188
THR B 330
GLY B 331
 None
 0.93A 6mb9C-1tqyB:
0.2		 6mb9C-1tqyB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd5 HYPOTHETICAL PROTEIN
TT1426

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 TYR A 109
ASP A 196
ASP A  39
GLY A  33
ASP A 128
 None
 1.36A 6mb9C-1wd5A:
1.6		 6mb9C-1wd5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 ASP A 622
ASP A 574
THR A 572
THR A 428
GLY A 427
 None
 1.34A 6mb9C-2b8eA:
0.0		 6mb9C-2b8eA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.49A 6mb9C-2cgjA:
0.0		 6mb9C-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2feb APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		5 ASP A  17
THR A   9
HIS A   5
GLY A  36
ASP A  82
 None
 1.42A 6mb9C-2febA:
undetectable		 6mb9C-2febA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 ASP A  57
THR A  62
GLY A  69
ASP A  68
GLU A  75
 None
None
None
CA  A 500 (-2.4A)
CA  A 500 (-2.0A)
 1.31A 6mb9C-2ggzA:
undetectable		 6mb9C-2ggzA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml1 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind) 		5 ASP A  73
ASP A  29
THR A  47
GLY A  21
ASP A   8
 CA  A 205 (-2.2A)
None
None
CA  A 201 (-4.7A)
CA  A 201 (-3.4A)
 1.50A 6mb9C-2ml1A:
undetectable		 6mb9C-2ml1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 THR A 277
THR A  74
GLY A  73
ASP A  72
GLU A  71
 None
 1.43A 6mb9C-2p2mA:
0.0		 6mb9C-2p2mA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 ASP I 622
ASP I 574
THR I 572
THR I 428
GLY I 427
 None
 1.34A 6mb9C-2voyI:
undetectable		 6mb9C-2voyI:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 TYR A 413
THR A 310
HIS A 308
GLY A 383
ASP A 382
 PGR  A1757 (-4.8A)
PGR  A1758 ( 3.8A)
PGR  A1744 ( 3.8A)
None
None
 1.47A 6mb9C-2xe4A:
undetectable		 6mb9C-2xe4A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		5 ASP A 254
ASP A 366
THR A 259
GLY A 260
GLU A 367
 None
 1.41A 6mb9C-2z6vA:
undetectable		 6mb9C-2z6vA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5o UPF0311 PROTEIN
RPA1785

(Rhodopseudomonas
palustris) 		PF11578
(DUF3237) 		5 TYR A 126
THR A  12
THR A  76
GLY A  48
GLU A  40
 None
 1.28A 6mb9C-3c5oA:
undetectable		 6mb9C-3c5oA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc7 PUTATIVE
UNCHARACTERIZED
PROTEIN LP_3323

(Lactobacillus
plantarum) 		PF13472
(Lipase_GDSL_2) 		5 TYR A  42
ASP A  56
HIS A  43
THR A  32
GLY A  59
 None
 1.49A 6mb9C-3dc7A:
undetectable		 6mb9C-3dc7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I

(Cytophaga
hutchinsonii) 		PF00425
(Chorismate_bind) 		5 TYR A 368
ASP A 370
THR A 236
GLY A 237
ASP A 238
 None
 1.14A 6mb9C-3h9mA:
undetectable		 6mb9C-3h9mA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		5 ASP A 136
ASP A 244
THR A 263
THR A 215
GLY A 216
 None
EDO  A 403 ( 2.8A)
EDO  A 403 ( 4.2A)
None
None
 1.37A 6mb9C-3td9A:
undetectable		 6mb9C-3td9A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		5 ASP A 241
THR A 215
GLY A 216
ASP A 161
GLU A 220
 PHE  A 400 (-2.7A)
None
None
None
None
 1.33A 6mb9C-3td9A:
undetectable		 6mb9C-3td9A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx METASTASIS-ASSOCIATE
D PROTEIN MTA1
HISTONE DEACETYLASE
1

(Homo sapiens;
Homo sapiens) 		PF00249
(Myb_DNA-binding)
PF01448
(ELM2)
PF00850
(Hist_deacetyl) 		5 ASP A 256
ASP B 332
HIS B  39
GLY B  17
GLU A 325
 None
 1.32A 6mb9C-4bkxA:
undetectable		 6mb9C-4bkxA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx METASTASIS-ASSOCIATE
D PROTEIN MTA1
HISTONE DEACETYLASE
1

(Homo sapiens;
Homo sapiens) 		PF00249
(Myb_DNA-binding)
PF01448
(ELM2)
PF00850
(Hist_deacetyl) 		5 TYR B  48
ASP B 332
HIS B  39
GLY B  17
GLU A 325
 None
 1.37A 6mb9C-4bkxB:
undetectable		 6mb9C-4bkxB:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvv APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		5 TYR A   9
ASP A  73
THR A  16
GLY A  60
ASP A  57
 SO4  A1082 (-4.7A)
None
None
None
CPF  A1081 (-3.9A)
 1.39A 6mb9C-4bvvA:
undetectable		 6mb9C-4bvvA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4coy EPITHELIAL ADHESIN 6

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 TYR A 130
ASP A 124
THR A 125
GLY A 230
ASP A 229
 None
None
None
CA  A1270 ( 4.7A)
None
 1.49A 6mb9C-4coyA:
undetectable		 6mb9C-4coyA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 TYR A  92
ASP A 155
THR A  99
GLY A 142
ASP A 139
 None
 1.45A 6mb9C-4duuA:
undetectable		 6mb9C-4duuA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 TYR A 470
ASP A 534
THR A 477
GLY A 521
ASP A 518
 None
 1.38A 6mb9C-4duuA:
undetectable		 6mb9C-4duuA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ASP A 186
ASP A 437
THR A 422
GLY A 423
GLU A 435
 None
None
None
15P  A 504 (-3.8A)
None
 1.44A 6mb9C-4grhA:
undetectable		 6mb9C-4grhA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		5 ASP A 435
THR A 409
THR A 400
GLY A 401
GLU A 406
 None
 1.13A 6mb9C-4ijmA:
undetectable		 6mb9C-4ijmA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.02A 6mb9C-4nfuA:
undetectable		 6mb9C-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		5 ASP A 435
THR A 409
THR A 400
GLY A 401
GLU A 406
 None
 1.01A 6mb9C-4o0mA:
undetectable		 6mb9C-4o0mA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		5 ASP A 222
ASP A 292
THR A 156
GLY A 288
GLU A 293
 None
 1.48A 6mb9C-4pfrA:
undetectable		 6mb9C-4pfrA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		5 TYR A 245
ASP A 277
THR A 381
GLY A 386
ASP A 281
 None
 1.36A 6mb9C-4r7fA:
undetectable		 6mb9C-4r7fA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1h SPINDLIN-3

(Homo sapiens) 		PF02513
(Spin-Ssty) 		5 TYR A 175
ASP A  91
TYR A 166
ASP A 183
HIS A 135
 None
 1.38A 6mb9C-5a1hA:
undetectable		 6mb9C-5a1hA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		8 TYR A  62
ASP A  64
TYR A 138
ASP A 162
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
None
COA  A 301 (-3.9A)
None
None
None
 0.56A 6mb9C-5ht0A:
39.6		 6mb9C-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
fabrum) 		PF00497
(SBP_bac_3) 		5 TYR A  39
ASP A 187
THR A 188
THR A 168
GLY A 167
 6DB  A 304 (-3.9A)
None
None
6DB  A 304 ( 4.1A)
1PE  A 303 (-3.9A)
 1.34A 6mb9C-5itoA:
undetectable		 6mb9C-5itoA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 TYR A  98
ASP A 464
THR A 441
HIS A 171
ASP A 467
 None
 1.36A 6mb9C-5t81A:
undetectable		 6mb9C-5t81A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vp3 MNEMIOPSIN 1

(Mnemiopsis
leidyi) 		no annotation 5 ASP A  48
ASP A 100
THR A  52
GLY A  95
ASP A  91
 CD  A 201 (-2.7A)
None
CD  A 201 ( 4.9A)
None
None
 1.41A 6mb9C-5vp3A:
undetectable		 6mb9C-5vp3A:
24.44