SIMILAR PATTERNS OF AMINO ACIDS FOR 6JMJ_A_ASCA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 GLY A 242
THR A 243
SER A 333
SER A 332
 None
 0.88A 6jmjA-1axkA:
undetectable		 6jmjA-1axkA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		4 GLY A   8
THR A   9
HIS A  17
SER A 118
 CTP  A 130 ( 3.8A)
CTP  A 130 (-4.3A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.9A)
 0.75A 6jmjA-1cozA:
12.9		 6jmjA-1cozA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 GLY A  83
THR A 151
SER A  58
SER A  59
 SAH  A 699 (-3.2A)
SAH  A 699 (-3.2A)
SAH  A 699 ( 4.9A)
SAH  A 699 ( 3.9A)
 1.11A 6jmjA-1dl5A:
2.7		 6jmjA-1dl5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 GLY A  84
THR A  87
HIS A  14
SER A  48
 None
 1.14A 6jmjA-1ex9A:
undetectable		 6jmjA-1ex9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		4 GLY A  95
THR A  96
SER A 182
SER A 181
 None
 0.76A 6jmjA-1hixA:
undetectable		 6jmjA-1hixA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hy5 YERSINIA PESTIS
VIRULENCE PROTEIN
YOPE

(Yersinia pestis) 		PF03545
(YopE)
PF09020
(YopE_N) 		4 GLY A1182
THR A1183
HIS A1133
SER A1189
 None
 0.91A 6jmjA-1hy5A:
undetectable		 6jmjA-1hy5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4m NAMN
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 GLY A  10
THR A  11
HIS A  19
SER A 180
 NAD  A 601 (-3.4A)
NAD  A 601 (-4.7A)
NAD  A 601 (-4.5A)
CIT  A 604 (-3.5A)
 0.66A 6jmjA-1k4mA:
15.0		 6jmjA-1k4mA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		4 GLY A   9
THR A  10
HIS A  18
SER A 155
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
DND  A 601 (-4.0A)
None
 0.23A 6jmjA-1kaqA:
15.9		 6jmjA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		4 GLY A   9
THR A  10
SER A 155
SER A 156
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
None
None
 0.96A 6jmjA-1kaqA:
15.9		 6jmjA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		4 GLY A  15
HIS A  24
SER A 222
SER A 223
 DND  A 301 (-3.4A)
DND  A 301 ( 4.7A)
None
DND  A 301 ( 4.7A)
 0.37A 6jmjA-1kqoA:
14.2		 6jmjA-1kqoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 GLY B 374
THR B 375
HIS B 382
SER B 380
 None
 1.16A 6jmjA-1lpbB:
undetectable		 6jmjA-1lpbB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxb NEUROTOXIN B

(Laticauda
semifasciata) 		PF00087
(Toxin_TOLIP) 		4 GLY A  34
THR A  35
SER A   9
SER A   8
 None
 1.07A 6jmjA-1nxbA:
undetectable		 6jmjA-1nxbA:
16.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o6b PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		4 GLY A   9
HIS A  18
SER A 128
SER A 129
 ADP  A 173 (-3.3A)
ADP  A 173 ( 3.9A)
PO4  A 170 (-4.6A)
PO4  A 170 (-3.4A)
 0.47A 6jmjA-1o6bA:
25.2		 6jmjA-1o6bA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01467
(CTP_transf_like) 		4 GLY A   7
HIS A  16
SER A 128
SER A 129
 PNS  A1161 (-3.6A)
SO4  A1163 (-4.1A)
None
SO4  A1163 (-3.3A)
 0.31A 6jmjA-1od6A:
24.6		 6jmjA-1od6A:
49.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		5 GLY A   9
THR A  10
HIS A  18
SER A 128
SER A 129
 None
None
SO4  A1161 (-4.2A)
SO4  A1161 (-4.8A)
SO4  A1161 (-3.0A)
 0.38A 6jmjA-1qjcA:
24.7		 6jmjA-1qjcA:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 GLY A   6
HIS A  15
SER A 136
SER A 137
 None
 0.68A 6jmjA-1t6xA:
8.6		 6jmjA-1t6xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		4 GLY B  93
THR B  94
SER B 181
SER B 180
 EDO  B 208 ( 4.5A)
None
None
None
 0.86A 6jmjA-1te1B:
undetectable		 6jmjA-1te1B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tfd TRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		4 GLY A 290
HIS A  14
SER A 182
SER A 180
 None
 1.07A 6jmjA-1tfdA:
undetectable		 6jmjA-1tfdA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 GLY A 339
HIS A 440
SER A 239
SER A 238
 None
EDO  A1902 ( 4.9A)
None
None
 1.12A 6jmjA-1ukcA:
undetectable		 6jmjA-1ukcA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 GLY A 257
HIS A 272
SER A 252
SER A 253
 None
 0.73A 6jmjA-1uz4A:
undetectable		 6jmjA-1uz4A:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vlh PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01467
(CTP_transf_like) 		4 GLY A   7
HIS A  16
SER A 126
SER A 127
 PNS  A 200 (-3.3A)
None
None
None
 0.27A 6jmjA-1vlhA:
24.7		 6jmjA-1vlhA:
43.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 GLY A 630
THR A 631
HIS A 303
SER A 296
 None
 0.99A 6jmjA-1wacA:
undetectable		 6jmjA-1wacA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4g NUCLEOLYSIN TIAR

(Homo sapiens) 		PF00076
(RRM_1) 		4 THR A  27
HIS A  71
SER A  22
SER A  21
 None
 0.94A 6jmjA-1x4gA:
undetectable		 6jmjA-1x4gA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		4 GLY X  89
THR X  92
HIS X  15
SER X  50
 None
 1.05A 6jmjA-1ys2X:
undetectable		 6jmjA-1ys2X:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		4 GLY A  10
THR A  11
HIS A  19
SER A 178
 None
None
CIT  A 230 (-3.8A)
CIT  A 230 (-3.3A)
 0.51A 6jmjA-1yulA:
14.4		 6jmjA-1yulA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE

(Alcaligenaceae
bacterium FB188) 		PF00850
(Hist_deacetyl) 		4 GLY A 186
THR A 187
HIS A 183
SER A 201
 None
None
None
K  A1450 (-2.6A)
 1.15A 6jmjA-1zz3A:
undetectable		 6jmjA-1zz3A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		4 GLY A 404
HIS A 346
SER A 349
SER A 324
 None
 1.10A 6jmjA-2bf6A:
undetectable		 6jmjA-2bf6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dck XYLANASE J

(Bacillus sp.
41M-1) 		PF00457
(Glyco_hydro_11)
PF03422
(CBM_6) 		4 GLY A 101
THR A 102
SER A 188
SER A 187
 None
 0.88A 6jmjA-2dckA:
undetectable		 6jmjA-2dckA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 GLY B 653
THR B 652
SER B 691
SER B 694
 None
 1.15A 6jmjA-2fffB:
undetectable		 6jmjA-2fffB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		4 GLY A   9
HIS A  18
SER A 155
SER A 156
 DND  A 998 (-3.2A)
DND  A 998 ( 4.6A)
None
None
 0.23A 6jmjA-2h29A:
15.4		 6jmjA-2h29A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		4 GLY A  12
HIS A  21
SER A 138
SER A 139
 NAD  A 601 (-3.3A)
NAD  A 601 (-4.5A)
POP  A 701 (-2.9A)
POP  A 701 (-3.9A)
 0.56A 6jmjA-2qjoA:
14.5		 6jmjA-2qjoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		4 GLY A   8
HIS A  18
SER A 155
SER A 156
 None
None
GOL  A 191 (-3.8A)
GOL  A 191 (-4.1A)
 0.75A 6jmjA-2qtnA:
14.7		 6jmjA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		4 GLY A   9
THR A  10
HIS A  18
SER A 156
 GOL  A 191 ( 4.0A)
GOL  A 191 (-3.2A)
None
GOL  A 191 (-4.1A)
 0.86A 6jmjA-2qtnA:
14.7		 6jmjA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		4 THR A  10
HIS A  18
SER A 155
SER A 156
 GOL  A 191 (-3.2A)
None
GOL  A 191 (-3.8A)
GOL  A 191 (-4.1A)
 0.77A 6jmjA-2qtnA:
14.7		 6jmjA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 GLY A 567
THR A 568
HIS A   0
SER A 572
 None
 0.89A 6jmjA-2quaA:
undetectable		 6jmjA-2quaA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90

(Hordeum vulgare) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 GLY A 172
THR A 173
SER A  41
SER A  40
 None
ADP  A1211 (-3.4A)
None
ADP  A1211 ( 4.0A)
 1.12A 6jmjA-2xcmA:
undetectable		 6jmjA-2xcmA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		4 GLY A 272
HIS A 200
SER A 268
SER A 267
 None
 1.06A 6jmjA-3epmA:
undetectable		 6jmjA-3epmA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 295
THR A 296
HIS A 246
SER A 195
 None
GAE  A 411 (-4.6A)
MG  A 401 ( 3.3A)
GAE  A 411 ( 4.8A)
 1.01A 6jmjA-3hpfA:
undetectable		 6jmjA-3hpfA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 GLY B 309
HIS B 306
SER B 331
SER B 324
 None
 1.06A 6jmjA-3jcmB:
undetectable		 6jmjA-3jcmB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 GLY A   9
THR A  10
SER A 125
SER A  34
 FAD  A 401 (-3.6A)
None
None
FAD  A 401 (-3.4A)
 1.08A 6jmjA-3kkjA:
2.6		 6jmjA-3kkjA:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l93 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Yersinia pestis) 		PF01467
(CTP_transf_like) 		5 GLY A   9
THR A  10
HIS A  18
SER A 128
SER A 129
 None
 0.55A 6jmjA-3l93A:
26.6		 6jmjA-3l93A:
56.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 GLY A 151
THR A 152
SER A  56
SER A  55
 None
 0.85A 6jmjA-3lb9A:
undetectable		 6jmjA-3lb9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwa SECRETED
THIOL-DISULFIDE
ISOMERASE

(Corynebacterium
glutamicum) 		PF00578
(AhpC-TSA) 		4 GLY A 123
THR A 124
HIS A 181
SER A  79
 None
 1.16A 6jmjA-3lwaA:
2.6		 6jmjA-3lwaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mf9 ENDO-1,4-BETA-XYLANA
SE

(Thermopolyspora
flexuosa) 		PF00457
(Glyco_hydro_11) 		4 GLY A  96
THR A  97
SER A 182
SER A 181
 None
 0.90A 6jmjA-3mf9A:
undetectable		 6jmjA-3mf9A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		4 GLY A 302
THR A 303
SER A 308
SER A 307
 None
 1.11A 6jmjA-3n2oA:
undetectable		 6jmjA-3n2oA:
14.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nbk PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		4 GLY A   8
HIS A  17
SER A 126
SER A 127
 PNS  A 200 (-3.2A)
None
None
None
 0.34A 6jmjA-3nbkA:
24.7		 6jmjA-3nbkA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nd6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Enterococcus
faecalis) 		PF01467
(CTP_transf_like) 		4 GLY A   9
HIS A  18
SER A 129
SER A 130
 ATP  A 961 ( 3.7A)
ATP  A 961 (-4.3A)
ATP  A 961 (-3.4A)
ATP  A 961 (-3.6A)
 0.31A 6jmjA-3nd6A:
23.9		 6jmjA-3nd6A:
35.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 GLY A  24
HIS A  33
SER A 163
SER A 164
 GOL  A 318 (-3.6A)
SO4  A 311 (-4.3A)
SO4  A 311 (-4.8A)
SO4  A 311 (-2.9A)
 0.64A 6jmjA-3op1A:
8.4		 6jmjA-3op1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61

(Homo sapiens) 		PF00400
(WD40) 		4 GLY A 124
THR A 123
SER A  83
SER A  82
 None
 0.77A 6jmjA-3ow8A:
undetectable		 6jmjA-3ow8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 GLY A1159
HIS A1155
SER A1245
SER A1324
 None
 1.00A 6jmjA-3pvlA:
undetectable		 6jmjA-3pvlA:
13.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Burkholderia
pseudomallei) 		PF01467
(CTP_transf_like) 		4 GLY A   8
THR A   9
HIS A  17
SER A 127
 COD  A 201 (-3.1A)
COD  A 201 (-3.6A)
COD  A 201 (-4.3A)
SO4  A 205 (-3.0A)
 0.74A 6jmjA-3pxuA:
25.4		 6jmjA-3pxuA:
52.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s36 VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF00047
(ig) 		4 THR X 298
HIS X 267
SER X 265
SER X 264
 None
 0.96A 6jmjA-3s36X:
undetectable		 6jmjA-3s36X:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 GLY A 133
THR A 132
SER A  97
SER A  96
 None
 0.92A 6jmjA-3sdoA:
undetectable		 6jmjA-3sdoA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 GLY A  86
THR A  87
SER A 177
SER A 176
 None
 0.93A 6jmjA-3vzmA:
undetectable		 6jmjA-3vzmA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 4 GLY B 108
THR B 109
SER B 257
SER B 258
 F6R  B 701 (-3.6A)
F6R  B 701 (-3.7A)
F6R  B 701 ( 4.7A)
F6R  B 701 (-3.4A)
 1.03A 6jmjA-3w0lB:
undetectable		 6jmjA-3w0lB:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 4 GLY A  49
THR A  50
HIS A 279
SER A 249
 SO4  A 901 ( 3.7A)
SO4  A 901 (-3.8A)
SO4  A 901 ( 4.4A)
None
 1.09A 6jmjA-3wlaA:
undetectable		 6jmjA-3wlaA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx5 CELLULASE

(uncultured
bacterium) 		PF01670
(Glyco_hydro_12) 		4 GLY A 103
THR A 150
HIS A 234
SER A 146
 None
 1.07A 6jmjA-3wx5A:
undetectable		 6jmjA-3wx5A:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1j PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		5 GLY A   8
THR A   9
HIS A  17
SER A 127
SER A 128
 ACO  A 201 (-3.2A)
ACO  A 201 (-3.9A)
ACO  A 201 (-4.1A)
ACO  A 201 (-3.0A)
ACO  A 201 (-3.1A)
 0.79A 6jmjA-3x1jA:
26.1		 6jmjA-3x1jA:
67.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 GLY A 339
THR A 340
SER A  63
SER A  64
 None
 0.99A 6jmjA-3zbyA:
undetectable		 6jmjA-3zbyA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zse ENDO-1,4-BETA-XYLANA
SE

(Thermobifida
fusca) 		PF00457
(Glyco_hydro_11) 		4 GLY A 135
THR A 136
SER A 221
SER A 220
 None
 0.81A 6jmjA-3zseA:
undetectable		 6jmjA-3zseA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLY A1040
THR A1082
SER A 770
SER A 771
 None
MTE  A3003 (-4.3A)
None
None
 1.08A 6jmjA-3zyvA:
undetectable		 6jmjA-3zyvA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k DNA DAMAGE-BINDING
PROTEIN 2

(Danio rerio) 		PF00400
(WD40) 		4 GLY D 255
THR D 254
SER D 212
SER D 211
 None
 0.95A 6jmjA-4a0kD:
undetectable		 6jmjA-4a0kD:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 GLY A 139
THR A 140
SER A 105
SER A 104
 None
 1.13A 6jmjA-4be9A:
undetectable		 6jmjA-4be9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLY A1543
THR A1544
HIS A1577
SER A1539
SER A1538
 None
 1.08A 6jmjA-4c6oA:
undetectable		 6jmjA-4c6oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0u ALLOPHYCOCYANIN,
BETA SUBUNIT

(Synechococcus
elongatus) 		PF00502
(Phycobilisome) 		4 GLY B 127
THR B 129
SER B 171
SER B 170
 None
CYC  B 201 (-4.2A)
None
None
 1.12A 6jmjA-4f0uB:
undetectable		 6jmjA-4f0uB:
24.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f3r PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Coxiella
burnetii) 		PF01467
(CTP_transf_like) 		4 GLY A   9
THR A  10
HIS A  18
SER A 127
 None
 0.23A 6jmjA-4f3rA:
23.2		 6jmjA-4f3rA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Escherichia
coli) 		PF02401
(LYTB) 		4 THR A 167
HIS A 124
SER A 225
SER A 226
 SF4  A 401 (-3.5A)
10D  A 402 (-4.0A)
10D  A 402 (-2.4A)
10D  A 402 (-4.3A)
 1.10A 6jmjA-4h4cA:
undetectable		 6jmjA-4h4cA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk9 ENDO-1,4-BETA-XYLANA
SE 2

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		4 GLY A  94
THR A  95
SER A 182
SER A 181
 None
 0.88A 6jmjA-4hk9A:
undetectable		 6jmjA-4hk9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixl XYLANASE

(Bacillus sp.
(in: Bacteria)) 		PF00457
(Glyco_hydro_11) 		4 GLY A 101
THR A 102
SER A 188
SER A 187
 None
 0.85A 6jmjA-4ixlA:
undetectable		 6jmjA-4ixlA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp9 PAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1) 		4 GLY A 201
THR A 204
SER A 131
SER A 206
 None
 1.03A 6jmjA-4kp9A:
undetectable		 6jmjA-4kp9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum) 		PF00082
(Peptidase_S8) 		4 GLY A 604
THR A 605
HIS A 428
SER A 490
 None
 1.15A 6jmjA-4lvoA:
undetectable		 6jmjA-4lvoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE
SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF00082
(Peptidase_S8)
no annotation 		4 GLY A 604
THR A 605
HIS A 428
SER P 215
 None
 0.98A 6jmjA-4lvoA:
undetectable		 6jmjA-4lvoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF02934
(GatB_N) 		4 GLY B 223
THR B 222
SER B  52
SER B  55
 None
 1.01A 6jmjA-4n0iB:
undetectable		 6jmjA-4n0iB:
17.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nat PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		4 GLY A  10
HIS A  19
SER A 129
SER A 130
 ADP  A 203 (-3.3A)
ADP  A 203 (-4.0A)
None
ADP  A 203 ( 4.6A)
 0.36A 6jmjA-4natA:
24.5		 6jmjA-4natA:
43.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 GLY A 494
HIS A 601
SER A 599
SER A 598
 None
 1.10A 6jmjA-4pw5A:
undetectable		 6jmjA-4pw5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 GLY A 474
THR A 473
HIS A 449
SER A 787
 None
 1.13A 6jmjA-4qi6A:
undetectable		 6jmjA-4qi6A:
10.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0n PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		4 GLY A   8
HIS A  17
SER A 126
SER A 127
 None
SO4  A 201 (-4.1A)
SO4  A 201 (-4.7A)
SO4  A 201 (-2.9A)
 0.26A 6jmjA-4r0nA:
24.4		 6jmjA-4r0nA:
41.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		4 GLY A 107
HIS A 112
SER A  82
SER A  81
 None
 1.06A 6jmjA-4ug4A:
undetectable		 6jmjA-4ug4A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		5 GLY A  11
THR A  12
HIS A  20
SER A 167
SER A 168
 None
 0.67A 6jmjA-4x0eA:
14.9		 6jmjA-4x0eA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybr NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		5 GLY A  11
THR A  12
HIS A  20
SER A 167
SER A 168
 NAP  A 301 (-3.4A)
NAP  A 301 (-3.7A)
NAP  A 301 (-3.8A)
None
NAP  A 301 (-2.4A)
 0.93A 6jmjA-4ybrA:
15.1		 6jmjA-4ybrA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0n PROTEIN F2 LIKE
FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 GLY A  98
HIS A 132
SER A 136
SER A 135
 None
 1.14A 6jmjA-5a0nA:
undetectable		 6jmjA-5a0nA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01467
(CTP_transf_like) 		5 GLY A  13
THR A  14
HIS A  22
SER A 168
SER A 169
 ATP  A 301 (-3.6A)
ATP  A 301 (-4.4A)
ATP  A 301 (-4.0A)
ATP  A 301 (-4.2A)
ATP  A 301 (-3.1A)
 0.50A 6jmjA-5db4A:
16.0		 6jmjA-5db4A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 GLY A 163
THR A 164
SER A 151
SER A 150
 None
LEU  A 602 (-4.7A)
None
None
 0.95A 6jmjA-5ecoA:
undetectable		 6jmjA-5ecoA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 GLY A 331
THR A 332
SER A  22
SER A  23
 None
 1.10A 6jmjA-5ee0A:
undetectable		 6jmjA-5ee0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		4 GLY A  95
THR A  96
SER A 182
SER A 181
 None
 0.88A 6jmjA-5ej3A:
undetectable		 6jmjA-5ej3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 GLY A  22
HIS A  31
SER A 163
SER A 164
 PPV  A1339 ( 3.8A)
PPV  A1339 (-3.8A)
PPV  A1339 (-4.7A)
PPV  A1339 (-3.2A)
 0.49A 6jmjA-5fo1A:
10.7		 6jmjA-5fo1A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 GLY A1579
THR A1528
HIS A1575
SER A1551
 None
 1.06A 6jmjA-5gutA:
2.2		 6jmjA-5gutA:
11.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h16 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Acinetobacter
baumannii) 		PF01467
(CTP_transf_like) 		5 GLY A  10
THR A  11
HIS A  19
SER A 129
SER A 130
 CIT  A 201 (-3.2A)
CIT  A 201 (-3.6A)
CIT  A 201 (-3.8A)
CIT  A 201 (-3.5A)
CIT  A 201 (-2.6A)
 0.19A 6jmjA-5h16A:
29.8		 6jmjA-5h16A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 499
THR A 496
HIS A 214
SER A 171
 None
None
ATP  A 601 ( 4.2A)
ATP  A 601 (-2.9A)
 1.13A 6jmjA-5ie2A:
2.9		 6jmjA-5ie2A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioo AVPA

(Nanoarchaeota
archaeon JGI
OTU-1) 		no annotation 4 GLY A 129
HIS A 171
SER A 125
SER A 126
 None
 1.00A 6jmjA-5iooA:
undetectable		 6jmjA-5iooA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Plasmodium
falciparum) 		PF01467
(CTP_transf_like) 		4 GLY A  11
HIS A  20
SER A 167
SER A 168
 DND  A 301 (-3.6A)
DND  A 301 (-4.2A)
None
DND  A 301 ( 4.6A)
 0.15A 6jmjA-5lltA:
16.0		 6jmjA-5lltA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o0d PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01467
(CTP_transf_like) 		4 GLY A   8
HIS A  17
SER A 126
SER A 127
 None
 0.30A 6jmjA-5o0dA:
25.7		 6jmjA-5o0dA:
39.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 GLY A 549
HIS A  91
SER A 207
SER A 200
 None
FAD  A 602 (-4.3A)
None
None
 1.10A 6jmjA-5oc1A:
undetectable		 6jmjA-5oc1A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		4 GLY A  89
THR A 517
HIS A  95
SER A  93
 None
 1.11A 6jmjA-5tj3A:
undetectable		 6jmjA-5tj3A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u81 ACID CERAMIDASE
ISOFORM B

(Heterocephalus
glaber) 		no annotation 4 GLY A 213
THR A 212
HIS A 157
SER A 145
 None
 1.15A 6jmjA-5u81A:
undetectable		 6jmjA-5u81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 GLY A1077
THR A1073
HIS A1082
SER A1102
 None
 1.12A 6jmjA-5vkqA:
undetectable		 6jmjA-5vkqA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w16 GLUTAMATE RACEMASE

(Thermus
thermophilus) 		no annotation 4 GLY A 115
THR A 116
SER A  79
SER A  80
 None
DGL  A 301 (-3.5A)
None
None
 1.15A 6jmjA-5w16A:
2.9		 6jmjA-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 GLY B 269
THR B 366
SER B 230
SER B 231
 None
 1.09A 6jmjA-5w3jB:
undetectable		 6jmjA-5w3jB:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 GLY A 615
THR A 616
HIS A 279
SER A 346
 AES  A1701 (-3.5A)
AES  A1701 ( 4.7A)
AES  A1701 (-3.4A)
AES  A1701 ( 4.7A)
 0.94A 6jmjA-5xyaA:
undetectable		 6jmjA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		4 GLY A 325
THR A 322
HIS A 467
SER A 366
 None
None
A9Y  A 602 (-4.1A)
None
 1.11A 6jmjA-5xzbA:
undetectable		 6jmjA-5xzbA:
19.06