SIMILAR PATTERNS OF AMINO ACIDS FOR 6J20_A_GBQA1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		5 PRO A 357
ILE A 190
TYR A 348
THR A 203
ILE A 354
 None
 1.18A 6j20A-1aj8A:
0.0		 6j20A-1aj8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5m GAF

(Saccharomyces
cerevisiae) 		PF13185
(GAF_2) 		5 ASN A  65
VAL A 100
ILE A  53
THR A 110
PHE A 158
 None
 1.46A 6j20A-1f5mA:
0.8		 6j20A-1f5mA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		5 PRO A 146
VAL A 149
ILE A 153
PHE A 166
PHE A 187
 None
 1.01A 6j20A-1fuuA:
0.0		 6j20A-1fuuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		5 VAL A  69
THR A 247
ILE A 250
PHE A 263
MET A 180
 None
 1.12A 6j20A-1kgpA:
1.2		 6j20A-1kgpA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98

(Homo sapiens) 		PF04096
(Nucleoporin2) 		5 ASN A 765
VAL A 775
ILE A 744
THR A 749
ILE A 750
 None
 1.45A 6j20A-1ko6A:
undetectable		 6j20A-1ko6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		5 VAL A 216
TYR A 361
ILE A 229
PHE A 284
PHE A 329
 None
 1.43A 6j20A-1ndfA:
0.4		 6j20A-1ndfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album) 		PF00082
(Peptidase_S8) 		5 ASN E 263
ASN E 163
TYR E 169
THR E 179
PHE E 202
 None
 1.44A 6j20A-1pekE:
0.0		 6j20A-1pekE:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		5 ASN A 217
PRO A 262
VAL A 264
ILE A 216
ILE A 295
 None
 1.23A 6j20A-1xp3A:
0.0		 6j20A-1xp3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apn PROTEIN HI1723

(Haemophilus
influenzae) 		PF01521
(Fe-S_biosyn) 		5 ASN A  98
THR A  38
ILE A  37
PHE A  49
PHE A  95
 None
 1.26A 6j20A-2apnA:
undetectable		 6j20A-2apnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		5 VAL A 462
ILE A 753
PHE A 484
HIS A 486
MET A 496
 None
 1.27A 6j20A-2cn3A:
undetectable		 6j20A-2cn3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		5 ASN A 245
PRO A 173
VAL A 177
THR A 234
ILE A 149
 None
 1.43A 6j20A-2d7iA:
undetectable		 6j20A-2d7iA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE

(Pyrococcus
horikoshii) 		PF03576
(Peptidase_S58) 		5 ASN A  19
ILE A 244
THR A  53
PHE A 165
HIS A  31
 None
 1.30A 6j20A-2drhA:
undetectable		 6j20A-2drhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 ASN A 188
VAL A 360
ILE A 371
ILE A 353
PHE A 157
 None
 1.46A 6j20A-2fncA:
undetectable		 6j20A-2fncA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gux GRIFFITHSIN

(Griffithsia) 		PF01419
(Jacalin) 		5 VAL A 100
ILE A  33
ILE A 116
PHE A  74
PHE A  82
 None
 1.37A 6j20A-2guxA:
undetectable		 6j20A-2guxA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 PRO A 106
ILE A 285
THR A 295
HIS A 296
PHE A 293
 None
 1.49A 6j20A-2h98A:
undetectable		 6j20A-2h98A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ASN A 180
PRO A 178
VAL A 176
ILE A 212
PHE A 204
 None
 1.36A 6j20A-2i80A:
undetectable		 6j20A-2i80A:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ksb SUBSTANCE-P RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 TYR A 196
THR A 201
ILE A 204
HIS A 265
MET A 295
 None
 0.90A 6j20A-2ksbA:
26.3		 6j20A-2ksbA:
74.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ksb SUBSTANCE-P RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 VAL A 116
TYR A 196
THR A 201
PHE A 264
HIS A 265
 None
 0.96A 6j20A-2ksbA:
26.3		 6j20A-2ksbA:
74.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnf SULFUR
COVALENTLY-BINDING
PROTEIN

(Chlorobium
limicola) 		PF13501
(SoxY) 		5 ASN A  58
VAL A  49
ILE A  25
ILE A  33
PHE A  62
 None
 1.06A 6j20A-2nnfA:
undetectable		 6j20A-2nnfA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 INTERCELLULAR
ADHESION MOLECULE 1
FAB FRAGMENT, HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		no annotation
PF07654
(C1-set)
PF07686
(V-set) 		5 ASN A 397
PRO A 400
THR H  53
ILE H  54
PHE H  32
 None
 1.28A 6j20A-2oz4A:
undetectable		 6j20A-2oz4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		5 ASN A 309
VAL A 215
ILE A 235
ILE A 213
PHE A 264
 None
 1.02A 6j20A-2qzwA:
undetectable		 6j20A-2qzwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3h K5 LYASE

(Escherichia
virus K1-5) 		no annotation 5 ILE A 392
THR A 314
ILE A 315
PHE A 318
PHE A 341
 None
 1.32A 6j20A-2x3hA:
undetectable		 6j20A-2x3hA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aal PROBABLE
ENDONUCLEASE 4

(Geobacillus
kaustophilus) 		PF01261
(AP_endonuc_2) 		5 ASN A 216
PRO A 261
VAL A 263
ILE A 215
ILE A 294
 CAC  A 300 ( 4.8A)
None
None
None
None
 1.31A 6j20A-3aalA:
undetectable		 6j20A-3aalA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 ASN A 346
ASN A 333
TYR A 280
ILE A 357
PHE A 437
 None
 1.49A 6j20A-3ciaA:
0.0		 6j20A-3ciaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		5 TYR A 211
THR A  98
ILE A  99
PHE A  90
PHE A  31
 None
 1.27A 6j20A-3cl6A:
undetectable		 6j20A-3cl6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 3

(Schizosaccharomyces
pombe) 		PF00022
(Actin) 		5 PRO A 308
VAL A 311
ILE A 292
THR A 208
ILE A 193
 None
 1.37A 6j20A-3dwlA:
undetectable		 6j20A-3dwlA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00616
(RasGAP) 		5 ASN A1197
ILE A1200
ILE A1156
PHE A1266
PHE A1262
 None
 1.41A 6j20A-3fayA:
undetectable		 6j20A-3fayA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		5 ASN A 143
ILE A 151
ILE A 218
PHE A 137
PHE A 156
 None
 1.19A 6j20A-3g0tA:
undetectable		 6j20A-3g0tA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyy LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE

(Enterococcus
faecium) 		no annotation 5 ILE A  81
TYR A  71
THR A  77
HIS A  91
PHE A  90
 None
 1.49A 6j20A-3jyyA:
undetectable		 6j20A-3jyyA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfl METHIONYL-TRNA
SYNTHETASE

(Leishmania
major) 		PF09334
(tRNA-synt_1g) 		5 ASN A 221
ILE A 487
TYR A 450
THR A 253
PHE A 284
 POP  A 802 (-3.3A)
ME8  A 801 (-4.0A)
ME8  A 801 (-4.7A)
None
None
 1.46A 6j20A-3kflA:
undetectable		 6j20A-3kflA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll1 GRIFFITHSIN

(Griffithsia sp.
Q66D336) 		PF01419
(Jacalin) 		5 VAL A 100
ILE A  33
ILE A 116
PHE A  74
PHE A  82
 None
 1.39A 6j20A-3ll1A:
undetectable		 6j20A-3ll1A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0o MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
B-0618) 		PF01266
(DAO) 		5 PRO A 257
VAL A 146
ILE A 130
ILE A  50
PHE A 140
 None
None
None
FAD  A 400 (-4.0A)
None
 1.27A 6j20A-3m0oA:
undetectable		 6j20A-3m0oA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 PRO B 131
VAL B 133
THR B 101
ILE B  93
PHE B 121
 None
 1.35A 6j20A-3m2rB:
undetectable		 6j20A-3m2rB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		5 VAL A  69
THR A 247
ILE A 250
PHE A 263
MET A 180
 None
 1.39A 6j20A-3mjoA:
0.9		 6j20A-3mjoA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 VAL A1337
ILE A1310
TYR A1326
THR A1340
PHE A1304
 None
 1.34A 6j20A-3mmpA:
undetectable		 6j20A-3mmpA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 ASN A 126
PRO A 106
ILE A 136
THR A  97
ILE A  99
 None
 1.20A 6j20A-3mwgA:
undetectable		 6j20A-3mwgA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 ILE A  57
TYR A 103
THR A 109
ILE A 110
MET A 239
 None
 1.49A 6j20A-3ng0A:
0.1		 6j20A-3ng0A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwy CELL DEATH
ABNORMALITY PROTEIN
2

(Caenorhabditis
elegans) 		PF00017
(SH2)
PF00018
(SH3_1) 		5 ASN A 169
VAL A 121
ILE A 145
PHE A 137
PHE A 127
 None
 1.49A 6j20A-3qwyA:
undetectable		 6j20A-3qwyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qye TBC1 DOMAIN FAMILY
MEMBER 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 ILE A1050
THR A1041
ILE A1042
PHE A 974
MET A 973
 None
 1.33A 6j20A-3qyeA:
undetectable		 6j20A-3qyeA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 VAL A  65
ILE A 208
ILE A 217
PHE A 222
PHE A 251
 None
 1.40A 6j20A-3tqoA:
undetectable		 6j20A-3tqoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Eptatretus
burgeri;
Danio rerio) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 ASN A 239
ILE A 161
THR A 256
ILE A 258
PHE A 249
 None
 1.31A 6j20A-3v44A:
undetectable		 6j20A-3v44A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Eptatretus
burgeri;
Danio rerio) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 ILE A 161
THR A 256
ILE A 258
PHE A 249
MET A 245
 None
 1.31A 6j20A-3v44A:
undetectable		 6j20A-3v44A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq4 SN-GLYCEROL-3-PHOSPH
ATE-BINDING
PERIPLASMIC PROTEIN
UGPB

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ASN A  45
PRO A  59
ILE A  78
TYR A 298
ILE A   4
 None
 1.24A 6j20A-4aq4A:
undetectable		 6j20A-4aq4A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		5 ASN A 626
VAL A 610
ILE A 598
THR A 605
PHE A 668
 None
 1.39A 6j20A-4cvuA:
undetectable		 6j20A-4cvuA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		5 PRO A 185
VAL A 169
ILE A 224
TYR A 234
ILE A 191
 None
 1.36A 6j20A-4ddqA:
undetectable		 6j20A-4ddqA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		5 ASN A 309
VAL A 251
ILE A  32
THR A 181
ILE A 209
 None
 1.46A 6j20A-4hwvA:
undetectable		 6j20A-4hwvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7s BTRN

(Bacillus
circulans) 		PF13186
(SPASM) 		5 VAL A 184
TYR A  41
ILE A 200
PHE A   5
PHE A  53
 None
 1.45A 6j20A-4m7sA:
undetectable		 6j20A-4m7sA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1

(Escherichia
coli;
Homo sapiens) 		PF00003
(7tm_3)
PF07361
(Cytochrom_B562) 		5 VAL A 622
ILE A 787
ILE A 837
PHE A 614
PHE A 831
 None
 1.29A 6j20A-4or2A:
17.3		 6j20A-4or2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		5 PRO A 170
ILE A  70
THR A 216
PHE A 145
PHE A  33
 G3P  A 407 (-4.2A)
None
G3P  A 407 ( 4.5A)
None
G3P  A 407 (-4.4A)
 1.49A 6j20A-4pfbA:
undetectable		 6j20A-4pfbA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Bacillus
anthracis) 		PF13407
(Peripla_BP_4) 		5 ASN A 144
VAL A 336
ILE A 182
THR A 249
PHE A 251
 None
EDO  A 403 ( 4.8A)
None
None
None
 1.48A 6j20A-4pz0A:
undetectable		 6j20A-4pz0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 5 ASN H 798
PRO H 568
VAL H 606
ILE H 801
ILE H 603
 None
 1.47A 6j20A-4qslH:
undetectable		 6j20A-4qslH:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 PRO A 641
ILE A 331
THR A 607
PHE A 622
PHE A 609
 None
 1.42A 6j20A-4u90A:
undetectable		 6j20A-4u90A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1

(Capnocytophaga
gingivalis) 		no annotation 5 ASN C 179
ILE C  76
THR C 145
ILE C 147
PHE C 133
 None
 1.39A 6j20A-4xruC:
undetectable		 6j20A-4xruC:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		5 ILE A 301
TYR A  81
ILE A  90
PHE A 191
MET A 187
 None
 1.42A 6j20A-4zpdA:
undetectable		 6j20A-4zpdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L9

(Dictyostelium
discoideum) 		PF00347
(Ribosomal_L6) 		5 ASN B  77
VAL B  55
ILE B  68
PHE B  38
HIS B  40
 G  N3448 ( 3.1A)
None
None
None
A  N3459 ( 4.2A)
 1.50A 6j20A-5an9B:
undetectable		 6j20A-5an9B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 VAL A 441
ILE A 559
THR A 506
ILE A 507
PHE A 448
 None
 1.50A 6j20A-5bn4A:
undetectable		 6j20A-5bn4A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00144
(Beta-lactamase) 		5 PRO B 121
VAL B 124
TYR B 221
ILE B 215
PHE B 134
 None
 1.15A 6j20A-5eviB:
undetectable		 6j20A-5eviB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5haf DEUBIQUITINASE SSEL

(Salmonella
enterica) 		no annotation 5 VAL A 270
ILE A 196
ILE A 240
PHE A 229
PHE A 216
 None
 1.39A 6j20A-5hafA:
undetectable		 6j20A-5hafA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4q ELONGATION FACTOR TU

(Escherichia
coli) 		PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 VAL C 338
ILE C 311
TYR C 327
THR C 341
PHE C 305
 None
None
SO4  C 401 (-4.9A)
None
None
 1.25A 6j20A-5i4qC:
undetectable		 6j20A-5i4qC:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0y IG DOMAIN PROTEIN
GROUP 2 DOMAIN
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 VAL B 102
ILE B  15
TYR B 164
PHE B  19
MET B 141
 None
 1.42A 6j20A-5m0yB:
undetectable		 6j20A-5m0yB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkf POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		5 PRO A 453
VAL A 451
TYR A 386
THR A 419
PHE A 279
 None
 1.38A 6j20A-5mkfA:
5.1		 6j20A-5mkfA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufl PROTEIN CIP2A

(Homo sapiens) 		no annotation 5 ILE A 393
ILE A 374
PHE A 321
PHE A 385
MET A 320
 None
 1.07A 6j20A-5uflA:
undetectable		 6j20A-5uflA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		5 ILE A 296
TYR A  77
ILE A  86
PHE A 187
MET A 183
 None
 1.40A 6j20A-5xe0A:
undetectable		 6j20A-5xe0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		5 VAL A 143
ILE A 166
PHE A 151
PHE A1081
MET A 154
 None
 1.45A 6j20A-5xeiA:
undetectable		 6j20A-5xeiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASN A  81
ILE A  57
TYR A 115
ILE A 202
MET A 251
 BGC  A 802 ( 4.0A)
None
None
None
BGC  A 802 (-3.7A)
 1.32A 6j20A-5xxoA:
undetectable		 6j20A-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN

(Ornithorhynchus
anatinus) 		no annotation 5 VAL A 269
TYR A  58
THR A  92
PHE A 262
PHE A  30
 None
 1.41A 6j20A-6b4mA:
undetectable		 6j20A-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1

(Homo sapiens) 		no annotation 5 PRO A 712
ILE A 852
TYR A 433
THR A 438
ILE A 441
 None
 1.36A 6j20A-6caaA:
1.3		 6j20A-6caaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE

(Acetobacterium
woodii) 		no annotation 5 ILE A 341
TYR A 336
THR A 305
ILE A 273
PHE A 292
 FAD  A 401 (-4.1A)
None
None
None
None
 1.42A 6j20A-6fahA:
undetectable		 6j20A-6fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayy GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		4 ILE B 239
GLU B 207
HIS B 205
VAL B 255
 None
 1.10A 6j20A-1ayyB:
0.0		 6j20A-1ayyB:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjx PROTEIN DISULFIDE
ISOMERASE

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		4 ILE A 212
GLN A 216
GLU A 137
VAL A 140
 None
 1.12A 6j20A-1bjxA:
undetectable		 6j20A-1bjxA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 ILE A 251
GLN A 288
HIS A 223
VAL A 664
 None
PLP  A 955 (-4.3A)
PLP  A 955 (-3.4A)
None
 1.17A 6j20A-1c4kA:
0.0		 6j20A-1c4kA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ILE A 180
TRP A 176
GLU A 669
HIS A 668
 None
 0.92A 6j20A-1dgjA:
0.0		 6j20A-1dgjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		4 ILE A  77
GLN A  48
GLU A  43
VAL A  36
 None
 1.05A 6j20A-1fuuA:
0.0		 6j20A-1fuuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 ILE A 357
GLU A 363
VAL A 390
TRP A 394
 None
 1.10A 6j20A-1h81A:
0.0		 6j20A-1h81A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 ILE A  57
GLN A  53
GLU A  72
VAL A  69
 None
None
NA  A 501 (-3.2A)
None
 1.03A 6j20A-1ka0A:
0.1		 6j20A-1ka0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		4 ILE A 168
TRP A 178
GLU A 138
VAL A 145
 None
 0.68A 6j20A-1kj9A:
0.0		 6j20A-1kj9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii) 		PF00331
(Glyco_hydro_10) 		4 ILE A 108
GLU A 152
VAL A 124
TRP A  48
 None
 1.17A 6j20A-1nq6A:
0.0		 6j20A-1nq6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 ILE A 261
GLU A  40
HIS A  41
VAL A  46
 None
 1.10A 6j20A-1og6A:
undetectable		 6j20A-1og6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qva INITIATION FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		4 ILE A  77
GLN A  48
GLU A  43
VAL A  36
 None
 0.98A 6j20A-1qvaA:
undetectable		 6j20A-1qvaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r57 CONSERVED
HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF14542
(Acetyltransf_CG) 		4 ILE A  71
GLU A  66
HIS A  63
VAL A  60
 None
 1.19A 6j20A-1r57A:
undetectable		 6j20A-1r57A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2j PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ILE A 109
GLU A 140
VAL A  38
TRP A 170
 None
 1.18A 6j20A-1s2jA:
undetectable		 6j20A-1s2jA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 ILE A 386
GLU A 331
VAL A 334
TRP A 293
 None
 1.04A 6j20A-1vclA:
undetectable		 6j20A-1vclA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj7 BIFUNCTIONAL
RELA/SPOT

(Streptococcus
dysgalactiae) 		PF04607
(RelA_SpoT)
PF13328
(HD_4) 		4 ILE A 324
GLU A 287
HIS A 286
VAL A 315
 None
 0.98A 6j20A-1vj7A:
undetectable		 6j20A-1vj7A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4g NUCLEOLYSIN TIAR

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  78
GLU A  72
HIS A  71
VAL A  17
 None
 1.19A 6j20A-1x4gA:
undetectable		 6j20A-1x4gA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd0 HYPOTHETICAL PROTEIN
PF0523

(Pyrococcus
furiosus) 		PF08617
(CGI-121) 		4 ILE A 123
GLN A  29
GLU A  98
VAL A  23
 None
None
UNX  A 406 ( 4.4A)
None
 0.78A 6j20A-1zd0A:
undetectable		 6j20A-1zd0A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ILE A  60
GLU A  40
HIS A  36
VAL A 105
 None
None
GOL  A 222 (-4.4A)
None
 1.15A 6j20A-1zybA:
undetectable		 6j20A-1zybA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE

(Vespula
vulgaris) 		PF01630
(Glyco_hydro_56) 		4 ILE A  88
GLU A  55
HIS A  83
TRP A 177
 None
 1.14A 6j20A-2atmA:
undetectable		 6j20A-2atmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2coy DYNACTIN-1

(Homo sapiens) 		PF01302
(CAP_GLY) 		4 ILE A  94
GLU A  41
VAL A  67
TRP A  64
 None
 0.90A 6j20A-2coyA:
undetectable		 6j20A-2coyA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 ILE A 269
GLN A 116
VAL A 396
TRP A 291
 None
 0.95A 6j20A-2gq3A:
0.0		 6j20A-2gq3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A  67
GLU A 343
HIS A 342
VAL A 347
 None
 1.01A 6j20A-2gz3A:
undetectable		 6j20A-2gz3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A  48
GLU A 118
HIS A 119
TRP A  72
 None
 0.93A 6j20A-2lgzA:
undetectable		 6j20A-2lgzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lmi G-RICH SEQUENCE
FACTOR 1

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  14
GLU A  73
HIS A  75
VAL A  86
 None
 1.19A 6j20A-2lmiA:
undetectable		 6j20A-2lmiA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404

(Mycobacterium
tuberculosis) 		PF01047
(MarR) 		4 ILE A  36
GLU A 123
HIS A 119
VAL A 116
 None
 0.93A 6j20A-2nyxA:
undetectable		 6j20A-2nyxA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A 280
GLU A 273
HIS A 357
VAL A 356
 None
 1.00A 6j20A-2o7qA:
undetectable		 6j20A-2o7qA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 ILE A 554
GLU A 536
HIS A 514
VAL A 551
 None
 1.02A 6j20A-2oajA:
undetectable		 6j20A-2oajA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnd V-SET AND
IMMUNOGLOBULIN
DOMAIN CONTAINING 4

(Mus musculus) 		PF07686
(V-set) 		4 ILE A  48
GLN A  60
HIS A  41
VAL A  39
 None
 1.19A 6j20A-2pndA:
undetectable		 6j20A-2pndA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 ILE A 243
GLU A 184
HIS A 186
TRP A 138
 None
None
FMN  A7401 (-3.3A)
None
 1.20A 6j20A-2q3oA:
undetectable		 6j20A-2q3oA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		4 ILE A  58
GLN A  98
GLU A 103
VAL A   6
 None
 1.16A 6j20A-2qv6A:
undetectable		 6j20A-2qv6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 GLN A 244
GLU A 239
HIS A 238
VAL A 188
 None
 1.04A 6j20A-2vy0A:
undetectable		 6j20A-2vy0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 ILE A  54
GLU A  81
HIS A  80
VAL A  86
 None
 1.16A 6j20A-2vycA:
undetectable		 6j20A-2vycA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 165
GLN A   9
GLU A  49
HIS A  45
 None
 1.16A 6j20A-2w40A:
undetectable		 6j20A-2w40A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ILE A  20
GLU A  33
HIS A  32
VAL A 206
 None
 1.14A 6j20A-2wnrA:
undetectable		 6j20A-2wnrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		4 ILE A 184
TRP A  46
GLU A  39
VAL A 206
 None
 1.11A 6j20A-2wu0A:
undetectable		 6j20A-2wu0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xb3 PSBP PROTEIN

(Thermosynechococcus
elongatus) 		PF01789
(PsbP) 		4 ILE A 124
TRP A 166
GLU A 170
VAL A 177
 None
None
ZN  A1003 (-2.1A)
None
 1.19A 6j20A-2xb3A:
undetectable		 6j20A-2xb3A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 ILE A  66
TRP A  99
HIS A  79
VAL A  95
 None
 1.00A 6j20A-3a18A:
undetectable		 6j20A-3a18A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		4 ILE A 189
TRP A 205
GLU A 209
VAL A 214
 None
 0.99A 6j20A-3b1rA:
undetectable		 6j20A-3b1rA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 ILE A 179
GLN A 181
GLU A  95
VAL A 139
 None
 0.93A 6j20A-3buzA:
undetectable		 6j20A-3buzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx7 GLUTAMATE
TRANSPORTER
ASSOCIATED PROTEIN
48

(Rattus
norvegicus) 		PF09128
(RGS-like) 		4 ILE B 396
GLN B 401
GLU B 387
VAL B 394
 None
 1.04A 6j20A-3cx7B:
undetectable		 6j20A-3cx7B:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE

(Staphylococcus
aureus) 		PF13738
(Pyr_redox_3) 		4 ILE A  20
GLU A 101
HIS A  99
VAL A  96
 None
 1.06A 6j20A-3d1cA:
0.0		 6j20A-3d1cA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 186
GLN A 190
GLU A 223
VAL A 332
 None
 1.06A 6j20A-3db2A:
undetectable		 6j20A-3db2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		4 TRP A  64
GLU A  67
HIS A  66
VAL A  71
 None
 1.06A 6j20A-3evcA:
undetectable		 6j20A-3evcA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f43 PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1081

(Thermotoga
maritima) 		PF01740
(STAS) 		4 ILE A  43
TRP A  30
GLU A  34
VAL A  11
 None
 1.16A 6j20A-3f43A:
undetectable		 6j20A-3f43A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 164
GLN A  10
GLU A  50
HIS A  46
 None
 1.11A 6j20A-3g25A:
undetectable		 6j20A-3g25A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		4 ILE A 295
GLN A 291
GLU A 309
VAL A 304
 None
 0.95A 6j20A-3gr8A:
undetectable		 6j20A-3gr8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 ILE A 272
GLU A 182
HIS A 185
VAL A 532
 FMN  A1002 ( 4.1A)
None
J5Z  A1001 (-4.0A)
J5Z  A1001 (-4.2A)
 1.11A 6j20A-3i6rA:
undetectable		 6j20A-3i6rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 ILE A 381
GLN A 378
GLU A 372
HIS A 373
 None
 0.96A 6j20A-3iu1A:
undetectable		 6j20A-3iu1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A   8
GLN A  35
GLU A 101
VAL A  98
 None
 1.18A 6j20A-3iwaA:
undetectable		 6j20A-3iwaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 ILE A 573
GLU A 672
VAL A 120
TRP A 660
 None
 1.13A 6j20A-3jb9A:
undetectable		 6j20A-3jb9A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		4 ILE A 167
GLN A 170
GLU A 237
VAL A 252
 None
 1.11A 6j20A-3k2kA:
undetectable		 6j20A-3k2kA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 276
GLU A 224
HIS A 222
VAL A 202
 None
 1.07A 6j20A-3my0A:
1.5		 6j20A-3my0A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 ILE A 115
GLU A 103
HIS A 118
VAL A 119
 None
 1.18A 6j20A-3nvaA:
undetectable		 6j20A-3nvaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 ILE A  98
GLN A  94
GLU A 133
VAL A 138
 None
 1.19A 6j20A-3odmA:
undetectable		 6j20A-3odmA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ILE A 193
GLU A  58
HIS A  56
VAL A  46
 None
 0.98A 6j20A-3ogrA:
undetectable		 6j20A-3ogrA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqp PUTATIVE
ISOCHORISMATASE

(Paraburkholderia
xenovorans) 		PF00857
(Isochorismatase) 		4 ILE A  36
GLU A  79
HIS A  74
VAL A  13
 None
 0.85A 6j20A-3oqpA:
undetectable		 6j20A-3oqpA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		4 ILE A 189
GLU A 292
HIS A 293
VAL A 203
 None
 1.18A 6j20A-3r7pA:
undetectable		 6j20A-3r7pA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1
GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA)
PF04670
(Gtr1_RagA) 		4 ILE A 268
GLN A 295
GLU B 304
VAL B 272
 None
 1.16A 6j20A-3r7wA:
undetectable		 6j20A-3r7wA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uav PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus cereus) 		PF01048
(PNP_UDP_1) 		4 ILE A  16
GLN A  60
GLU A  75
VAL A  82
 None
None
GOL  A 238 (-4.8A)
None
 1.17A 6j20A-3uavA:
undetectable		 6j20A-3uavA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		4 ILE A  66
TRP A  99
HIS A  79
VAL A  95
 None
 1.10A 6j20A-3w08A:
undetectable		 6j20A-3w08A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 ILE A 155
GLU A 141
HIS A 143
VAL A 135
 None
 1.06A 6j20A-3wzfA:
undetectable		 6j20A-3wzfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		4 ILE A 167
GLN A 170
GLU A 237
VAL A 252
 None
 1.04A 6j20A-4b6zA:
undetectable		 6j20A-4b6zA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bd3 PHD FINGER PROTEIN
19

(Homo sapiens) 		no annotation 4 ILE A  87
GLU A  42
VAL A  46
TRP A  50
 None
 1.13A 6j20A-4bd3A:
undetectable		 6j20A-4bd3A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		4 ILE A  39
GLU A 227
HIS A 229
VAL A  42
 None
MN  A1263 (-2.5A)
None
None
 1.08A 6j20A-4c1lA:
undetectable		 6j20A-4c1lA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		4 ILE A  17
GLU A 157
HIS A 148
VAL A  87
 None
 0.95A 6j20A-4dokA:
undetectable		 6j20A-4dokA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4

(Homo sapiens) 		PF00023
(Ank) 		4 ILE A 300
GLN A 297
GLU A 247
VAL A 254
 None
 1.07A 6j20A-4dx2A:
undetectable		 6j20A-4dx2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 187
GLN A  33
GLU A  73
HIS A  69
 None
 1.20A 6j20A-4e1jA:
undetectable		 6j20A-4e1jA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		4 ILE A 270
GLN A 116
VAL A 401
TRP A 292
 None
 0.90A 6j20A-4ex4A:
undetectable		 6j20A-4ex4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 ILE A 501
TRP A 561
HIS A 559
VAL A 493
 None
 1.17A 6j20A-4fm9A:
undetectable		 6j20A-4fm9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 340
GLN A 311
HIS A 315
VAL A 314
 None
 1.14A 6j20A-4h19A:
undetectable		 6j20A-4h19A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Saccharomyces
cerevisiae) 		PF10156
(Med17) 		4 ILE Q 569
GLU Q 671
HIS Q 675
VAL Q 678
 None
 1.02A 6j20A-4h62Q:
undetectable		 6j20A-4h62Q:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 ILE A 119
GLU A 279
HIS A 131
VAL A 132
 None
 0.85A 6j20A-4hpvA:
undetectable		 6j20A-4hpvA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 ILE A 323
GLU A 305
HIS A 281
VAL A  42
 None
 1.00A 6j20A-4mifA:
undetectable		 6j20A-4mifA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A1616
GLN A1181
HIS A1159
TRP A1156
 None
 1.13A 6j20A-4o9xA:
undetectable		 6j20A-4o9xA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 ILE A  82
GLU A 131
HIS A 127
VAL A 143
 None
 1.08A 6j20A-4oyaA:
undetectable		 6j20A-4oyaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ILE A 128
GLU A  41
HIS A  17
VAL A 133
 None
 1.07A 6j20A-4qmeA:
undetectable		 6j20A-4qmeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpa PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ILE A  91
GLU A  78
HIS A  76
VAL A  94
 None
None
None
OCS  A 110 ( 4.6A)
 1.09A 6j20A-4rpaA:
undetectable		 6j20A-4rpaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ILE A 671
GLN A 884
GLU A 880
VAL A 677
 None
 1.19A 6j20A-4xgtA:
undetectable		 6j20A-4xgtA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B

(Pseudomonas
putida) 		PF12706
(Lactamase_B_2) 		4 ILE A 270
TRP A 224
GLU A 283
VAL A 294
 None
 0.95A 6j20A-4z5yA:
undetectable		 6j20A-4z5yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgc KELCH PROTEIN

(Plasmodium
falciparum) 		PF01344
(Kelch_1)
PF02214
(BTB_2)
PF13418
(Kelch_4) 		4 ILE A 683
GLU A 461
HIS A 719
VAL A 721
 None
 0.98A 6j20A-4zgcA:
undetectable		 6j20A-4zgcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 360
GLN A 221
GLU A 267
VAL A 297
 None
 1.17A 6j20A-5aviA:
undetectable		 6j20A-5aviA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cr9 ABC-TYPE
FE3+-HYDROXAMATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Saccharomonospora
viridis) 		PF01497
(Peripla_BP_2) 		4 ILE A 328
GLN A 240
GLU A 315
VAL A 274
 None
 0.95A 6j20A-5cr9A:
undetectable		 6j20A-5cr9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 ILE A 100
GLU A 130
VAL A  80
TRP A  93
 None
 1.15A 6j20A-5dp2A:
undetectable		 6j20A-5dp2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 ILE A 443
GLN A 440
GLU A 435
VAL A 415
 None
CYT  A 602 (-2.9A)
None
None
 1.12A 6j20A-5ereA:
undetectable		 6j20A-5ereA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 ILE A  68
GLU A  82
VAL A  79
TRP A  71
 None
None
None
GLC  A1115 (-3.6A)
 1.04A 6j20A-5f7uA:
undetectable		 6j20A-5f7uA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff5 PAAA

(Pantoea
agglomerans) 		PF00899
(ThiF) 		4 ILE A 156
GLU A 205
HIS A 203
VAL A 202
 None
 1.05A 6j20A-5ff5A:
undetectable		 6j20A-5ff5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 ILE A 403
GLU A 385
VAL A 430
TRP A 365
 None
 1.09A 6j20A-5ikpA:
undetectable		 6j20A-5ikpA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj8 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25

(Rattus
norvegicus;
Rattus
norvegicus) 		no annotation
no annotation 		4 ILE D 181
GLN D 177
GLU C  55
VAL C  60
 None
CA  C 101 ( 4.0A)
None
None
 1.20A 6j20A-5kj8D:
undetectable		 6j20A-5kj8D:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF03814
(KdpA)
PF02669
(KdpC) 		4 ILE C  55
GLN C  57
VAL A 204
TRP C  36
 None
 1.09A 6j20A-5mrwC:
undetectable		 6j20A-5mrwC:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 270
GLN A 116
VAL A 394
TRP A 292
 None
 0.91A 6j20A-5oasA:
undetectable		 6j20A-5oasA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Caenorhabditis
elegans) 		no annotation 4 ILE A  14
GLU A 138
HIS A 134
VAL A 131
 None
 1.06A 6j20A-5ojiA:
undetectable		 6j20A-5ojiA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		4 ILE A 239
GLU A 207
HIS A 205
VAL A 255
 None
 1.08A 6j20A-5v2iA:
undetectable		 6j20A-5v2iA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 ILE A1068
GLN A1170
GLU A1171
VAL A1073
 None
None
PRO  A1602 ( 4.7A)
None
 1.18A 6j20A-5vadA:
undetectable		 6j20A-5vadA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana) 		no annotation 4 ILE A 215
GLN A 291
GLU A 286
VAL A 228
 None
 1.19A 6j20A-5w75A:
undetectable		 6j20A-5w75A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 ILE A 117
GLU A 151
VAL A 223
TRP A 229
 None
GOL  A 802 ( 3.2A)
None
None
 1.07A 6j20A-5xb7A:
undetectable		 6j20A-5xb7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 ILE A2090
GLU A2085
HIS A2127
VAL A2129
 None
 1.16A 6j20A-5y2aA:
undetectable		 6j20A-5y2aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		4 ILE A 269
GLN A 116
VAL A 400
TRP A 291
 None
 0.92A 6j20A-6axeA:
undetectable		 6j20A-6axeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk8 PRE-MRNA-SPLICING
FACTOR SYF1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE U 735
GLN U 734
GLU U 727
VAL U 692
 None
 1.02A 6j20A-6bk8U:
undetectable		 6j20A-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 ILE A 831
TRP A 882
HIS A 854
VAL A 818
 None
 1.07A 6j20A-6d6yA:
undetectable		 6j20A-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6geb DOTB

(Legionella
pneumophila) 		no annotation 4 ILE A  72
GLU A  92
HIS A  90
VAL A 105
 None
 1.08A 6j20A-6gebA:
undetectable		 6j20A-6gebA:
undetectable