SIMILAR PATTERNS OF AMINO ACIDS FOR 6I0Y_A_TRPA3001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 TRP A 446
ILE A 404
ASP A 405
 None
 0.49A 6i0y7-1bhgA:
undetectable		 6i0y7-1bhgA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 TRP A  78
ILE A  90
ASP A  91
 None
 0.90A 6i0y7-1g7cA:
undetectable		 6i0y7-1g7cA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdm PROTEIN (CLASS II
HISTOCOMPATIBILITY
ANTIGEN, M ALPHA
CHAIN)

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		3 TRP A 188
ILE A 170
ASP A 169
 None
 0.89A 6i0y7-1hdmA:
undetectable		 6i0y7-1hdmA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4g ENTEROTOXIN TYPE A

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 TRP A 130
ILE A 228
ASP A 227
 None
None
ZN  A 460 (-2.2A)
 0.80A 6i0y7-1i4gA:
undetectable		 6i0y7-1i4gA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE

(Macrophoma
commelinae) 		PF03328
(HpcH_HpaI) 		3 TRP A  68
ILE A  69
ASP A  70
 None
 0.69A 6i0y7-1izcA:
undetectable		 6i0y7-1izcA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6n GAG POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00540
(Gag_p17)
PF00607
(Gag_p24) 		3 TRP A 249
ILE A 236
ASP A 235
 None
 0.80A 6i0y7-1l6nA:
undetectable		 6i0y7-1l6nA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		3 TRP D 794
ILE D 803
ASP D 802
 None
 0.90A 6i0y7-1pytD:
undetectable		 6i0y7-1pytD:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		3 TRP A  39
ILE A  40
ASP A  72
 None
 0.78A 6i0y7-1rpxA:
undetectable		 6i0y7-1rpxA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbs MONOCLONAL ANTIBODY
3A2

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP H  33
ILE H  51
ASP H  50
 None
 0.85A 6i0y7-1sbsH:
undetectable		 6i0y7-1sbsH:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sji CALSEQUESTRIN,
CARDIAC MUSCLE
ISOFORM

(Canis lupus) 		PF01216
(Calsequestrin) 		3 TRP A 286
ILE A 287
ASP A 288
 None
 0.82A 6i0y7-1sjiA:
undetectable		 6i0y7-1sjiA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq4 GLYOXYLATE-INDUCED
PROTEIN

(Pseudomonas
aeruginosa) 		PF07883
(Cupin_2) 		3 TRP A  55
ILE A  41
ASP A  40
 None
 0.76A 6i0y7-1sq4A:
undetectable		 6i0y7-1sq4A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		3 TRP A  34
ILE A  35
ASP A  68
 None
 0.79A 6i0y7-1tqxA:
undetectable		 6i0y7-1tqxA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfk FORMIMIDOYLGLUTAMASE

(Vibrio cholerae) 		PF00491
(Arginase) 		3 TRP A 320
ILE A 322
ASP A 321
 None
 0.91A 6i0y7-1xfkA:
undetectable		 6i0y7-1xfkA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT

(Gallus gallus) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		3 TRP B 190
ILE B 192
ASP B 193
 None
 0.82A 6i0y7-1yq3B:
undetectable		 6i0y7-1yq3B:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 TRP A 336
ILE A 300
ASP A 299
 None
 0.90A 6i0y7-1zgjA:
undetectable		 6i0y7-1zgjA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		3 TRP A 488
ILE A 484
ASP A 485
 None
 0.90A 6i0y7-1zsqA:
undetectable		 6i0y7-1zsqA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnl MODULATOR PROTEIN
RSBR

(Bacillus
subtilis) 		PF08678
(Rsbr_N) 		3 TRP A 114
ILE A 116
ASP A 117
 None
 0.75A 6i0y7-2bnlA:
undetectable		 6i0y7-2bnlA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 TRP A  31
ILE A  30
ASP A  32
 FAD  A 600 (-3.6A)
None
None
 0.84A 6i0y7-2bvgA:
undetectable		 6i0y7-2bvgA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3u HYPOTHETICAL PROTEIN
PH1566

(Pyrococcus
horikoshii) 		PF00013
(KH_1) 		3 TRP A  77
ILE A  69
ASP A  70
 None
 0.87A 6i0y7-2e3uA:
undetectable		 6i0y7-2e3uA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		3 TRP A  60
ILE A  47
ASP A  61
 None
 0.87A 6i0y7-2ekmA:
undetectable		 6i0y7-2ekmA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		3 TRP A 369
ILE A 371
ASP A 374
 NAG  A 585 (-3.9A)
None
None
 0.82A 6i0y7-2gjmA:
undetectable		 6i0y7-2gjmA:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkp HYPOTHETICAL PROTEIN
NMB0488

(Neisseria
meningitidis) 		PF07262
(CdiI) 		3 TRP A  10
ILE A 113
ASP A 112
 None
None
EDO  A 402 (-3.1A)
 0.91A 6i0y7-2gkpA:
undetectable		 6i0y7-2gkpA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkp HYPOTHETICAL PROTEIN
NMB0488

(Neisseria
meningitidis) 		PF07262
(CdiI) 		3 TRP A  25
ILE A 113
ASP A 112
 NA  A 403 (-4.4A)
None
EDO  A 402 (-3.1A)
 0.67A 6i0y7-2gkpA:
undetectable		 6i0y7-2gkpA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		3 TRP A  47
ILE A  39
ASP A  40
 None
 0.91A 6i0y7-2ibpA:
undetectable		 6i0y7-2ibpA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kks UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF14464
(Prok-JAB) 		3 TRP A  38
ILE A   2
ASP A  36
 None
 0.88A 6i0y7-2kksA:
undetectable		 6i0y7-2kksA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 216
ILE A 214
ASP A 215
 None
 0.69A 6i0y7-2p88A:
undetectable		 6i0y7-2p88A:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 369
ILE A 370
ASP A 160
 None
 0.88A 6i0y7-2pp3A:
undetectable		 6i0y7-2pp3A:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vve SPIKE PROTEIN P1

(Pseudoalteromonas
virus PM2) 		no annotation 3 TRP A 126
ILE A 125
ASP A 124
 None
 0.90A 6i0y7-2vveA:
undetectable		 6i0y7-2vveA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7i MEVALONATE KINASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 TRP A 300
ILE A 177
ASP A 178
 None
 0.88A 6i0y7-2x7iA:
undetectable		 6i0y7-2x7iA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		3 TRP A  49
ILE A  50
ASP A  79
 None
 0.74A 6i0y7-2zpaA:
undetectable		 6i0y7-2zpaA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsj THREONINE SYNTHASE

(Aquifex
aeolicus) 		PF00291
(PALP) 		3 TRP A 219
ILE A 265
ASP A 266
 None
 0.64A 6i0y7-2zsjA:
undetectable		 6i0y7-2zsjA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 TRP A 479
ILE A 432
ASP A 433
 None
 0.57A 6i0y7-3bgaA:
undetectable		 6i0y7-3bgaA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnv PUTATIVE GNTR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bordetella
bronchiseptica) 		PF07702
(UTRA) 		3 TRP A 164
ILE A 147
ASP A 162
 None
 0.91A 6i0y7-3cnvA:
undetectable		 6i0y7-3cnvA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 TRP A 455
ILE A 408
ASP A 409
 None
 0.67A 6i0y7-3decA:
undetectable		 6i0y7-3decA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TRP A 320
ILE A 318
ASP A 317
 None
 0.79A 6i0y7-3jq1A:
undetectable		 6i0y7-3jq1A:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		3 TRP A 158
ILE A 160
ASP A 159
 None
 0.74A 6i0y7-3lhlA:
undetectable		 6i0y7-3lhlA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 TRP A 187
ILE A 237
ASP A 238
 None
 0.88A 6i0y7-3mgaA:
undetectable		 6i0y7-3mgaA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo) 		3 TRP W 321
ILE W 291
ASP W 292
 None
 0.66A 6i0y7-3mwyW:
undetectable		 6i0y7-3mwyW:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		3 TRP A 477
ILE A 408
ASP A 409
 None
 0.57A 6i0y7-3ob8A:
undetectable		 6i0y7-3ob8A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 TRP A 424
ILE A  57
ASP A 134
 None
 0.91A 6i0y7-3oneA:
undetectable		 6i0y7-3oneA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmi PWWP
DOMAIN-CONTAINING
PROTEIN MUM1

(Homo sapiens) 		no annotation 3 TRP A 488
ILE A 486
ASP A 485
 None
 0.66A 6i0y7-3pmiA:
undetectable		 6i0y7-3pmiA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		3 TRP A  51
ILE A  38
ASP A  37
 None
 0.66A 6i0y7-3q4iA:
undetectable		 6i0y7-3q4iA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 TRP A 374
ILE A 372
ASP A 371
 TRP  A 374 ( 0.5A)
ILE  A 372 ( 0.7A)
ASP  A 371 ( 0.5A)
 0.77A 6i0y7-3sagA:
undetectable		 6i0y7-3sagA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 3 TRP B 895
ILE B 897
ASP B 894
 None
 0.84A 6i0y7-3tixB:
undetectable		 6i0y7-3tixB:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u24 PUTATIVE LIPOPROTEIN

(Shewanella
oneidensis) 		PF05960
(DUF885) 		3 TRP A 123
ILE A 125
ASP A 124
 None
None
ACY  A 599 (-2.4A)
 0.76A 6i0y7-3u24A:
undetectable		 6i0y7-3u24A:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		3 TRP A 443
ILE A 442
ASP A 441
 None
 0.84A 6i0y7-3ukfA:
undetectable		 6i0y7-3ukfA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE

(Ascaris suum) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		3 TRP B 214
ILE B 216
ASP B 217
 None
 0.81A 6i0y7-3vrbB:
undetectable		 6i0y7-3vrbB:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE

(Trichoderma
reesei) 		PF00704
(Glyco_hydro_18) 		3 TRP X 189
ILE X 187
ASP X 188
 None
 0.75A 6i0y7-4ac1X:
undetectable		 6i0y7-4ac1X:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		3 TRP A  42
ILE A 242
ASP A 241
 None
 0.82A 6i0y7-4binA:
undetectable		 6i0y7-4binA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		3 TRP A  57
ILE A  90
ASP A  91
 None
PCA  A  23 ( 4.2A)
None
 0.60A 6i0y7-4haqA:
undetectable		 6i0y7-4haqA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		3 TRP B 101
ILE B 118
ASP B 117
 None
 0.64A 6i0y7-4hstB:
undetectable		 6i0y7-4hstB:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 3 TRP D 194
ILE D 195
ASP D 196
 None
 0.76A 6i0y7-4igbD:
undetectable		 6i0y7-4igbD:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igo OS05G0196500 PROTEIN

(Oryza sativa) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 TRP A 141
ILE A 302
ASP A 301
 None
 0.87A 6i0y7-4igoA:
undetectable		 6i0y7-4igoA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 TRP A 408
ILE A 349
ASP A 350
 None
 0.64A 6i0y7-4jhzA:
undetectable		 6i0y7-4jhzA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 TRP A 403
ILE A 348
ASP A 349
 None
 0.61A 6i0y7-4jklA:
undetectable		 6i0y7-4jklA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 TRP A 407
ILE A 351
ASP A 352
 None
 0.59A 6i0y7-4jkmA:
undetectable		 6i0y7-4jkmA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 TRP A 177
ILE A 126
ASP A 127
 None
 0.70A 6i0y7-4lixA:
undetectable		 6i0y7-4lixA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE

(Helicobacter
pylori) 		PF01522
(Polysacc_deac_1) 		3 TRP A 165
ILE A 182
ASP A 163
 None
 0.86A 6i0y7-4ly4A:
undetectable		 6i0y7-4ly4A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbr SERINE-RICH REPEAT
PROTEIN 2

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		3 TRP A 347
ILE A 290
ASP A 291
 None
 0.86A 6i0y7-4mbrA:
undetectable		 6i0y7-4mbrA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqd DNA-ENTRY NUCLEASE
INHIBITOR

(Bacillus
subtilis) 		PF11033
(ComJ) 		3 TRP A 111
ILE A 127
ASP A 128
 None
 0.85A 6i0y7-4mqdA:
undetectable		 6i0y7-4mqdA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n80 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 3 TRP A 103
ILE A 104
ASP A 101
 None
 0.81A 6i0y7-4n80A:
undetectable		 6i0y7-4n80A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
desulfuricans) 		PF03480
(DctP) 		3 TRP A 257
ILE A 258
ASP A 254
 None
 0.86A 6i0y7-4nhbA:
undetectable		 6i0y7-4nhbA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7h GLUTATHIONE
S-TRANSFERASE

(Rhodospirillum
rubrum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 TRP A 146
ILE A 148
ASP A 149
 None
 0.87A 6i0y7-4o7hA:
undetectable		 6i0y7-4o7hA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		3 TRP A 207
ILE A 154
ASP A 155
 None
 0.79A 6i0y7-4oecA:
undetectable		 6i0y7-4oecA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnw CHANOCLAVINE-I
ALDEHYDE REDUCTASE

(Aspergillus
fumigatus) 		PF00724
(Oxidored_FMN) 		3 TRP A  81
ILE A  67
ASP A  66
 None
 0.80A 6i0y7-4qnwA:
undetectable		 6i0y7-4qnwA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 TRP A2952
ILE A2833
ASP A2834
 None
 0.89A 6i0y7-4qyrA:
undetectable		 6i0y7-4qyrA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 TRP A 303
ILE A 304
ASP A 305
 None
 0.64A 6i0y7-4rvwA:
undetectable		 6i0y7-4rvwA:
2.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx4 HIV-1 CLADE A
Q842.D12 GP120

(Human
immunodeficiency
virus 1) 		no annotation 3 TRP G  69
ILE G 109
ASP G 107
 None
 0.87A 6i0y7-4rx4G:
undetectable		 6i0y7-4rx4G:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1x TRUNCATED
HEMAGGLUTININ

(unidentified
influenza virus) 		no annotation 3 TRP A  42
ILE A  45
ASP A  46
 None
 0.66A 6i0y7-4s1xA:
undetectable		 6i0y7-4s1xA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uul L-LACTATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TRP A 230
ILE A 232
ASP A 231
 None
 0.72A 6i0y7-4uulA:
undetectable		 6i0y7-4uulA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		3 TRP A 402
ILE A  34
ASP A  47
 None
 0.88A 6i0y7-4xwtA:
undetectable		 6i0y7-4xwtA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 TRP A 250
ILE A 251
ASP A 252
 None
 0.86A 6i0y7-4y1bA:
undetectable		 6i0y7-4y1bA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybl STABILIZED INNER
DOMAIN OF CLADE A/E
GP120

(Human
immunodeficiency
virus 1) 		no annotation 3 TRP G  69
ILE G 109
ASP G 107
 None
 0.89A 6i0y7-4yblG:
undetectable		 6i0y7-4yblG:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 TRP A 409
ILE A 351
ASP A 352
 None
 0.61A 6i0y7-5c70A:
undetectable		 6i0y7-5c70A:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgy HEAVY CHAIN OF FAB

(Homo sapiens) 		no annotation 3 TRP H  50
ILE H  51
ASP H  52
 None
 0.79A 6i0y7-5cgyH:
undetectable		 6i0y7-5cgyH:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqb DITRANS,POLYCIS-UNDE
CAPRENYL-DIPHOSPHATE
SYNTHASE
((2E,6E)-FARNESYL-DI
PHOSPHATE SPECIFIC)

(Escherichia
coli) 		PF01255
(Prenyltransf) 		3 TRP A 149
ILE A 151
ASP A 150
 None
 0.82A 6i0y7-5cqbA:
undetectable		 6i0y7-5cqbA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e59 FRNE PROTEIN

(Deinococcus
radiodurans) 		PF01323
(DSBA) 		3 TRP A  17
ILE A  16
ASP A  15
 None
 0.60A 6i0y7-5e59A:
undetectable		 6i0y7-5e59A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		3 TRP A1513
ILE A1515
ASP A1516
 None
 0.75A 6i0y7-5ffjA:
undetectable		 6i0y7-5ffjA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		3 TRP A 477
ILE A 479
ASP A 478
 None
 0.90A 6i0y7-5fq6A:
undetectable		 6i0y7-5fq6A:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		3 TRP A 184
ILE A 185
ASP A 327
 None
 0.84A 6i0y7-5g5zA:
undetectable		 6i0y7-5g5zA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E

(Thalictrum
flavum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 TRP A 321
ILE A 286
ASP A 285
 None
 0.91A 6i0y7-5icgA:
undetectable		 6i0y7-5icgA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		3 TRP C 170
ILE C  46
ASP C  47
 None
 0.71A 6i0y7-5ip7C:
undetectable		 6i0y7-5ip7C:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		3 TRP A  59
ILE A  92
ASP A  93
 None
PCA  A  20 ( 4.1A)
None
 0.59A 6i0y7-5mchA:
undetectable		 6i0y7-5mchA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 3 TRP A 448
ILE A 446
ASP A 445
 None
 0.55A 6i0y7-5t3bA:
undetectable		 6i0y7-5t3bA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN

(Squalimorphii) 		PF00566
(RabGAP-TBC) 		3 TRP A 410
ILE A 459
ASP A 458
 None
 0.85A 6i0y7-5tubA:
undetectable		 6i0y7-5tubA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuc SUS TBC1D15 GAP
DOMAIN

(Sus scrofa) 		PF00566
(RabGAP-TBC) 		3 TRP A 373
ILE A 422
ASP A 421
 None
 0.83A 6i0y7-5tucA:
undetectable		 6i0y7-5tucA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bacillus
anthracis) 		PF00496
(SBP_bac_5) 		3 TRP A 506
ILE A 507
ASP A 508
 None
 0.87A 6i0y7-5u4oA:
undetectable		 6i0y7-5u4oA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6p ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE HRD1

(Saccharomyces
cerevisiae) 		no annotation 3 TRP A 305
ILE A 307
ASP A 306
 None
 0.88A 6i0y7-5v6pA:
undetectable		 6i0y7-5v6pA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 3 TRP A  61
ILE A  63
ASP A  64
 None
 0.66A 6i0y7-5v9xA:
undetectable		 6i0y7-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 TRP J 299
ILE J 297
ASP J 296
 None
None
A  M  16 ( 3.6A)
 0.89A 6i0y7-5vzjJ:
undetectable		 6i0y7-5vzjJ:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila) 		no annotation 3 TRP A  40
ILE A  73
ASP A  74
 None
PCA  A   1 ( 4.8A)
None
 0.59A 6i0y7-5w11A:
undetectable		 6i0y7-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		no annotation 3 TRP C 170
ILE C  46
ASP C  47
 None
 0.55A 6i0y7-5w4uC:
undetectable		 6i0y7-5w4uC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 3 TRP A 930
ILE A 932
ASP A 931
 None
None
A  B  -6 ( 3.9A)
 0.84A 6i0y7-5wlhA:
undetectable		 6i0y7-5wlhA:
1.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE

(Komagataella
phaffii) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		3 TRP C 170
ILE C  45
ASP C  46
 None
 0.78A 6i0y7-5xogC:
undetectable		 6i0y7-5xogC:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 3 TRP A 421
ILE A 377
ASP A 378
 None
 0.57A 6i0y7-6b6lA:
undetectable		 6i0y7-6b6lA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 3 TRP A 420
ILE A 362
ASP A 363
 None
 0.50A 6i0y7-6bo6A:
undetectable		 6i0y7-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 3 TRP A 102
ILE A  74
ASP A  75
 EWM  A 301 (-4.9A)
None
EWM  A 301 (-3.3A)
 0.79A 6i0y7-6cc0A:
undetectable		 6i0y7-6cc0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es4 SYNCRIP, ISOFORM K

(Drosophila
melanogaster) 		no annotation 3 TRP A 191
ILE A 190
ASP A 192
 None
EDO  A 306 (-4.0A)
None
 0.86A 6i0y7-6es4A:
undetectable		 6i0y7-6es4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Sus scrofa) 		no annotation 3 TRP C 176
ILE C  47
ASP C  48
 None
 0.70A 6i0y7-6exvC:
undetectable		 6i0y7-6exvC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE

(Pseudomonas
aeruginosa) 		no annotation 3 TRP A 346
ILE A 599
ASP A 596
 None
 0.90A 6i0y7-6fbtA:
undetectable		 6i0y7-6fbtA:
undetectable