SIMILAR PATTERNS OF AMINO ACIDS FOR 6JI6_A_ACTA305_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b8x PROTEIN (AML-1B)

(Escherichia
coli) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLY A  11
LEU A  12
SER A 106
TYR A 110
 None
 0.81A 6ji6A-1b8xA:
33.5		 6ji6A-1b8xA:
82.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b8x PROTEIN (AML-1B)

(Escherichia
coli) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLY A  11
LEU A  12
TYR A 110
GLN A 203
 None
 0.84A 6ji6A-1b8xA:
33.5		 6ji6A-1b8xA:
82.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bg5 FUSION PROTEIN OF
ALPHA-NA,K-ATPASE
WITH GLUTATHIONE
S-TRANSFERASE

(Rattus
norvegicus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLY A  12
SER A 107
TYR A 111
GLN A 204
 None
 1.15A 6ji6A-1bg5A:
30.7		 6ji6A-1bg5A:
87.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 GLY A 181
LEU A 231
SER A 176
TYR A 171
 None
 1.07A 6ji6A-1bxtA:
undetectable		 6ji6A-1bxtA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 GLY A 180
LEU A 174
SER A 166
GLN A 183
 None
 0.98A 6ji6A-1e1hA:
0.0		 6ji6A-1e1hA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 GLY A1170
LEU A1218
SER A1165
TYR A1160
 None
 1.17A 6ji6A-1ha5A:
undetectable		 6ji6A-1ha5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 GLY A 231
LEU A 341
TYR A 239
GLN A 235
 FAD  A 450 (-3.5A)
None
None
None
 1.25A 6ji6A-1i8tA:
0.0		 6ji6A-1i8tA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLY A 483
LEU A 412
TYR A 390
GLN A 392
 None
 1.30A 6ji6A-1j0nA:
4.5		 6ji6A-1j0nA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgy TRIACYLGLYCEROL
LIPASE

(Rhizopus niveus) 		PF01764
(Lipase_3) 		4 GLY A 155
LEU A 152
TYR A 188
GLN A 160
 None
 1.29A 6ji6A-1lgyA:
undetectable		 6ji6A-1lgyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLY A 158
LEU A 161
TYR A 148
GLN A 150
 None
 1.23A 6ji6A-1obbA:
0.1		 6ji6A-1obbA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 GLY A 225
LEU A 332
SER A 271
GLN A 219
 None
None
ONL  A2511 (-3.2A)
ONL  A2511 (-4.3A)
 1.21A 6ji6A-1ofeA:
undetectable		 6ji6A-1ofeA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		4 GLY A  44
SER A 174
TYR A 178
GLN A 112
 None
 1.30A 6ji6A-1pjaA:
undetectable		 6ji6A-1pjaA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		PF00590
(TP_methylase) 		4 GLY A 109
LEU A  19
SER A  82
GLN A  78
 None
 1.19A 6ji6A-1s4dA:
undetectable		 6ji6A-1s4dA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 GLY A 570
LEU A 588
SER A 561
GLN A 591
 None
 1.31A 6ji6A-1sqjA:
undetectable		 6ji6A-1sqjA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		4 GLY A 220
LEU A 221
SER A 353
TYR A 357
 None
 1.05A 6ji6A-1umfA:
undetectable		 6ji6A-1umfA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4f MATRIN 3

(Mus musculus) 		PF00076
(RRM_1) 		4 GLY A  91
SER A  36
TYR A  38
GLN A  90
 None
 1.34A 6ji6A-1x4fA:
undetectable		 6ji6A-1x4fA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 GLY A 149
LEU A 145
SER A 180
TYR A 120
 None
 1.27A 6ji6A-1xr5A:
undetectable		 6ji6A-1xr5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00266
(Aminotran_5) 		4 GLY A  71
LEU A  70
SER A  77
TYR A 108
 None
 1.20A 6ji6A-2bkwA:
undetectable		 6ji6A-2bkwA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		4 GLY A 116
LEU A 115
SER A  65
TYR A  63
 None
 1.01A 6ji6A-2c4mA:
undetectable		 6ji6A-2c4mA:
14.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fhe GLUTATHIONE
S-TRANSFERASE

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLY A  11
LEU A  12
SER A 106
TYR A 110
 None
GSH  A 233 (-4.5A)
None
None
 0.68A 6ji6A-2fheA:
33.9		 6ji6A-2fheA:
59.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 GLY A 137
LEU A 136
SER A  86
TYR A  84
 None
 0.95A 6ji6A-2gj4A:
undetectable		 6ji6A-2gj4A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 GLY 1 332
LEU 1 328
SER 1 363
TYR 1 303
 None
 1.20A 6ji6A-2ijd1:
undetectable		 6ji6A-2ijd1:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 GLY A 193
LEU A 197
SER A 334
TYR A 335
 None
 1.22A 6ji6A-2iyoA:
undetectable		 6ji6A-2iyoA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		4 GLY A 121
LEU A 122
TYR A 488
GLN A 113
 None
 1.32A 6ji6A-2jf4A:
undetectable		 6ji6A-2jf4A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		4 GLY A  93
LEU A  92
SER A   2
GLN A  88
 None
 1.01A 6ji6A-2m9pA:
undetectable		 6ji6A-2m9pA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mu3 ACINIFORM SPIDROIN 1

(Argiope
trifasciata) 		PF12042
(RP1-2) 		4 GLY A 178
LEU A  25
SER A 151
GLN A 158
 None
 1.35A 6ji6A-2mu3A:
undetectable		 6ji6A-2mu3A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		4 GLY A 195
SER A 267
TYR A 261
GLN A 199
 None
 1.24A 6ji6A-2pfvA:
2.9		 6ji6A-2pfvA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		4 GLY A 211
LEU A 181
SER A 129
GLN A 210
 None
 1.32A 6ji6A-2rdlA:
undetectable		 6ji6A-2rdlA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfg DIHYDRODIPICOLINATE
SYNTHASE

(Hahella
chejuensis) 		PF00701
(DHDPS) 		4 GLY A   4
LEU A   6
SER A 181
GLN A 199
 None
 1.30A 6ji6A-2rfgA:
undetectable		 6ji6A-2rfgA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLY A 253
LEU A 444
SER A 436
GLN A 254
 None
 1.27A 6ji6A-2w40A:
undetectable		 6ji6A-2w40A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 GLY X 749
LEU X 751
SER X  95
TYR X  96
 None
 1.26A 6ji6A-2y9eX:
undetectable		 6ji6A-2y9eX:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy7 L-THREONINE
DEHYDROGENASE

(Flavobacterium
frigidimaris) 		PF01370
(Epimerase) 		4 GLY A 172
LEU A 173
SER A 118
TYR A 143
 NAD  A3001 ( 3.9A)
NAD  A3001 (-3.7A)
GOL  A1001 ( 2.8A)
GOL  A1001 ( 4.1A)
 1.30A 6ji6A-2yy7A:
undetectable		 6ji6A-2yy7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za8 FERRITIN LIGHT CHAIN

(Equus caballus) 		PF00210
(Ferritin) 		4 GLY A 118
LEU A 126
SER A  10
GLN A 121
 None
 1.23A 6ji6A-2za8A:
undetectable		 6ji6A-2za8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Chromohalobacter
salexigens) 		PF01370
(Epimerase) 		4 GLY A  71
LEU A  70
SER A  74
TYR A 135
 None
 1.20A 6ji6A-3ay3A:
undetectable		 6ji6A-3ay3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvm ENTEROTOXIN TYPE C-3

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 GLY A 184
LEU A 234
SER A 179
TYR A 174
 None
 1.12A 6ji6A-3bvmA:
undetectable		 6ji6A-3bvmA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 GLY A 137
LEU A 136
SER A  86
TYR A  84
 None
NBG  A   1 (-4.1A)
None
None
 0.96A 6ji6A-3cemA:
undetectable		 6ji6A-3cemA:
14.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME

(Schistosoma
japonicum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 GLY A  12
LEU A  13
SER A 107
TYR A 111
GLN A 204
 None
GSH  A 215 (-4.5A)
None
None
None
 0.24A 6ji6A-3cruA:
36.6		 6ji6A-3cruA:
99.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 757
SER A 152
TYR A 843
GLN A 168
 None
 1.28A 6ji6A-3ddrA:
undetectable		 6ji6A-3ddrA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dse BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 GLY A 181
LEU A 175
SER A 167
GLN A 184
 None
 1.03A 6ji6A-3dseA:
undetectable		 6ji6A-3dseA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 180
LEU A 304
SER A 146
GLN A 150
 None
 1.03A 6ji6A-3f2aA:
undetectable		 6ji6A-3f2aA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy3 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		4 GLY A 148
LEU A 188
SER A 155
TYR A 134
 None
 1.35A 6ji6A-3fy3A:
undetectable		 6ji6A-3fy3A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h35 UNCHARACTERIZED
PROTEIN ABO_0056

(Alcanivorax
borkumensis) 		no annotation 4 GLY A  93
LEU A  59
SER A  90
TYR A  89
 None
 1.34A 6ji6A-3h35A:
undetectable		 6ji6A-3h35A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 GLY A 103
LEU A 175
SER A  99
GLN A 101
 None
 1.06A 6ji6A-3hwrA:
undetectable		 6ji6A-3hwrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 GLY A  76
LEU A  74
TYR A  83
GLN A  67
 None
 1.31A 6ji6A-3i5aA:
undetectable		 6ji6A-3i5aA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 152
LEU A  93
SER A  68
TYR A  83
 None
None
CD  A 501 ( 3.7A)
None
 1.25A 6ji6A-3ip1A:
undetectable		 6ji6A-3ip1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd8 NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		PF02460
(Patched)
PF12349
(Sterol-sensing)
PF16414
(NPC1_N) 		4 GLY A 725
LEU A 728
SER A1169
GLN A 723
 None
 0.99A 6ji6A-3jd8A:
undetectable		 6ji6A-3jd8A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3q BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 GLY B 181
LEU B 175
SER B 167
GLN B 184
 None
 1.00A 6ji6A-3k3qB:
undetectable		 6ji6A-3k3qB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A1052
LEU A1051
SER A1150
GLN A1169
 None
 1.14A 6ji6A-3k9bA:
undetectable		 6ji6A-3k9bA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg6 CURF

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 GLY A1715
LEU A1717
TYR A1885
GLN A1881
 None
 1.04A 6ji6A-3kg6A:
undetectable		 6ji6A-3kg6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		4 GLY A  85
LEU A  88
SER A 105
TYR A 126
 None
None
VAL  A 393 (-3.4A)
VAL  A 393 (-4.8A)
 1.29A 6ji6A-3lkbA:
undetectable		 6ji6A-3lkbA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C)
PF12932
(Sec16) 		4 GLY B1050
LEU B1049
SER B1323
TYR B1324
 None
 1.20A 6ji6A-3mzkB:
undetectable		 6ji6A-3mzkB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 4 GLY I  90
LEU I 126
TYR I 122
GLN I  88
 None
 1.30A 6ji6A-3opyI:
undetectable		 6ji6A-3opyI:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 GLY A 442
LEU A 434
SER A 419
TYR A 358
 None
 1.12A 6ji6A-3t5oA:
undetectable		 6ji6A-3t5oA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb6 ARABINOSE METABOLISM
TRANSCRIPTIONAL
REPRESSOR

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		4 GLY A 299
LEU A 313
SER A 303
TYR A  92
 None
None
None
ARB  A 400 (-4.7A)
 1.28A 6ji6A-3tb6A:
undetectable		 6ji6A-3tb6A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLY A 592
LEU A 445
TYR A 403
GLN A 588
 None
 1.30A 6ji6A-3vskA:
undetectable		 6ji6A-3vskA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1

(Yersinia pestis) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 GLY A  52
LEU A  55
SER A  86
GLN A 277
 NAI  A1400 (-3.5A)
None
None
NAI  A1400 (-4.7A)
 1.27A 6ji6A-3zu4A:
undetectable		 6ji6A-3zu4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 GLY A 181
LEU A 175
SER A 167
GLN A 184
 None
 1.02A 6ji6A-3zusA:
undetectable		 6ji6A-3zusA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLY A 663
LEU A 658
SER A1061
TYR A 791
 None
 1.30A 6ji6A-4c3hA:
undetectable		 6ji6A-4c3hA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 707
LEU A 773
TYR A 792
GLN A 711
 None
DI1  A1000 (-4.5A)
None
None
 1.19A 6ji6A-4ckrA:
undetectable		 6ji6A-4ckrA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		4 GLY A 187
LEU A  33
SER A 523
TYR A 521
 GOL  A 603 (-4.7A)
None
None
None
 1.31A 6ji6A-4fj6A:
undetectable		 6ji6A-4fj6A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 GLY A 306
LEU A 305
TYR A 270
GLN A 311
 None
 1.15A 6ji6A-4ga4A:
undetectable		 6ji6A-4ga4A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5s CYTOTOXIC AND
REGULATORY T-CELL
MOLECULE
CELL ADHESION
MOLECULE 1

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 GLY A  38
LEU A  34
TYR B  83
GLN B  81
 None
 1.23A 6ji6A-4h5sA:
undetectable		 6ji6A-4h5sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1p NHEA

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 GLY A 185
SER A 285
TYR A  38
GLN A 188
 None
 0.92A 6ji6A-4k1pA:
undetectable		 6ji6A-4k1pA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt3 UNCHARACTERIZED
PROTEIN
PUTATIVE LIPOPROTEIN

(Pseudomonas
protegens;
Pseudomonas
protegens) 		PF01832
(Glucosaminidase)
no annotation 		4 GLY A  75
SER B  85
TYR B  98
GLN A  71
 None
 1.21A 6ji6A-4kt3A:
undetectable		 6ji6A-4kt3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3w LIPASE

(Rhizopus
microsporus) 		PF01764
(Lipase_3) 		4 GLY A 182
LEU A 179
TYR A 215
GLN A 187
 None
 1.27A 6ji6A-4l3wA:
undetectable		 6ji6A-4l3wA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l5o PUTATIVE GLUTATHIONE
TRANSFERASE

(Clonorchis
sinensis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLY A  12
LEU A  13
SER A 107
TYR A 111
 None
GSH  A 301 (-4.4A)
None
None
 0.27A 6ji6A-4l5oA:
33.7		 6ji6A-4l5oA:
59.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLY A  31
LEU A   5
TYR A 204
GLN A  33
 None
 1.14A 6ji6A-4n0fA:
undetectable		 6ji6A-4n0fA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 GLY A 475
SER A 482
TYR A 486
GLN A 485
 None
 0.95A 6ji6A-4pxnA:
undetectable		 6ji6A-4pxnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		4 GLY A 207
LEU A  52
SER A 543
TYR A 541
 None
 1.32A 6ji6A-4q6kA:
undetectable		 6ji6A-4q6kA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 GLY A 190
LEU A 373
SER A 207
TYR A 177
 None
 1.22A 6ji6A-4uaqA:
undetectable		 6ji6A-4uaqA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3d ENDOTHELIAL PROTEIN
C RECEPTOR

(Homo sapiens) 		PF16497
(MHC_I_3) 		4 GLY B  29
LEU B  14
TYR B  18
GLN B  28
 PTY  B 200 ( 4.9A)
None
None
NAG  B 205 ( 4.3A)
 1.07A 6ji6A-4v3dB:
undetectable		 6ji6A-4v3dB:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME

(Schistosoma
japonicum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 GLY A  11
LEU A  12
SER A 106
TYR A 110
GLN A 203
 None
GSH  A 301 (-4.1A)
None
None
None
 0.30A 6ji6A-4wr4A:
34.8		 6ji6A-4wr4A:
87.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 GLY A 814
LEU A 817
TYR A 793
GLN A 791
 None
 1.35A 6ji6A-4zxiA:
undetectable		 6ji6A-4zxiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		4 GLY A 297
LEU A 295
SER A 342
GLN A 340
 None
 1.03A 6ji6A-4zxoA:
undetectable		 6ji6A-4zxoA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 GLY A 785
LEU A 828
SER A 295
GLN A 308
 None
 1.35A 6ji6A-5a42A:
4.3		 6ji6A-5a42A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 GLY A 785
SER A 295
TYR A 932
GLN A 308
 None
 1.25A 6ji6A-5a42A:
4.3		 6ji6A-5a42A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 GLY A 702
SER A 699
TYR A 175
GLN A 149
 None
 1.31A 6ji6A-5d0fA:
4.4		 6ji6A-5d0fA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		4 GLY A 229
LEU A 225
TYR A 164
GLN A 162
 None
 1.20A 6ji6A-5d1pA:
undetectable		 6ji6A-5d1pA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6p PLEXIN-B2
RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11

(Mus musculus;
Homo sapiens) 		PF08337
(Plexin_cytopl)
PF00595
(PDZ) 		4 GLY B  63
LEU B  68
TYR A1799
GLN A1803
 None
 1.24A 6ji6A-5e6pB:
undetectable		 6ji6A-5e6pB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		4 GLY A 743
LEU A 741
TYR A 212
GLN A 216
 None
 0.78A 6ji6A-5firA:
undetectable		 6ji6A-5firA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Myxococcus
xanthus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 GLY A 241
LEU A 239
SER A 292
GLN A 296
 None
 1.20A 6ji6A-5hwqA:
undetectable		 6ji6A-5hwqA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		4 GLY A 930
LEU A 916
TYR A  10
GLN A 871
 None
 0.82A 6ji6A-5ijlA:
undetectable		 6ji6A-5ijlA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nb3 PHYCOERYTHRIN ALPHA
SUBUNIT,PHYCOERYTHRI
N ALPHA
SUBUNIT,PHYCOERYTHRI
N ALPHA SUBUNIT

(Phormidium
rubidum) 		PF00502
(Phycobilisome) 		4 GLY A 109
LEU A 105
SER A 162
GLN A 113
 PEB  A 166 ( 4.7A)
None
None
None
 0.90A 6ji6A-5nb3A:
undetectable		 6ji6A-5nb3A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 4 GLY A  84
LEU A  85
SER A 132
GLN A 162
 UPG  A 601 (-3.2A)
None
None
UPG  A 601 (-3.3A)
 1.21A 6ji6A-5nzgA:
undetectable		 6ji6A-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 GLY A  31
LEU A  30
SER A 219
GLN A 221
 None
 1.35A 6ji6A-5szsA:
undetectable		 6ji6A-5szsA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		4 GLY A 382
LEU A 335
TYR A 149
GLN A 280
 None
 1.09A 6ji6A-5u0lA:
undetectable		 6ji6A-5u0lA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unl 3-KETOACYL-ACP
REDUCTASE

(Burkholderia
multivorans) 		PF13561
(adh_short_C2) 		4 GLY A 151
LEU A 153
SER A 257
GLN A 190
 None
 1.34A 6ji6A-5unlA:
undetectable		 6ji6A-5unlA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 4 GLY A 229
LEU A 231
SER A 247
GLN A 202
 GGB  A 403 (-3.3A)
None
None
None
 1.27A 6ji6A-5utiA:
undetectable		 6ji6A-5utiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 GLY A 367
LEU A 366
SER A  83
TYR A  81
 ANP  A 901 (-3.5A)
None
None
None
 1.31A 6ji6A-5v9xA:
undetectable		 6ji6A-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A
VESICLE-TRAFFICKING
PROTEIN SEC22B

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
PF13774
(Longin) 		4 GLY A 257
LEU A 306
SER C 129
GLN A 256
 None
 1.10A 6ji6A-5vniA:
undetectable		 6ji6A-5vniA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 GLY B  29
LEU B  30
TYR B 242
GLN B  43
 None
 1.23A 6ji6A-5w3jB:
undetectable		 6ji6A-5w3jB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6

(Saccharomyces
cerevisiae) 		PF10214
(Rrn6) 		4 GLY O 262
LEU O 260
SER O 289
GLN O 270
 None
 1.22A 6ji6A-5w5yO:
undetectable		 6ji6A-5w5yO:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 GLY A 145
LEU A 141
SER A 176
TYR A 116
 None
 1.14A 6ji6A-5xe0A:
undetectable		 6ji6A-5xe0A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y63 ALKYL HYDROPEROXIDE
REDUCTASE, C SUBUNIT

(Enterococcus
faecalis) 		no annotation 4 GLY A  31
LEU A  30
SER A  34
TYR A  69
 None
 1.17A 6ji6A-5y63A:
undetectable		 6ji6A-5y63A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 4 GLY A  46
LEU A  44
SER A 428
GLN A  49
 None
 1.11A 6ji6A-5ykdA:
undetectable		 6ji6A-5ykdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 4 GLY A 293
LEU A 290
SER A  49
GLN A 295
 None
FAD  A 501 (-3.7A)
None
None
 1.35A 6ji6A-6brdA:
undetectable		 6ji6A-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 4 GLY A 292
LEU A 289
SER A  49
GLN A 294
 None
FAD  A 501 (-3.7A)
None
None
 1.29A 6ji6A-6c7sA:
undetectable		 6ji6A-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1

(Homo sapiens) 		no annotation 4 GLY A 444
LEU A 447
SER A 484
TYR A 797
 None
 1.01A 6ji6A-6caaA:
undetectable		 6ji6A-6caaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 GLY A 397
LEU A  28
SER A 245
GLN A 420
 None
 1.13A 6ji6A-6chjA:
undetectable		 6ji6A-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 4 GLY A 553
LEU A 554
TYR A 613
GLN A 617
 None
 0.92A 6ji6A-6etiA:
undetectable		 6ji6A-6etiA:
undetectable