SIMILAR PATTERNS OF AMINO ACIDS FOR 6J20_A_GBQA1201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayy GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		4 ILE B 239
GLU B 207
HIS B 205
VAL B 255
 None
 1.10A 6j20A-1ayyB:
0.0		 6j20A-1ayyB:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjx PROTEIN DISULFIDE
ISOMERASE

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		4 ILE A 212
GLN A 216
GLU A 137
VAL A 140
 None
 1.12A 6j20A-1bjxA:
undetectable		 6j20A-1bjxA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 ILE A 251
GLN A 288
HIS A 223
VAL A 664
 None
PLP  A 955 (-4.3A)
PLP  A 955 (-3.4A)
None
 1.17A 6j20A-1c4kA:
0.0		 6j20A-1c4kA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ILE A 180
TRP A 176
GLU A 669
HIS A 668
 None
 0.92A 6j20A-1dgjA:
0.0		 6j20A-1dgjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		4 ILE A  77
GLN A  48
GLU A  43
VAL A  36
 None
 1.05A 6j20A-1fuuA:
0.0		 6j20A-1fuuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 ILE A 357
GLU A 363
VAL A 390
TRP A 394
 None
 1.10A 6j20A-1h81A:
0.0		 6j20A-1h81A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 ILE A  57
GLN A  53
GLU A  72
VAL A  69
 None
None
NA  A 501 (-3.2A)
None
 1.03A 6j20A-1ka0A:
0.1		 6j20A-1ka0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		4 ILE A 168
TRP A 178
GLU A 138
VAL A 145
 None
 0.68A 6j20A-1kj9A:
0.0		 6j20A-1kj9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii) 		PF00331
(Glyco_hydro_10) 		4 ILE A 108
GLU A 152
VAL A 124
TRP A  48
 None
 1.17A 6j20A-1nq6A:
0.0		 6j20A-1nq6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 ILE A 261
GLU A  40
HIS A  41
VAL A  46
 None
 1.10A 6j20A-1og6A:
undetectable		 6j20A-1og6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qva INITIATION FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		4 ILE A  77
GLN A  48
GLU A  43
VAL A  36
 None
 0.98A 6j20A-1qvaA:
undetectable		 6j20A-1qvaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r57 CONSERVED
HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF14542
(Acetyltransf_CG) 		4 ILE A  71
GLU A  66
HIS A  63
VAL A  60
 None
 1.19A 6j20A-1r57A:
undetectable		 6j20A-1r57A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2j PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ILE A 109
GLU A 140
VAL A  38
TRP A 170
 None
 1.18A 6j20A-1s2jA:
undetectable		 6j20A-1s2jA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 ILE A 386
GLU A 331
VAL A 334
TRP A 293
 None
 1.04A 6j20A-1vclA:
undetectable		 6j20A-1vclA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj7 BIFUNCTIONAL
RELA/SPOT

(Streptococcus
dysgalactiae) 		PF04607
(RelA_SpoT)
PF13328
(HD_4) 		4 ILE A 324
GLU A 287
HIS A 286
VAL A 315
 None
 0.98A 6j20A-1vj7A:
undetectable		 6j20A-1vj7A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4g NUCLEOLYSIN TIAR

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  78
GLU A  72
HIS A  71
VAL A  17
 None
 1.19A 6j20A-1x4gA:
undetectable		 6j20A-1x4gA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd0 HYPOTHETICAL PROTEIN
PF0523

(Pyrococcus
furiosus) 		PF08617
(CGI-121) 		4 ILE A 123
GLN A  29
GLU A  98
VAL A  23
 None
None
UNX  A 406 ( 4.4A)
None
 0.78A 6j20A-1zd0A:
undetectable		 6j20A-1zd0A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ILE A  60
GLU A  40
HIS A  36
VAL A 105
 None
None
GOL  A 222 (-4.4A)
None
 1.15A 6j20A-1zybA:
undetectable		 6j20A-1zybA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE

(Vespula
vulgaris) 		PF01630
(Glyco_hydro_56) 		4 ILE A  88
GLU A  55
HIS A  83
TRP A 177
 None
 1.14A 6j20A-2atmA:
undetectable		 6j20A-2atmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2coy DYNACTIN-1

(Homo sapiens) 		PF01302
(CAP_GLY) 		4 ILE A  94
GLU A  41
VAL A  67
TRP A  64
 None
 0.90A 6j20A-2coyA:
undetectable		 6j20A-2coyA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 ILE A 269
GLN A 116
VAL A 396
TRP A 291
 None
 0.95A 6j20A-2gq3A:
0.0		 6j20A-2gq3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A  67
GLU A 343
HIS A 342
VAL A 347
 None
 1.01A 6j20A-2gz3A:
undetectable		 6j20A-2gz3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A  48
GLU A 118
HIS A 119
TRP A  72
 None
 0.93A 6j20A-2lgzA:
undetectable		 6j20A-2lgzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lmi G-RICH SEQUENCE
FACTOR 1

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  14
GLU A  73
HIS A  75
VAL A  86
 None
 1.19A 6j20A-2lmiA:
undetectable		 6j20A-2lmiA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404

(Mycobacterium
tuberculosis) 		PF01047
(MarR) 		4 ILE A  36
GLU A 123
HIS A 119
VAL A 116
 None
 0.93A 6j20A-2nyxA:
undetectable		 6j20A-2nyxA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A 280
GLU A 273
HIS A 357
VAL A 356
 None
 1.00A 6j20A-2o7qA:
undetectable		 6j20A-2o7qA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 ILE A 554
GLU A 536
HIS A 514
VAL A 551
 None
 1.02A 6j20A-2oajA:
undetectable		 6j20A-2oajA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnd V-SET AND
IMMUNOGLOBULIN
DOMAIN CONTAINING 4

(Mus musculus) 		PF07686
(V-set) 		4 ILE A  48
GLN A  60
HIS A  41
VAL A  39
 None
 1.19A 6j20A-2pndA:
undetectable		 6j20A-2pndA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 ILE A 243
GLU A 184
HIS A 186
TRP A 138
 None
None
FMN  A7401 (-3.3A)
None
 1.20A 6j20A-2q3oA:
undetectable		 6j20A-2q3oA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		4 ILE A  58
GLN A  98
GLU A 103
VAL A   6
 None
 1.16A 6j20A-2qv6A:
undetectable		 6j20A-2qv6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 GLN A 244
GLU A 239
HIS A 238
VAL A 188
 None
 1.04A 6j20A-2vy0A:
undetectable		 6j20A-2vy0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 ILE A  54
GLU A  81
HIS A  80
VAL A  86
 None
 1.16A 6j20A-2vycA:
undetectable		 6j20A-2vycA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 165
GLN A   9
GLU A  49
HIS A  45
 None
 1.16A 6j20A-2w40A:
undetectable		 6j20A-2w40A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ILE A  20
GLU A  33
HIS A  32
VAL A 206
 None
 1.14A 6j20A-2wnrA:
undetectable		 6j20A-2wnrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		4 ILE A 184
TRP A  46
GLU A  39
VAL A 206
 None
 1.11A 6j20A-2wu0A:
undetectable		 6j20A-2wu0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xb3 PSBP PROTEIN

(Thermosynechococcus
elongatus) 		PF01789
(PsbP) 		4 ILE A 124
TRP A 166
GLU A 170
VAL A 177
 None
None
ZN  A1003 (-2.1A)
None
 1.19A 6j20A-2xb3A:
undetectable		 6j20A-2xb3A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 ILE A  66
TRP A  99
HIS A  79
VAL A  95
 None
 1.00A 6j20A-3a18A:
undetectable		 6j20A-3a18A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		4 ILE A 189
TRP A 205
GLU A 209
VAL A 214
 None
 0.99A 6j20A-3b1rA:
undetectable		 6j20A-3b1rA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 ILE A 179
GLN A 181
GLU A  95
VAL A 139
 None
 0.93A 6j20A-3buzA:
undetectable		 6j20A-3buzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx7 GLUTAMATE
TRANSPORTER
ASSOCIATED PROTEIN
48

(Rattus
norvegicus) 		PF09128
(RGS-like) 		4 ILE B 396
GLN B 401
GLU B 387
VAL B 394
 None
 1.04A 6j20A-3cx7B:
undetectable		 6j20A-3cx7B:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE

(Staphylococcus
aureus) 		PF13738
(Pyr_redox_3) 		4 ILE A  20
GLU A 101
HIS A  99
VAL A  96
 None
 1.06A 6j20A-3d1cA:
0.0		 6j20A-3d1cA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 186
GLN A 190
GLU A 223
VAL A 332
 None
 1.06A 6j20A-3db2A:
undetectable		 6j20A-3db2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		4 TRP A  64
GLU A  67
HIS A  66
VAL A  71
 None
 1.06A 6j20A-3evcA:
undetectable		 6j20A-3evcA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f43 PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1081

(Thermotoga
maritima) 		PF01740
(STAS) 		4 ILE A  43
TRP A  30
GLU A  34
VAL A  11
 None
 1.16A 6j20A-3f43A:
undetectable		 6j20A-3f43A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 164
GLN A  10
GLU A  50
HIS A  46
 None
 1.11A 6j20A-3g25A:
undetectable		 6j20A-3g25A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		4 ILE A 295
GLN A 291
GLU A 309
VAL A 304
 None
 0.95A 6j20A-3gr8A:
undetectable		 6j20A-3gr8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 ILE A 272
GLU A 182
HIS A 185
VAL A 532
 FMN  A1002 ( 4.1A)
None
J5Z  A1001 (-4.0A)
J5Z  A1001 (-4.2A)
 1.11A 6j20A-3i6rA:
undetectable		 6j20A-3i6rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 ILE A 381
GLN A 378
GLU A 372
HIS A 373
 None
 0.96A 6j20A-3iu1A:
undetectable		 6j20A-3iu1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A   8
GLN A  35
GLU A 101
VAL A  98
 None
 1.18A 6j20A-3iwaA:
undetectable		 6j20A-3iwaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 ILE A 573
GLU A 672
VAL A 120
TRP A 660
 None
 1.13A 6j20A-3jb9A:
undetectable		 6j20A-3jb9A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		4 ILE A 167
GLN A 170
GLU A 237
VAL A 252
 None
 1.11A 6j20A-3k2kA:
undetectable		 6j20A-3k2kA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 276
GLU A 224
HIS A 222
VAL A 202
 None
 1.07A 6j20A-3my0A:
1.5		 6j20A-3my0A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 ILE A 115
GLU A 103
HIS A 118
VAL A 119
 None
 1.18A 6j20A-3nvaA:
undetectable		 6j20A-3nvaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 ILE A  98
GLN A  94
GLU A 133
VAL A 138
 None
 1.19A 6j20A-3odmA:
undetectable		 6j20A-3odmA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ILE A 193
GLU A  58
HIS A  56
VAL A  46
 None
 0.98A 6j20A-3ogrA:
undetectable		 6j20A-3ogrA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqp PUTATIVE
ISOCHORISMATASE

(Paraburkholderia
xenovorans) 		PF00857
(Isochorismatase) 		4 ILE A  36
GLU A  79
HIS A  74
VAL A  13
 None
 0.85A 6j20A-3oqpA:
undetectable		 6j20A-3oqpA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		4 ILE A 189
GLU A 292
HIS A 293
VAL A 203
 None
 1.18A 6j20A-3r7pA:
undetectable		 6j20A-3r7pA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1
GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA)
PF04670
(Gtr1_RagA) 		4 ILE A 268
GLN A 295
GLU B 304
VAL B 272
 None
 1.16A 6j20A-3r7wA:
undetectable		 6j20A-3r7wA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uav PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus cereus) 		PF01048
(PNP_UDP_1) 		4 ILE A  16
GLN A  60
GLU A  75
VAL A  82
 None
None
GOL  A 238 (-4.8A)
None
 1.17A 6j20A-3uavA:
undetectable		 6j20A-3uavA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		4 ILE A  66
TRP A  99
HIS A  79
VAL A  95
 None
 1.10A 6j20A-3w08A:
undetectable		 6j20A-3w08A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 ILE A 155
GLU A 141
HIS A 143
VAL A 135
 None
 1.06A 6j20A-3wzfA:
undetectable		 6j20A-3wzfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		4 ILE A 167
GLN A 170
GLU A 237
VAL A 252
 None
 1.04A 6j20A-4b6zA:
undetectable		 6j20A-4b6zA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bd3 PHD FINGER PROTEIN
19

(Homo sapiens) 		no annotation 4 ILE A  87
GLU A  42
VAL A  46
TRP A  50
 None
 1.13A 6j20A-4bd3A:
undetectable		 6j20A-4bd3A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		4 ILE A  39
GLU A 227
HIS A 229
VAL A  42
 None
MN  A1263 (-2.5A)
None
None
 1.08A 6j20A-4c1lA:
undetectable		 6j20A-4c1lA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		4 ILE A  17
GLU A 157
HIS A 148
VAL A  87
 None
 0.95A 6j20A-4dokA:
undetectable		 6j20A-4dokA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4

(Homo sapiens) 		PF00023
(Ank) 		4 ILE A 300
GLN A 297
GLU A 247
VAL A 254
 None
 1.07A 6j20A-4dx2A:
undetectable		 6j20A-4dx2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 187
GLN A  33
GLU A  73
HIS A  69
 None
 1.20A 6j20A-4e1jA:
undetectable		 6j20A-4e1jA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		4 ILE A 270
GLN A 116
VAL A 401
TRP A 292
 None
 0.90A 6j20A-4ex4A:
undetectable		 6j20A-4ex4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 ILE A 501
TRP A 561
HIS A 559
VAL A 493
 None
 1.17A 6j20A-4fm9A:
undetectable		 6j20A-4fm9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 340
GLN A 311
HIS A 315
VAL A 314
 None
 1.14A 6j20A-4h19A:
undetectable		 6j20A-4h19A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Saccharomyces
cerevisiae) 		PF10156
(Med17) 		4 ILE Q 569
GLU Q 671
HIS Q 675
VAL Q 678
 None
 1.02A 6j20A-4h62Q:
undetectable		 6j20A-4h62Q:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 ILE A 119
GLU A 279
HIS A 131
VAL A 132
 None
 0.85A 6j20A-4hpvA:
undetectable		 6j20A-4hpvA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 ILE A 323
GLU A 305
HIS A 281
VAL A  42
 None
 1.00A 6j20A-4mifA:
undetectable		 6j20A-4mifA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A1616
GLN A1181
HIS A1159
TRP A1156
 None
 1.13A 6j20A-4o9xA:
undetectable		 6j20A-4o9xA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 ILE A  82
GLU A 131
HIS A 127
VAL A 143
 None
 1.08A 6j20A-4oyaA:
undetectable		 6j20A-4oyaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ILE A 128
GLU A  41
HIS A  17
VAL A 133
 None
 1.07A 6j20A-4qmeA:
undetectable		 6j20A-4qmeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ILE A  91
GLU A  78
HIS A  76
VAL A  94
 None
None
None
OCS  A 110 ( 4.6A)
 1.09A 6j20A-4rpaA:
undetectable		 6j20A-4rpaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ILE A 671
GLN A 884
GLU A 880
VAL A 677
 None
 1.19A 6j20A-4xgtA:
undetectable		 6j20A-4xgtA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B

(Pseudomonas
putida) 		PF12706
(Lactamase_B_2) 		4 ILE A 270
TRP A 224
GLU A 283
VAL A 294
 None
 0.95A 6j20A-4z5yA:
undetectable		 6j20A-4z5yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgc KELCH PROTEIN

(Plasmodium
falciparum) 		PF01344
(Kelch_1)
PF02214
(BTB_2)
PF13418
(Kelch_4) 		4 ILE A 683
GLU A 461
HIS A 719
VAL A 721
 None
 0.98A 6j20A-4zgcA:
undetectable		 6j20A-4zgcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 360
GLN A 221
GLU A 267
VAL A 297
 None
 1.17A 6j20A-5aviA:
undetectable		 6j20A-5aviA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cr9 ABC-TYPE
FE3+-HYDROXAMATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Saccharomonospora
viridis) 		PF01497
(Peripla_BP_2) 		4 ILE A 328
GLN A 240
GLU A 315
VAL A 274
 None
 0.95A 6j20A-5cr9A:
undetectable		 6j20A-5cr9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 ILE A 100
GLU A 130
VAL A  80
TRP A  93
 None
 1.15A 6j20A-5dp2A:
undetectable		 6j20A-5dp2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 ILE A 443
GLN A 440
GLU A 435
VAL A 415
 None
CYT  A 602 (-2.9A)
None
None
 1.12A 6j20A-5ereA:
undetectable		 6j20A-5ereA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 ILE A  68
GLU A  82
VAL A  79
TRP A  71
 None
None
None
GLC  A1115 (-3.6A)
 1.04A 6j20A-5f7uA:
undetectable		 6j20A-5f7uA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff5 PAAA

(Pantoea
agglomerans) 		PF00899
(ThiF) 		4 ILE A 156
GLU A 205
HIS A 203
VAL A 202
 None
 1.05A 6j20A-5ff5A:
undetectable		 6j20A-5ff5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 ILE A 403
GLU A 385
VAL A 430
TRP A 365
 None
 1.09A 6j20A-5ikpA:
undetectable		 6j20A-5ikpA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj8 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25

(Rattus
norvegicus;
Rattus
norvegicus) 		no annotation
no annotation 		4 ILE D 181
GLN D 177
GLU C  55
VAL C  60
 None
CA  C 101 ( 4.0A)
None
None
 1.20A 6j20A-5kj8D:
undetectable		 6j20A-5kj8D:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF03814
(KdpA)
PF02669
(KdpC) 		4 ILE C  55
GLN C  57
VAL A 204
TRP C  36
 None
 1.09A 6j20A-5mrwC:
undetectable		 6j20A-5mrwC:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 270
GLN A 116
VAL A 394
TRP A 292
 None
 0.91A 6j20A-5oasA:
undetectable		 6j20A-5oasA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Caenorhabditis
elegans) 		no annotation 4 ILE A  14
GLU A 138
HIS A 134
VAL A 131
 None
 1.06A 6j20A-5ojiA:
undetectable		 6j20A-5ojiA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		4 ILE A 239
GLU A 207
HIS A 205
VAL A 255
 None
 1.08A 6j20A-5v2iA:
undetectable		 6j20A-5v2iA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 ILE A1068
GLN A1170
GLU A1171
VAL A1073
 None
None
PRO  A1602 ( 4.7A)
None
 1.18A 6j20A-5vadA:
undetectable		 6j20A-5vadA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana) 		no annotation 4 ILE A 215
GLN A 291
GLU A 286
VAL A 228
 None
 1.19A 6j20A-5w75A:
undetectable		 6j20A-5w75A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 ILE A 117
GLU A 151
VAL A 223
TRP A 229
 None
GOL  A 802 ( 3.2A)
None
None
 1.07A 6j20A-5xb7A:
undetectable		 6j20A-5xb7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 ILE A2090
GLU A2085
HIS A2127
VAL A2129
 None
 1.16A 6j20A-5y2aA:
undetectable		 6j20A-5y2aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		4 ILE A 269
GLN A 116
VAL A 400
TRP A 291
 None
 0.92A 6j20A-6axeA:
undetectable		 6j20A-6axeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk8 PRE-MRNA-SPLICING
FACTOR SYF1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE U 735
GLN U 734
GLU U 727
VAL U 692
 None
 1.02A 6j20A-6bk8U:
undetectable		 6j20A-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 ILE A 831
TRP A 882
HIS A 854
VAL A 818
 None
 1.07A 6j20A-6d6yA:
undetectable		 6j20A-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6geb DOTB

(Legionella
pneumophila) 		no annotation 4 ILE A  72
GLU A  92
HIS A  90
VAL A 105
 None
 1.08A 6j20A-6gebA:
undetectable		 6j20A-6gebA:
undetectable