SIMILAR PATTERNS OF AMINO ACIDS FOR 6JNH_A_ASCA202_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b04 PROTEIN (DNA LIGASE)

(Geobacillus
stearothermophilus) 		PF01653
(DNA_ligase_aden) 		3 ASN A  18
PRO A  60
GLN A  62
 None
 0.92A 6jnhA-1b04A:
undetectable		 6jnhA-1b04A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		3 ASN A 174
PRO A 179
GLN A   5
 None
 0.88A 6jnhA-1cs1A:
0.0		 6jnhA-1cs1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		3 ASN A 376
PRO A 282
GLN A 284
 None
 0.70A 6jnhA-1fbwA:
undetectable		 6jnhA-1fbwA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		3 ASN A1282
PRO A1245
GLN A1247
 None
 0.92A 6jnhA-1fdjA:
0.9		 6jnhA-1fdjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		3 ASN A 336
PRO A 367
GLN A 353
 None
 0.94A 6jnhA-1h3gA:
0.0		 6jnhA-1h3gA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		3 ASN A 298
PRO A 297
GLN A 292
 None
 0.91A 6jnhA-1hqsA:
2.1		 6jnhA-1hqsA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		3 ASN A6001
PRO A5928
GLN A5929
 None
 0.94A 6jnhA-1koaA:
0.0		 6jnhA-1koaA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lba T7 LYSOZYME

(Escherichia
virus T7) 		PF01510
(Amidase_2) 		3 ASN A  94
PRO A  23
GLN A  25
 None
 0.75A 6jnhA-1lbaA:
1.0		 6jnhA-1lbaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk2 SMAD 3

(Homo sapiens) 		PF03166
(MH2) 		3 ASN A 344
PRO A 402
GLN A 404
 None
 0.87A 6jnhA-1mk2A:
0.0		 6jnhA-1mk2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		3 ASN A  63
PRO A  44
GLN A  17
 NAG  A 926 (-1.9A)
NAG  A 926 (-3.5A)
None
 0.84A 6jnhA-1qozA:
undetectable		 6jnhA-1qozA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		3 ASN A 232
PRO A 130
GLN A 132
 None
 0.92A 6jnhA-1r2fA:
undetectable		 6jnhA-1r2fA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		3 ASN A  30
PRO A 311
GLN A 294
 None
 0.93A 6jnhA-1r76A:
undetectable		 6jnhA-1r76A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwu HYPOTHETICAL UPF0250
PROTEIN YBED

(Escherichia
coli) 		PF04359
(DUF493) 		3 ASN A  63
PRO A  40
GLN A  36
 None
 0.87A 6jnhA-1rwuA:
undetectable		 6jnhA-1rwuA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		3 ASN A  42
PRO A 262
GLN A 266
 None
 0.85A 6jnhA-1u10A:
undetectable		 6jnhA-1u10A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		3 ASN A 298
PRO A 105
GLN A 103
 None
 0.83A 6jnhA-1wd3A:
undetectable		 6jnhA-1wd3A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csg PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07350
(DUF1479) 		3 ASN A 371
PRO A 366
GLN A 159
 None
 0.90A 6jnhA-2csgA:
undetectable		 6jnhA-2csgA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		3 ASN A 243
PRO A 128
GLN A  92
 None
 0.80A 6jnhA-2d7iA:
4.9		 6jnhA-2d7iA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbn HYPOTHETICAL PROTEIN
YBIU

(Escherichia
coli) 		PF07350
(DUF1479) 		3 ASN A 371
PRO A 366
GLN A 159
 None
 0.94A 6jnhA-2dbnA:
undetectable		 6jnhA-2dbnA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		3 ASN A 152
PRO A  88
GLN A  93
 None
 0.88A 6jnhA-2guuA:
undetectable		 6jnhA-2guuA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		3 ASN A 359
PRO A 321
GLN A 323
 None
 0.86A 6jnhA-2ilrA:
undetectable		 6jnhA-2ilrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9k RNA-BINDING PROTEIN
WITH MULTIPLE
SPLICING 2

(Homo sapiens) 		PF00076
(RRM_1) 		3 ASN A  97
PRO A  39
GLN A  68
 None
 0.87A 6jnhA-2m9kA:
undetectable		 6jnhA-2m9kA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqa CALPAIN 8

(Homo sapiens) 		PF00648
(Peptidase_C2) 		3 ASN A 174
PRO A  85
GLN A 132
 CSO  A  82 ( 4.7A)
CSO  A  82 ( 4.1A)
None
 0.93A 6jnhA-2nqaA:
undetectable		 6jnhA-2nqaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzk PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		3 ASN A  15
PRO A 169
GLN A 289
 None
 0.94A 6jnhA-2pzkA:
undetectable		 6jnhA-2pzkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		3 ASN A 112
PRO A 111
GLN A 109
 None
 0.95A 6jnhA-2x1cA:
undetectable		 6jnhA-2x1cA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygt DELTA TOXIN

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		3 ASN A 136
PRO A 111
GLN A 161
 None
None
ZN  A1292 ( 4.8A)
 0.90A 6jnhA-2ygtA:
undetectable		 6jnhA-2ygtA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z69 DNR PROTEIN

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding) 		3 ASN A 123
PRO A  19
GLN A  12
 None
 0.85A 6jnhA-2z69A:
undetectable		 6jnhA-2z69A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 ASN A 462
PRO A 497
GLN A 493
 None
 0.88A 6jnhA-3a24A:
1.5		 6jnhA-3a24A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axl VALPHA 10

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ASN A 188
PRO A 128
GLN A  14
 None
 0.93A 6jnhA-3axlA:
undetectable		 6jnhA-3axlA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		3 ASN A  71
PRO A  73
GLN A  74
 None
 0.83A 6jnhA-3b1bA:
undetectable		 6jnhA-3b1bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 ASN A 545
PRO A 224
GLN A 229
 None
 0.94A 6jnhA-3egwA:
undetectable		 6jnhA-3egwA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02820
(MBT) 		3 ASN A  53
PRO A 116
GLN A 120
 None
 0.58A 6jnhA-3feoA:
undetectable		 6jnhA-3feoA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		3 ASN A 157
PRO A 124
GLN A 126
 None
 0.84A 6jnhA-3gf7A:
undetectable		 6jnhA-3gf7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmj PROTEIN MOTHERS
AGAINST DPP

(Drosophila
melanogaster) 		no annotation 3 ASN D 375
PRO D 433
GLN D 435
 None
 0.76A 6jnhA-3gmjD:
undetectable		 6jnhA-3gmjD:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		3 ASN A 136
PRO A 144
GLN A 174
 None
 0.86A 6jnhA-3h0lA:
undetectable		 6jnhA-3h0lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijd UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF02219
(MTHFR) 		3 ASN A 145
PRO A 110
GLN A 114
 None
 0.92A 6jnhA-3ijdA:
undetectable		 6jnhA-3ijdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y ML43
ML50

(Homo sapiens;
Homo sapiens) 		no annotation
PF01281
(Ribosomal_L9_N) 		3 ASN h 151
PRO b  59
GLN b  24
 None
 0.88A 6jnhA-3j7yh:
undetectable		 6jnhA-3j7yh:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9t PUTATIVE PEPTIDASE

(Clostridium
acetobutylicum) 		PF09940
(DUF2172)
PF16221
(HTH_47)
PF16254
(DUF4910) 		3 ASN A 362
PRO A 367
GLN A 368
 None
 0.78A 6jnhA-3k9tA:
undetectable		 6jnhA-3k9tA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ASN A 112
PRO A 175
GLN A 260
 None
 0.95A 6jnhA-3ldrA:
undetectable		 6jnhA-3ldrA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 ASN B  20
PRO B  22
GLN B  23
 None
 0.78A 6jnhA-3ml0B:
undetectable		 6jnhA-3ml0B:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
ovatus) 		PF00877
(NLPC_P60) 		3 ASN A 322
PRO A  77
GLN A  75
 GOL  A 337 ( 4.1A)
None
None
 0.72A 6jnhA-3npfA:
undetectable		 6jnhA-3npfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2u NEDD8-CONJUGATING
ENZYME UBC12

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		3 ASN A1017
PRO A1023
GLN A1022
 None
 0.88A 6jnhA-3o2uA:
undetectable		 6jnhA-3o2uA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)

(Mycolicibacterium
thermoresistibile) 		PF13561
(adh_short_C2) 		3 ASN A  62
PRO A  61
GLN A  59
 None
 0.80A 6jnhA-3oecA:
3.8		 6jnhA-3oecA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 3 ASN B 238
PRO B 233
GLN B 231
 None
None
FAD  B 405 (-3.8A)
 0.86A 6jnhA-3ozvB:
4.0		 6jnhA-3ozvB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so5 LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 3

(Mus musculus) 		PF13927
(Ig_3) 		3 ASN A 585
PRO A 499
GLN A 500
 MLY  A 498 ( 3.9A)
MLY  A 498 ( 2.6A)
MLY  A 498 ( 4.0A)
 0.90A 6jnhA-3so5A:
undetectable		 6jnhA-3so5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis) 		PF12705
(PDDEXK_1) 		3 ASN B 610
PRO B 670
GLN B 316
 None
 0.94A 6jnhA-3u44B:
3.3		 6jnhA-3u44B:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1e FLAGELLA BASAL-BODY
PROTEIN

(Vibrio
alginolyticus) 		PF16538
(FlgT_C)
PF16539
(FlgT_M)
PF16548
(FlgT_N) 		3 ASN A 277
PRO A 338
GLN A 337
 None
 0.95A 6jnhA-3w1eA:
undetectable		 6jnhA-3w1eA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif PVIII

(Bovine
mastadenovirus
B) 		PF01310
(Adeno_PVIII) 		3 ASN R  52
PRO R   8
GLN R  25
 None
 0.80A 6jnhA-3zifR:
undetectable		 6jnhA-3zifR:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zn6 VP16

(Thermus virus
P23-77) 		no annotation 3 ASN B  53
PRO B 128
GLN B 126
 None
 0.86A 6jnhA-3zn6B:
undetectable		 6jnhA-3zn6B:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		3 ASN A 449
PRO A 300
GLN A 302
 None
 0.91A 6jnhA-4ag6A:
undetectable		 6jnhA-4ag6A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA

(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		PF01267
(F-actin_cap_A)
PF01115
(F_actin_cap_B) 		3 ASN A 199
PRO B  18
GLN B  20
 None
 0.91A 6jnhA-4akrA:
undetectable		 6jnhA-4akrA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 ASN A  64
PRO A 347
GLN A 349
 None
 0.91A 6jnhA-4eo4A:
undetectable		 6jnhA-4eo4A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		3 ASN A 281
PRO A 283
GLN A 284
 None
 0.83A 6jnhA-4fdhA:
undetectable		 6jnhA-4fdhA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6w N-TERMINAL
CYANOBACTIN PROTEASE

(Planktothrix
agardhii) 		PF00082
(Peptidase_S8) 		3 ASN A 147
PRO A 247
GLN A 238
 None
 0.90A 6jnhA-4h6wA:
undetectable		 6jnhA-4h6wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvl MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
thermoresistibile) 		PF00082
(Peptidase_S8) 		3 ASN A 230
PRO A 356
GLN A 358
 None
 0.90A 6jnhA-4hvlA:
undetectable		 6jnhA-4hvlA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuy SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE

(Acinetobacter
baumannii) 		PF00106
(adh_short) 		3 ASN A  92
PRO A 121
GLN A 123
 None
 0.89A 6jnhA-4iuyA:
2.9		 6jnhA-4iuyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ASN A3380
PRO A3445
GLN A3391
 None
 0.89A 6jnhA-4kc5A:
undetectable		 6jnhA-4kc5A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		3 ASN A 383
PRO A 301
GLN A 278
 None
 0.91A 6jnhA-4kg7A:
undetectable		 6jnhA-4kg7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		3 ASN A 152
PRO A 131
GLN A  74
 None
 0.83A 6jnhA-4m5pA:
undetectable		 6jnhA-4m5pA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		3 ASN A 976
PRO A 833
GLN A 834
 ATP  A1401 ( 4.8A)
ATP  A1401 ( 4.7A)
ATP  A1401 (-3.6A)
 0.91A 6jnhA-4n1aA:
undetectable		 6jnhA-4n1aA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3w CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		3 ASN A1163
PRO A1258
GLN A1259
 None
 0.78A 6jnhA-4n3wA:
undetectable		 6jnhA-4n3wA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		3 ASN A  31
PRO A  37
GLN A  85
 None
 0.93A 6jnhA-4pneA:
2.9		 6jnhA-4pneA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0k DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
thetaiotaomicron) 		PF00877
(NLPC_P60) 		3 ASN A 322
PRO A  77
GLN A  75
 GOL  A 403 (-3.6A)
EDO  A 406 ( 4.8A)
None
 0.71A 6jnhA-4r0kA:
undetectable		 6jnhA-4r0kA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN

(Zobellia
galactanivorans) 		no annotation 3 ASN A 218
PRO A 195
GLN A 181
 None
None
3DY  A 521 (-3.2A)
 0.59A 6jnhA-4u6dA:
undetectable		 6jnhA-4u6dA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		3 ASN A 256
PRO A 411
GLN A 409
 None
 0.95A 6jnhA-4uooA:
undetectable		 6jnhA-4uooA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5p CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		3 ASN A 247
PRO A 392
GLN A 393
 None
 0.89A 6jnhA-4z5pA:
undetectable		 6jnhA-4z5pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		3 ASN A  39
PRO A  50
GLN A  51
 C  C  29 ( 3.6A)
G  C  28 ( 4.4A)
None
 0.68A 6jnhA-4z7lA:
undetectable		 6jnhA-4z7lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		3 ASN A 729
PRO A 728
GLN A 666
 None
 0.88A 6jnhA-5a42A:
undetectable		 6jnhA-5a42A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btb AFR263CP

(Eremothecium
gossypii) 		PF08652
(RAI1) 		3 ASN A  42
PRO A 195
GLN A  70
 None
 0.93A 6jnhA-5btbA:
2.1		 6jnhA-5btbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Homo sapiens) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 ASN O  81
PRO O 153
GLN O 155
 NAD  O 501 (-2.9A)
None
None
 0.80A 6jnhA-5c7oO:
undetectable		 6jnhA-5c7oO:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e55 CONTACTIN-6

(Mus musculus) 		PF00041
(fn3) 		3 ASN A 883
PRO A 802
GLN A 803
 None
 0.92A 6jnhA-5e55A:
undetectable		 6jnhA-5e55A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		3 ASN A 301
PRO A  53
GLN A  51
 None
 0.84A 6jnhA-5fq6A:
undetectable		 6jnhA-5fq6A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		3 ASN A 237
PRO A 124
GLN A 250
 None
 0.95A 6jnhA-5fsaA:
undetectable		 6jnhA-5fsaA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		3 ASN A  59
PRO A  82
GLN A 122
 None
 0.79A 6jnhA-5g5nA:
undetectable		 6jnhA-5g5nA:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h16 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Acinetobacter
baumannii) 		PF01467
(CTP_transf_like) 		3 ASN A  17
PRO A 148
GLN A 149
 None
 0.27A 6jnhA-5h16A:
30.2		 6jnhA-5h16A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 ASN A 619
PRO A 418
GLN A 428
 None
 0.88A 6jnhA-5i4eA:
undetectable		 6jnhA-5i4eA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 ASN A 264
PRO A 298
GLN A 300
 None
 0.77A 6jnhA-5j9gA:
undetectable		 6jnhA-5j9gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		3 ASN A 343
PRO A  78
GLN A  80
 None
 0.80A 6jnhA-5jowA:
undetectable		 6jnhA-5jowA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k70 PROTEIN SIDEKICK-2

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 ASN A 364
PRO A 288
GLN A 289
 None
 0.90A 6jnhA-5k70A:
undetectable		 6jnhA-5k70A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE

(Acinetobacter
baumannii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 ASN A  21
PRO A  13
GLN A 207
 None
 0.95A 6jnhA-5khaA:
4.6		 6jnhA-5khaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		3 ASN A 237
PRO A 258
GLN A 294
 None
 0.92A 6jnhA-5kzsA:
undetectable		 6jnhA-5kzsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		3 ASN N 900
PRO N 876
GLN N 878
 None
 0.92A 6jnhA-5mpdN:
undetectable		 6jnhA-5mpdN:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomyces
pombe) 		PF08638
(Med14) 		3 ASN A 245
PRO A 227
GLN A 206
 None
 0.81A 6jnhA-5n9jA:
undetectable		 6jnhA-5n9jA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN
POL PROTEIN

(Feline
immunodeficiency
virus;
Feline
immunodeficiency
virus) 		no annotation
no annotation 		3 ASN B 135
PRO A  94
GLN A 268
 None
 0.86A 6jnhA-5ovnB:
undetectable		 6jnhA-5ovnB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 ASN A 311
PRO A 305
GLN A  86
 None
 0.84A 6jnhA-5uowA:
undetectable		 6jnhA-5uowA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v51 PR-1 PROTEIN

(Moniliophthora
perniciosa) 		PF00188
(CAP) 		3 ASN A  90
PRO A 117
GLN A 119
 None
None
SEY  A 201 (-4.9A)
 0.87A 6jnhA-5v51A:
undetectable		 6jnhA-5v51A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT

(Oryctolagus
cuniculus) 		no annotation 3 ASN B 329
PRO B 253
GLN B 252
 None
 0.82A 6jnhA-5w7aB:
undetectable		 6jnhA-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 3 ASN C 330
PRO C 254
GLN C 253
 None
 0.89A 6jnhA-5w7cC:
undetectable		 6jnhA-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 3 ASN A 329
PRO A 253
GLN A 252
 None
 0.95A 6jnhA-5w7dA:
undetectable		 6jnhA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
SUBUNIT B12.5

(Komagataella
phaffii) 		PF13656
(RNA_pol_L_2) 		3 ASN K  29
PRO K  83
GLN K  85
 None
 0.89A 6jnhA-5xogK:
undetectable		 6jnhA-5xogK:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0e -

(-) 		no annotation 3 ASN A 196
PRO A 188
GLN A 186
 None
 0.82A 6jnhA-5y0eA:
undetectable		 6jnhA-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 3 ASN A 331
PRO A  58
GLN A  60
 None
 0.78A 6jnhA-5z5dA:
undetectable		 6jnhA-5z5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 ASN A 352
PRO A 357
GLN A 358
 None
 0.80A 6jnhA-5zqzA:
4.3		 6jnhA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 ASN A 683
PRO A 746
GLN A 748
 None
 0.85A 6jnhA-5zqzA:
4.3		 6jnhA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arr ACETYL-COA
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		no annotation 3 ASN A 332
PRO A 298
GLN A 289
 None
 0.90A 6jnhA-6arrA:
undetectable		 6jnhA-6arrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 ASN A 783
PRO A 678
GLN A 680
 None
 0.84A 6jnhA-6bf6A:
undetectable		 6jnhA-6bf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bn2 ACETYL-COA
ACETYLTRANSFERASE

(Elizabethkingia
anophelis) 		no annotation 3 ASN A 326
PRO A 292
GLN A 283
 None
None
GOL  A 405 ( 3.9A)
 0.87A 6jnhA-6bn2A:
undetectable		 6jnhA-6bn2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckg D-GLYCERATE 3-KINASE

(Cryptococcus
neoformans) 		no annotation 3 ASN A 116
PRO A 157
GLN A 155
 None
 0.94A 6jnhA-6ckgA:
undetectable		 6jnhA-6ckgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 ASN A1541
PRO A 858
GLN A1583
 None
 0.90A 6jnhA-6emkA:
undetectable		 6jnhA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 3 ASN D 268
PRO D 667
GLN D 665
 None
 0.95A 6jnhA-6eq8D:
undetectable		 6jnhA-6eq8D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 3 ASN D 135
PRO D 236
GLN D 237
 None
 0.89A 6jnhA-6f45D:
undetectable		 6jnhA-6f45D:
undetectable