SIMILAR PATTERNS OF AMINO ACIDS FOR 6IBL_A_H98A501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 ASP A 125
SER A 116
SER A 118
ASN A 173
 None
 1.48A 6iblA-1ms8A:
0.0		 6iblA-1ms8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1typ TRYPANOTHIONE
REDUCTASE

(Crithidia
fasciculata) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASP A 432
SER A 406
SER A 404
ASN A  68
 None
 1.12A 6iblA-1typA:
0.0		 6iblA-1typA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASP A 113
SER A 203
SER A 207
ASN A 312
 ERC  A1201 (-3.7A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-3.0A)
 0.65A 6iblA-3pdsA:
32.2		 6iblA-3pdsA:
37.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbi TRAF PROTEIN
TRAO PROTEIN

(Escherichia
coli;
Escherichia
coli) 		PF03743
(TrbI)
PF03524
(CagX) 		4 ASP A 883
SER B 968
SER B 970
ASN A 826
 None
 1.47A 6iblA-3zbiA:
0.0		 6iblA-3zbiA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASP A1113
SER A1203
SER A1207
ASN A1312
 P0G  A1401 (-2.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 (-2.9A)
 0.20A 6iblA-4ldeA:
41.0		 6iblA-4ldeA:
45.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASP A1113
SER A1204
SER A1207
ASN A1312
 P0G  A1401 (-2.9A)
P0G  A1401 ( 3.7A)
P0G  A1401 (-2.8A)
P0G  A1401 (-2.9A)
 1.11A 6iblA-4ldeA:
41.0		 6iblA-4ldeA:
45.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 ASP A 573
SER A 643
SER A 651
ASN A 602
 CA  A 802 (-2.1A)
None
None
CA  A 802 (-3.0A)
 1.46A 6iblA-4m00A:
0.0		 6iblA-4m00A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		4 ASP A 216
SER A 197
SER A 155
ASN A 220
 GOL  A 401 ( 4.0A)
ACT  A 402 (-4.9A)
ACT  A 402 ( 4.4A)
None
 1.28A 6iblA-4r6yA:
0.0		 6iblA-4r6yA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 ASP A  23
SER A  27
SER A  28
ASN A 121
 None
 1.44A 6iblA-5ah5A:
0.0		 6iblA-5ah5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 ANTI-REPEBODY
ANTI-MBP

(Mus musculus;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 ASP H 133
SER H 127
SER H 126
ASN D  61
 None
 1.41A 6iblA-5gs2H:
undetectable		 6iblA-5gs2H:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4u ENDO-BETA-1,4-GLUCAN
ASE

(Cryptopygus
antarcticus) 		PF02015
(Glyco_hydro_45) 		4 ASP A  13
SER A  55
SER A  48
ASN A 111
 None
 1.33A 6iblA-5h4uA:
undetectable		 6iblA-5h4uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ASP A  52
SER A  90
SER A  94
ASN A 280
 None
 1.46A 6iblA-6aqfA:
25.2		 6iblA-6aqfA:
undetectable