SIMILAR PATTERNS OF AMINO ACIDS FOR 6IE8_A_CHDA201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byw PROTEIN (HUMAN ERG
POTASSIUM CHANNEL)

(Homo sapiens) 		PF13426
(PAS_9) 		5 THR A  74
ILE A  96
ALA A  32
ARG A  62
LEU A  86
 None
 1.18A 6ie8A-1bywA:
undetectable		 6ie8A-1bywA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		5 THR A 406
ILE A 407
ALA A 309
ASP A 258
LEU A 260
 None
 1.08A 6ie8A-1c7gA:
0.4		 6ie8A-1c7gA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 THR A 409
LEU A 307
MET A 306
ARG A 284
ASP A 282
 None
 1.25A 6ie8A-1dedA:
0.0		 6ie8A-1dedA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 THR A 409
LEU A 307
MET A 306
ARG A 284
ASP A 282
 None
 1.16A 6ie8A-1kclA:
0.0		 6ie8A-1kclA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 370
THR A 356
ALA A 344
ASP A 341
LEU A 340
 None
 1.18A 6ie8A-1lxtA:
0.6		 6ie8A-1lxtA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 LEU A  65
ALA A  30
CYH A 137
LEU A 203
LEU A 119
 NAD  A5500 ( 4.6A)
None
None
None
None
 0.91A 6ie8A-1m2wA:
0.0		 6ie8A-1m2wA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 300
ALA A 218
LEU A  89
ARG A  93
ASP A  91
 None
 1.29A 6ie8A-1po0A:
undetectable		 6ie8A-1po0A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 THR A 199
ILE A 272
TYR A 206
LEU A  57
LEU A  49
 None
 1.32A 6ie8A-1rtrA:
2.5		 6ie8A-1rtrA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sei RIBOSOMAL PROTEIN S8

(Geobacillus
stearothermophilus) 		PF00410
(Ribosomal_S8) 		5 LEU A  75
ILE A  35
ALA A  16
LEU A  59
LEU A  63
 None
 1.10A 6ie8A-1seiA:
undetectable		 6ie8A-1seiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Mycobacterium
tuberculosis) 		PF01513
(NAD_kinase) 		5 THR A  21
ILE A 121
ALA A 282
LEU A  82
LEU A  78
 None
 1.15A 6ie8A-1u0tA:
0.0		 6ie8A-1u0tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 THR A  48
ALA A 171
LEU A  45
ARG A   2
LEU A 181
 None
 1.32A 6ie8A-1uzgA:
undetectable		 6ie8A-1uzgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 LEU A 267
THR A 186
ALA A 274
ASP A 217
LEU A 181
 None
 1.32A 6ie8A-1vcnA:
0.0		 6ie8A-1vcnA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg0 PHYCOERYTHRIN
ALPHA-3 CHAIN
B-PHYCOERYTHRIN BETA
CHAIN

(Rhodomonas sp.
CS24;
Rhodomonas sp.
CS24) 		PF02972
(Phycoerythr_ab)
PF00502
(Phycobilisome) 		5 ILE C  31
ALA A  31
LEU C  38
ARG A  17
ASP A  35
 None
None
PEB  C 258 (-4.2A)
PEB  C 258 (-3.0A)
None
 1.19A 6ie8A-1xg0C:
undetectable		 6ie8A-1xg0C:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 ILE B 174
ALA B 163
LEU B 189
MET B 184
LEU B   9
 None
 1.32A 6ie8A-2f2aB:
undetectable		 6ie8A-2f2aB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 LEU A 617
THR A 826
ALA A 568
ARG A 853
LEU A 624
 None
 1.14A 6ie8A-2hg4A:
undetectable		 6ie8A-2hg4A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE

(Pyrococcus
horikoshii) 		PF16363
(GDP_Man_Dehyd) 		5 LYS A 194
THR A 210
ALA A 199
LEU A 270
LEU A 258
 None
 1.09A 6ie8A-2hunA:
undetectable		 6ie8A-2hunA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 LEU A 239
THR A 277
ILE A 279
LEU A 333
LEU A 306
 None
 1.29A 6ie8A-2j1qA:
undetectable		 6ie8A-2j1qA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		5 LEU A 637
THR A 584
ILE A 569
ALA A 456
LEU A 580
 None
 1.22A 6ie8A-2o2qA:
undetectable		 6ie8A-2o2qA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A 462
ILE A 470
ALA A 434
LEU A 475
MET A 476
 None
 1.24A 6ie8A-2oudA:
undetectable		 6ie8A-2oudA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1z PHOSPHORIBOSYLTRANSF
ERASE

(Corynebacterium
diphtheriae) 		PF00156
(Pribosyltran) 		5 LYS A   1
THR A  56
ALA A   8
LEU A  52
LEU A 169
 None
 1.22A 6ie8A-2p1zA:
undetectable		 6ie8A-2p1zA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A  99
THR A 228
ILE A 218
LEU A 232
LEU A 110
 None
 1.30A 6ie8A-2qdxA:
undetectable		 6ie8A-2qdxA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvk YJHT

(Escherichia
coli) 		PF01344
(Kelch_1) 		5 LEU A  48
ILE A  24
TYR A  23
LEU A   3
ASP A  37
 None
 1.31A 6ie8A-2uvkA:
undetectable		 6ie8A-2uvkA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 THR A 386
ILE A 256
TYR A 257
LEU A 534
MET A 538
 THR  A 386 ( 0.8A)
ILE  A 256 ( 0.7A)
TYR  A 257 ( 1.3A)
LEU  A 534 ( 0.6A)
MET  A 538 ( 0.0A)
 1.30A 6ie8A-2vbfA:
undetectable		 6ie8A-2vbfA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		5 LEU A 548
THR A 526
ILE A 787
ALA A 574
LEU A 803
 None
 1.23A 6ie8A-2vf8A:
undetectable		 6ie8A-2vf8A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x31 MAGNESIUM-CHELATASE
60 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF13519
(VWA_2) 		5 ILE A  50
ALA A  40
LEU A  61
ASP A  45
LEU A  37
 None
 1.33A 6ie8A-2x31A:
undetectable		 6ie8A-2x31A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N
LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus;
Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro)
PF00148
(Oxidored_nitro) 		5 THR A 108
ILE A 112
LEU A  70
MET B   1
LEU A 119
 None
 1.07A 6ie8A-2xdqA:
undetectable		 6ie8A-2xdqA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 THR A 152
TYR A 158
ALA A 357
LEU A 346
LEU A 370
 None
 1.27A 6ie8A-2yn9A:
1.2		 6ie8A-2yn9A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		5 THR A  50
ILE A  49
ALA A 164
LEU A 228
LEU A 161
 None
 1.22A 6ie8A-2z55A:
2.9		 6ie8A-2z55A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		5 LEU A 245
ILE A 524
ALA A 483
LEU A 472
ASP A 479
 None
 1.22A 6ie8A-3ce2A:
undetectable		 6ie8A-3ce2A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		5 THR A 223
ILE A 224
LEU A 134
ASP A 217
LEU A 122
 None
 1.21A 6ie8A-3e9zA:
undetectable		 6ie8A-3e9zA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 LEU A 341
THR A  45
ILE A  46
ALA A  69
LEU A  50
 None
 1.28A 6ie8A-3eafA:
undetectable		 6ie8A-3eafA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		5 LEU A 537
THR A  54
ILE A  55
LEU A 155
ASP A 505
 None
 1.26A 6ie8A-3epmA:
undetectable		 6ie8A-3epmA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1n PROBABLE GLUTATHIONE
S-TRANSFERASE

(Bordetella
bronchiseptica) 		PF14497
(GST_C_3) 		5 ILE A  71
TYR A  57
ALA A  33
LEU A  22
ASP A  31
 None
 1.29A 6ie8A-3h1nA:
undetectable		 6ie8A-3h1nA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		5 LEU A 142
ALA A 127
CYH A  75
ASP A 123
LEU A 122
 None
 1.02A 6ie8A-3hlkA:
undetectable		 6ie8A-3hlkA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		5 LEU A 723
ILE A 681
TYR A 720
MET A 793
LEU A 742
 None
 1.32A 6ie8A-3j9dA:
undetectable		 6ie8A-3j9dA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd3 PHOSPHOSERINE
PHOSPHOHYDROLASE-LIK
E PROTEIN

(Francisella
tularensis) 		PF12710
(HAD) 		5 ALA A 166
MET A  44
ARG A 194
ASP A 173
LEU A 176
 None
MG  A 401 ( 4.6A)
None
MG  A 401 ( 4.9A)
None
 1.27A 6ie8A-3kd3A:
undetectable		 6ie8A-3kd3A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00496
(SBP_bac_5) 		5 LEU A 490
ILE A 467
LEU A 418
ARG A 331
LEU A 337
 None
 1.05A 6ie8A-3lvuA:
undetectable		 6ie8A-3lvuA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5y SENSOR PROTEIN

(Bacillus
halodurans) 		PF13492
(GAF_3) 		5 LEU A  33
THR A  75
TYR A  66
LEU A 102
LEU A  93
 None
None
ACT  A   2 (-4.6A)
None
None
 1.31A 6ie8A-3o5yA:
undetectable		 6ie8A-3o5yA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 THR A 582
ILE A 595
TYR A 594
ALA A 607
LEU A 749
 None
 1.28A 6ie8A-3o8lA:
undetectable		 6ie8A-3o8lA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 LEU A 873
ALA A 854
LEU A1124
ASP A 851
LEU A 880
 None
 1.01A 6ie8A-3psfA:
undetectable		 6ie8A-3psfA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qf2 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF02758
(PYRIN) 		5 LEU A  14
ILE A  74
ALA A  49
ARG A  43
LEU A  57
 None
 1.29A 6ie8A-3qf2A:
undetectable		 6ie8A-3qf2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		5 LEU A 151
TYR A 162
LEU A 206
MET A 216
LEU A 169
 None
 1.30A 6ie8A-3qfoA:
undetectable		 6ie8A-3qfoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6h ENOYL-COA HYDRATASE,
ECHA3

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 LEU A  34
THR A 101
ALA A  41
LEU A 185
LEU A  49
 None
 1.22A 6ie8A-3r6hA:
undetectable		 6ie8A-3r6hA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		5 LYS A 361
LEU A 357
THR A 339
ILE A 340
ASP A  62
 None
 1.12A 6ie8A-3r9bA:
undetectable		 6ie8A-3r9bA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		6 LEU A 385
THR A 485
ILE A 486
ALA A 403
LEU A 448
MET A 444
 None
 1.49A 6ie8A-3rimA:
undetectable		 6ie8A-3rimA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 172
LEU A 339
ARG A 165
ASP A 224
LEU A 228
 None
 1.22A 6ie8A-3sheA:
undetectable		 6ie8A-3sheA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tih HIV-1 CLADE C
ZM109F.PB4 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 LEU A 349
THR A 283
ILE A 284
LEU A 453
LEU A 288
 None
 1.30A 6ie8A-3tihA:
undetectable		 6ie8A-3tihA:
17.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vw1 PUTATIVE REGULATORY
PROTEIN

(Salmonella
enterica) 		PF00440
(TetR_N) 		7 LEU A  66
THR A  85
ILE A  88
TYR A  92
ALA A 110
ASP A 152
LEU A 156
 None
 0.64A 6ie8A-3vw1A:
27.3		 6ie8A-3vw1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vw1 PUTATIVE REGULATORY
PROTEIN

(Salmonella
enterica) 		PF00440
(TetR_N) 		7 LYS A  63
LEU A  66
THR A  85
ILE A  88
ALA A 110
ASP A 152
LEU A 156
 None
 0.75A 6ie8A-3vw1A:
27.3		 6ie8A-3vw1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 901
ILE A 888
ALA A 866
CYH A1024
LEU A1049
 None
LEV  A1201 (-3.9A)
LEV  A1201 (-3.5A)
DTT  A1202 (-2.0A)
LEV  A1201 ( 4.5A)
 1.11A 6ie8A-3wzdA:
undetectable		 6ie8A-3wzdA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zog FMN-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01613
(Flavin_Reduct) 		5 THR A 163
ALA A  77
LEU A  68
ARG A  72
LEU A  14
 None
 1.32A 6ie8A-3zogA:
undetectable		 6ie8A-3zogA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		5 LEU A 333
ILE A 448
ALA A 381
LEU A 320
LEU A 423
 None
 1.22A 6ie8A-3zs6A:
undetectable		 6ie8A-3zs6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		5 LYS A 264
THR A 381
ILE A 302
LEU A 371
LEU A 256
 None
 1.24A 6ie8A-4c0tA:
undetectable		 6ie8A-4c0tA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 LEU A 146
ILE A 162
TYR A 161
ARG A 142
LEU A 448
 None
 1.28A 6ie8A-4c7gA:
undetectable		 6ie8A-4c7gA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN

(Plasmodium
berghei;
synthetic
construct) 		PF00022
(Actin) 		5 THR A 278
ILE A 275
LEU A 179
ASP A 185
LEU A 268
 None
 1.19A 6ie8A-4cbwA:
undetectable		 6ie8A-4cbwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 ILE A 312
LEU A 248
ARG A 154
ASP A 253
LEU A 256
 None
 1.24A 6ie8A-4cj0A:
0.5		 6ie8A-4cj0A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  18
ILE A  97
ALA A 183
ASP A 182
LEU A 156
 None
 1.14A 6ie8A-4cokA:
undetectable		 6ie8A-4cokA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 LEU A 445
ILE A 377
TYR A 373
LEU A 409
LEU A 401
 None
 1.24A 6ie8A-4cyjA:
undetectable		 6ie8A-4cyjA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d73 1-CYS PEROXIREDOXIN

(Plasmodium
falciparum) 		PF08534
(Redoxin) 		5 LEU B  98
THR B 145
ILE B 144
TYR B 142
LEU B 152
 None
 1.16A 6ie8A-4d73B:
undetectable		 6ie8A-4d73B:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 228
THR A 126
ALA A 205
LEU A 326
LEU A 175
 None
 1.29A 6ie8A-4gmfA:
undetectable		 6ie8A-4gmfA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 596
THR A 552
ILE A 578
LEU A 545
LEU A 628
 None
 1.13A 6ie8A-4lk2A:
undetectable		 6ie8A-4lk2A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mcx ANTIDOTE PROTEIN
KILLER PROTEIN

(Proteus
vulgaris;
Proteus
vulgaris) 		PF01381
(HTH_3)
PF05015
(HigB-like_toxin) 		5 LEU B  86
ILE B  30
ALA B  40
MET A  12
LEU B  46
 None
 1.18A 6ie8A-4mcxB:
undetectable		 6ie8A-4mcxB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		5 LEU A  22
ALA A  57
LEU A 255
MET A 251
ASP A  54
 None
 1.21A 6ie8A-4n2xA:
undetectable		 6ie8A-4n2xA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 237
THR A 223
TYR A 183
ALA A 244
LEU A 118
 None
 1.12A 6ie8A-4nleA:
2.1		 6ie8A-4nleA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		5 LEU A 254
TYR A 304
ALA A 233
LEU A 172
LEU A 249
 None
 1.28A 6ie8A-4nphA:
undetectable		 6ie8A-4nphA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt RETINOID X RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		5 LEU U 369
ILE U 361
ALA U 273
ARG U 267
LEU U 259
 None
 1.31A 6ie8A-4oztU:
3.5		 6ie8A-4oztU:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdb 30S RIBOSOMAL
PROTEIN S8

(Bacillus
anthracis) 		PF00410
(Ribosomal_S8) 		5 LEU A 100
ILE A  59
ALA A  40
LEU A  83
LEU A  87
 None
 1.08A 6ie8A-4pdbA:
undetectable		 6ie8A-4pdbA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		5 ILE A1094
ALA A1042
LEU A 862
ARG A 878
LEU A 850
 None
 1.26A 6ie8A-4pj3A:
1.4		 6ie8A-4pj3A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qei GLYCINE--TRNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A 415
ILE A 250
ALA A 428
CYH A 126
LEU A 265
 None
 1.32A 6ie8A-4qeiA:
undetectable		 6ie8A-4qeiA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 LEU A  65
THR A 118
ILE A 119
LEU A 147
LEU A  42
 None
 1.29A 6ie8A-4qgkA:
undetectable		 6ie8A-4qgkA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r01 PUTATIVE NADH-FLAVIN
REDUCTASE

(Streptococcus
pneumoniae) 		PF13460
(NAD_binding_10) 		6 LEU A  47
ILE A  80
ALA A   4
LEU A 143
ARG A  93
LEU A  55
 None
 1.44A 6ie8A-4r01A:
undetectable		 6ie8A-4r01A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpf HOMOSERINE KINASE

(Yersinia pestis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LYS A   3
LEU A 308
THR A  30
ALA A 105
ASP A  34
 None
 1.31A 6ie8A-4rpfA:
undetectable		 6ie8A-4rpfA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uir OLEATE HYDRATASE

(Elizabethkingia
meningoseptica) 		PF06100
(MCRA) 		5 LEU A 193
ILE A 206
TYR A 209
LEU A 215
ASP A 186
 None
 1.12A 6ie8A-4uirA:
undetectable		 6ie8A-4uirA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwm PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Brucella ovis) 		PF13420
(Acetyltransf_4) 		5 ILE A  88
ALA A  69
LEU A 133
ASP A  84
LEU A 105
 None
 1.23A 6ie8A-5dwmA:
undetectable		 6ie8A-5dwmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		5 LEU A  21
THR A   6
TYR A  13
ALA A  51
ARG A  44
 None
 1.19A 6ie8A-5dx9A:
undetectable		 6ie8A-5dx9A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1m PHOSPHORYLATED
PROTEIN PHOSPHATASE

(Staphylococcus
aureus) 		PF13672
(PP2C_2) 		5 LEU A 183
THR A 135
ILE A 134
ALA A   4
LEU A  33
 None
 1.22A 6ie8A-5f1mA:
undetectable		 6ie8A-5f1mA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 LEU A  91
THR A 220
ALA A 199
LEU A 234
LEU A  57
 None
 1.23A 6ie8A-5f56A:
undetectable		 6ie8A-5f56A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE
PROTEASOME SUBUNIT
ALPHA TYPE

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 LEU C 175
THR C  34
ILE C  35
LEU C 135
LEU D  53
 None
 1.32A 6ie8A-5fmgC:
undetectable		 6ie8A-5fmgC:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 479
THR A 546
ILE A 566
TYR A 393
ALA A 326
 None
 1.30A 6ie8A-5fr8A:
undetectable		 6ie8A-5fr8A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		5 LEU A 425
ILE A 406
LEU A 779
MET A 778
LEU A 744
 None
 1.23A 6ie8A-5hb3A:
undetectable		 6ie8A-5hb3A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00459
(Inositol_P) 		5 LEU A 213
THR A  74
ALA A 184
LEU A  63
LEU A 204
 None
None
PO4  A 301 ( 4.8A)
None
None
 1.20A 6ie8A-5i3sA:
undetectable		 6ie8A-5i3sA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12) 		5 LEU A 899
THR A 853
ILE A 854
ALA A 865
LEU A 786
 None
 1.29A 6ie8A-5ic9A:
2.5		 6ie8A-5ic9A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 338
ALA A 291
LEU A 306
MET A 283
LEU A 276
 None
 1.27A 6ie8A-5ixqA:
undetectable		 6ie8A-5ixqA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 338
ILE A 327
ALA A 291
LEU A 306
LEU A 276
 None
 0.93A 6ie8A-5ixqA:
undetectable		 6ie8A-5ixqA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7

(Zea mays) 		PF00248
(Aldo_ket_red) 		5 LEU A 250
ILE A  43
LEU A 100
ARG A  47
LEU A 109
 None
 1.33A 6ie8A-5jh1A:
undetectable		 6ie8A-5jh1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 5 THR A 135
ILE A 134
ALA A  30
LEU A 105
LEU A  75
 None
 1.25A 6ie8A-5jnmA:
undetectable		 6ie8A-5jnmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 LEU A  85
ILE A 118
ALA A 161
LEU A 125
LEU A 157
 None
 1.00A 6ie8A-5kdxA:
undetectable		 6ie8A-5kdxA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		5 LEU A 355
ILE A 361
ALA A 350
LEU A 340
ASP A 346
 None
 1.26A 6ie8A-5mswA:
undetectable		 6ie8A-5mswA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 5 LEU A 447
ILE A 421
TYR A 419
LEU A 321
LEU A 463
 None
 1.20A 6ie8A-5oatA:
undetectable		 6ie8A-5oatA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 ILE B  71
ALA B 218
LEU B 109
ASP B 219
LEU B 220
 None
 1.31A 6ie8A-5of4B:
undetectable		 6ie8A-5of4B:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 401
THR A 340
ILE A 343
LEU A 384
LEU A 392
 None
 1.29A 6ie8A-5oqrA:
undetectable		 6ie8A-5oqrA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tov ADENOSYLHOMOCYSTEINA
SE

(Thermotoga
maritima) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LYS A 317
LEU A 313
ALA A 277
MET A 245
LEU A 279
 None
 1.04A 6ie8A-5tovA:
undetectable		 6ie8A-5tovA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 THR A 191
TYR A 185
ALA A 400
LEU A 425
ASP A 396
 None
 1.06A 6ie8A-5ucyA:
undetectable		 6ie8A-5ucyA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufy ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 5 LEU A 507
THR A 432
ALA A 542
LEU A 594
LEU A 515
 None
None
NA  A 701 (-4.9A)
None
None
 1.11A 6ie8A-5ufyA:
undetectable		 6ie8A-5ufyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ug1 ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 5 LEU A 507
THR A 432
ALA A 542
LEU A 594
LEU A 515
 None
None
NA  A 702 (-4.9A)
None
None
 1.13A 6ie8A-5ug1A:
undetectable		 6ie8A-5ug1A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 THR A 192
TYR A 186
ALA A 401
LEU A 426
ASP A 397
 None
 1.04A 6ie8A-5w3fA:
undetectable		 6ie8A-5w3fA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wf2 UNCHARACTERIZED
PROTEIN

(Equus caballus) 		no annotation 5 LEU A 364
ALA A 382
CYH A 434
LEU A 427
LEU A 371
 None
 1.12A 6ie8A-5wf2A:
undetectable		 6ie8A-5wf2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 5 LEU A1356
ILE A1328
ALA A1345
ARG A1311
LEU A1317
 None
 1.30A 6ie8A-5yudA:
undetectable		 6ie8A-5yudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 5 LYS A 292
ALA A 177
ARG A 240
ASP A 173
LEU A 168
 None
 1.25A 6ie8A-5zb8A:
undetectable		 6ie8A-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 5 LEU G 349
THR G 283
ILE G 284
LEU G 453
LEU G 288
 None
 1.27A 6ie8A-6ck9G:
undetectable		 6ie8A-6ck9G:
undetectable