SIMILAR PATTERNS OF AMINO ACIDS FOR 6JNH_A_ASCA201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 GLY A 242
THR A 243
SER A 333
SER A 332
 None
 0.85A 6jnhA-1axkA:
undetectable		 6jnhA-1axkA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		5 GLY A   8
THR A   9
PHE A  10
HIS A  17
SER A 118
 CTP  A 130 ( 3.8A)
CTP  A 130 (-4.3A)
CTP  A 130 (-4.3A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.9A)
 0.81A 6jnhA-1cozA:
13.0		 6jnhA-1cozA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9a HYPOTHETICAL PROTEIN
MJ0541

(Methanocaldococcus
jannaschii) 		PF01467
(CTP_transf_like) 		4 GLY A   7
PHE A   9
HIS A  16
SER A 125
 ATP  A 700 (-3.6A)
ATP  A 700 (-4.9A)
ATP  A 700 (-4.2A)
ATP  A 700 (-4.3A)
 0.27A 6jnhA-1f9aA:
15.5		 6jnhA-1f9aA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 104
THR A 105
PHE A 106
ARG A 423
 None
 0.81A 6jnhA-1gycA:
undetectable		 6jnhA-1gycA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 104
THR A 105
PHE A 106
ARG A 424
 None
 0.80A 6jnhA-1hfuA:
undetectable		 6jnhA-1hfuA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		4 GLY A  95
THR A  96
SER A 182
SER A 181
 None
 0.73A 6jnhA-1hixA:
undetectable		 6jnhA-1hixA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hy5 YERSINIA PESTIS
VIRULENCE PROTEIN
YOPE

(Yersinia pestis) 		PF03545
(YopE)
PF09020
(YopE_N) 		4 GLY A1182
THR A1183
HIS A1133
SER A1189
 None
 0.91A 6jnhA-1hy5A:
undetectable		 6jnhA-1hy5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4m NAMN
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 GLY A  10
PHE A  12
HIS A  19
SER A 180
 NAD  A 601 (-3.4A)
NAD  A 601 (-4.5A)
NAD  A 601 (-4.5A)
CIT  A 604 (-3.5A)
 0.56A 6jnhA-1k4mA:
15.0		 6jnhA-1k4mA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4m NAMN
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 GLY A  10
THR A  11
PHE A  12
HIS A  19
 NAD  A 601 (-3.4A)
NAD  A 601 (-4.7A)
NAD  A 601 (-4.5A)
NAD  A 601 (-4.5A)
 0.40A 6jnhA-1k4mA:
15.0		 6jnhA-1k4mA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		5 GLY A   9
THR A  10
PHE A  11
HIS A  18
SER A 155
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
None
DND  A 601 (-4.0A)
None
 0.34A 6jnhA-1kaqA:
16.0		 6jnhA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		5 GLY A  15
PHE A  17
HIS A  24
SER A 222
SER A 223
 DND  A 301 (-3.4A)
DND  A 301 (-4.6A)
DND  A 301 ( 4.7A)
None
DND  A 301 ( 4.7A)
 0.38A 6jnhA-1kqoA:
14.2		 6jnhA-1kqoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 104
THR A 105
PHE A 106
ARG A 423
 None
 0.81A 6jnhA-1kyaA:
undetectable		 6jnhA-1kyaA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR

(Haemophilus
influenzae) 		PF01467
(CTP_transf_like)
PF13521
(AAA_28) 		4 GLY A  65
PHE A  67
HIS A  74
SER A 202
 NAD  A 601 (-3.6A)
None
NAD  A 601 (-4.5A)
SO4  A 501 (-2.5A)
 0.49A 6jnhA-1lw7A:
14.5		 6jnhA-1lw7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nuq FKSG76

(Homo sapiens) 		PF01467
(CTP_transf_like) 		4 GLY A  13
PHE A  15
HIS A  22
SER A 201
 NXX  A 401 (-3.2A)
NXX  A 401 (-4.5A)
NXX  A 401 (-4.3A)
SO4  A 302 ( 4.1A)
 0.70A 6jnhA-1nuqA:
15.0		 6jnhA-1nuqA:
23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o6b PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		6 GLY A   9
PHE A  11
HIS A  18
ARG A  91
SER A 128
SER A 129
 ADP  A 173 (-3.3A)
ADP  A 173 (-3.8A)
ADP  A 173 ( 3.9A)
None
PO4  A 170 (-4.6A)
PO4  A 170 (-3.4A)
 0.52A 6jnhA-1o6bA:
25.3		 6jnhA-1o6bA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01467
(CTP_transf_like) 		6 GLY A   7
PHE A   9
HIS A  16
ARG A  91
SER A 128
SER A 129
 PNS  A1161 (-3.6A)
None
SO4  A1163 (-4.1A)
SO4  A1163 (-3.7A)
None
SO4  A1163 (-3.3A)
 0.64A 6jnhA-1od6A:
24.8		 6jnhA-1od6A:
49.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		4 GLY B 450
THR B 451
ARG B 282
SER B 459
 None
 0.96A 6jnhA-1oedB:
undetectable		 6jnhA-1oedB:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		6 GLY A   9
THR A  10
PHE A  11
HIS A  18
SER A 128
SER A 129
 None
None
None
SO4  A1161 (-4.2A)
SO4  A1161 (-4.8A)
SO4  A1161 (-3.0A)
 0.39A 6jnhA-1qjcA:
24.8		 6jnhA-1qjcA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		5 GLY A   9
THR A  10
PHE A  11
SER A 130
SER A 129
 None
None
None
None
SO4  A1161 (-3.0A)
 1.48A 6jnhA-1qjcA:
24.8		 6jnhA-1qjcA:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 GLY A   6
PHE A   8
HIS A  15
SER A 136
SER A 137
 None
 0.87A 6jnhA-1t6xA:
8.6		 6jnhA-1t6xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		4 GLY B  93
THR B  94
SER B 181
SER B 180
 EDO  B 208 ( 4.5A)
None
None
None
 0.84A 6jnhA-1te1B:
undetectable		 6jnhA-1te1B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		4 GLY A 160
THR A 161
ARG A 155
SER A 152
 None
 0.89A 6jnhA-1tjrA:
undetectable		 6jnhA-1tjrA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 GLY A 257
HIS A 272
SER A 252
SER A 253
 None
 0.69A 6jnhA-1uz4A:
2.3		 6jnhA-1uz4A:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vlh PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01467
(CTP_transf_like) 		5 GLY A   7
PHE A   9
HIS A  16
SER A 126
SER A 127
 PNS  A 200 (-3.3A)
None
None
None
None
 0.27A 6jnhA-1vlhA:
24.8		 6jnhA-1vlhA:
43.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4g NUCLEOLYSIN TIAR

(Homo sapiens) 		PF00076
(RRM_1) 		4 THR A  27
HIS A  71
SER A  22
SER A  21
 None
 0.93A 6jnhA-1x4gA:
undetectable		 6jnhA-1x4gA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		4 GLY A  94
THR A  95
SER A 183
SER A 182
 None
 0.94A 6jnhA-1ynaA:
undetectable		 6jnhA-1ynaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		5 GLY A  10
THR A  11
PHE A  12
HIS A  19
SER A 178
 None
None
None
CIT  A 230 (-3.8A)
CIT  A 230 (-3.3A)
 0.54A 6jnhA-1yulA:
14.4		 6jnhA-1yulA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amy PHOSPHOMANNOMUTASE 2

(Homo sapiens) 		PF03332
(PMM) 		4 GLY A 117
THR A 118
PHE A 119
SER A 179
 None
 0.69A 6jnhA-2amyA:
3.0		 6jnhA-2amyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dck XYLANASE J

(Bacillus sp.
41M-1) 		PF00457
(Glyco_hydro_11)
PF03422
(CBM_6) 		4 GLY A 101
THR A 102
SER A 188
SER A 187
 None
 0.86A 6jnhA-2dckA:
undetectable		 6jnhA-2dckA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		5 GLY A   9
PHE A  11
HIS A  18
SER A 155
SER A 156
 DND  A 998 (-3.2A)
None
DND  A 998 ( 4.6A)
None
None
 0.24A 6jnhA-2h29A:
15.4		 6jnhA-2h29A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 104
THR A 105
PHE A 106
ARG A 423
 None
 0.80A 6jnhA-2hzhA:
undetectable		 6jnhA-2hzhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i54 PHOSPHOMANNOMUTASE

(Leishmania
mexicana) 		PF03332
(PMM) 		4 GLY A 116
THR A 117
PHE A 118
SER A 178
 None
None
None
CIT  A3001 (-3.0A)
 0.67A 6jnhA-2i54A:
3.8		 6jnhA-2i54A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwf MONOTHIOL
GLUTAREDOXIN-S16,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 GLY A 103
PHE A 101
HIS A 115
SER A 113
 None
 0.83A 6jnhA-2lwfA:
undetectable		 6jnhA-2lwfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv4 UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF11269
(DUF3069) 		4 THR A  53
PHE A  52
HIS A  73
ARG A   9
 None
None
None
GOL  A 145 (-4.3A)
 0.91A 6jnhA-2pv4A:
undetectable		 6jnhA-2pv4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		5 GLY A  12
PHE A  14
HIS A  21
SER A 138
SER A 139
 NAD  A 601 (-3.3A)
NAD  A 601 (-4.8A)
NAD  A 601 (-4.5A)
POP  A 701 (-2.9A)
POP  A 701 (-3.9A)
 0.59A 6jnhA-2qjoA:
14.3		 6jnhA-2qjoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 104
THR A 105
PHE A 106
ARG A 422
 None
 0.83A 6jnhA-2qt6A:
undetectable		 6jnhA-2qt6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		5 GLY A   8
PHE A  11
HIS A  18
SER A 155
SER A 156
 None
None
None
GOL  A 191 (-3.8A)
GOL  A 191 (-4.1A)
 0.94A 6jnhA-2qtnA:
14.7		 6jnhA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		6 GLY A   9
THR A  10
PHE A  11
HIS A  18
SER A 155
SER A 156
 GOL  A 191 ( 4.0A)
GOL  A 191 (-3.2A)
None
None
GOL  A 191 (-3.8A)
GOL  A 191 (-4.1A)
 0.83A 6jnhA-2qtnA:
14.7		 6jnhA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 GLY A 567
THR A 568
HIS A   0
SER A 572
 None
 0.93A 6jnhA-2quaA:
undetectable		 6jnhA-2quaA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 GLY A 124
THR A 125
PHE A 126
ARG A 270
 None
 0.86A 6jnhA-2vmjA:
undetectable		 6jnhA-2vmjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8r GLYCOSYL HYDROLASE

(Aspergillus
fumigatus) 		PF01183
(Glyco_hydro_25) 		4 GLY A  79
THR A  81
HIS A  70
ARG A  73
 None
 0.96A 6jnhA-2x8rA:
undetectable		 6jnhA-2x8rA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 104
THR A 105
PHE A 106
ARG A 423
 None
 0.83A 6jnhA-2xybA:
undetectable		 6jnhA-2xybA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 GLY A 148
THR A 147
HIS A 617
ARG A 585
 None
 0.96A 6jnhA-3ciaA:
undetectable		 6jnhA-3ciaA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do8 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01467
(CTP_transf_like) 		4 GLY A   7
THR A   8
PHE A   9
HIS A  16
 None
 0.49A 6jnhA-3do8A:
9.6		 6jnhA-3do8A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9r PHOSPHOMANNOMUTASE

(Trypanosoma
brucei) 		PF03332
(PMM) 		4 GLY A 116
THR A 117
PHE A 118
SER A 178
 None
None
None
SO4  A 247 ( 3.7A)
 0.70A 6jnhA-3f9rA:
3.6		 6jnhA-3f9rA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		4 GLY A 169
THR A 170
PHE A 172
HIS A 200
 None
 0.87A 6jnhA-3gf7A:
undetectable		 6jnhA-3gf7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go5 MULTIDOMAIN PROTEIN
WITH S1 RNA-BINDING
DOMAINS

(Streptococcus
pneumoniae) 		PF13509
(S1_2) 		4 GLY A 166
THR A 167
PHE A 179
SER A 212
 None
 0.96A 6jnhA-3go5A:
undetectable		 6jnhA-3go5A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl4 CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A

(Rattus
norvegicus) 		PF01467
(CTP_transf_like) 		4 GLY A  83
PHE A  85
HIS A  92
SER A 201
 CDC  A 237 (-3.3A)
CDC  A 237 (-4.4A)
CDC  A 237 (-4.3A)
None
 0.77A 6jnhA-3hl4A:
10.6		 6jnhA-3hl4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF17

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 GLY L 308
PHE L 335
SER L 330
SER L 329
 None
 0.94A 6jnhA-3jb9L:
undetectable		 6jnhA-3jb9L:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 104
THR A 105
PHE A 106
ARG A 428
 None
 0.83A 6jnhA-3kw7A:
undetectable		 6jnhA-3kw7A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Jannaschia sp.
CCS1) 		PF07848
(PaaX) 		4 THR A 204
PHE A 203
SER A  48
SER A  49
 None
 0.96A 6jnhA-3l09A:
undetectable		 6jnhA-3l09A:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l93 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Yersinia pestis) 		PF01467
(CTP_transf_like) 		6 GLY A   9
THR A  10
PHE A  11
HIS A  18
SER A 128
SER A 129
 None
 0.56A 6jnhA-3l93A:
26.6		 6jnhA-3l93A:
56.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 GLY A 151
THR A 152
SER A  56
SER A  55
 None
 0.82A 6jnhA-3lb9A:
undetectable		 6jnhA-3lb9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		5 GLY A 574
PHE A 575
HIS A 589
SER A 587
SER A 586
 None
 1.32A 6jnhA-3lvvA:
undetectable		 6jnhA-3lvvA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 GLY A  73
THR A  74
PHE A  40
HIS A  57
 None
 0.93A 6jnhA-3m4xA:
3.1		 6jnhA-3m4xA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		4 GLY A  96
THR A  97
SER A 182
SER A 181
 None
 0.89A 6jnhA-3mf9A:
undetectable		 6jnhA-3mf9A:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nbk PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		6 GLY A   8
PHE A  10
HIS A  17
ARG A  90
SER A 126
SER A 127
 PNS  A 200 (-3.2A)
None
None
None
None
None
 0.65A 6jnhA-3nbkA:
24.8		 6jnhA-3nbkA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nd6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Enterococcus
faecalis) 		PF01467
(CTP_transf_like) 		5 GLY A   9
PHE A  11
HIS A  18
SER A 129
SER A 130
 ATP  A 961 ( 3.7A)
None
ATP  A 961 (-4.3A)
ATP  A 961 (-3.4A)
ATP  A 961 (-3.6A)
 0.29A 6jnhA-3nd6A:
24.0		 6jnhA-3nd6A:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nd6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Enterococcus
faecalis) 		PF01467
(CTP_transf_like) 		4 HIS A  18
ARG A  92
SER A 129
SER A 130
 ATP  A 961 (-4.3A)
ATP  A 961 (-3.5A)
ATP  A 961 (-3.4A)
ATP  A 961 (-3.6A)
 0.85A 6jnhA-3nd6A:
24.0		 6jnhA-3nd6A:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nv7 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Helicobacter
pylori) 		PF01467
(CTP_transf_like) 		5 GLY A   9
THR A  10
PHE A  11
HIS A  18
ARG A  91
 ACY  A 162 (-3.6A)
SO4  A 160 (-4.0A)
ACY  A 162 (-4.1A)
SO4  A 158 ( 4.1A)
SO4  A 158 ( 3.8A)
 0.98A 6jnhA-3nv7A:
12.1		 6jnhA-3nv7A:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415

(Drosophila
melanogaster) 		PF00106
(adh_short)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 GLY A 519
THR A 522
ARG A 548
SER A 585
 None
 0.76A 6jnhA-3omlA:
undetectable		 6jnhA-3omlA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 GLY A  24
PHE A  26
HIS A  33
SER A 163
SER A 164
 GOL  A 318 (-3.6A)
None
SO4  A 311 (-4.3A)
SO4  A 311 (-4.8A)
SO4  A 311 (-2.9A)
 0.71A 6jnhA-3op1A:
7.8		 6jnhA-3op1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61

(Homo sapiens) 		PF00400
(WD40) 		4 GLY A 124
THR A 123
SER A  83
SER A  82
 None
 0.80A 6jnhA-3ow8A:
undetectable		 6jnhA-3ow8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 104
THR A 105
PHE A 106
ARG A 423
 None
 0.81A 6jnhA-3pxlA:
undetectable		 6jnhA-3pxlA:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Burkholderia
pseudomallei) 		PF01467
(CTP_transf_like) 		5 GLY A   8
THR A   9
PHE A  10
HIS A  17
SER A 127
 COD  A 201 (-3.1A)
COD  A 201 (-3.6A)
COD  A 201 (-4.5A)
COD  A 201 (-4.3A)
SO4  A 205 (-3.0A)
 0.75A 6jnhA-3pxuA:
25.6		 6jnhA-3pxuA:
52.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s36 VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF00047
(ig) 		4 THR X 298
HIS X 267
SER X 265
SER X 264
 None
 0.93A 6jnhA-3s36X:
undetectable		 6jnhA-3s36X:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 GLY A 133
THR A 132
SER A  97
SER A  96
 None
 0.95A 6jnhA-3sdoA:
undetectable		 6jnhA-3sdoA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Lactobacillus
acidophilus) 		PF00215
(OMPdecase) 		4 GLY A 158
PHE A 177
SER A 208
SER A 209
 None
 0.95A 6jnhA-3tfxA:
undetectable		 6jnhA-3tfxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 GLY A  86
THR A  87
SER A 177
SER A 176
 None
 0.89A 6jnhA-3vzmA:
undetectable		 6jnhA-3vzmA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 125
THR A 126
PHE A 127
ARG A 445
 None
 0.87A 6jnhA-3x1bA:
undetectable		 6jnhA-3x1bA:
15.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1j PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		7 GLY A   8
THR A   9
PHE A  10
HIS A  17
ARG A  90
SER A 127
SER A 128
 ACO  A 201 (-3.2A)
ACO  A 201 (-3.9A)
ACO  A 201 ( 4.5A)
ACO  A 201 (-4.1A)
ACO  A 201 (-4.4A)
ACO  A 201 (-3.0A)
ACO  A 201 (-3.1A)
 0.93A 6jnhA-3x1jA:
26.2		 6jnhA-3x1jA:
67.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		4 GLY A 135
THR A 136
SER A 221
SER A 220
 None
 0.80A 6jnhA-3zseA:
undetectable		 6jnhA-3zseA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k DNA DAMAGE-BINDING
PROTEIN 2

(Danio rerio) 		PF00400
(WD40) 		4 GLY D 255
THR D 254
SER D 212
SER D 211
 None
 0.96A 6jnhA-4a0kD:
undetectable		 6jnhA-4a0kD:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLY A1543
THR A1544
HIS A1577
SER A1539
SER A1538
 None
 1.08A 6jnhA-4c6oA:
undetectable		 6jnhA-4c6oA:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f3r PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Coxiella
burnetii) 		PF01467
(CTP_transf_like) 		6 GLY A   9
THR A  10
PHE A  11
HIS A  18
ARG A  90
SER A 127
 None
 0.41A 6jnhA-4f3rA:
23.2		 6jnhA-4f3rA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 119
THR A 120
PHE A 121
ARG A 395
 None
 0.79A 6jnhA-4f7kA:
undetectable		 6jnhA-4f7kA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		4 GLY A  94
THR A  95
SER A 182
SER A 181
 None
 0.83A 6jnhA-4hk9A:
undetectable		 6jnhA-4hk9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixl XYLANASE

(Bacillus sp.
(in: Bacteria)) 		PF00457
(Glyco_hydro_11) 		4 GLY A 101
THR A 102
SER A 188
SER A 187
 None
 0.83A 6jnhA-4ixlA:
undetectable		 6jnhA-4ixlA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 104
THR A 105
PHE A 106
ARG A 422
 None
 0.81A 6jnhA-4jhvA:
undetectable		 6jnhA-4jhvA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mow GLUCOSE
1-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		4 GLY A 166
THR A 165
ARG A 178
SER A 135
 None
 0.85A 6jnhA-4mowA:
3.5		 6jnhA-4mowA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A

(Rattus
norvegicus) 		PF01467
(CTP_transf_like) 		4 GLY A  83
PHE A  85
HIS A  92
SER A 201
 CDC  A 401 (-3.0A)
CDC  A 401 (-4.6A)
CDC  A 401 ( 4.5A)
None
 0.72A 6jnhA-4mvcA:
9.8		 6jnhA-4mvcA:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		5 GLY A  10
PHE A  12
HIS A  19
SER A 129
SER A 130
 ADP  A 203 (-3.3A)
ADP  A 203 (-4.4A)
ADP  A 203 (-4.0A)
None
ADP  A 203 ( 4.6A)
 0.34A 6jnhA-4natA:
24.5		 6jnhA-4natA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0n PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		5 GLY A   8
PHE A  10
HIS A  17
SER A 126
SER A 127
 None
None
SO4  A 201 (-4.1A)
SO4  A 201 (-4.7A)
SO4  A 201 (-2.9A)
 0.27A 6jnhA-4r0nA:
24.5		 6jnhA-4r0nA:
41.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0n PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		5 PHE A  10
HIS A  17
ARG A  90
SER A 126
SER A 127
 None
SO4  A 201 (-4.1A)
SO4  A 201 (-3.8A)
SO4  A 201 (-4.7A)
SO4  A 201 (-2.9A)
 0.67A 6jnhA-4r0nA:
24.5		 6jnhA-4r0nA:
41.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Burkholderia
thailandensis) 		PF01467
(CTP_transf_like) 		4 GLY A  36
THR A  37
PHE A  38
HIS A  45
 NAD  A 301 (-3.2A)
NAD  A 301 (-3.6A)
NAD  A 301 (-4.7A)
PO4  A 302 ( 4.0A)
 0.45A 6jnhA-4wsoA:
13.1		 6jnhA-4wsoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		6 GLY A  11
THR A  12
PHE A  13
HIS A  20
SER A 167
SER A 168
 None
 0.66A 6jnhA-4x0eA:
15.0		 6jnhA-4x0eA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybr NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		6 GLY A  11
THR A  12
PHE A  13
HIS A  20
SER A 167
SER A 168
 NAP  A 301 (-3.4A)
NAP  A 301 (-3.7A)
NAP  A 301 ( 4.9A)
NAP  A 301 (-3.8A)
None
NAP  A 301 (-2.4A)
 0.90A 6jnhA-4ybrA:
15.2		 6jnhA-4ybrA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01467
(CTP_transf_like) 		6 GLY A  13
THR A  14
PHE A  15
HIS A  22
SER A 168
SER A 169
 ATP  A 301 (-3.6A)
ATP  A 301 (-4.4A)
None
ATP  A 301 (-4.0A)
ATP  A 301 (-4.2A)
ATP  A 301 (-3.1A)
 0.54A 6jnhA-5db4A:
15.9		 6jnhA-5db4A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 GLY A 163
THR A 164
SER A 151
SER A 150
 None
LEU  A 602 (-4.7A)
None
None
 0.95A 6jnhA-5ecoA:
undetectable		 6jnhA-5ecoA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 104
THR A 105
PHE A 106
ARG A 423
 None
 0.82A 6jnhA-5ehfA:
undetectable		 6jnhA-5ehfA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		4 GLY A  95
THR A  96
SER A 182
SER A 181
 None
 0.86A 6jnhA-5ej3A:
undetectable		 6jnhA-5ej3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 GLY A  22
PHE A  24
HIS A  31
SER A 163
SER A 164
 PPV  A1339 ( 3.8A)
PPV  A1339 (-4.7A)
PPV  A1339 (-3.8A)
PPV  A1339 (-4.7A)
PPV  A1339 (-3.2A)
 0.75A 6jnhA-5fo1A:
10.7		 6jnhA-5fo1A:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h16 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Acinetobacter
baumannii) 		PF01467
(CTP_transf_like) 		6 GLY A  10
THR A  11
PHE A  12
HIS A  19
SER A 129
SER A 130
 CIT  A 201 (-3.2A)
CIT  A 201 (-3.6A)
CIT  A 201 (-4.0A)
CIT  A 201 (-3.8A)
CIT  A 201 (-3.5A)
CIT  A 201 (-2.6A)
 0.17A 6jnhA-5h16A:
30.2		 6jnhA-5h16A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Plasmodium
falciparum) 		PF01467
(CTP_transf_like) 		5 GLY A  11
PHE A  13
HIS A  20
SER A 167
SER A 168
 DND  A 301 (-3.6A)
DND  A 301 (-4.4A)
DND  A 301 (-4.2A)
None
DND  A 301 ( 4.6A)
 0.23A 6jnhA-5lltA:
16.1		 6jnhA-5lltA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 105
THR A 106
PHE A 107
ARG A 425
 None
 0.78A 6jnhA-5mewA:
undetectable		 6jnhA-5mewA:
14.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o0d PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01467
(CTP_transf_like) 		6 GLY A   8
PHE A  10
HIS A  17
ARG A  90
SER A 126
SER A 127
 None
 0.37A 6jnhA-5o0dA:
25.7		 6jnhA-5o0dA:
39.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue7 PHOSPHOMANNOMUTASE

(Candida
albicans) 		PF03332
(PMM) 		4 GLY A 121
THR A 122
PHE A 123
SER A 183
 None
 0.70A 6jnhA-5ue7A:
3.6		 6jnhA-5ue7A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1

(Electrophorus
electricus) 		no annotation 4 GLY B 120
THR B 121
PHE B  63
SER B  69
 None
 0.90A 6jnhA-5xsyB:
undetectable		 6jnhA-5xsyB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 GLY A 615
THR A 616
HIS A 279
SER A 346
 AES  A1701 (-3.5A)
AES  A1701 ( 4.7A)
AES  A1701 (-3.4A)
AES  A1701 ( 4.7A)
 0.96A 6jnhA-5xyaA:
undetectable		 6jnhA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfs PHOSPHOMANNOMUTASE 1

(Homo sapiens) 		no annotation 4 GLY A 126
THR A 127
PHE A 128
SER A 188
 None
 0.65A 6jnhA-6cfsA:
4.1		 6jnhA-6cfsA:
undetectable