SIMILAR PATTERNS OF AMINO ACIDS FOR 6MB9_B_NMYB302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		5 TYR A 235
ASP A 149
THR A 151
HIS A 142
GLY A 230
 None
 1.30A 6mb9B-1eb3A:
0.9		 6mb9B-1eb3A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 TYR A 404
ASP A 547
THR A 504
HIS A 501
THR A 538
 None
 1.47A 6mb9B-1i2dA:
0.0		 6mb9B-1i2dA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		5 ASP A 351
THR A 361
HIS A 251
THR A 265
GLU A 270
 None
 1.43A 6mb9B-1m7jA:
0.0		 6mb9B-1m7jA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ASP B 341
TYR B  21
ASP B 188
THR B 330
GLY B 331
 None
 0.94A 6mb9B-1tqyB:
0.2		 6mb9B-1tqyB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.50A 6mb9B-2cgjA:
0.0		 6mb9B-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2feb APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		5 ASP A  17
THR A   9
HIS A   5
GLY A  36
ASP A  82
 None
 1.41A 6mb9B-2febA:
undetectable		 6mb9B-2febA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 ASP A  57
THR A  62
GLY A  69
ASP A  68
GLU A  75
 None
None
None
CA  A 500 (-2.4A)
CA  A 500 (-2.0A)
 1.35A 6mb9B-2ggzA:
undetectable		 6mb9B-2ggzA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		5 TYR A 295
ASP A 316
THR A 322
GLY A  87
GLU A 317
 None
 1.25A 6mb9B-2glfA:
0.0		 6mb9B-2glfA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 THR A 277
THR A  74
GLY A  73
ASP A  72
GLU A  71
 None
 1.46A 6mb9B-2p2mA:
0.0		 6mb9B-2p2mA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1z ANTI-SIGMA FACTOR
CHRR,
TRANSCRIPTIONAL
ACTIVATOR CHRR

(Rhodobacter
sphaeroides) 		PF12973
(Cupin_7)
PF13490
(zf-HC2) 		5 ASP B 194
THR B 193
THR B 121
GLY B 122
GLU B 124
 None
 1.49A 6mb9B-2q1zB:
undetectable		 6mb9B-2q1zB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 TYR A 413
THR A 310
HIS A 308
GLY A 383
ASP A 382
 PGR  A1757 (-4.8A)
PGR  A1758 ( 3.8A)
PGR  A1744 ( 3.8A)
None
None
 1.46A 6mb9B-2xe4A:
undetectable		 6mb9B-2xe4A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		5 ASP A 254
ASP A 366
THR A 259
GLY A 260
GLU A 367
 None
 1.43A 6mb9B-2z6vA:
undetectable		 6mb9B-2z6vA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5o UPF0311 PROTEIN
RPA1785

(Rhodopseudomonas
palustris) 		PF11578
(DUF3237) 		5 TYR A 126
THR A  12
THR A  76
GLY A  48
GLU A  40
 None
 1.26A 6mb9B-3c5oA:
undetectable		 6mb9B-3c5oA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc7 PUTATIVE
UNCHARACTERIZED
PROTEIN LP_3323

(Lactobacillus
plantarum) 		PF13472
(Lipase_GDSL_2) 		5 TYR A  42
ASP A  56
HIS A  43
THR A  32
GLY A  59
 None
 1.48A 6mb9B-3dc7A:
undetectable		 6mb9B-3dc7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I

(Cytophaga
hutchinsonii) 		PF00425
(Chorismate_bind) 		5 TYR A 368
ASP A 370
THR A 236
GLY A 237
ASP A 238
 None
 1.18A 6mb9B-3h9mA:
undetectable		 6mb9B-3h9mA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 TYR A 158
ASP A 102
THR A  50
GLY A  51
ASP A  53
 None
NAE  A 311 (-3.5A)
None
NAE  A 311 (-3.5A)
MG  A 306 ( 2.5A)
 1.43A 6mb9B-3i3oA:
undetectable		 6mb9B-3i3oA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		5 ASP A 241
THR A 215
GLY A 216
ASP A 161
GLU A 220
 PHE  A 400 (-2.7A)
None
None
None
None
 1.35A 6mb9B-3td9A:
undetectable		 6mb9B-3td9A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx METASTASIS-ASSOCIATE
D PROTEIN MTA1
HISTONE DEACETYLASE
1

(Homo sapiens;
Homo sapiens) 		PF00249
(Myb_DNA-binding)
PF01448
(ELM2)
PF00850
(Hist_deacetyl) 		5 ASP A 256
ASP B 332
HIS B  39
GLY B  17
GLU A 325
 None
 1.31A 6mb9B-4bkxA:
undetectable		 6mb9B-4bkxA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx METASTASIS-ASSOCIATE
D PROTEIN MTA1
HISTONE DEACETYLASE
1

(Homo sapiens;
Homo sapiens) 		PF00249
(Myb_DNA-binding)
PF01448
(ELM2)
PF00850
(Hist_deacetyl) 		5 TYR B  48
ASP B 332
HIS B  39
GLY B  17
GLU A 325
 None
 1.41A 6mb9B-4bkxB:
undetectable		 6mb9B-4bkxB:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvv APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		5 TYR A   9
ASP A  73
THR A  16
GLY A  60
ASP A  57
 SO4  A1082 (-4.7A)
None
None
None
CPF  A1081 (-3.9A)
 1.38A 6mb9B-4bvvA:
undetectable		 6mb9B-4bvvA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4coy EPITHELIAL ADHESIN 6

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 TYR A 130
ASP A 124
THR A 125
GLY A 230
ASP A 229
 None
None
None
CA  A1270 ( 4.7A)
None
 1.48A 6mb9B-4coyA:
undetectable		 6mb9B-4coyA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 TYR A  92
ASP A 155
THR A  99
GLY A 142
ASP A 139
 None
 1.45A 6mb9B-4duuA:
undetectable		 6mb9B-4duuA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 TYR A 470
ASP A 534
THR A 477
GLY A 521
ASP A 518
 None
 1.37A 6mb9B-4duuA:
undetectable		 6mb9B-4duuA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ASP A 186
ASP A 437
THR A 422
GLY A 423
GLU A 435
 None
None
None
15P  A 504 (-3.8A)
None
 1.39A 6mb9B-4grhA:
undetectable		 6mb9B-4grhA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.03A 6mb9B-4nfuA:
undetectable		 6mb9B-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		5 ASP A 222
ASP A 292
THR A 156
GLY A 288
GLU A 293
 None
 1.48A 6mb9B-4pfrA:
undetectable		 6mb9B-4pfrA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		5 TYR A 245
ASP A 277
THR A 381
GLY A 386
ASP A 281
 None
 1.37A 6mb9B-4r7fA:
undetectable		 6mb9B-4r7fA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy4 SPINDLIN-4

(Homo sapiens) 		PF02513
(Spin-Ssty) 		5 TYR A 161
ASP A  82
TYR A 152
ASP A 169
HIS A 125
 None
 1.37A 6mb9B-4uy4A:
undetectable		 6mb9B-4uy4A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1h SPINDLIN-3

(Homo sapiens) 		PF02513
(Spin-Ssty) 		5 TYR A 175
ASP A  91
TYR A 166
ASP A 183
HIS A 135
 None
 1.36A 6mb9B-5a1hA:
undetectable		 6mb9B-5a1hA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 ASP A1253
ASP A1336
THR A1333
THR A1371
GLY A1307
 None
 1.36A 6mb9B-5gzuA:
undetectable		 6mb9B-5gzuA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		8 TYR A  62
ASP A  64
TYR A 138
ASP A 162
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
None
COA  A 301 (-3.9A)
None
None
None
 0.53A 6mb9B-5ht0A:
39.8		 6mb9B-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		5 TYR A 327
TYR A  55
ASP A 333
THR A 329
THR A 415
 None
 1.47A 6mb9B-5i92A:
undetectable		 6mb9B-5i92A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 TYR A  98
ASP A 464
THR A 441
HIS A 171
ASP A 467
 None
 1.36A 6mb9B-5t81A:
undetectable		 6mb9B-5t81A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vp3 MNEMIOPSIN 1

(Mnemiopsis
leidyi) 		no annotation 5 ASP A  48
ASP A 100
THR A  52
GLY A  95
ASP A  91
 CD  A 201 (-2.7A)
None
CD  A 201 ( 4.9A)
None
None
 1.44A 6mb9B-5vp3A:
undetectable		 6mb9B-5vp3A:
24.44