SIMILAR PATTERNS OF AMINO ACIDS FOR 6MB7_A_PARA900_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		5 ASP A 351
THR A 361
HIS A 251
THR A 265
GLU A 270
 None
 1.43A 6mb7A-1m7jA:
0.0		 6mb7A-1m7jA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASN A  73
HIS A 159
THR A  99
GLY A  97
ASP A 101
 None
 1.09A 6mb7A-1vf1A:
undetectable		 6mb7A-1vf1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		5 ASN A 143
TYR A  39
THR A  37
GLY A  36
GLU A  35
 None
 1.17A 6mb7A-2c1lA:
0.0		 6mb7A-2c1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.49A 6mb7A-2cgjA:
0.0		 6mb7A-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2feb APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		5 ASP A  17
THR A   9
HIS A   5
GLY A  36
ASP A  82
 None
 1.42A 6mb7A-2febA:
undetectable		 6mb7A-2febA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 ASP A  57
THR A  62
GLY A  69
ASP A  68
GLU A  75
 None
None
None
CA  A 500 (-2.4A)
CA  A 500 (-2.0A)
 1.29A 6mb7A-2ggzA:
undetectable		 6mb7A-2ggzA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou6 HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF04978
(DUF664) 		5 TYR A  19
ASN A  14
THR A  12
THR A  46
GLU A  52
 None
 1.44A 6mb7A-2ou6A:
undetectable		 6mb7A-2ou6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 THR A 277
THR A  74
GLY A  73
ASP A  72
GLU A  71
 None
 1.49A 6mb7A-2p2mA:
0.0		 6mb7A-2p2mA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 TYR A 413
THR A 310
HIS A 308
GLY A 383
ASP A 382
 PGR  A1757 (-4.8A)
PGR  A1758 ( 3.8A)
PGR  A1744 ( 3.8A)
None
None
 1.44A 6mb7A-2xe4A:
0.0		 6mb7A-2xe4A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN

(Galaxea
fascicularis) 		PF01353
(GFP) 		5 ASN A  32
TYR A 116
THR A  37
GLY A  29
ASP A  41
 None
CRQ  A  64 ( 4.6A)
None
None
None
 1.21A 6mb7A-3adfA:
0.0		 6mb7A-3adfA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5o UPF0311 PROTEIN
RPA1785

(Rhodopseudomonas
palustris) 		PF11578
(DUF3237) 		5 TYR A 126
THR A  12
THR A  76
GLY A  48
GLU A  40
 None
 1.21A 6mb7A-3c5oA:
undetectable		 6mb7A-3c5oA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eix HTSA PROTEIN

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 ASN A 131
THR A 140
THR A  47
GLY A  46
GLU A  44
 None
 1.36A 6mb7A-3eixA:
0.0		 6mb7A-3eixA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I

(Cytophaga
hutchinsonii) 		PF00425
(Chorismate_bind) 		5 TYR A 368
ASP A 370
THR A 236
GLY A 237
ASP A 238
 None
 1.16A 6mb7A-3h9mA:
undetectable		 6mb7A-3h9mA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 TYR A 158
ASN A 154
THR A  50
GLY A  51
ASP A  53
 None
None
None
NAE  A 311 (-3.5A)
MG  A 306 ( 2.5A)
 1.25A 6mb7A-3i3oA:
undetectable		 6mb7A-3i3oA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		5 TYR A 292
ASN A  39
THR A 275
GLY A 276
GLU A 278
 None
 1.43A 6mb7A-3om5A:
undetectable		 6mb7A-3om5A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		5 ASP A 241
THR A 215
GLY A 216
ASP A 161
GLU A 220
 PHE  A 400 (-2.7A)
None
None
None
None
 1.36A 6mb7A-3td9A:
2.0		 6mb7A-3td9A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		5 TYR A 213
THR A 215
GLY A 216
ASP A 161
GLU A 220
 None
 1.15A 6mb7A-3td9A:
2.0		 6mb7A-3td9A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdf DIHYDRODIPICOLINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF00701
(DHDPS) 		5 ASN A 108
TYR A 119
HIS A 118
GLY A  78
GLU A  84
 None
 1.14A 6mb7A-3tdfA:
undetectable		 6mb7A-3tdfA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 TYR A 513
ASP A 515
ASN A 429
THR A 706
GLY A 709
 None
 1.40A 6mb7A-4bedA:
undetectable		 6mb7A-4bedA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		5 TYR A 250
ASP A 225
ASN A 227
TYR A 254
GLU A  44
 None
 1.38A 6mb7A-4gfhA:
undetectable		 6mb7A-4gfhA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF11175
(DUF2961) 		5 ASN A 357
TYR A 263
THR A 295
GLY A 294
ASP A 297
 None
None
None
None
PG4  A 504 (-3.2A)
 1.37A 6mb7A-4kq7A:
undetectable		 6mb7A-4kq7A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 ASP A 481
ASN A 483
THR A 486
HIS A 455
ASP A 411
 None
 1.41A 6mb7A-4ktpA:
undetectable		 6mb7A-4ktpA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.01A 6mb7A-4nfuA:
undetectable		 6mb7A-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Shewanella
benthica) 		PF00701
(DHDPS) 		5 ASN A 108
TYR A 119
HIS A 118
GLY A  78
GLU A  84
 None
None
None
None
LYS  A 302 (-2.9A)
 1.34A 6mb7A-4pfmA:
undetectable		 6mb7A-4pfmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2g CARBOXYLIC ESTER
HYDROLASE

(Hungatella
hathewayi) 		PF00135
(COesterase) 		5 TYR A 152
ASN A 148
HIS A 145
GLY A 113
GLU A 123
 None
 1.27A 6mb7A-5a2gA:
undetectable		 6mb7A-5a2gA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		5 ASN A 300
THR A 304
THR A 294
GLY A 295
GLU A 200
 None
 1.43A 6mb7A-5du9A:
undetectable		 6mb7A-5du9A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		7 TYR A  62
ASP A  64
TYR A 138
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
COA  A 301 (-3.9A)
None
None
None
 0.54A 6mb7A-5ht0A:
39.3		 6mb7A-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ASN A 689
TYR A 720
THR A 314
GLY A 320
GLU A 324
 None
NAG  A 917 (-3.7A)
None
None
None
 1.31A 6mb7A-5ju6A:
undetectable		 6mb7A-5ju6A:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 TYR A 399
ASN A 469
TYR A 382
HIS A 407
GLY A 446
 None
 1.48A 6mb7A-5l6fA:
undetectable		 6mb7A-5l6fA:
11.69