SIMILAR PATTERNS OF AMINO ACIDS FOR 6MB5_A_NMYA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		5 ASP A 266
ASN A 243
ASP A 220
GLY A  87
ASP A 195
 MN  A1001 ( 2.8A)
None
None
None
None
 1.28A 6mb5A-1a3xA:
0.0		 6mb5A-1a3xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP2)

(Cricket
paralysis virus) 		no annotation 5 ASP B 174
THR B 173
THR B 181
GLY B 180
GLU B 176
 None
 1.30A 6mb5A-1b35B:
0.0		 6mb5A-1b35B:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		5 TYR A 235
ASP A 149
THR A 151
HIS A 142
GLY A 230
 None
 1.30A 6mb5A-1eb3A:
0.7		 6mb5A-1eb3A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 TYR A 404
ASP A 547
THR A 504
HIS A 501
THR A 538
 None
 1.46A 6mb5A-1i2dA:
0.0		 6mb5A-1i2dA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		5 ASP A 351
THR A 361
HIS A 251
THR A 265
GLU A 270
 None
 1.45A 6mb5A-1m7jA:
0.0		 6mb5A-1m7jA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pkr PLASMINOGEN

(Homo sapiens) 		PF00051
(Kringle) 		5 TYR A   9
ASP A  73
THR A  16
GLY A  60
ASP A  57
 None
 1.41A 6mb5A-1pkrA:
undetectable		 6mb5A-1pkrA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ASP A 136
ASN A 139
ASP A 175
GLY A 183
ASP A 182
 None
NAG  A 639 (-1.9A)
NAG  A 639 ( 3.4A)
None
None
 1.47A 6mb5A-1r47A:
0.0		 6mb5A-1r47A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ASP B 341
TYR B  21
ASP B 188
THR B 330
GLY B 331
 None
 0.96A 6mb5A-1tqyB:
0.4		 6mb5A-1tqyB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASN A  73
HIS A 159
THR A  99
GLY A  97
ASP A 101
 None
 1.10A 6mb5A-1vf1A:
undetectable		 6mb5A-1vf1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima) 		PF03537
(Glyco_hydro_114) 		5 ASN A 124
TYR A 141
ASP A  97
GLY A  65
ASP A  64
 UNL  A   1 ( 4.6A)
None
None
UNL  A   1 ( 3.8A)
None
 1.36A 6mb5A-2aamA:
0.0		 6mb5A-2aamA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 ASP A 622
ASP A 574
THR A 572
THR A 428
GLY A 427
 None
 1.34A 6mb5A-2b8eA:
undetectable		 6mb5A-2b8eA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.46A 6mb5A-2cgjA:
undetectable		 6mb5A-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2feb APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		5 ASP A  17
THR A   9
HIS A   5
GLY A  36
ASP A  82
 None
 1.41A 6mb5A-2febA:
undetectable		 6mb5A-2febA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jay PROTEASOME

(Mycobacterium
tuberculosis) 		PF00227
(Proteasome) 		5 TYR A 211
ASP A 216
THR A 215
GLY A  68
ASP A 255
 None
 1.39A 6mb5A-2jayA:
undetectable		 6mb5A-2jayA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 ASN A 487
THR A 489
THR A 372
GLY A 369
ASP A 336
 None
 1.40A 6mb5A-2v5dA:
undetectable		 6mb5A-2v5dA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 ASP I 622
ASP I 574
THR I 572
THR I 428
GLY I 427
 None
 1.34A 6mb5A-2voyI:
undetectable		 6mb5A-2voyI:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 TYR A 413
THR A 310
HIS A 308
GLY A 383
ASP A 382
 PGR  A1757 (-4.8A)
PGR  A1758 ( 3.8A)
PGR  A1744 ( 3.8A)
None
None
 1.49A 6mb5A-2xe4A:
undetectable		 6mb5A-2xe4A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ASP A 106
THR A 157
GLY A 169
ASP A 173
GLU A 174
 None
 1.14A 6mb5A-3bqyA:
undetectable		 6mb5A-3bqyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc7 PUTATIVE
UNCHARACTERIZED
PROTEIN LP_3323

(Lactobacillus
plantarum) 		PF13472
(Lipase_GDSL_2) 		5 TYR A  42
ASP A  56
HIS A  43
THR A  32
GLY A  59
 None
 1.49A 6mb5A-3dc7A:
undetectable		 6mb5A-3dc7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eix HTSA PROTEIN

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 ASN A 135
THR A 140
THR A  47
GLY A  46
GLU A  44
 None
 1.06A 6mb5A-3eixA:
undetectable		 6mb5A-3eixA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I

(Cytophaga
hutchinsonii) 		PF00425
(Chorismate_bind) 		5 TYR A 368
ASP A 370
THR A 236
GLY A 237
ASP A 238
 None
 1.19A 6mb5A-3h9mA:
undetectable		 6mb5A-3h9mA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		6 TYR A 158
ASN A 154
THR A  50
GLY A  51
ASP A  53
GLU A  78
 None
None
None
NAE  A 311 (-3.5A)
MG  A 306 ( 2.5A)
NAE  A 311 ( 2.9A)
 1.35A 6mb5A-3i3oA:
undetectable		 6mb5A-3i3oA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 TYR A 158
ASP A 102
THR A  50
GLY A  51
ASP A  53
 None
NAE  A 311 (-3.5A)
None
NAE  A 311 (-3.5A)
MG  A 306 ( 2.5A)
 1.48A 6mb5A-3i3oA:
undetectable		 6mb5A-3i3oA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C

(Streptococcus
mutans) 		PF08282
(Hydrolase_3) 		5 ASP A 254
ASN A 237
ASP A   9
THR A  13
GLY A  19
 None
None
MG  A 271 (-2.9A)
None
None
 1.47A 6mb5A-3l7yA:
undetectable		 6mb5A-3l7yA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 TYR A 401
ASN A 195
THR A 432
GLY A 433
GLU A 410
 None
None
None
None
ZN  A 504 ( 2.1A)
 1.41A 6mb5A-3pfeA:
undetectable		 6mb5A-3pfeA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttk POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		5 TYR A 131
ASN A 313
ASP A 307
THR A 306
THR A  43
 None
 1.14A 6mb5A-3ttkA:
undetectable		 6mb5A-3ttkA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 ASP A 575
ASN A 237
THR A 566
GLY A 567
GLU A 472
 None
ACR  A1001 (-3.0A)
None
None
None
 1.49A 6mb5A-3welA:
undetectable		 6mb5A-3welA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 TYR A 513
ASP A 515
ASN A 429
GLY A 709
GLU A 849
 None
 1.48A 6mb5A-4bedA:
undetectable		 6mb5A-4bedA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 TYR A 513
ASP A 515
ASN A 429
THR A 706
GLY A 709
 None
 1.42A 6mb5A-4bedA:
undetectable		 6mb5A-4bedA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx METASTASIS-ASSOCIATE
D PROTEIN MTA1
HISTONE DEACETYLASE
1

(Homo sapiens;
Homo sapiens) 		PF00249
(Myb_DNA-binding)
PF01448
(ELM2)
PF00850
(Hist_deacetyl) 		5 TYR B  48
ASP B 332
HIS B  39
GLY B  17
GLU A 325
 None
 1.43A 6mb5A-4bkxB:
undetectable		 6mb5A-4bkxB:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvv APOLIPOPROTEIN(A)

(Homo sapiens) 		PF00051
(Kringle) 		5 TYR A   9
ASP A  73
THR A  16
GLY A  60
ASP A  57
 SO4  A1082 (-4.7A)
None
None
None
CPF  A1081 (-3.9A)
 1.35A 6mb5A-4bvvA:
undetectable		 6mb5A-4bvvA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4coy EPITHELIAL ADHESIN 6

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 TYR A 130
ASP A 124
THR A 125
GLY A 230
ASP A 229
 None
None
None
CA  A1270 ( 4.7A)
None
 1.45A 6mb5A-4coyA:
undetectable		 6mb5A-4coyA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 TYR A  92
ASP A 155
THR A  99
GLY A 142
ASP A 139
 None
 1.41A 6mb5A-4duuA:
undetectable		 6mb5A-4duuA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 TYR A 470
ASP A 534
THR A 477
GLY A 521
ASP A 518
 None
 1.33A 6mb5A-4duuA:
undetectable		 6mb5A-4duuA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e13 DIKETOREDUCTASE

(Acinetobacter
baylyi) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ASP A 137
THR A 115
THR A 133
GLY A 134
GLU A 109
 None
 1.42A 6mb5A-4e13A:
undetectable		 6mb5A-4e13A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 ASN A 125
TYR A 243
ASP A 169
THR A 126
GLY A 134
 None
 1.34A 6mb5A-4gmfA:
undetectable		 6mb5A-4gmfA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnf GLUTAMINE SYNTHETASE

(Bacillus
subtilis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 ASN A 342
ASP A  27
THR A  26
GLY A 106
GLU A  58
 None
None
None
None
MG  A 505 ( 4.4A)
 1.27A 6mb5A-4lnfA:
undetectable		 6mb5A-4lnfA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 TYR A 494
ASP A 469
TYR A 461
THR A 492
GLY A 430
 None
 1.04A 6mb5A-4nfuA:
undetectable		 6mb5A-4nfuA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		5 TYR A 245
ASP A 277
THR A 381
GLY A 386
ASP A 281
 None
 1.35A 6mb5A-4r7fA:
undetectable		 6mb5A-4r7fA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy4 SPINDLIN-4

(Homo sapiens) 		PF02513
(Spin-Ssty) 		5 TYR A 161
ASP A  82
TYR A 152
ASP A 169
HIS A 125
 None
 1.36A 6mb5A-4uy4A:
undetectable		 6mb5A-4uy4A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus) 		PF13088
(BNR_2) 		5 ASP A 696
ASN A 635
THR A 634
THR A 609
GLY A 608
 None
 1.34A 6mb5A-4x6kA:
undetectable		 6mb5A-4x6kA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		5 ASP A 296
ASN A 273
ASP A 250
GLY A 116
ASP A 225
 PYR  A 601 (-3.5A)
None
None
None
None
 1.32A 6mb5A-4yj5A:
undetectable		 6mb5A-4yj5A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1h SPINDLIN-3

(Homo sapiens) 		PF02513
(Spin-Ssty) 		5 TYR A 175
ASP A  91
TYR A 166
ASP A 183
HIS A 135
 None
 1.34A 6mb5A-5a1hA:
undetectable		 6mb5A-5a1hA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 ASP A  69
ASN A  71
THR A 203
GLY A 204
ASP A 205
 None
 1.29A 6mb5A-5bnzA:
undetectable		 6mb5A-5bnzA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Pseudoalteromonas
atlantica) 		PF03480
(DctP) 		5 ASN A 279
ASP A 217
THR A 231
GLY A 232
GLU A 210
 None
None
None
None
NA  A 402 ( 3.2A)
 0.94A 6mb5A-5cm6A:
undetectable		 6mb5A-5cm6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		5 ASN A 273
ASP A 453
THR A 431
ASP A 280
GLU A 283
 None
 1.37A 6mb5A-5gtkA:
undetectable		 6mb5A-5gtkA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		5 ASN A  95
TYR A 138
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-3.9A)
None
None
None
None
 1.13A 6mb5A-5ht0A:
39.4		 6mb5A-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		8 TYR A  62
ASP A  64
TYR A 138
ASP A 162
THR A 163
HIS A 168
THR A 204
ASP A 206
 COA  A 301 (-4.7A)
None
None
None
COA  A 301 (-3.9A)
None
None
None
 0.60A 6mb5A-5ht0A:
39.4		 6mb5A-5ht0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1u GERMACRADIEN-4-OL
SYNTHASE

(Streptomyces
citricolor) 		no annotation 5 TYR A 168
ASP A 212
THR A 175
GLY A 174
GLU A 179
 None
 1.50A 6mb5A-5i1uA:
undetectable		 6mb5A-5i1uA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
fabrum) 		PF00497
(SBP_bac_3) 		5 TYR A  39
ASP A 187
THR A 188
THR A 168
GLY A 167
 6DB  A 304 (-3.9A)
None
None
6DB  A 304 ( 4.1A)
1PE  A 303 (-3.9A)
 1.32A 6mb5A-5itoA:
undetectable		 6mb5A-5itoA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox)
PF13181
(TPR_8)
PF13432
(TPR_16) 		5 ASP A 720
HIS A 725
THR A 680
GLY A 681
GLU A 617
 None
MN  A 801 ( 3.4A)
None
None
None
 1.36A 6mb5A-5jz8A:
undetectable		 6mb5A-5jz8A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 TYR A  98
ASP A 464
THR A 441
HIS A 171
ASP A 467
 None
 1.34A 6mb5A-5t81A:
undetectable		 6mb5A-5t81A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vp3 MNEMIOPSIN 1

(Mnemiopsis
leidyi) 		no annotation 5 ASP A  48
ASP A 100
THR A  52
GLY A  95
ASP A  91
 CD  A 201 (-2.7A)
None
CD  A 201 ( 4.9A)
None
None
 1.39A 6mb5A-5vp3A:
undetectable		 6mb5A-5vp3A:
24.44