SIMILAR PATTERNS OF AMINO ACIDS FOR 6IFT_A_SAMA301

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1f82	BOTULINUM NEUROTOXIN TYPE B (Clostridium botulinum)	PF01742 (Peptidase_M27)	5	ILE A 158 GLY A 188 ILE A 172 ASP A 173 PRO A  24	None	1.05A	6iftA-1f82A: undetectable	6iftA-1f82A: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1m2w	MANNITOL DEHYDROGENASE (Pseudomonas fluorescens)	PF01232 (Mannitol_dh) PF08125 (Mannitol_dh_C)	5	LEU A  56 ILE A  99 GLY A 100 ASP A  80 PRO A  18	None	1.04A	6iftA-1m2wA: undetectable	6iftA-1m2wA: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1mjf	SPERMIDINE SYNTHASE (Pyrococcus furiosus)	PF01564 (Spermine_synth) PF17284 (Spermine_synt_N)	5	ILE A  81 GLY A  82 GLY A  84 ILE A 105 ASP A 106	None	0.50A	6iftA-1mjfA: 10.1	6iftA-1mjfA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ne2	HYPOTHETICAL PROTEIN TA1320 (Thermoplasma acidophilum)	PF06325 (PrmA)	5	GLY A  56 GLY A  58 ILE A  79 ASP A  80 VAL A 101	None	0.50A	6iftA-1ne2A: 12.6	6iftA-1ne2A: 23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1o5w	AMINE OXIDASE [FLAVIN-CONTAINING] A (Rattus norvegicus)	PF01593 (Amino_oxidase)	5	ILE A  19 GLY A  20 GLY A  22 ALA A  27 VAL A 244	FAD  A 652 (-4.8A) FAD  A 652 (-3.3A) FAD  A 652 (-3.4A) None FAD  A 652 (-3.9A)	0.69A	6iftA-1o5wA: undetectable	6iftA-1o5wA: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1obb	ALPHA-GLUCOSIDASE (Thermotoga maritima)	PF02056 (Glyco_hydro_4) PF11975 (Glyco_hydro_4C)	5	ILE A   9 GLY A  10 GLY A  12 ILE A  40 ASP A  41	None NAD  A 500 (-3.5A) NAD  A 500 (-3.0A) NAD  A 500 (-3.9A) None	0.68A	6iftA-1obbA: 2.7	6iftA-1obbA: 23.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1qyr	HIGH LEVEL KASUGAMYCIN RESISTANCE PROTEIN (Escherichia coli)	PF00398 (RrnaAD)	8	PHE A  19 LEU A  20 GLU A  43 GLY A  45 GLY A  47 ALA A  50 ASP A  68 PRO A 115	None	0.77A	6iftA-1qyrA: 28.4	6iftA-1qyrA: 33.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1qyr	HIGH LEVEL KASUGAMYCIN RESISTANCE PROTEIN (Escherichia coli)	PF00398 (RrnaAD)	9	PHE A  19 LEU A  20 GLU A  43 ILE A  44 GLY A  45 GLY A  47 ALA A  50 ASP A  68 LEU A  71	None	0.62A	6iftA-1qyrA: 28.4	6iftA-1qyrA: 33.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1sez	PROTOPORPHYRINOGEN OXIDASE, MITOCHONDRIAL (Nicotiana tabacum)	PF01593 (Amino_oxidase)	5	ILE A  19 GLY A  20 GLY A  22 ALA A  27 VAL A 264	FAD  A 600 (-4.7A) FAD  A 600 (-3.4A) FAD  A 600 (-3.3A) None FAD  A 600 (-3.8A)	0.74A	6iftA-1sezA: 3.2	6iftA-1sezA: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1tt7	YHFP (Bacillus subtilis)	PF00107 (ADH_zinc_N) PF08240 (ADH_N)	5	GLY A  48 GLY A  51 ALA A  53 ILE A  43 LEU A  65	None	1.06A	6iftA-1tt7A: 4.6	6iftA-1tt7A: 22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1up4	6-PHOSPHO-BETA-GLUCO SIDASE (Thermotoga maritima)	PF02056 (Glyco_hydro_4) PF11975 (Glyco_hydro_4C)	5	ILE A   6 GLY A   7 GLY A   9 ILE A  37 ASP A  38	None	0.77A	6iftA-1up4A: 3.0	6iftA-1up4A: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1v6t	HYPOTHETICAL UPF0271 PROTEIN PH0986 (Pyrococcus horikoshii)	PF03746 (LamB_YcsF)	5	GLY A  60 ALA A  31 ILE A 132 LEU A 105 PRO A 110	None	1.02A	6iftA-1v6tA: undetectable	6iftA-1v6tA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1vbf	231AA LONG HYPOTHETICAL PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE (Sulfurisphaera tokodaii)	PF01135 (PCMT)	5	GLU A  76 ILE A  77 GLY A  78 GLY A  80 ILE A 100	None	0.27A	6iftA-1vbfA: 9.1	6iftA-1vbfA: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1vqz	LIPOATE-PROTEIN LIGASE, PUTATIVE (Streptococcus pneumoniae)	PF03099 (BPL_LplA_LipB) PF10437 (Lip_prot_lig_C)	5	PHE A 262 ILE A 252 GLY A 251 ALA A 263 ASP A 167	EDO  A 408 (-4.1A) None UNL  A 400 (-3.5A) None None	1.02A	6iftA-1vqzA: undetectable	6iftA-1vqzA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1xj5	SPERMIDINE SYNTHASE 1 (Arabidopsis thaliana)	PF01564 (Spermine_synth) PF17284 (Spermine_synt_N)	5	ILE A 127 GLY A 128 GLY A 130 ILE A 152 ASP A 153	None	0.36A	6iftA-1xj5A: 10.5	6iftA-1xj5A: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1zkd	DUF185 (Rhodopseudomonas palustris)	PF02636 (Methyltransf_28)	6	GLU A  86 ILE A  87 GLY A  88 GLY A  90 ILE A 119 LEU A 123	None	0.56A	6iftA-1zkdA: 8.1	6iftA-1zkdA: 22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1zq9	PROBABLE DIMETHYLADENOSINE TRANSFERASE (Homo sapiens)	PF00398 (RrnaAD)	6	GLU A  62 GLY A  64 GLY A  66 ASP A  87 LEU A  90 VAL A 114	None SAM  A4000 (-3.1A) SAM  A4000 (-3.2A) None SAM  A4000 (-4.8A) SAM  A4000 (-3.9A)	0.62A	6iftA-1zq9A: 27.0	6iftA-1zq9A: 31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1zq9	PROBABLE DIMETHYLADENOSINE TRANSFERASE (Homo sapiens)	PF00398 (RrnaAD)	6	LEU A  39 GLU A  62 GLY A  64 GLY A  66 LEU A  90 VAL A 114	None None SAM  A4000 (-3.1A) SAM  A4000 (-3.2A) SAM  A4000 (-4.8A) SAM  A4000 (-3.9A)	0.58A	6iftA-1zq9A: 27.0	6iftA-1zq9A: 31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2b2c	SPERMIDINE SYNTHASE (Caenorhabditis elegans)	PF01564 (Spermine_synth) PF17284 (Spermine_synt_N)	5	ILE A 115 GLY A 116 GLY A 118 ILE A 140 ASP A 141	None	0.72A	6iftA-2b2cA: 9.2	6iftA-2b2cA: 24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2dw4	LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 (Homo sapiens)	PF01593 (Amino_oxidase) PF04433 (SWIRM)	5	ILE A 284 GLY A 285 GLY A 287 ALA A 292 VAL A 590	None FAD  A1001 (-3.2A) FAD  A1001 (-3.3A) None FAD  A1001 (-3.8A)	0.76A	6iftA-2dw4A: 3.0	6iftA-2dw4A: 19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2h1r	DIMETHYLADENOSINE TRANSFERASE, PUTATIVE (Plasmodium falciparum)	PF00398 (RrnaAD)	6	GLU A  27 ILE A  28 GLY A  29 GLY A  31 ILE A  51 ASP A  52	None	0.90A	6iftA-2h1rA: 24.3	6iftA-2h1rA: 31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2h1r	DIMETHYLADENOSINE TRANSFERASE, PUTATIVE (Plasmodium falciparum)	PF00398 (RrnaAD)	5	LEU A   4 GLU A  27 ILE A  28 GLY A  29 GLY A  31	None	0.62A	6iftA-2h1rA: 24.3	6iftA-2h1rA: 31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ipp	CATHEPSIN B (Homo sapiens)	PF00112 (Peptidase_C1)	5	GLU B 171 ILE B 201 GLY B 172 ALA B  77 VAL B 217	None	0.98A	6iftA-2ippB: undetectable	6iftA-2ippB: 19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2pbh	PROCATHEPSIN B (Homo sapiens)	PF00112 (Peptidase_C1) PF08127 (Propeptide_C1)	5	GLU A 171 ILE A 201 GLY A 172 ALA A  77 VAL A 217	None	0.91A	6iftA-2pbhA: undetectable	6iftA-2pbhA: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2uzz	N-METHYL-L-TRYPTOPHA N OXIDASE (Escherichia coli)	PF01266 (DAO)	5	ILE A   8 GLY A   9 GLY A  11 ALA A  16 VAL A 172	None FAD  A1373 (-3.5A) FAD  A1373 (-3.4A) None FAD  A1373 (-3.7A)	0.70A	6iftA-2uzzA: 2.9	6iftA-2uzzA: 22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ypf	AVRBS3 (Xanthomonas campestris)	PF03377 (TAL_effector)	5	LEU A 238 ILE A 263 GLY A 267 ALA A 237 VAL A 295	None	1.05A	6iftA-2ypfA: undetectable	6iftA-2ypfA: 16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yxe	PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE (Methanocaldococcus jannaschii)	PF01135 (PCMT)	5	GLU A  83 ILE A  84 GLY A  85 GLY A  87 LEU A 114	None	0.49A	6iftA-2yxeA: 10.1	6iftA-2yxeA: 22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zsu	SPERMIDINE SYNTHASE (Pyrococcus horikoshii)	PF01564 (Spermine_synth) PF17284 (Spermine_synt_N)	5	ILE A  83 GLY A  84 GLY A  86 ILE A 108 ASP A 109	None	0.51A	6iftA-2zsuA: 10.2	6iftA-2zsuA: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zwv	PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE (Thermus thermophilus)	PF05175 (MTS)	5	GLY A 241 ALA A 246 ASP A 264 VAL A 289 PRO A 307	SAH  A 376 (-3.1A) SAH  A 376 (-3.3A) None SAH  A 376 (-4.0A) SAH  A 376 ( 4.3A)	0.79A	6iftA-2zwvA: 9.2	6iftA-2zwvA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zwv	PROBABLE RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE (Thermus thermophilus)	PF05175 (MTS)	5	GLY A 241 GLY A 243 ALA A 246 ASP A 264 PRO A 307	SAH  A 376 (-3.1A) SAH  A 376 (-3.4A) SAH  A 376 (-3.3A) None SAH  A 376 ( 4.3A)	0.57A	6iftA-2zwvA: 9.2	6iftA-2zwvA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3anx	SPERMIDINE SYNTHASE (Thermus thermophilus)	PF01564 (Spermine_synth) PF17284 (Spermine_synt_N)	5	GLY A  85 GLY A  87 ALA A  90 ILE A 109 ASP A 110	MTA  A 315 (-3.2A) MTA  A 315 (-4.0A) None MTA  A 315 (-3.7A) None	0.60A	6iftA-3anxA: 9.5	6iftA-3anxA: 23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3bkx	SAM-DEPENDENT METHYLTRANSFERASE (Lactobacillus paracasei)	PF13649 (Methyltransf_25)	5	GLU A  48 ILE A  49 GLY A  50 GLY A  52 ILE A  75	None	0.77A	6iftA-3bkxA: 10.9	6iftA-3bkxA: 24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cin	MYO-INOSITOL-1-PHOSP HATE SYNTHASE-RELATED PROTEIN (Thermotoga maritima)	PF01658 (Inos-1-P_synth) PF07994 (NAD_binding_5)	5	GLU A 118 GLY A  86 ALA A 111 ILE A  83 ASP A  53	None None None None NAD  A 400 (-2.9A)	1.06A	6iftA-3cinA: 3.9	6iftA-3cinA: 23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cin	MYO-INOSITOL-1-PHOSP HATE SYNTHASE-RELATED PROTEIN (Thermotoga maritima)	PF01658 (Inos-1-P_synth) PF07994 (NAD_binding_5)	5	LEU A  35 GLY A 322 GLY A  32 ALA A  36 VAL A  12	None None None None NAD  A 400 ( 3.7A)	1.01A	6iftA-3cinA: 3.9	6iftA-3cinA: 23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3dlc	PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE (Methanococcus maripaludis)	PF08241 (Methyltransf_11)	5	ILE A  49 GLY A  50 GLY A  52 ALA A  55 VAL A 101	None SAM  A 220 (-3.5A) SAM  A 220 (-3.2A) SAM  A 220 ( 4.9A) SAM  A 220 ( 4.2A)	0.80A	6iftA-3dlcA: 9.8	6iftA-3dlcA: 24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3evz	METHYLTRANSFERASE (Pyrococcus furiosus)	PF05175 (MTS)	5	GLU A  86 ILE A  87 GLY A  88 GLY A  90 ASP A 113	None	0.62A	6iftA-3evzA: 12.4	6iftA-3evzA: 23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3fdb	PUTATIVE PLP-DEPENDENT BETA-CYSTATHIONASE (Corynebacterium diphtheriae)	PF00155 (Aminotran_1_2)	5	LEU A 120 ILE A 153 GLY A 128 VAL A 142 PRO A 110	None	1.06A	6iftA-3fdbA: undetectable	6iftA-3fdbA: 23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	PF00398 (RrnaAD)	7	LEU A  30 GLU A  52 GLY A  54 GLY A  56 ALA A  59 ASP A  77 LEU A  80	None	0.54A	6iftA-3futA: 29.0	6iftA-3futA: 37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3fut	DIMETHYLADENOSINE TRANSFERASE (Thermus thermophilus)	PF00398 (RrnaAD)	6	PHE A  29 LEU A  30 GLY A  54 GLY A  56 ASP A  77 LEU A  80	None	0.54A	6iftA-3futA: 29.0	6iftA-3futA: 37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3fyd	PROBABLE DIMETHYLADENOSINE TRANSFERASE (Methanocaldococcus jannaschii)	PF00398 (RrnaAD)	6	LEU A  44 ILE A  58 GLY A  40 ILE A  60 ASP A  61 LEU A  64	None	1.33A	6iftA-3fydA: 28.7	6iftA-3fydA: 37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3fyd	PROBABLE DIMETHYLADENOSINE TRANSFERASE (Methanocaldococcus jannaschii)	PF00398 (RrnaAD)	9	PHE A  12 GLU A  36 ILE A  37 GLY A  38 GLY A  40 ILE A  60 ASP A  61 LEU A  64 PRO A 103	None	0.57A	6iftA-3fydA: 28.7	6iftA-3fydA: 37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3fyd	PROBABLE DIMETHYLADENOSINE TRANSFERASE (Methanocaldococcus jannaschii)	PF00398 (RrnaAD)	7	PHE A  12 LEU A  13 GLU A  36 GLY A  38 ILE A  60 ASP A  61 LEU A  64	None	0.61A	6iftA-3fydA: 28.7	6iftA-3fydA: 37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3gry	DIMETHYLADENOSINE TRANSFERASE (Methanocaldococcus jannaschii)	PF00398 (RrnaAD)	9	PHE A  12 GLU A  36 ILE A  37 GLY A  38 GLY A  40 ILE A  60 ASP A  61 LEU A  64 PRO A 103	None SAM  A 300 (-4.4A) None SAM  A 300 (-3.3A) SAM  A 300 (-3.3A) SAM  A 300 (-3.9A) None SAM  A 300 (-4.8A) SAM  A 300 (-3.8A)	0.53A	6iftA-3gryA: 28.5	6iftA-3gryA: 36.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3gry	DIMETHYLADENOSINE TRANSFERASE (Methanocaldococcus jannaschii)	PF00398 (RrnaAD)	9	PHE A  12 LEU A  13 GLU A  36 ILE A  37 GLY A  38 GLY A  40 ILE A  60 ASP A  61 LEU A  64	None SAM  A 300 (-4.0A) SAM  A 300 (-4.4A) None SAM  A 300 (-3.3A) SAM  A 300 (-3.3A) SAM  A 300 (-3.9A) None SAM  A 300 (-4.8A)	0.53A	6iftA-3gryA: 28.5	6iftA-3gryA: 36.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3hrd	NICOTINATE DEHYDROGENASE FAD-SUBUNIT (Eubacterium barkeri)	PF00941 (FAD_binding_5) PF03450 (CO_deh_flav_C)	5	ILE C 223 GLY C 220 GLY C 202 ALA C 127 VAL C 258	NO3  C5659 ( 4.8A) None None None None	1.03A	6iftA-3hrdC: undetectable	6iftA-3hrdC: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i4t	DIPHTHINE SYNTHASE (Entamoeba histolytica)	PF00590 (TP_methylase)	5	ILE A   5 GLY A   6 GLY A  83 ALA A  88 ASP A  14	None	0.82A	6iftA-3i4tA: undetectable	6iftA-3i4tA: 23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	PF01593 (Amino_oxidase)	5	ILE A  11 GLY A  12 GLY A  14 ALA A  19 VAL A 256	None FAD  A 600 (-3.4A) FAD  A 600 (-3.2A) None FAD  A 600 (-4.3A)	0.76A	6iftA-3i6dA: 2.9	6iftA-3i6dA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3k0b	PREDICTED N6-ADENINE-SPECIFIC DNA METHYLASE (Listeria monocytogenes)	PF01170 (UPF0020) PF02926 (THUMP)	5	GLY A 200 ILE A 260 ASP A 261 LEU A 264 VAL A 288	None	0.87A	6iftA-3k0bA: 11.9	6iftA-3k0bA: 24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3l4g	PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (Homo sapiens)	PF03483 (B3_4) PF03484 (B5)	5	LEU B 413 ILE B 480 GLY B 457 ILE B 423 ASP B 422	None	0.83A	6iftA-3l4gB: undetectable	6iftA-3l4gB: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lga	SAM-DEPENDENT METHYLTRANSFERASE (Pyrococcus abyssi)	PF08704 (GCD14) PF14801 (GCD14_N)	5	GLU A  99 GLY A 101 GLY A 103 ALA A 106 ILE A 126	SAH  A 301 ( 4.7A) SAH  A 301 (-3.1A) SAH  A 301 (-3.5A) SAH  A 301 (-3.4A) SAH  A 301 (-4.1A)	0.70A	6iftA-3lgaA: 13.7	6iftA-3lgaA: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3liu	PUTATIVE CELL ADHESION PROTEIN (Parabacteroides distasonis)	PF06321 (P_gingi_FimA)	5	GLY A  71 GLY A  74 ILE A 125 ASP A 124 VAL A 105	None	1.01A	6iftA-3liuA: undetectable	6iftA-3liuA: 22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3mgg	METHYLTRANSFERASE (Methanosarcina mazei)	PF13847 (Methyltransf_31)	5	GLU A  41 GLY A  43 GLY A  45 ALA A  48 ILE A  67	None	0.83A	6iftA-3mggA: 11.2	6iftA-3mggA: 23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3n3a	PROTEIN NRDI (Escherichia coli)	PF07972 (Flavodoxin_NdrI)	5	ILE C  97 GLY C  94 GLY C  91 ALA C  89 ILE C  79	None None FMN  C 134 (-3.9A) FMN  C 134 (-3.6A) None	1.03A	6iftA-3n3aC: undetectable	6iftA-3n3aC: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o4f	SPERMIDINE SYNTHASE (Escherichia coli)	PF01564 (Spermine_synth) PF17284 (Spermine_synt_N)	5	ILE A  84 GLY A  85 GLY A  87 ALA A  90 ILE A 109	None	0.66A	6iftA-3o4fA: 9.5	6iftA-3o4fA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3qsg	NAD-BINDING PHOSPHOGLUCONATE DEHYDROGENASE-LIKE PROTEIN (Alicyclobacillus acidocaldarius)	PF03807 (F420_oxidored) PF09130 (DUF1932)	5	ILE A   6 GLY A   7 GLY A   9 ALA A  11 VAL A  53	None None None CL  A 290 ( 4.4A) None	0.88A	6iftA-3qsgA: undetectable	6iftA-3qsgA: 21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3qvl	PUTATIVE HYDANTOIN RACEMASE (Klebsiella pneumoniae)	PF01177 (Asp_Glu_race)	5	ILE A   6 GLY A  74 GLY A  94 ILE A  97 VAL A 210	None	1.02A	6iftA-3qvlA: undetectable	6iftA-3qvlA: 24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rw9	SPERMIDINE SYNTHASE (Homo sapiens)	PF01564 (Spermine_synth) PF17284 (Spermine_synt_N)	5	ILE A 100 GLY A 101 GLY A 103 ILE A 125 ASP A 126	None DSH  A 303 (-3.4A) DSH  A 303 (-3.5A) DSH  A 303 (-3.8A) None	0.66A	6iftA-3rw9A: 9.6	6iftA-3rw9A: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3tcq	MATRIX PROTEIN VP40 (Sudan ebolavirus)	PF07447 (VP40)	5	PHE A 209 LEU A 207 ILE A 284 GLY A 260 ILE A 258	None	0.99A	6iftA-3tcqA: undetectable	6iftA-3tcqA: 21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3tqs	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A (Coxiella burnetii)	PF00398 (RrnaAD)	9	PHE A  14 LEU A  15 GLU A  38 ILE A  39 GLY A  40 GLY A  42 ALA A  45 ASP A  63 LEU A  66	None	0.73A	6iftA-3tqsA: 27.9	6iftA-3tqsA: 32.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3uzu	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A (Burkholderia pseudomallei)	PF00398 (RrnaAD)	9	PHE A  20 LEU A  21 GLU A  44 ILE A  45 GLY A  46 GLY A  48 ALA A  51 ASP A  73 LEU A  76	None	0.64A	6iftA-3uzuA: 26.0	6iftA-3uzuA: 30.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3v4p	INTEGRIN ALPHA-4 (Homo sapiens)	PF01839 (FG-GAP) PF08441 (Integrin_alpha2)	5	LEU A 325 ILE A 367 GLY A 356 GLY A 336 VAL A 417	None	0.80A	6iftA-3v4pA: undetectable	6iftA-3v4pA: 18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3zqj	UVRABC SYSTEM PROTEIN A (Mycobacterium tuberculosis)	PF00005 (ABC_tran)	5	ILE A 888 ALA A 854 ILE A 881 ASP A 880 PRO A 872	None	1.06A	6iftA-3zqjA: undetectable	6iftA-3zqjA: 14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3zuq	BOTULINUM NEUROTOXIN TYPE B (Clostridium botulinum)	PF01742 (Peptidase_M27) PF07952 (Toxin_trans)	5	ILE A 159 GLY A 189 ILE A 173 ASP A 174 PRO A  25	None	0.99A	6iftA-3zuqA: undetectable	6iftA-3zuqA: 15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4apb	FUMARATE HYDRATASE CLASS II (Mycobacterium tuberculosis)	PF00206 (Lyase_1) PF10415 (FumaraseC_C)	5	ILE A 226 GLY A 227 GLY A 234 ASP A 239 VAL A 245	None	0.85A	6iftA-4apbA: undetectable	6iftA-4apbA: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4bgu	MALATE DEHYDROGENASE (Haloferax volcanii)	PF00056 (Ldh_1_N) PF02866 (Ldh_1_C)	5	ILE A   7 GLY A   8 GLY A  11 ALA A  16 ILE A  35	None None None None CL  A1316 ( 3.9A)	0.81A	6iftA-4bguA: 3.3	6iftA-4bguA: 22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4c60	OCHRATOXINASE (Aspergillus niger)	PF01979 (Amidohydro_1)	5	LEU A 107 GLY A 376 ALA A 407 ASP A 378 PRO A 384	None	0.97A	6iftA-4c60A: undetectable	6iftA-4c60A: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4e0b	MALATE DEHYDROGENASE (Vibrio vulnificus)	PF00056 (Ldh_1_N) PF02866 (Ldh_1_C)	5	ILE A   6 GLY A   7 GLY A  10 ALA A  15 ILE A  35	None	0.83A	6iftA-4e0bA: 3.8	6iftA-4e0bA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4e6w	CLBP PEPTIDASE (Escherichia coli)	PF00144 (Beta-lactamase)	5	GLU A 199 ILE A 198 GLY A 195 ALA A 166 VAL A 104	None	1.04A	6iftA-4e6wA: undetectable	6iftA-4e6wA: 21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4fr2	1,3-PROPANEDIOL DEHYDROGENASE (Oenococcus oeni)	PF00465 (Fe-ADH)	5	LEU A  56 ILE A 138 ASP A 180 LEU A 183 VAL A 176	None	1.02A	6iftA-4fr2A: undetectable	6iftA-4fr2A: 20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4gc5	DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL (Mus musculus)	PF00398 (RrnaAD)	5	LEU A  38 GLU A  61 GLY A  63 GLY A  65 ASP A  87	None None ACT  A 402 (-3.4A) None None	0.49A	6iftA-4gc5A: 27.3	6iftA-4gc5A: 30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4gc5	DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL (Mus musculus)	PF00398 (RrnaAD)	5	LEU A  38 GLY A  63 GLY A  65 ASP A  87 PRO A 143	None ACT  A 402 (-3.4A) None None ACT  A 402 ( 4.9A)	0.84A	6iftA-4gc5A: 27.3	6iftA-4gc5A: 30.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hsu	LYSINE-SPECIFIC HISTONE DEMETHYLASE 1B (Homo sapiens)	PF01593 (Amino_oxidase) PF04433 (SWIRM) PF07496 (zf-CW)	5	ILE A 388 GLY A 389 GLY A 391 ALA A 396 VAL A 598	FAD  A 901 (-4.8A) FAD  A 901 (-3.3A) FAD  A 901 (-3.6A) None FAD  A 901 (-4.2A)	0.79A	6iftA-4hsuA: 2.9	6iftA-4hsuA: 17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4i59	CYCLOHEXYLAMINE OXIDASE (Microbacterium oxydans)	PF01593 (Amino_oxidase)	5	ILE A  37 GLY A  38 GLY A  40 ALA A  45 VAL A 263	FAD  A 501 (-4.7A) FAD  A 501 (-3.2A) FAD  A 501 (-3.5A) None FAD  A 501 (-3.9A)	0.71A	6iftA-4i59A: undetectable	6iftA-4i59A: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4itu	SHORT-CHAIN DEHYDROGENASE/REDUCT ASE SDR (Xanthobacter autotrophicus)	PF13561 (adh_short_C2)	5	GLY A  14 GLY A  16 ASP A  40 LEU A  43 VAL A  65	NAI  A 301 (-3.3A) NAI  A 301 ( 4.6A) None None NAI  A 301 (-3.5A)	0.90A	6iftA-4ituA: 5.6	6iftA-4ituA: 24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4jxj	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A (Rickettsia bellii)	PF00398 (RrnaAD)	6	GLU A  48 ILE A  49 GLY A  50 GLY A  52 ASP A  74 PRO A 118	None	0.53A	6iftA-4jxjA: 27.8	6iftA-4jxjA: 33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4jxj	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A (Rickettsia bellii)	PF00398 (RrnaAD)	6	PHE A  24 GLU A  48 ILE A  49 GLY A  50 GLY A  52 PRO A 118	None	0.47A	6iftA-4jxjA: 27.8	6iftA-4jxjA: 33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kam	O-ACETYLHOMOSERINE SULFHYDRYLASE METC (Mycobacterium marinum)	PF01053 (Cys_Met_Meta_PP)	5	ILE A 380 GLY A 381 GLY A 224 ALA A 227 VAL A 352	None	0.81A	6iftA-4kamA: 2.6	6iftA-4kamA: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kc5	RHIE PROTEIN (Paraburkholderia rhizoxinica)	PF00109 (ketoacyl-synt) PF02801 (Ketoacyl-synt_C)	5	PHE A3223 LEU A3222 GLY A3253 GLY A3178 ILE A3296	None	1.04A	6iftA-4kc5A: 2.1	6iftA-4kc5A: 16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kqn	D-HYDANTOINASE (Bacillus sp. AR9)	PF01979 (Amidohydro_1)	5	GLY A  53 GLY A 383 ALA A 372 ILE A 393 VAL A 430	GLY  A  53 ( 0.0A) GLY  A 383 ( 0.0A) ALA  A 372 ( 0.0A) ILE  A 393 ( 0.4A) VAL  A 430 ( 0.5A)	1.04A	6iftA-4kqnA: undetectable	6iftA-4kqnA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4l7v	PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE (Vibrio cholerae)	PF01135 (PCMT)	5	GLU A  81 ILE A  82 GLY A  83 GLY A  85 LEU A 109	SAH  A 301 ( 4.6A) SAH  A 301 ( 4.7A) SAH  A 301 (-3.3A) SAH  A 301 (-3.5A) SAH  A 301 (-4.6A)	0.55A	6iftA-4l7vA: 10.2	6iftA-4l7vA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4m38	PROTEIN ARGININE N-METHYLTRANSFERASE 7 (Trypanosoma brucei)	PF06325 (PrmA)	5	GLU A 101 ILE A 102 GLY A 103 GLY A 105 LEU A 130	SAH  A 401 (-3.9A) None SAH  A 401 (-3.0A) SAH  A 401 ( 3.8A) SAH  A 401 (-4.5A)	0.57A	6iftA-4m38A: 9.5	6iftA-4m38A: 23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4nas	RIBULOSE-BISPHOSPHAT E CARBOXYLASE (Alicyclobacillus acidocaldarius)	PF00016 (RuBisCO_large)	5	ILE A 298 GLY A 299 ALA A 294 LEU A 287 VAL A 356	None	1.05A	6iftA-4nasA: undetectable	6iftA-4nasA: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4o29	PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE (Pyrobaculum aerophilum)	PF01135 (PCMT)	5	GLU A  78 GLY A  80 GLY A  82 ILE A 105 LEU A 109	SAH  A 500 (-4.3A) SAH  A 500 (-3.1A) SAH  A 500 (-3.3A) SAH  A 500 (-3.7A) SAH  A 500 (-3.8A)	0.60A	6iftA-4o29A: 9.8	6iftA-4o29A: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4piv	FATTY ACID SYNTHASE (Homo sapiens)	PF08242 (Methyltransf_12) PF08659 (KR)	5	GLY A1895 GLY A1897 ALA A1901 ILE A2068 VAL A2070	NDP  A2202 (-3.6A) None None 2W4  A2205 (-3.9A) None	1.06A	6iftA-4pivA: 9.1	6iftA-4pivA: 18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4q3o	MGS-MT1 (unidentified)	PF07859 (Abhydrolase_3)	5	ILE A 124 GLY A 192 GLY A 221 ALA A 321 ILE A 218	None	1.02A	6iftA-4q3oA: 3.2	6iftA-4q3oA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rep	GAMMA-CAROTENE DESATURASE (Nonlabens dokdonensis)	PF01593 (Amino_oxidase)	5	ILE A   7 GLY A   8 GLY A  10 ALA A  15 VAL A 247	None FAD  A 501 (-3.3A) FAD  A 501 (-3.4A) None FAD  A 501 (-4.1A)	0.93A	6iftA-4repA: 3.5	6iftA-4repA: 23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4tsk	KETOL-ACID REDUCTOISOMERASE (Alicyclobacillus acidocaldarius)	PF01450 (IlvC) PF07991 (IlvN)	5	ILE A  23 GLY A  24 GLY A  26 ALA A  31 VAL A  66	None NDP  A 405 ( 3.8A) NDP  A 405 (-3.3A) None None	1.00A	6iftA-4tskA: 3.4	6iftA-4tskA: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4u8t	ZYRO0G01672P (Zygosaccharomyces rouxii)	PF04146 (YTH)	5	LEU A 225 ILE A 309 GLY A 237 ALA A 239 ASP A 273	None	1.05A	6iftA-4u8tA: undetectable	6iftA-4u8tA: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4yv2	SPERMIDINE SYNTHASE, PUTATIVE (Trypanosoma cruzi)	PF01564 (Spermine_synth) PF17284 (Spermine_synt_N)	5	ILE A  94 GLY A  95 GLY A  97 ILE A 119 ASP A 120	None S4M  A 301 (-3.5A) S4M  A 301 ( 4.5A) S4M  A 301 (-3.9A) None	0.61A	6iftA-4yv2A: 9.3	6iftA-4yv2A: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5bxy	RNA METHYLTRANSFERASE (Salinibacter ruber)	PF13847 (Methyltransf_31)	5	GLY A  31 GLY A  33 ILE A  54 ASP A  55 LEU A  58	SAH  A 201 (-3.4A) SAH  A 201 (-3.4A) SAH  A 201 (-3.9A) None SAH  A 201 (-4.4A)	0.65A	6iftA-5bxyA: 13.3	6iftA-5bxyA: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5by7	3-OXOACYL-ACP SYNTHASE III (Verrucosispora maris)	PF08541 (ACP_syn_III_C) PF08545 (ACP_syn_III)	5	LEU A 111 ILE A 284 GLY A 283 GLY A 130 ALA A 110	None	1.03A	6iftA-5by7A: undetectable	6iftA-5by7A: 22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5eku	ARGININE N-METHYLTRANSFERASE, PUTATIVE (Trypanosoma brucei)	PF06325 (PrmA)	5	GLU A 101 ILE A 102 GLY A 103 GLY A 105 LEU A 130	SAH  A 401 (-3.9A) SAH  A 401 (-4.9A) SAH  A 401 (-3.0A) SAH  A 401 (-3.6A) SAH  A 401 (-4.2A)	0.61A	6iftA-5ekuA: 8.8	6iftA-5ekuA: 23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5evy	SALICYLATE HYDROXYLASE (Pseudomonas putida)	PF01494 (FAD_binding_3)	5	ILE X  11 GLY X  12 GLY X  14 ALA X  19 VAL X 131	None FAD  X 501 ( 4.0A) FAD  X 501 (-3.7A) None None	0.86A	6iftA-5evyX: undetectable	6iftA-5evyX: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ha5	BRUCELLA OVIS OXIDOREDUCTASE (Brucella ovis)	PF13561 (adh_short_C2)	5	GLY A  21 ALA A  29 ILE A  46 ASP A  47 VAL A  72	None	0.67A	6iftA-5ha5A: 5.2	6iftA-5ha5A: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ha5	BRUCELLA OVIS OXIDOREDUCTASE (Brucella ovis)	PF13561 (adh_short_C2)	5	GLY A  21 GLY A  23 ILE A  46 ASP A  47 VAL A  72	None	0.73A	6iftA-5ha5A: 5.2	6iftA-5ha5A: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ipy	FLAVIN-CONTAINING MONOOXYGENASE (Roseovarius nubinhibens)	PF00743 (FMO-like)	5	ILE A   8 GLY A   9 GLY A  11 ALA A  16 VAL A 126	None FAD  A 502 (-3.3A) FAD  A 502 (-3.4A) None FAD  A 502 (-4.0A)	0.77A	6iftA-5ipyA: 2.9	6iftA-5ipyA: 20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5l3d	LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A (Homo sapiens)	PF01593 (Amino_oxidase) PF04433 (SWIRM)	5	ILE A 284 GLY A 285 GLY A 287 ALA A 292 VAL A 590	None FAD  A 901 (-3.3A) FAD  A 901 (-3.5A) None FAD  A 901 (-3.9A)	0.76A	6iftA-5l3dA: 2.7	6iftA-5l3dA: 16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5thz	CURJ (Moorea producens)	no annotation	5	GLU B 203 ILE B 204 GLY B 205 GLY B 207 ILE B 231	None None SAH  B 501 (-3.5A) SAH  B 501 (-3.3A) SAH  B 501 (-3.7A)	0.55A	6iftA-5thzB: 9.5	6iftA-5thzB: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	no annotation	5	ILE A 304 GLY A 301 GLY A 299 ALA A 166 LEU A  86	None None None None 42Y  A 118 ( 4.7A)	0.97A	6iftA-5wgcA: undetectable	6iftA-5wgcA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	no annotation	5	GLU A 835 ILE A 836 GLY A 837 GLY A 839 ILE A 865	None None SAH  A1102 (-3.5A) SAH  A1102 (-3.4A) SAH  A1102 (-3.6A)	0.52A	6iftA-6d6yA: 9.3	6iftA-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1bxk	PROTEIN (DTDP-GLUCOSE 4,6-DEHYDRATASE) (Escherichia coli)	PF16363 (GDP_Man_Dehyd)	4	GLN A 342 GLU A 198 ASN A  40 TYR A 331	None	1.33A	6iftA-1bxkA: 4.9	6iftA-1bxkA: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1pk6	COMPLEMENT C1Q SUBCOMPONENT, A CHAIN PRECURSOR COMPLEMENT C1Q SUBCOMPONENT, B CHAIN PRECURSOR (Homo sapiens; Homo sapiens)	PF00386 (C1q) PF00386 (C1q)	4	GLN A 146 GLU A 209 ASP A 211 ASN B 152	None	1.38A	6iftA-1pk6A: undetectable	6iftA-1pk6A: 17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wy7	HYPOTHETICAL PROTEIN PH1948 (Pyrococcus horikoshii)	PF05175 (MTS)	4	GLN A  27 GLU A  79 ASP A 105 ASN A 119	SAH  A1001 (-3.8A) SAH  A1001 (-2.8A) SAH  A1001 (-3.2A) SAH  A1001 (-4.6A)	0.45A	6iftA-1wy7A: 15.7	6iftA-1wy7A: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ae0	MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE A (Escherichia coli)	PF03562 (MltA) PF06725 (3D)	4	GLN X  42 GLU X  41 ASN X  35 TYR X 310	None	1.30A	6iftA-2ae0X: undetectable	6iftA-2ae0X: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2e7z	ACETYLENE HYDRATASE AHY (Pelobacter acetylenicus)	PF00384 (Molybdopterin) PF01568 (Molydop_binding)	4	GLN A 444 GLU A 464 ASP A 493 TYR A 442	MGD  A 801 (-3.5A) None None MGD  A 801 (-3.7A)	0.90A	6iftA-2e7zA: 0.0	6iftA-2e7zA: 18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2eyq	TRANSCRIPTION-REPAIR COUPLING FACTOR (Escherichia coli)	PF00270 (DEAD) PF00271 (Helicase_C) PF02559 (CarD_CdnL_TRCF) PF03461 (TRCF)	4	GLN A 261 GLU A 216 ASP A  72 TYR A 259	None	1.41A	6iftA-2eyqA: 2.0	6iftA-2eyqA: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2gl5	PUTATIVE DEHYDRATASE PROTEIN (Salmonella enterica)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	4	GLN A 134 GLU A 349 ASP A 297 TYR A  46	MG  A 699 ( 4.9A) None None None	1.07A	6iftA-2gl5A: 0.0	6iftA-2gl5A: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2o56	PUTATIVE MANDELATE RACEMASE (Salmonella enterica)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	4	GLN A 134 GLU A 346 ASP A 294 TYR A  46	None	1.09A	6iftA-2o56A: 1.1	6iftA-2o56A: 19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ox4	PUTATIVE MANDELATE RACEMASE (Zymomonas mobilis)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	4	GLN A 130 GLU A 340 ASP A 288 TYR A  42	None	1.14A	6iftA-2ox4A: 1.8	6iftA-2ox4A: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xn1	ALPHA-GALACTOSIDASE (Lactobacillus acidophilus)	PF02065 (Melibiase) PF16874 (Glyco_hydro_36C) PF16875 (Glyco_hydro_36N)	4	GLU A 717 ASP A 714 ASN A 594 TYR A 726	None None None GOL  A1737 ( 4.3A)	0.96A	6iftA-2xn1A: undetectable	6iftA-2xn1A: 17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yd0	ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 (Homo sapiens)	PF01433 (Peptidase_M1) PF11838 (ERAP1_C)	4	GLN A 358 GLU A 354 ASN A 375 TYR A 293	None BES  A1950 (-3.3A) None None	1.36A	6iftA-2yd0A: undetectable	6iftA-2yd0A: 16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zym	SOLUTE-BINDING PROTEIN (Thermoactinomyces vulgaris)	PF13416 (SBP_bac_8)	4	GLN A 152 GLU A 221 ASN A 158 TYR A 147	None	1.42A	6iftA-2zymA: undetectable	6iftA-2zymA: 23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3b1e	BETAC-S LYASE (Streptococcus anginosus)	PF00155 (Aminotran_1_2)	4	GLU A 278 ASP A  65 ASN A 243 TYR A  62	None	1.47A	6iftA-3b1eA: 2.8	6iftA-3b1eA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o98	BIFUNCTIONAL GLUTATHIONYLSPERMIDI NE SYNTHETASE/AMIDASE (Escherichia coli)	PF03738 (GSP_synth) PF05257 (CHAP)	4	GLN A 239 GLU A 229 ASP A 231 ASN A 241	None	1.39A	6iftA-3o98A: undetectable	6iftA-3o98A: 19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3q2k	OXIDOREDUCTASE (Bordetella pertussis)	PF01408 (GFO_IDH_MocA) PF02894 (GFO_IDH_MocA_C)	4	GLN A 139 GLU A 319 ASP A 306 ASN A 132	None None None HP7  A 550 ( 3.9A)	1.36A	6iftA-3q2kA: 2.6	6iftA-3q2kA: 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3q5e	ATLASTIN-1 (Homo sapiens)	PF02263 (GBP)	4	GLN A 431 ASP A 426 ASN A 436 TYR A 367	None	1.50A	6iftA-3q5eA: undetectable	6iftA-3q5eA: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3uz0	STAGE III SPORULATION PROTEIN AH STAGE II SPORULATION PROTEIN Q (Bacillus subtilis; Bacillus subtilis)	PF12685 (SpoIIIAH) PF01551 (Peptidase_M23)	4	GLN B 168 GLU B 206 ASP A 209 TYR B 195	None	1.49A	6iftA-3uz0B: undetectable	6iftA-3uz0B: 22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3zgb	PHOSPHOENOLPYRUVATE CARBOXYLASE (Flaveria pringlei)	PF00311 (PEPcase)	4	GLN A 963 GLU A 109 ASP A 889 ASN A 103	ASP  A1967 ( 4.2A) None None None	1.33A	6iftA-3zgbA: 2.1	6iftA-3zgbA: 14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4cyf	PANTETHEINASE (Homo sapiens)	PF00795 (CN_hydrolase)	4	GLN A 179 GLU A 195 ASP A 163 ASN A 189	None	1.42A	6iftA-4cyfA: undetectable	6iftA-4cyfA: 20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4d1i	BETA-GALACTOSIDASE, PUTATIVE, BGL35A (Cellvibrio japonicus)	PF02449 (Glyco_hydro_42)	4	GLN A 354 ASP A 327 ASN A 352 TYR A 359	None	1.45A	6iftA-4d1iA: 2.4	6iftA-4d1iA: 20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4zuz	SIDC (Legionella pneumophila)	no annotation	4	GLN A 656 GLU A 702 ASN A 650 TYR A 635	None	1.34A	6iftA-4zuzA: undetectable	6iftA-4zuzA: 16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5c2u	NUP54 NANOBODY (Xenopus laevis; Camelus dromedarius)	no annotation PF07686 (V-set)	4	GLN B  98 GLU A 294 ASP B  51 TYR B 105	None	1.44A	6iftA-5c2uB: undetectable	6iftA-5c2uB: 18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5giv	CARBOXYPEPTIDASE 1 (Deinococcus radiodurans)	PF02074 (Peptidase_M32)	4	GLN A 420 GLU A 368 ASP A 407 TYR A 422	None	1.38A	6iftA-5givA: undetectable	6iftA-5givA: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5gkq	ALYGC MUTANT - R241A (Paraglaciecola chathamensis)	PF14592 (Chondroitinas_B)	4	GLN A 414 GLU A 416 ASN A 250 TYR A 400	None	1.46A	6iftA-5gkqA: undetectable	6iftA-5gkqA: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5k04	UNCHARACTERIZED PROTEIN (Candida albicans)	PF09797 (NatB_MDM20)	4	GLN A 312 GLU A 280 ASP A 282 ASN A 273	None	1.42A	6iftA-5k04A: undetectable	6iftA-5k04A: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5mzn	HELICASE SEN1,HELICASE SEN1 (Saccharomyces cerevisiae)	PF13086 (AAA_11) PF13087 (AAA_12)	4	GLN A1654 ASP A1616 ASN A1336 TYR A1670	None None ADP  A2001 (-4.0A) None	1.35A	6iftA-5mznA: 2.0	6iftA-5mznA: 17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ysx	- (-)	no annotation	4	GLN A 117 ASP A 160 ASN A 165 TYR A  80	None	1.49A	6iftA-5ysxA: undetectable	6iftA-5ysxA: undetectable