SIMILAR PATTERNS OF AMINO ACIDS FOR 6MA6_A_MYTA603

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 ARG A 401
ALA A  39
THR A  41
ALA A  16
 None
 1.08A 6ma6A-1csjA:
0.0		 6ma6A-1csjA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 SER A 729
ARG A 540
THR A 633
ALA A 742
 None
 1.08A 6ma6A-1e4oA:
0.0		 6ma6A-1e4oA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 4 ARG B 355
SER B 954
ALA B 957
ALA B 936
 None
 1.15A 6ma6A-1ej6B:
0.0		 6ma6A-1ej6B:
4.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 SER A 595
ALA A 507
THR A 368
ALA A 530
 None
 1.03A 6ma6A-1itzA:
undetectable		 6ma6A-1itzA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldi GLYCEROL UPTAKE
FACILITATOR PROTEIN

(Escherichia
coli) 		PF00230
(MIP) 		4 ARG A 206
SER A 136
ALA A 214
ALA A 100
 None
 1.15A 6ma6A-1ldiA:
2.3		 6ma6A-1ldiA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m41 FMNH2-DEPENDENT
ALKANESULFONATE
MONOOXYGENASE

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		4 ARG A 101
SER A  98
ALA A  62
ALA A  35
 None
 1.16A 6ma6A-1m41A:
0.0		 6ma6A-1m41A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Neisseria
meningitidis) 		PF02548
(Pantoate_transf) 		4 SER A 194
ALA A 173
THR A 122
ALA A 167
 None
 1.07A 6ma6A-1o66A:
0.0		 6ma6A-1o66A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyz HYPOTHETICAL PROTEIN
YIBA

(Escherichia
coli) 		PF13646
(HEAT_2) 		4 ARG A 145
SER A 141
ALA A 109
ALA A 149
 None
 1.16A 6ma6A-1oyzA:
0.0		 6ma6A-1oyzA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
mansoni) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ARG A  16
ALA A  75
THR A  23
ALA A 165
 GSH  A 301 (-4.2A)
None
None
None
 1.14A 6ma6A-1u3iA:
0.0		 6ma6A-1u3iA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		4 SER A 313
ALA A 182
THR A 186
ALA A 255
 None
 0.88A 6ma6A-1un9A:
undetectable		 6ma6A-1un9A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		4 ARG A 162
ALA A 169
THR A 172
ALA A 206
 None
 1.14A 6ma6A-1uuoA:
undetectable		 6ma6A-1uuoA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		4 ARG A  55
ALA A   7
THR A 135
ALA A 112
 None
 1.05A 6ma6A-1v19A:
undetectable		 6ma6A-1v19A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2a GLUTATHIONE
TRANSFERASE GST1-6

(Anopheles dirus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ARG A 185
ALA A 199
THR A 202
ALA A 163
 None
 1.02A 6ma6A-1v2aA:
undetectable		 6ma6A-1v2aA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 SER B 226
ALA B 235
THR B 238
ALA B 193
 None
 1.09A 6ma6A-1wa5B:
undetectable		 6ma6A-1wa5B:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhd PUTATIVE
ACETYLTRANSFERASE/AC
YLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 SER A 118
ALA A 132
THR A 130
ALA A  94
 None
 1.01A 6ma6A-1xhdA:
undetectable		 6ma6A-1xhdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 114
ALA A 352
THR A 322
ALA A  45
 None
 0.99A 6ma6A-2akzA:
undetectable		 6ma6A-2akzA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		4 ARG A 197
SER A 178
ARG A 149
THR A  90
 None
 1.12A 6ma6A-2ffuA:
undetectable		 6ma6A-2ffuA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H   7
ALA H 214
THR H 116
ALA H  12
 None
 0.99A 6ma6A-2g60H:
undetectable		 6ma6A-2g60H:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ARG A  69
SER A 100
ALA A  64
ALA A 448
 None
 1.14A 6ma6A-2ihtA:
undetectable		 6ma6A-2ihtA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy0 RAN
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF07834
(RanGAP1_C) 		4 SER C 477
ALA C 472
THR C 461
ALA C 496
 None
 1.04A 6ma6A-2iy0C:
undetectable		 6ma6A-2iy0C:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j63 AP-ENDONUCLEASE

(Leishmania
major) 		PF03372
(Exo_endo_phos) 		4 ARG A 418
SER A 416
ALA A 271
ALA A 313
 None
 1.19A 6ma6A-2j63A:
undetectable		 6ma6A-2j63A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00120
(Gln-synt_C) 		4 ARG A 210
ALA A  77
THR A  84
ALA A  81
 None
 1.13A 6ma6A-2j9iA:
undetectable		 6ma6A-2j9iA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwm PUTATIVE TRP
REPRESSOR BINDING
PROTEIN

(Lactobacillus
acidophilus) 		PF12682
(Flavodoxin_4) 		4 SER A  14
ALA A  45
THR A  50
ALA A  92
 None
 1.03A 6ma6A-2mwmA:
undetectable		 6ma6A-2mwmA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 ARG A  67
SER A  63
ALA A 274
ALA A  71
 None
 0.96A 6ma6A-2o0rA:
undetectable		 6ma6A-2o0rA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN

(Haemophilus
influenzae) 		PF01547
(SBP_bac_1) 		4 ARG A 103
SER A 102
ALA A 285
ALA A 148
 None
 0.89A 6ma6A-2o69A:
undetectable		 6ma6A-2o69A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 SER A 151
ALA A 157
THR A 161
ALA A 186
 NAP  A1400 (-3.7A)
None
None
None
 1.13A 6ma6A-2obyA:
undetectable		 6ma6A-2obyA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		4 ARG B  37
SER B  34
THR B 372
ALA B 470
 None
 1.13A 6ma6A-2odrB:
undetectable		 6ma6A-2odrB:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 113
ALA A 353
THR A 323
ALA A  46
 None
 0.95A 6ma6A-2ptzA:
undetectable		 6ma6A-2ptzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 ARG A 337
ALA A 334
THR A 339
ALA A 369
 None
 1.05A 6ma6A-2vfvA:
undetectable		 6ma6A-2vfvA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 SER A 387
ARG A 579
ALA A 484
ALA A 559
 None
 1.19A 6ma6A-2wpgA:
undetectable		 6ma6A-2wpgA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 SER A 414
ALA A 419
THR A 446
ALA A 355
 None
 1.11A 6ma6A-2wpgA:
undetectable		 6ma6A-2wpgA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		4 SER A 486
ALA A 459
THR A 462
ALA A 424
 None
 0.79A 6ma6A-2x24A:
undetectable		 6ma6A-2x24A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 ARG A 149
SER A 694
THR A 730
ALA A 706
 None
 1.18A 6ma6A-2xzlA:
undetectable		 6ma6A-2xzlA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y89 PHOSPHORIBOSYL
ISOMERASE A

(Mycobacterium
tuberculosis) 		PF00977
(His_biosynth) 		4 ARG A  60
ARG A  85
THR A 105
ALA A  57
 None
SO4  A1246 (-4.1A)
SO4  A1246 (-3.0A)
SO4  A1246 ( 3.9A)
 1.16A 6ma6A-2y89A:
undetectable		 6ma6A-2y89A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqy HYPOTHETICAL PROTEIN
TTHA0303

(Thermus
thermophilus) 		PF12867
(DinB_2) 		4 SER A  20
ALA A 152
THR A  61
ALA A 116
 None
 1.16A 6ma6A-2yqyA:
undetectable		 6ma6A-2yqyA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 SER A 413
ALA A 418
THR A 445
ALA A 354
 None
 1.09A 6ma6A-3czeA:
undetectable		 6ma6A-3czeA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A  84
SER A  80
THR A  50
ALA A  88
 None
 1.18A 6ma6A-3dipA:
undetectable		 6ma6A-3dipA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyj TALIN-1

(Mus musculus) 		no annotation 4 SER A2273
ALA A2189
THR A2204
ALA A2211
 None
 1.18A 6ma6A-3dyjA:
undetectable		 6ma6A-3dyjA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fm0 PROTEIN CIAO1

(Homo sapiens) 		PF00400
(WD40) 		4 SER A  70
ALA A  77
THR A  85
ALA A 121
 None
 1.15A 6ma6A-3fm0A:
undetectable		 6ma6A-3fm0A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw7 UNCHARACTERIZED
PROTEIN YEDJ

(Escherichia
coli) 		PF01966
(HD) 		4 SER A 108
ALA A  77
THR A  81
ALA A  54
 None
 0.94A 6ma6A-3gw7A:
undetectable		 6ma6A-3gw7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		4 ARG A 181
SER A  93
ALA A 108
ALA A 184
 None
 1.18A 6ma6A-3gzgA:
undetectable		 6ma6A-3gzgA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h90 FERROUS-IRON EFFLUX
PUMP FIEF

(Escherichia
coli) 		PF01545
(Cation_efflux)
PF16916
(ZT_dimer) 		4 ARG A  11
ALA A  13
THR A 142
ALA A 146
 None
 1.12A 6ma6A-3h90A:
undetectable		 6ma6A-3h90A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		4 ARG A 210
SER A 207
THR A   5
ALA A 433
 None
 0.80A 6ma6A-3hd6A:
0.8		 6ma6A-3hd6A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ARG B 427
ALA B 707
THR B 705
ALA B 652
 None
 1.14A 6ma6A-3hkzB:
undetectable		 6ma6A-3hkzB:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		4 SER A  91
ALA A 105
THR A 108
ALA A  86
 None
 1.17A 6ma6A-3hl0A:
undetectable		 6ma6A-3hl0A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ARG A 136
ALA A 394
THR A 398
ALA A 130
 None
 1.02A 6ma6A-3kfuA:
undetectable		 6ma6A-3kfuA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt0 UNCHARACTERIZED
PROTEIN PA1789

(Pseudomonas
aeruginosa) 		PF00582
(Usp) 		4 ARG A  23
ALA A  20
THR A 123
ALA A 126
 CL  A 288 (-4.1A)
None
None
None
 0.82A 6ma6A-3mt0A:
undetectable		 6ma6A-3mt0A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 120
ALA A 365
THR A 335
ALA A  47
 None
 1.05A 6ma6A-3otrA:
undetectable		 6ma6A-3otrA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue6 AUREOCHROME1

(Vaucheria
frigida) 		PF13426
(PAS_9) 		4 ARG A 304
ALA A 224
THR A 222
ALA A 301
 None
None
FMN  A 500 (-3.4A)
None
 1.13A 6ma6A-3ue6A:
undetectable		 6ma6A-3ue6A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnp HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00132
(Hexapep) 		4 SER A 118
ALA A 132
THR A 130
ALA A  94
 None
 1.00A 6ma6A-3vnpA:
undetectable		 6ma6A-3vnpA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		4 SER A  70
ARG A 220
ALA A 217
ALA A  54
 None
 1.10A 6ma6A-3wgcA:
undetectable		 6ma6A-3wgcA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 ARG A 220
ARG A 250
ALA A 245
THR A 294
 None
 1.10A 6ma6A-3zq4A:
undetectable		 6ma6A-3zq4A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		4 SER A 133
ARG A 176
ALA A 177
ALA A  52
 None
EDO  A1392 (-3.7A)
EDO  A1392 (-3.3A)
None
 1.11A 6ma6A-4akkA:
1.6		 6ma6A-4akkA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ARG A 397
ALA A 443
THR A 405
ALA A 400
 None
 1.01A 6ma6A-4b18A:
undetectable		 6ma6A-4b18A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		4 ARG A 238
ALA A 266
THR A 374
ALA A 219
 None
 1.12A 6ma6A-4binA:
undetectable		 6ma6A-4binA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgk SECRETED 45 KDA
PROTEIN

(Streptococcus
pneumoniae) 		PF05257
(CHAP) 		4 ARG A 242
ALA A 188
THR A 191
ALA A 236
 None
 1.02A 6ma6A-4cgkA:
2.4		 6ma6A-4cgkA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0a PROTEIN WNT-8

(Xenopus laevis) 		PF00110
(wnt) 		4 SER B 144
ALA B  48
THR B  70
ALA B  74
 None
 1.16A 6ma6A-4f0aB:
undetectable		 6ma6A-4f0aB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 113
ALA A 353
THR A 323
ALA A  46
 None
 1.11A 6ma6A-4g7fA:
undetectable		 6ma6A-4g7fA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 ARG A 106
SER A 122
ALA A 317
THR A 321
 HEM  A 601 (-2.7A)
HEM  A 601 (-3.4A)
BHF  A 602 ( 3.4A)
HEM  A 601 (-3.4A)
 1.14A 6ma6A-4i8vA:
34.2		 6ma6A-4i8vA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 SER A  52
ALA A 147
THR A 150
ALA A 108
 None
None
None
EDO  A 405 (-3.5A)
 1.15A 6ma6A-4idaA:
undetectable		 6ma6A-4idaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irv CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
APOPTOSIS-STIMULATIN
G OF P53 PROTEIN 2

(Helicobacter
pylori;
Homo sapiens) 		no annotation
no annotation 		4 SER A 110
ALA A 168
THR A 126
ALA E 760
 None
 1.06A 6ma6A-4irvA:
undetectable		 6ma6A-4irvA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 252
ARG A 301
ALA A 300
ALA A 260
 None
 1.10A 6ma6A-4ktoA:
undetectable		 6ma6A-4ktoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		4 ARG A  18
ARG A  51
ALA A  47
ALA A  16
 None
 1.18A 6ma6A-4m8sA:
undetectable		 6ma6A-4m8sA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)

(Paraburkholderia
xenovorans) 		PF02441
(Flavoprotein) 		4 SER A  32
ALA A  97
THR A 101
ALA A  50
 None
None
SO4  A 201 (-3.8A)
None
 1.15A 6ma6A-4mwgA:
undetectable		 6ma6A-4mwgA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt1 ACCELERATED-CELL-DEA
TH 11

(Arabidopsis
thaliana) 		PF08718
(GLTP) 		4 SER A  37
ARG A  70
ALA A  71
ALA A  63
 None
None
None
KCX  A  64 ( 3.2A)
 1.13A 6ma6A-4nt1A:
undetectable		 6ma6A-4nt1A:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 105
SER A 119
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 3.1A)
 0.38A 6ma6A-4ny4A:
57.9		 6ma6A-4ny4A:
97.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 ARG A 103
SER A 100
ALA A  84
THR A 282
 None
 1.12A 6ma6A-4otkA:
undetectable		 6ma6A-4otkA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		4 ARG A 127
ALA A 128
THR A 158
ALA A  43
 None
PC  A 301 ( 3.8A)
None
None
 1.06A 6ma6A-4r6wA:
undetectable		 6ma6A-4r6wA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2x IMPORTIN SUBUNIT
ALPHA-6

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ARG D 398
ALA D 444
THR D 406
ALA D 401
 None
 1.03A 6ma6A-4u2xD:
undetectable		 6ma6A-4u2xD:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ARG A 395
ALA A 441
THR A 403
ALA A 398
 None
 0.97A 6ma6A-4uadA:
undetectable		 6ma6A-4uadA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwr LARGE PROLINE-RICH
PROTEIN BAG6
UBIQUITIN-LIKE
PROTEIN 4A

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ARG B 125
SER B 126
ALA A1060
ALA A1067
 None
 1.13A 6ma6A-4wwrB:
undetectable		 6ma6A-4wwrB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		4 SER A 278
ARG A 228
ALA A 227
ALA A  72
 NAP  A 401 (-3.0A)
SO4  A 402 ( 2.8A)
None
NAP  A 401 ( 3.9A)
 1.18A 6ma6A-4zqbA:
undetectable		 6ma6A-4zqbA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		4 ARG A 146
SER A 145
ALA A 244
ALA A 118
 PO4  A 401 (-3.7A)
PO4  A 401 (-2.6A)
None
None
 1.02A 6ma6A-5b04A:
undetectable		 6ma6A-5b04A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		4 SER A  71
ALA A  74
THR A  97
ALA A  93
 None
 1.17A 6ma6A-5b48A:
undetectable		 6ma6A-5b48A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE

(Escherichia
coli) 		PF00128
(Alpha-amylase) 		4 ARG A 379
ALA A 355
THR A 358
ALA A 384
 None
 1.15A 6ma6A-5bn7A:
undetectable		 6ma6A-5bn7A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eq6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILM

(Pseudomonas
aeruginosa) 		PF11104
(PilM_2) 		4 SER A  19
ALA A 202
THR A 297
ALA A 341
 ANP  A 401 (-2.7A)
ANP  A 401 (-3.2A)
ANP  A 401 (-4.1A)
ANP  A 401 ( 4.0A)
 1.00A 6ma6A-5eq6A:
undetectable		 6ma6A-5eq6A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5n MONOOXYGENASE

(Micromonospora
sp. TP-A0468) 		PF05368
(NmrA) 		4 SER A  77
ALA A 101
THR A 104
ALA A  68
 None
 0.96A 6ma6A-5f5nA:
undetectable		 6ma6A-5f5nA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		4 ARG A 116
SER A 327
THR A 152
ALA A 124
 None
 1.12A 6ma6A-5g0aA:
undetectable		 6ma6A-5g0aA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 SER A1274
ALA A1263
THR A1371
ALA A1356
 None
 1.16A 6ma6A-5gzuA:
undetectable		 6ma6A-5gzuA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		4 SER A 189
ARG A 269
ALA A 229
ALA A 155
 None
 0.94A 6ma6A-5igpA:
undetectable		 6ma6A-5igpA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 SER A 355
ARG A 325
ALA A 363
THR A 365
 None
 1.12A 6ma6A-5im3A:
undetectable		 6ma6A-5im3A:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		4 SER C 150
ALA C 162
THR C 166
ALA C 239
 None
 1.11A 6ma6A-5iy5C:
undetectable		 6ma6A-5iy5C:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 ARG b 404
ARG b 448
THR b 412
ALA b 407
 None
 1.17A 6ma6A-5l9wb:
undetectable		 6ma6A-5l9wb:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		4 SER J  39
ALA J  80
THR J  84
ALA J  57
 None
 1.16A 6ma6A-5m32J:
undetectable		 6ma6A-5m32J:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgy FAD:PROTEIN FMN
TRANSFERASE

(Pseudomonas
stutzeri) 		no annotation 4 ARG H 257
ALA H 231
THR H 334
ALA H 284
 None
 1.18A 6ma6A-5mgyH:
undetectable		 6ma6A-5mgyH:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 4 ARG A 193
SER A 189
THR A 160
ALA A 197
 None
 1.11A 6ma6A-5ndxA:
undetectable		 6ma6A-5ndxA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		5 ARG F 288
SER F 293
ARG F 331
ALA F 330
ALA F 438
 None
 1.41A 6ma6A-5odrF:
undetectable		 6ma6A-5odrF:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oms CYTOCHROME P450

(Amycolatopsis
sp. ATCC 39116) 		no annotation 4 ARG A  73
ALA A  70
THR A  74
ALA A 187
 None
 1.01A 6ma6A-5omsA:
27.9		 6ma6A-5omsA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		4 SER C1180
ARG C1084
THR C1058
ALA C1272
 None
None
None
PGE  C1601 ( 4.4A)
 0.99A 6ma6A-5swvC:
undetectable		 6ma6A-5swvC:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		4 ARG A 131
SER A 128
ALA A  92
ALA A  44
 None
 1.17A 6ma6A-5tlcA:
undetectable		 6ma6A-5tlcA:
9.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 5 ARG A 105
SER A 119
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.75A 6ma6A-5veuA:
52.3		 6ma6A-5veuA:
76.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA

(Neurospora
crassa) 		no annotation 4 SER B 220
ALA B 229
THR B 232
ALA B 186
 None
 1.09A 6ma6A-5vqiB:
undetectable		 6ma6A-5vqiB:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 4 SER A 402
ALA A 430
THR A 433
ALA A 397
 None
 1.17A 6ma6A-5w1eA:
undetectable		 6ma6A-5w1eA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		4 SER A 219
ARG A 405
THR A 413
ALA A 213
 None
 1.07A 6ma6A-5w1uA:
undetectable		 6ma6A-5w1uA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 4 ARG A 709
SER A 705
THR A 965
ALA A 713
 None
 1.11A 6ma6A-5wblA:
undetectable		 6ma6A-5wblA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		4 ARG A 503
ALA A 388
THR A 414
ALA A 450
 None
 1.01A 6ma6A-5wx1A:
undetectable		 6ma6A-5wx1A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		4 ARG A 153
ALA A 246
THR A 212
ALA A 156
 None
 1.12A 6ma6A-5xa5A:
2.9		 6ma6A-5xa5A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases) 		4 ARG D 309
ARG D 353
ALA D 352
ALA D 458
 None
 1.13A 6ma6A-5xfaD:
undetectable		 6ma6A-5xfaD:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD

(Bacillus
thuringiensis) 		no annotation 4 SER A 164
ALA A 144
THR A 140
ALA A 129
 None
None
None
UD1  A 402 (-3.6A)
 1.17A 6ma6A-6bwcA:
undetectable		 6ma6A-6bwcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gi2 FERRIC ENTEROBACTIN
ESTERASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 176
ALA A 175
THR A 152
ALA A 274
 None
 1.18A 6ma6A-6gi2A:
undetectable		 6ma6A-6gi2A:
18.60