SIMILAR PATTERNS OF AMINO ACIDS FOR 6HUP_D_DZPD2001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 TYR A  47
ASN A 136
PHE A 277
TYR A 281
SER A 172
 None
 1.50A 6hupC-2ad1A:
0.0
6hupD-2ad1A:
0.0		 6hupC-2ad1A:
13.99
6hupD-2ad1A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1
TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4

(Mus musculus;
Homo sapiens) 		PF04099
(Sybindin)
PF04099
(Sybindin) 		5 PHE D 142
PHE C  48
VAL D 156
SER D   5
TYR D   7
 None
 1.13A 6hupC-2j3tD:
1.5
6hupD-2j3tD:
0.8		 6hupC-2j3tD:
16.13
6hupD-2j3tD:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 ASN A 395
PHE A 391
PHE A 381
TYR A 363
VAL A 308
 None
 1.43A 6hupC-3k1dA:
1.9
6hupD-3k1dA:
1.1		 6hupC-3k1dA:
6.83
6hupD-3k1dA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 ASN A 328
PHE A 324
PHE A 314
TYR A 297
VAL A 237
 None
 1.46A 6hupC-3vu2A:
1.7
6hupD-3vu2A:
0.9		 6hupC-3vu2A:
8.74
6hupD-3vu2A:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 ASN A 418
PHE A 414
PHE A 404
TYR A 386
VAL A 331
 None
 1.44A 6hupC-5gr1A:
2.6
6hupD-5gr1A:
1.8		 6hupC-5gr1A:
6.62
6hupD-5gr1A:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 5 PHE B 100
HIS B 102
TYR B 160
VAL B 203
TYR B 210
 None
 0.65A 6hupC-6d6uB:
33.5
6hupD-6d6uB:
35.0		 6hupC-6d6uB:
20.22
6hupD-6d6uB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 5 PHE B 100
TYR B 160
VAL B 203
SER B 205
TYR B 210
 None
 0.87A 6hupC-6d6uB:
33.5
6hupD-6d6uB:
35.0		 6hupC-6d6uB:
20.22
6hupD-6d6uB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1


(;
) 		no annotation
no annotation 		9 TYR D  58
ASN D  60
PHE D  77
PHE C  99
HIS C 101
TYR C 159
VAL C 202
SER C 204
TYR C 209
 None
 0.64A 6hupC-6dw1D:
29.5
6hupD-6dw1D:
28.8		 6hupC-6dw1D:
undetectable
6hupD-6dw1D:
undetectable