SIMILAR PATTERNS OF AMINO ACIDS FOR 6MA7_A_TPFA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 4 SER P 124
THR P 135
ILE P 315
ALA P 314
 None
 0.72A 6ma7A-1cf2P:
0.0		 6ma7A-1cf2P:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 ARG A 366
ALA A 332
THR A 336
ILE A 314
 None
 0.86A 6ma7A-1e4oA:
0.0		 6ma7A-1e4oA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		4 ALA A 118
THR A 163
ILE A 165
ALA A 166
 None
 0.98A 6ma7A-1ekqA:
0.0		 6ma7A-1ekqA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 SER A1298
ARG A1021
ILE A1018
ALA A1019
 None
 0.85A 6ma7A-1fdjA:
0.0		 6ma7A-1fdjA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 SER A 595
ALA A 507
THR A 368
ALA A 530
 None
 0.93A 6ma7A-1itzA:
0.0		 6ma7A-1itzA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqi SHORT CHAIN ACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 262
ALA A 361
THR A 364
ILE A 251
 None
 0.97A 6ma7A-1jqiA:
0.0		 6ma7A-1jqiA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ort ORNITHINE
TRANSCARBAMOYLASE

(Pseudomonas
aeruginosa) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ALA A 140
THR A 144
ILE A 312
ALA A 313
 None
 0.90A 6ma7A-1ortA:
0.0		 6ma7A-1ortA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli) 		no annotation 4 SER B  73
THR B 110
ILE B  83
ALA B  82
 None
 0.88A 6ma7A-1p3wB:
0.0		 6ma7A-1p3wB:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ARG A 224
ALA A 226
ILE A 221
ALA A 247
 None
None
FAD  A 612 (-3.8A)
FAD  A 612 ( 4.6A)
 0.91A 6ma7A-1poxA:
0.0		 6ma7A-1poxA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x79 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF03127
(GAT) 		4 ARG A 214
ALA A 267
ILE A 218
ALA A 217
 None
 0.80A 6ma7A-1x79A:
undetectable		 6ma7A-1x79A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 114
ALA A 352
THR A 322
ALA A  45
 None
 0.98A 6ma7A-2akzA:
undetectable		 6ma7A-2akzA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anc GUANYLATE KINASE

(Escherichia
coli) 		PF00625
(Guanylate_kin) 		4 ARG A 149
ALA A 153
ILE A 146
ALA A 147
 None
 0.99A 6ma7A-2ancA:
undetectable		 6ma7A-2ancA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		4 ARG A 200
ALA A 141
ILE A 146
ALA A 144
 None
NAD  A1378 (-3.6A)
None
GDC  A1376 ( 3.8A)
 0.95A 6ma7A-2c5aA:
undetectable		 6ma7A-2c5aA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dna UNNAMED PROTEIN
PRODUCT

(Mus musculus) 		PF00627
(UBA) 		4 SER A  58
ALA A  36
ILE A  42
ALA A  43
 None
 0.82A 6ma7A-2dnaA:
undetectable		 6ma7A-2dnaA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g38 PE FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00934
(PE) 		4 ARG A  22
ALA A  68
ILE A  26
ALA A  25
 None
 0.92A 6ma7A-2g38A:
undetectable		 6ma7A-2g38A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 ARG A 398
ALA A 364
THR A 368
ILE A 346
 None
 0.97A 6ma7A-2gj4A:
undetectable		 6ma7A-2gj4A:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		4 SER A 193
ALA A 393
ILE A 245
ALA A 246
 None
 0.83A 6ma7A-2i2xA:
undetectable		 6ma7A-2i2xA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icu HYPOTHETICAL PROTEIN
YEDK

(Escherichia
coli) 		PF02586
(SRAP) 		4 SER A 193
ARG A  84
ALA A  88
ALA A 157
 None
 0.90A 6ma7A-2icuA:
undetectable		 6ma7A-2icuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		4 SER A 214
ALA A 451
ILE A 462
ALA A 457
 None
 0.98A 6ma7A-2j3mA:
undetectable		 6ma7A-2j3mA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 ARG A  67
SER A  63
ALA A 274
ALA A  71
 None
 0.93A 6ma7A-2o0rA:
undetectable		 6ma7A-2o0rA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		4 ALA A 487
THR A 352
ILE A 436
ALA A 432
 None
 0.95A 6ma7A-2pggA:
undetectable		 6ma7A-2pggA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 113
ALA A 353
THR A 323
ALA A  46
 None
 0.93A 6ma7A-2ptzA:
undetectable		 6ma7A-2ptzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 SER A  45
ALA A 198
ILE A 218
ALA A 217
 None
None
EDO  A 801 ( 4.6A)
None
 0.80A 6ma7A-2qb6A:
undetectable		 6ma7A-2qb6A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 SER A 190
ALA A 182
ILE A 243
ALA A 268
 None
 0.85A 6ma7A-2qn0A:
undetectable		 6ma7A-2qn0A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1
SNURPORTIN-1

(Homo sapiens;
Homo sapiens) 		PF13513
(HEAT_EZ)
PF11538
(Snurportin1) 		4 ARG B  63
ARG A 851
ALA A 858
ALA A 865
 None
 0.96A 6ma7A-2qnaB:
undetectable		 6ma7A-2qnaB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9i PUTATIVE PHAGE
CAPSID PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 4 ARG A  21
ALA A  17
ILE A  24
ALA A  23
 None
 0.85A 6ma7A-2r9iA:
undetectable		 6ma7A-2r9iA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 SER A  76
ALA A  70
ILE A  64
ALA A  97
 None
 0.82A 6ma7A-2vhlA:
undetectable		 6ma7A-2vhlA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ARG A 404
ALA A 165
THR A 415
ALA A 405
 None
 0.75A 6ma7A-2vpwA:
undetectable		 6ma7A-2vpwA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 685
ALA A 683
ILE A 715
ALA A 714
 None
 0.94A 6ma7A-2vwkA:
undetectable		 6ma7A-2vwkA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 ALA A 310
THR A 367
ILE A 317
ALA A 316
 None
 0.90A 6ma7A-2w3pA:
undetectable		 6ma7A-2w3pA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aux DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Methanocaldococcus
jannaschii) 		PF13476
(AAA_23) 		4 ARG A 928
ALA A 924
ILE A 931
ALA A 930
 None
 0.95A 6ma7A-3auxA:
undetectable		 6ma7A-3auxA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 ARG A 398
ALA A 364
THR A 368
ILE A 346
 None
 0.96A 6ma7A-3cemA:
undetectable		 6ma7A-3cemA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		4 ARG A  20
ALA A  45
ILE A  24
ALA A  23
 None
 0.88A 6ma7A-3edmA:
undetectable		 6ma7A-3edmA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f11 IRON TRANSPORT
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		4 SER A 339
THR A 202
ILE A 353
ALA A 350
 None
 0.84A 6ma7A-3f11A:
undetectable		 6ma7A-3f11A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 ARG A 302
ALA A 300
ILE A 393
ALA A 389
 None
 0.89A 6ma7A-3fdhA:
undetectable		 6ma7A-3fdhA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 SER A 449
ALA A 389
ILE A 397
ALA A 396
 None
 0.89A 6ma7A-3fdhA:
undetectable		 6ma7A-3fdhA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A  71
THR A  10
ILE A  11
ALA A  14
 None
 0.99A 6ma7A-3fi9A:
undetectable		 6ma7A-3fi9A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw7 UNCHARACTERIZED
PROTEIN YEDJ

(Escherichia
coli) 		PF01966
(HD) 		4 SER A 108
ALA A  77
THR A  81
ALA A  54
 None
 0.94A 6ma7A-3gw7A:
undetectable		 6ma7A-3gw7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE

(Arabidopsis
thaliana) 		PF05724
(TPMT) 		4 SER A 111
ALA A  85
ILE A  56
ALA A  52
 None
 0.86A 6ma7A-3lccA:
undetectable		 6ma7A-3lccA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		4 ALA A 150
THR A 154
ILE A 114
ALA A 112
 None
 0.99A 6ma7A-3m62A:
undetectable		 6ma7A-3m62A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 2
ALLOPHANATE
HYDROLASE SUBUNIT 1

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 SER B 173
ALA B 129
ILE A 140
ALA A 139
 None
 0.88A 6ma7A-3mmlB:
undetectable		 6ma7A-3mmlB:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A  34
ALA A 340
ILE A 324
ALA A 320
 None
 0.90A 6ma7A-3mwcA:
undetectable		 6ma7A-3mwcA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB

(Thermus
thermophilus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A  16
ALA A  20
ILE A  13
ALA A  14
 HP7  A 312 ( 3.6A)
None
NAD  A 311 (-4.0A)
None
 0.99A 6ma7A-3oa0A:
undetectable		 6ma7A-3oa0A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A  16
ALA A  20
ILE A  13
ALA A  14
 None
None
NAD  A 317 (-3.8A)
None
 0.99A 6ma7A-3oa2A:
undetectable		 6ma7A-3oa2A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 ARG A 255
ALA A 202
THR A 206
ILE A 247
 A  B1531 ( 3.3A)
None
A  B1531 ( 4.7A)
A  B1531 ( 4.1A)
 0.87A 6ma7A-3r9wA:
undetectable		 6ma7A-3r9wA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 SER A 531
ARG A 571
ILE A 560
ALA A 559
 None
 0.86A 6ma7A-3shwA:
undetectable		 6ma7A-3shwA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 252
ALA A 230
ILE A 247
ALA A 248
 None
 0.92A 6ma7A-3sjnA:
undetectable		 6ma7A-3sjnA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ARG A 238
ALA A 236
ILE A 211
ALA A 207
 None
 1.00A 6ma7A-3tm5A:
undetectable		 6ma7A-3tm5A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii) 		PF00497
(SBP_bac_3) 		4 SER A  91
ALA A  46
ILE A 232
ALA A 233
 None
 0.85A 6ma7A-3tqlA:
undetectable		 6ma7A-3tqlA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 ARG A 114
ALA A 115
ILE A  94
ALA A  90
 None
 0.96A 6ma7A-3tqoA:
undetectable		 6ma7A-3tqoA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A

(Burkholderia
thailandensis) 		PF06026
(Rib_5-P_isom_A) 		4 SER A  70
ALA A  48
ILE A  32
ALA A  57
 None
 0.97A 6ma7A-3u7jA:
undetectable		 6ma7A-3u7jA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		4 ARG A  17
ALA A  15
ILE A  24
ALA A 334
 None
 0.98A 6ma7A-3upyA:
undetectable		 6ma7A-3upyA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		4 SER A 225
ALA A 411
ILE A 179
ALA A 176
 None
 0.94A 6ma7A-3zm8A:
undetectable		 6ma7A-3zm8A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 SER A 304
ALA A 374
ILE A 367
ALA A 366
 None
 0.76A 6ma7A-4c60A:
undetectable		 6ma7A-4c60A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgw RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3

(Homo sapiens) 		PF13181
(TPR_8) 		4 ARG A 356
ALA A 354
ILE A 343
ALA A 342
 None
 0.90A 6ma7A-4cgwA:
undetectable		 6ma7A-4cgwA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Burkholderia
thailandensis) 		PF01370
(Epimerase) 		4 ARG A 165
ALA A 114
ILE A 119
ALA A 118
 None
NAP  A 401 (-3.5A)
None
None
 0.77A 6ma7A-4ej0A:
undetectable		 6ma7A-4ej0A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00202
(Aminotran_3) 		4 ARG A 366
ALA A 383
ILE A 363
ALA A 364
 None
 0.96A 6ma7A-4grxA:
undetectable		 6ma7A-4grxA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 SER A 308
ALA A 305
ILE A 288
ALA A 285
 None
 0.93A 6ma7A-4jsoA:
undetectable		 6ma7A-4jsoA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 ALA A  14
THR A  12
ILE A 385
ALA A 386
 ALA  A  14 ( 0.0A)
THR  A  12 ( 0.8A)
ILE  A 385 ( 0.7A)
ALA  A 386 ( 0.0A)
 0.99A 6ma7A-4kqnA:
undetectable		 6ma7A-4kqnA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 SER A 625
ARG A 617
ILE A 557
ALA A 559
 None
 1.00A 6ma7A-4ktpA:
undetectable		 6ma7A-4ktpA:
7.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 105
SER A 119
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 3.1A)
 0.47A 6ma7A-4ny4A:
57.6		 6ma7A-4ny4A:
97.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5m ISOVALERYL-COA
DEHYDROGENASE

(Brucella suis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  13
ALA A  11
ILE A  71
ALA A  72
 None
 0.62A 6ma7A-4o5mA:
undetectable		 6ma7A-4o5mA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		4 ARG A 241
ALA A 220
ILE A 259
ALA A 260
 None
 0.89A 6ma7A-4ow2A:
undetectable		 6ma7A-4ow2A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		4 ARG A 421
ALA A 400
ILE A 439
ALA A 440
 None
 0.76A 6ma7A-4ow2A:
undetectable		 6ma7A-4ow2A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		4 ALA A 400
THR A 404
ILE A 144
ALA A 145
 None
 0.93A 6ma7A-4pj1A:
1.6		 6ma7A-4pj1A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py5 RIBONUCLEASE

(Thermovibrio
ammonificans) 		PF01351
(RNase_HII) 		4 ARG A  34
ALA A  20
ILE A  39
ALA A  38
 None
None
U  B  17 ( 4.6A)
None
 0.82A 6ma7A-4py5A:
undetectable		 6ma7A-4py5A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 ARG A 191
ARG A 197
ALA A 114
ILE A 179
 None
OGA  A 301 (-3.0A)
None
None
 0.95A 6ma7A-4qkfA:
undetectable		 6ma7A-4qkfA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgl FILAMENTATION
INDUCED BY CAMP
PROTEIN FIC

(Desulfovibrio
alaskensis) 		PF02661
(Fic) 		4 ARG A  50
ARG A 193
ILE A  58
ALA A  54
 None
 0.76A 6ma7A-4rglA:
undetectable		 6ma7A-4rglA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 ALA A 241
THR A 245
ILE A 287
ALA A 288
 HEM  A 501 ( 3.8A)
HEM  A 501 ( 3.3A)
None
HEM  A 501 ( 3.7A)
 0.84A 6ma7A-4ubsA:
28.1		 6ma7A-4ubsA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 SER A 101
ARG A  93
ILE A 309
ALA A 310
 None
 0.92A 6ma7A-4w87A:
undetectable		 6ma7A-4w87A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0u OPLOPHORUS-LUCIFERIN
2-MONOOXYGENASE
CATALYTIC SUBUNIT

(Oplophorus
gracilirostris) 		no annotation 4 SER A  47
THR A 103
ILE A 117
ALA A 118
 None
 0.83A 6ma7A-5b0uA:
undetectable		 6ma7A-5b0uA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvc SERINE RACEMASE

(Zea mays) 		PF00291
(PALP) 		4 ARG A  24
ALA A  26
ILE A  20
ALA A 204
 None
 0.95A 6ma7A-5cvcA:
undetectable		 6ma7A-5cvcA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da8 60 KDA CHAPERONIN

(Chlorobaculum
tepidum) 		PF00118
(Cpn60_TCP1) 		4 ALA A 399
THR A 403
ILE A 144
ALA A 145
 None
 0.93A 6ma7A-5da8A:
undetectable		 6ma7A-5da8A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elh RING FINGER PROTEIN
UNKEMPT HOMOLOG

(Mus musculus) 		no annotation 4 ARG A  71
SER A  74
THR A 127
ALA A 148
 None
 0.95A 6ma7A-5elhA:
undetectable		 6ma7A-5elhA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 SER A 103
THR A 240
ILE A 243
ALA A 218
 COI  A 601 (-2.4A)
None
None
COI  A 601 ( 4.3A)
 0.81A 6ma7A-5ereA:
undetectable		 6ma7A-5ereA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fus PUTATIVE ENOYL COA
HYDRATASE

(Burkholderia
cenocepacia) 		PF00378
(ECH_1) 		4 ALA A 212
THR A 216
ILE A 125
ALA A 126
 None
 0.84A 6ma7A-5fusA:
undetectable		 6ma7A-5fusA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 SER B1274
ALA B1263
THR B1371
ALA B1356
 None
 1.00A 6ma7A-5gztB:
undetectable		 6ma7A-5gztB:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 SER A1274
ALA A1263
THR A1371
ALA A1356
 None
 0.97A 6ma7A-5gzuA:
undetectable		 6ma7A-5gzuA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibo OPLOPHORUS-LUCIFERIN
2-MONOOXYGENASE
CATALYTIC SUBUNIT

(Oplophorus
gracilirostris) 		no annotation 4 SER A  47
THR A 103
ILE A 117
ALA A 118
 None
 0.86A 6ma7A-5iboA:
undetectable		 6ma7A-5iboA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5p DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ARG A 386
ALA A 388
ILE A 383
ALA A 382
 None
 0.97A 6ma7A-5j5pA:
undetectable		 6ma7A-5j5pA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnq PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

([Clostridium]
bolteae) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 ALA A   8
THR A  65
ILE A  15
ALA A  14
 None
 0.96A 6ma7A-5jnqA:
undetectable		 6ma7A-5jnqA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		4 ARG A 278
THR A 381
ILE A 437
ALA A 436
 FMN  A 901 (-2.9A)
FMN  A 901 (-4.6A)
FMN  A 901 (-4.7A)
FMN  A 901 (-3.5A)
 0.92A 6ma7A-5lq4A:
undetectable		 6ma7A-5lq4A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		4 ARG A 442
ALA A 408
THR A 412
ILE A 390
 None
 0.99A 6ma7A-5lrbA:
undetectable		 6ma7A-5lrbA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw0 BASIC
HELIX-LOOP-HELIX,
PUTATIVE, EXPRESSED

(Oryza sativa) 		PF01661
(Macro) 		4 SER A 109
ALA A 283
ILE A 254
ALA A 191
 AR6  A 301 (-4.2A)
None
None
None
 0.91A 6ma7A-5lw0A:
undetectable		 6ma7A-5lw0A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm8 SERINE PROTEASE SPLE

(Staphylococcus
aureus) 		no annotation 4 SER A 115
ALA A 158
ILE A 104
ALA A 105
 None
 0.97A 6ma7A-5mm8A:
undetectable		 6ma7A-5mm8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		4 SER A 256
ALA A 149
ILE A 155
ALA A 156
 None
 0.96A 6ma7A-5mscA:
undetectable		 6ma7A-5mscA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 ALA A 578
THR A 582
ILE A 594
ALA A 595
 None
 0.89A 6ma7A-5te1A:
undetectable		 6ma7A-5te1A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 ALA B 578
THR B 582
ILE B 594
ALA B 595
 None
 0.90A 6ma7A-5tetB:
undetectable		 6ma7A-5tetB:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr0 SEED LINOLEATE
13S-LIPOXYGENASE-1

(Glycine max) 		no annotation 4 ALA A 542
THR A 259
ILE A 753
ALA A 754
 None
 0.68A 6ma7A-5tr0A:
undetectable		 6ma7A-5tr0A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urb METHIONINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 ARG A 393
ALA A 391
ILE A 453
ALA A 449
 None
 0.89A 6ma7A-5urbA:
undetectable		 6ma7A-5urbA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		4 ARG A  49
ALA A  36
ILE A  89
ALA A  90
 None
 0.99A 6ma7A-5uxbA:
undetectable		 6ma7A-5uxbA:
14.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 ARG A 105
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 (-2.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.70A 6ma7A-5veuA:
52.0		 6ma7A-5veuA:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 ARG A 105
SER A 119
THR A 309
ALA A 370
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.66A 6ma7A-5veuA:
52.0		 6ma7A-5veuA:
76.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11

(Homo sapiens) 		no annotation 4 ALA X 276
THR X 284
ILE X 248
ALA X 247
 None
 1.00A 6ma7A-5vfrX:
undetectable		 6ma7A-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		no annotation 4 ALA A 466
THR A 451
ILE A 461
ALA A 463
 None
 0.83A 6ma7A-5xexA:
undetectable		 6ma7A-5xexA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S14

(Trichomonas
vaginalis) 		PF00411
(Ribosomal_S11) 		4 SER O 122
ALA O  86
ILE O  68
ALA O  69
 None
 0.96A 6ma7A-5xyiO:
undetectable		 6ma7A-5xyiO:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjj POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
epidermidis) 		no annotation 4 ALA A 466
THR A 451
ILE A 461
ALA A 463
 None
 0.77A 6ma7A-5yjjA:
undetectable		 6ma7A-5yjjA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0d AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Paraburkholderia
phymatum) 		no annotation 4 SER A  69
ALA A  75
ILE A 408
ALA A 405
 None
 0.93A 6ma7A-6c0dA:
undetectable		 6ma7A-6c0dA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdt -

(-) 		no annotation 4 ARG A 356
ALA A 354
ILE A 343
ALA A 342
 None
 0.94A 6ma7A-6fdtA:
undetectable		 6ma7A-6fdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gxz -

(-) 		no annotation 4 ARG A 356
ALA A 354
ILE A 343
ALA A 342
 None
 0.86A 6ma7A-6gxzA:
undetectable		 6ma7A-6gxzA:
undetectable