SIMILAR PATTERNS OF AMINO ACIDS FOR 6HU9_T_PCFT101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebp EPO RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		5 TYR A 192
VAL A 160
SER A 213
ALA A 123
VAL A 216
 None
 1.17A 6hu9L-1ebpA:
0.0
6hu9P-1ebpA:
0.0
6hu9T-1ebpA:
0.0		 6hu9L-1ebpA:
18.96
6hu9P-1ebpA:
23.04
6hu9T-1ebpA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F

(Escherichia
coli) 		PF00267
(Porin_1) 		5 SER A 278
TYR A 124
VAL A 130
GLY A 103
ALA A 154
 None
 1.49A 6hu9L-1gfnA:
0.0
6hu9P-1gfnA:
0.4
6hu9T-1gfnA:
0.0		 6hu9L-1gfnA:
20.68
6hu9P-1gfnA:
20.67
6hu9T-1gfnA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		5 TYR A  30
VAL A  42
SER A  70
ALA A  69
ASN A  27
 None
 1.43A 6hu9L-1hlgA:
undetectable
6hu9P-1hlgA:
0.0
6hu9T-1hlgA:
0.0		 6hu9L-1hlgA:
24.26
6hu9P-1hlgA:
19.89
6hu9T-1hlgA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE

(Arabidopsis
thaliana) 		PF01053
(Cys_Met_Meta_PP) 		5 MET A 257
GLY A 268
SER A 240
ASN A 254
VAL A 252
 None
 1.22A 6hu9L-1ibjA:
0.0
6hu9P-1ibjA:
0.0
6hu9T-1ibjA:
0.0		 6hu9L-1ibjA:
25.20
6hu9P-1ibjA:
21.30
6hu9T-1ibjA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		5 SER A 271
GLY A 116
ALA A  48
ASN A 217
VAL A  91
 None
None
None
AEP  A 683 (-3.6A)
None
 1.36A 6hu9L-1lfwA:
0.0
6hu9P-1lfwA:
0.0
6hu9T-1lfwA:
0.0		 6hu9L-1lfwA:
23.11
6hu9P-1lfwA:
17.15
6hu9T-1lfwA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		5 ASP A  14
SER A  72
VAL A  61
GLY A  63
VAL A  18
 None
 1.31A 6hu9L-1pjqA:
0.0
6hu9P-1pjqA:
0.0
6hu9T-1pjqA:
0.0		 6hu9L-1pjqA:
21.30
6hu9P-1pjqA:
16.78
6hu9T-1pjqA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 TYR A  15
VAL A  28
ALA A  84
ASN A  12
VAL A  31
 None
None
None
ZN  A 262 ( 4.6A)
None
 1.30A 6hu9L-1qh5A:
0.0
6hu9P-1qh5A:
0.0
6hu9T-1qh5A:
0.0		 6hu9L-1qh5A:
21.44
6hu9P-1qh5A:
21.67
6hu9T-1qh5A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		5 SER A 135
TYR A 138
GLY A 181
ALA A 184
VAL A  13
 None
 1.29A 6hu9L-1tf1A:
0.0
6hu9P-1tf1A:
0.0
6hu9T-1tf1A:
0.0		 6hu9L-1tf1A:
18.33
6hu9P-1tf1A:
22.49
6hu9T-1tf1A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		5 ASP A  89
GLY A 223
SER A 227
ALA A 230
ASN A 244
 None
 1.21A 6hu9L-1wpwA:
0.0
6hu9P-1wpwA:
0.0
6hu9T-1wpwA:
0.0		 6hu9L-1wpwA:
21.67
6hu9P-1wpwA:
22.67
6hu9T-1wpwA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 ASP A  92
GLY A 227
SER A 231
ALA A 234
ASN A 248
 None
 1.19A 6hu9L-1x0lA:
undetectable
6hu9P-1x0lA:
undetectable
6hu9T-1x0lA:
undetectable		 6hu9L-1x0lA:
21.92
6hu9P-1x0lA:
22.62
6hu9T-1x0lA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		5 ASP A 130
GLY A 310
SER A 314
ALA A 317
ASN A 331
 None
 1.09A 6hu9L-1xkdA:
undetectable
6hu9P-1xkdA:
undetectable
6hu9T-1xkdA:
undetectable		 6hu9L-1xkdA:
22.54
6hu9P-1xkdA:
18.89
6hu9T-1xkdA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum) 		PF12697
(Abhydrolase_6) 		5 ASP A 223
VAL A 206
SER A 251
ALA A 250
VAL A 203
 None
 1.41A 6hu9L-1y7iA:
undetectable
6hu9P-1y7iA:
undetectable
6hu9T-1y7iA:
undetectable		 6hu9L-1y7iA:
20.14
6hu9P-1y7iA:
19.78
6hu9T-1y7iA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y80 PREDICTED COBALAMIN
BINDING PROTEIN

(Moorella
thermoacetica) 		PF02310
(B12-binding) 		5 SER A  87
TYR A 120
VAL A  92
GLY A 144
ALA A 186
 None
None
None
B1M  A 301 (-3.5A)
None
 1.37A 6hu9L-1y80A:
undetectable
6hu9P-1y80A:
undetectable
6hu9T-1y80A:
undetectable		 6hu9L-1y80A:
20.05
6hu9P-1y80A:
25.60
6hu9T-1y80A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		6 ASP A 485
SER A 496
TYR A 537
VAL A 576
ALA A 448
VAL A 464
 None
 1.36A 6hu9L-1z8lA:
undetectable
6hu9P-1z8lA:
undetectable
6hu9T-1z8lA:
undetectable		 6hu9L-1z8lA:
22.45
6hu9P-1z8lA:
14.41
6hu9T-1z8lA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		5 ASP A  87
TYR A 145
VAL A 150
ALA A 183
VAL A 137
 None
 1.37A 6hu9L-2bs9A:
undetectable
6hu9P-2bs9A:
undetectable
6hu9T-2bs9A:
undetectable		 6hu9L-2bs9A:
21.16
6hu9P-2bs9A:
17.74
6hu9T-2bs9A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		5 ASP A 119
GLY A 297
SER A 301
ALA A 304
ASN A 318
 None
 1.21A 6hu9L-2dhtA:
undetectable
6hu9P-2dhtA:
undetectable
6hu9T-2dhtA:
undetectable		 6hu9L-2dhtA:
22.75
6hu9P-2dhtA:
17.34
6hu9T-2dhtA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe8 REPLICASE
POLYPROTEIN 1AB

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		5 SER A 240
TYR A 214
GLY A 220
ALA A 231
VAL A 236
 None
 1.29A 6hu9L-2fe8A:
undetectable
6hu9P-2fe8A:
undetectable
6hu9T-2fe8A:
undetectable		 6hu9L-2fe8A:
20.18
6hu9P-2fe8A:
20.00
6hu9T-2fe8A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 MET A 153
GLY A 126
SER A 124
ALA A 416
VAL A  91
 None
 1.47A 6hu9L-2iikA:
undetectable
6hu9P-2iikA:
undetectable
6hu9T-2iikA:
undetectable		 6hu9L-2iikA:
22.48
6hu9P-2iikA:
18.94
6hu9T-2iikA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		5 ASP A 119
GLY A 300
SER A 304
ALA A 307
ASN A 321
 None
 1.05A 6hu9L-2iv0A:
undetectable
6hu9P-2iv0A:
undetectable
6hu9T-2iv0A:
undetectable		 6hu9L-2iv0A:
22.01
6hu9P-2iv0A:
18.58
6hu9T-2iv0A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ASP A 134
SER A 360
VAL A 145
GLY A 147
VAL A 707
 None
 1.31A 6hu9L-2jirA:
undetectable
6hu9P-2jirA:
undetectable
6hu9T-2jirA:
undetectable		 6hu9L-2jirA:
21.31
6hu9P-2jirA:
15.38
6hu9T-2jirA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE

(Streptococcus
pyogenes) 		PF14437
(MafB19-deam) 		5 ASP A 123
TYR A 112
VAL A  90
GLY A  39
ASN A 116
 None
 1.17A 6hu9L-2nx8A:
undetectable
6hu9P-2nx8A:
undetectable
6hu9T-2nx8A:
undetectable		 6hu9L-2nx8A:
17.44
6hu9P-2nx8A:
22.22
6hu9T-2nx8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE

(Streptococcus
pyogenes) 		PF14437
(MafB19-deam) 		5 SER A 124
TYR A 112
VAL A  90
GLY A  39
SER A  30
 None
 1.27A 6hu9L-2nx8A:
undetectable
6hu9P-2nx8A:
undetectable
6hu9T-2nx8A:
undetectable		 6hu9L-2nx8A:
17.44
6hu9P-2nx8A:
22.22
6hu9T-2nx8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0f RNA URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		5 VAL A  67
GLY A  53
SER A 148
ALA A 149
VAL A  70
 None
UTP  A 501 (-3.6A)
UTP  A 501 (-3.3A)
None
None
 1.49A 6hu9L-2q0fA:
undetectable
6hu9P-2q0fA:
undetectable
6hu9T-2q0fA:
undetectable		 6hu9L-2q0fA:
22.00
6hu9P-2q0fA:
20.42
6hu9T-2q0fA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 TYR A  78
VAL A  42
GLY A  44
ALA A 147
VAL A  50
 None
 1.48A 6hu9L-2qcvA:
undetectable
6hu9P-2qcvA:
undetectable
6hu9T-2qcvA:
undetectable		 6hu9L-2qcvA:
21.85
6hu9P-2qcvA:
21.96
6hu9T-2qcvA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 SER A 109
VAL A  58
GLY A  56
ALA A 181
ASN A 107
 GOL  A1494 (-3.2A)
None
FAD  A1491 ( 3.7A)
None
None
 1.45A 6hu9L-2wbaA:
undetectable
6hu9P-2wbaA:
undetectable
6hu9T-2wbaA:
undetectable		 6hu9L-2wbaA:
21.71
6hu9P-2wbaA:
17.92
6hu9T-2wbaA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 TYR A 376
VAL A 406
GLY A 397
SER A 386
VAL A 409
 None
 1.27A 6hu9L-2wnwA:
undetectable
6hu9P-2wnwA:
undetectable
6hu9T-2wnwA:
undetectable		 6hu9L-2wnwA:
23.55
6hu9P-2wnwA:
17.89
6hu9T-2wnwA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 ASP A  61
TYR A 346
VAL A 297
SER A 190
ALA A 189
 None
 1.46A 6hu9L-2xymA:
undetectable
6hu9P-2xymA:
undetectable
6hu9T-2xymA:
undetectable		 6hu9L-2xymA:
22.70
6hu9P-2xymA:
15.62
6hu9T-2xymA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 ASP A 148
SER A 229
TYR A  50
SER A 274
VAL A 294
 None
 1.43A 6hu9L-2yijA:
undetectable
6hu9P-2yijA:
undetectable
6hu9T-2yijA:
undetectable		 6hu9L-2yijA:
22.71
6hu9P-2yijA:
17.18
6hu9T-2yijA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 ASP A 863
SER A 867
VAL A 728
GLY A 730
ALA A 758
 None
 1.45A 6hu9L-2yocA:
undetectable
6hu9P-2yocA:
undetectable
6hu9T-2yocA:
undetectable		 6hu9L-2yocA:
18.43
6hu9P-2yocA:
11.38
6hu9T-2yocA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 ASP A 863
SER A 867
VAL A 728
GLY A 745
ALA A 758
 None
 1.33A 6hu9L-2yocA:
undetectable
6hu9P-2yocA:
undetectable
6hu9T-2yocA:
undetectable		 6hu9L-2yocA:
18.43
6hu9P-2yocA:
11.38
6hu9T-2yocA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 SER A  74
GLY A 158
SER A 155
ALA A 153
VAL A  12
 None
 1.44A 6hu9L-2yv3A:
undetectable
6hu9P-2yv3A:
undetectable
6hu9T-2yv3A:
undetectable		 6hu9L-2yv3A:
20.00
6hu9P-2yv3A:
21.61
6hu9T-2yv3A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brk GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00483
(NTP_transferase) 		5 SER X  98
TYR X  16
GLY X 207
SER X 205
ALA X 204
 None
 1.45A 6hu9L-3brkX:
undetectable
6hu9P-3brkX:
undetectable
6hu9T-3brkX:
undetectable		 6hu9L-3brkX:
23.37
6hu9P-3brkX:
19.18
6hu9T-3brkX:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjm PUTATIVE
BETA-LACTAMASE

(Enterococcus
faecalis) 		PF13354
(Beta-lactamase2) 		5 VAL A  76
GLY A  84
SER A 209
ALA A 212
ASN A  69
 EDO  A   3 ( 4.7A)
None
None
None
None
 1.42A 6hu9L-3cjmA:
undetectable
6hu9P-3cjmA:
undetectable
6hu9T-3cjmA:
undetectable		 6hu9L-3cjmA:
21.07
6hu9P-3cjmA:
22.59
6hu9T-3cjmA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx5 CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00355
(Rieske)
PF02921
(UCR_TM) 		5 TYR E  57
VAL E  60
GLY E  64
SER E  68
ALA E  71
 None
 0.37A 6hu9L-3cx5E:
2.3
6hu9P-3cx5E:
undetectable
6hu9T-3cx5E:
undetectable		 6hu9L-3cx5E:
18.55
6hu9P-3cx5E:
100.00
6hu9T-3cx5E:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		5 ASP A 357
SER A 361
SER A 174
ALA A 177
VAL A 148
 None
 1.40A 6hu9L-3ez6A:
undetectable
6hu9P-3ez6A:
undetectable
6hu9T-3ez6A:
undetectable		 6hu9L-3ez6A:
24.30
6hu9P-3ez6A:
19.70
6hu9T-3ez6A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		6 ASP A 475
SER A 486
TYR A 527
VAL A 566
ALA A 438
VAL A 454
 None
 1.31A 6hu9L-3fedA:
undetectable
6hu9P-3fedA:
undetectable
6hu9T-3fedA:
undetectable		 6hu9L-3fedA:
21.65
6hu9P-3fedA:
13.97
6hu9T-3fedA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		5 ASP A 283
VAL A 111
GLY A 109
ALA A 326
ASN A 299
 None
 1.00A 6hu9L-3iu0A:
undetectable
6hu9P-3iu0A:
undetectable
6hu9T-3iu0A:
undetectable		 6hu9L-3iu0A:
21.91
6hu9P-3iu0A:
20.33
6hu9T-3iu0A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkv UNCHARACTERIZED
CONSERVED DOMAIN
PROTEIN

(Vibrio cholerae) 		PF04392
(ABC_sub_bind) 		5 TYR A 272
VAL A 113
GLY A  94
ALA A  77
VAL A 117
 None
None
None
None
PHE  A 601 (-3.7A)
 1.19A 6hu9L-3lkvA:
undetectable
6hu9P-3lkvA:
undetectable
6hu9T-3lkvA:
undetectable		 6hu9L-3lkvA:
23.83
6hu9P-3lkvA:
21.74
6hu9T-3lkvA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		5 ASP A  64
GLY A 100
ALA A 150
ASN A  62
VAL A 103
 None
 1.46A 6hu9L-3m3pA:
undetectable
6hu9P-3m3pA:
undetectable
6hu9T-3m3pA:
undetectable		 6hu9L-3m3pA:
20.23
6hu9P-3m3pA:
22.71
6hu9T-3m3pA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m85 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Archaeoglobus
fulgidus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 SER G 189
VAL G 108
GLY G 112
SER G 116
VAL G 185
 None
 1.45A 6hu9L-3m85G:
undetectable
6hu9P-3m85G:
undetectable
6hu9T-3m85G:
undetectable		 6hu9L-3m85G:
21.86
6hu9P-3m85G:
19.92
6hu9T-3m85G:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 ASP A 401
GLY A 323
SER A 298
ALA A 301
VAL A  33
 None
 1.42A 6hu9L-3mpnA:
undetectable
6hu9P-3mpnA:
undetectable
6hu9T-3mpnA:
undetectable		 6hu9L-3mpnA:
22.18
6hu9P-3mpnA:
17.01
6hu9T-3mpnA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1
NA+/K+ ATPASE GAMMA
SUBUNIT TRANSCRIPT
VARIANT A

(Sus scrofa;
Sus scrofa) 		PF00287
(Na_K-ATPase)
no annotation 		5 ASP B  70
TYR G  23
VAL G  26
GLY G  30
ALA G  37
 None
 1.35A 6hu9L-3n23B:
undetectable
6hu9P-3n23B:
undetectable
6hu9T-3n23B:
undetectable		 6hu9L-3n23B:
21.32
6hu9P-3n23B:
19.71
6hu9T-3n23B:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 SER A 228
VAL A 347
GLY A 332
ALA A 107
VAL A 351
 None
ACJ  A 478 (-4.4A)
ACJ  A 478 (-4.4A)
None
None
 1.48A 6hu9L-3nksA:
undetectable
6hu9P-3nksA:
undetectable
6hu9T-3nksA:
undetectable		 6hu9L-3nksA:
23.33
6hu9P-3nksA:
17.51
6hu9T-3nksA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 ASP A 125
SER A 122
TYR A 354
GLY A 338
ALA A  28
 None
 1.31A 6hu9L-3qlvA:
undetectable
6hu9P-3qlvA:
undetectable
6hu9T-3qlvA:
undetectable		 6hu9L-3qlvA:
22.52
6hu9P-3qlvA:
19.77
6hu9T-3qlvA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		5 VAL A 141
SER A 169
ALA A 172
ASN A 120
VAL A 177
 None
 1.37A 6hu9L-3s6kA:
undetectable
6hu9P-3s6kA:
undetectable
6hu9T-3s6kA:
undetectable		 6hu9L-3s6kA:
24.36
6hu9P-3s6kA:
20.18
6hu9T-3s6kA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 SER A  77
GLY A 163
SER A 160
ALA A 158
VAL A  14
 None
SO4  A 406 (-3.2A)
None
None
SO4  A 406 (-3.4A)
 1.44A 6hu9L-3tz6A:
undetectable
6hu9P-3tz6A:
undetectable
6hu9T-3tz6A:
undetectable		 6hu9L-3tz6A:
23.18
6hu9P-3tz6A:
20.06
6hu9T-3tz6A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ury EXOTOXIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 ASP A 156
TYR A 160
VAL A 184
GLY A 200
VAL A 180
 CL  A 309 (-4.5A)
None
None
None
None
 1.48A 6hu9L-3uryA:
undetectable
6hu9P-3uryA:
undetectable
6hu9T-3uryA:
undetectable		 6hu9L-3uryA:
18.10
6hu9P-3uryA:
20.81
6hu9T-3uryA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		5 SER A 178
TYR A 206
GLY A 191
ALA A 120
VAL A 183
 None
 1.47A 6hu9L-3vszA:
undetectable
6hu9P-3vszA:
undetectable
6hu9T-3vszA:
undetectable		 6hu9L-3vszA:
22.00
6hu9P-3vszA:
16.16
6hu9T-3vszA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zle APICAL MEMBRANE
ANTIGEN 1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		5 ASP A 360
SER A 387
VAL A 143
GLY A 431
VAL A 351
 None
 1.29A 6hu9L-3zleA:
undetectable
6hu9P-3zleA:
undetectable
6hu9T-3zleA:
undetectable		 6hu9L-3zleA:
21.55
6hu9P-3zleA:
17.47
6hu9T-3zleA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		5 GLY A  32
SER A  36
ALA A 578
ASN A 597
VAL A 586
 None
 1.16A 6hu9L-3zqjA:
undetectable
6hu9P-3zqjA:
undetectable
6hu9T-3zqjA:
undetectable		 6hu9L-3zqjA:
17.80
6hu9P-3zqjA:
13.61
6hu9T-3zqjA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 TYR A 388
VAL A 409
GLY A 407
SER A 230
ALA A 229
 None
None
None
NAP  A1447 (-3.6A)
None
 1.48A 6hu9L-4a0sA:
undetectable
6hu9P-4a0sA:
undetectable
6hu9T-4a0sA:
undetectable		 6hu9L-4a0sA:
21.71
6hu9P-4a0sA:
19.24
6hu9T-4a0sA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		5 ASP A 249
SER A 251
TYR A 185
VAL A 134
ALA A 127
 None
 1.47A 6hu9L-4conA:
undetectable
6hu9P-4conA:
undetectable
6hu9T-4conA:
undetectable		 6hu9L-4conA:
22.19
6hu9P-4conA:
14.11
6hu9T-4conA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ASP A  95
MET A 383
GLY A 271
ALA A 239
ASN A 384
 None
COA  A2598 (-4.1A)
None
None
COA  A2598 (-3.9A)
 1.37A 6hu9L-4eudA:
undetectable
6hu9P-4eudA:
undetectable
6hu9T-4eudA:
undetectable		 6hu9L-4eudA:
20.08
6hu9P-4eudA:
18.35
6hu9T-4eudA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A 347
GLY A 184
SER A 180
ALA A  12
VAL A  17
 None
 1.38A 6hu9L-4ewpA:
undetectable
6hu9P-4ewpA:
undetectable
6hu9T-4ewpA:
undetectable		 6hu9L-4ewpA:
21.19
6hu9P-4ewpA:
20.52
6hu9T-4ewpA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		5 SER A 284
VAL A 409
GLY A 407
SER A 405
ALA A 404
 None
 1.30A 6hu9L-4f53A:
undetectable
6hu9P-4f53A:
undetectable
6hu9T-4f53A:
undetectable		 6hu9L-4f53A:
22.61
6hu9P-4f53A:
16.44
6hu9T-4f53A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fer EXPANSIN-YOAJ

(Bacillus
subtilis) 		PF03330
(DPBB_1) 		5 SER A 122
TYR A 198
VAL A 200
GLY A 202
VAL A 131
 None
 1.38A 6hu9L-4ferA:
undetectable
6hu9P-4ferA:
undetectable
6hu9T-4ferA:
undetectable		 6hu9L-4ferA:
20.14
6hu9P-4ferA:
21.89
6hu9T-4ferA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		5 SER A 286
MET A 280
GLY A 340
ALA A 178
ASN A 279
 SER  A 286 ( 0.0A)
MET  A 280 ( 0.0A)
GLY  A 340 ( 0.0A)
ALA  A 178 ( 0.0A)
ASN  A 279 ( 0.6A)
 1.35A 6hu9L-4g9kA:
undetectable
6hu9P-4g9kA:
undetectable
6hu9T-4g9kA:
undetectable		 6hu9L-4g9kA:
23.60
6hu9P-4g9kA:
16.74
6hu9T-4g9kA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION

(synthetic
construct) 		PF01731
(Arylesterase) 		5 SER A 203
VAL A 268
GLY A 283
ALA A 335
ASN A 168
 None
None
None
None
CA  A 402 ( 3.8A)
 1.16A 6hu9L-4hhqA:
undetectable
6hu9P-4hhqA:
undetectable
6hu9T-4hhqA:
undetectable		 6hu9L-4hhqA:
24.18
6hu9P-4hhqA:
18.80
6hu9T-4hhqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis) 		PF00005
(ABC_tran)
PF02361
(CbiQ) 		5 SER A 132
MET A 130
GLY A  96
ALA T 222
VAL A 103
 None
 1.47A 6hu9L-4hzuA:
undetectable
6hu9P-4hzuA:
undetectable
6hu9T-4hzuA:
undetectable		 6hu9L-4hzuA:
22.48
6hu9P-4hzuA:
21.13
6hu9T-4hzuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 GLY A 263
SER A 265
ALA A 424
ASN A 162
VAL A 294
 None
None
None
NAD  A 601 (-3.3A)
None
 1.22A 6hu9L-4i8qA:
undetectable
6hu9P-4i8qA:
undetectable
6hu9T-4i8qA:
undetectable		 6hu9L-4i8qA:
22.11
6hu9P-4i8qA:
16.88
6hu9T-4i8qA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 MET A 167
GLY A 263
SER A 265
ALA A 424
VAL A 294
 NAD  A 601 ( 3.9A)
None
None
None
None
 1.44A 6hu9L-4i8qA:
undetectable
6hu9P-4i8qA:
undetectable
6hu9T-4i8qA:
undetectable		 6hu9L-4i8qA:
22.11
6hu9P-4i8qA:
16.88
6hu9T-4i8qA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 VAL A 967
GLY A 395
ALA A 471
ASN A 927
VAL A 923
 None
 1.45A 6hu9L-4k0eA:
undetectable
6hu9P-4k0eA:
undetectable
6hu9T-4k0eA:
undetectable		 6hu9L-4k0eA:
18.85
6hu9P-4k0eA:
11.84
6hu9T-4k0eA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 SER A 180
VAL A 186
GLY A 151
ALA A 159
VAL A 262
 None
 1.04A 6hu9L-4kpoA:
undetectable
6hu9P-4kpoA:
undetectable
6hu9T-4kpoA:
undetectable		 6hu9L-4kpoA:
22.17
6hu9P-4kpoA:
22.76
6hu9T-4kpoA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis) 		PF02222
(ATP-grasp) 		5 SER A  95
GLY A 268
SER A 271
ALA A 275
VAL A 264
 NA  A 404 (-4.7A)
None
None
None
None
 1.31A 6hu9L-4ma5A:
undetectable
6hu9P-4ma5A:
undetectable
6hu9T-4ma5A:
undetectable		 6hu9L-4ma5A:
22.62
6hu9P-4ma5A:
21.27
6hu9T-4ma5A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 270
SER A 272
ALA A 430
ASN A 169
VAL A 300
 None
 1.22A 6hu9L-4qyjA:
undetectable
6hu9P-4qyjA:
undetectable
6hu9T-4qyjA:
undetectable		 6hu9L-4qyjA:
23.13
6hu9P-4qyjA:
17.25
6hu9T-4qyjA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 MET A 174
GLY A 270
SER A 272
ALA A 430
VAL A 300
 None
 1.48A 6hu9L-4qyjA:
undetectable
6hu9P-4qyjA:
undetectable
6hu9T-4qyjA:
undetectable		 6hu9L-4qyjA:
23.13
6hu9P-4qyjA:
17.25
6hu9T-4qyjA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		5 ASP A 150
GLY A 251
SER A 255
ALA A 258
ASN A 146
 None
 1.48A 6hu9L-4r12A:
undetectable
6hu9P-4r12A:
undetectable
6hu9T-4r12A:
undetectable		 6hu9L-4r12A:
22.33
6hu9P-4r12A:
17.30
6hu9T-4r12A:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 ASP A  48
SER A  45
SER A 437
ALA A 435
VAL A  33
 None
 1.46A 6hu9L-4re2A:
undetectable
6hu9P-4re2A:
undetectable
6hu9T-4re2A:
undetectable		 6hu9L-4re2A:
23.29
6hu9P-4re2A:
18.47
6hu9T-4re2A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 TYR A 196
VAL A 193
GLY A 723
ALA A 701
VAL A 709
 None
 1.41A 6hu9L-4rvwA:
undetectable
6hu9P-4rvwA:
undetectable
6hu9T-4rvwA:
undetectable		 6hu9L-4rvwA:
20.79
6hu9P-4rvwA:
13.81
6hu9T-4rvwA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		5 VAL A 330
GLY A 396
ALA A  75
ASN A   3
VAL A 400
 None
 1.45A 6hu9L-4xzeA:
undetectable
6hu9P-4xzeA:
undetectable
6hu9T-4xzeA:
undetectable		 6hu9L-4xzeA:
25.05
6hu9P-4xzeA:
17.72
6hu9T-4xzeA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 SER A1269
VAL A1195
GLY A1260
SER A1080
ALA A1081
 None
 1.14A 6hu9L-4yswA:
undetectable
6hu9P-4yswA:
undetectable
6hu9T-4yswA:
undetectable		 6hu9L-4yswA:
15.73
6hu9P-4yswA:
9.34
6hu9T-4yswA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF00955
(HCO3_cotransp) 		5 TYR A 794
VAL A 797
SER A 525
ASN A 736
VAL A 732
 None
 1.27A 6hu9L-4yzfA:
undetectable
6hu9P-4yzfA:
undetectable
6hu9T-4yzfA:
undetectable		 6hu9L-4yzfA:
19.54
6hu9P-4yzfA:
10.75
6hu9T-4yzfA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csc CITRATE SYNTHASE

(Gallus gallus) 		PF00285
(Citrate_synt) 		5 SER B 142
VAL B 251
SER B 412
ALA B 414
VAL B 405
 None
 1.16A 6hu9L-5cscB:
undetectable
6hu9P-5cscB:
undetectable
6hu9T-5cscB:
undetectable		 6hu9L-5cscB:
21.54
6hu9P-5cscB:
17.16
6hu9T-5cscB:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 5 SER E 249
GLY E  14
SER E  18
ALA E 134
VAL E 329
 None
FAD  E 501 (-3.4A)
None
None
FAD  E 501 (-3.7A)
 1.25A 6hu9L-5dbjE:
undetectable
6hu9P-5dbjE:
undetectable
6hu9T-5dbjE:
undetectable		 6hu9L-5dbjE:
23.24
6hu9P-5dbjE:
18.38
6hu9T-5dbjE:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ASP A 130
MET A  52
TYR A 245
GLY A  37
VAL A  73
 None
 1.34A 6hu9L-5dn6A:
undetectable
6hu9P-5dn6A:
undetectable
6hu9T-5dn6A:
undetectable		 6hu9L-5dn6A:
26.47
6hu9P-5dn6A:
18.24
6hu9T-5dn6A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE

(Bacillus
subtilis) 		PF09819
(ABC_cobalt) 		5 TYR A 130
VAL A  94
GLY A  98
ALA A 105
VAL A 125
 None
MPG  A 203 ( 4.8A)
MPG  A 203 ( 4.1A)
None
None
 1.17A 6hu9L-5edlA:
undetectable
6hu9P-5edlA:
undetectable
6hu9T-5edlA:
undetectable		 6hu9L-5edlA:
18.45
6hu9P-5edlA:
20.75
6hu9T-5edlA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 ASP X 331
TYR X 356
VAL X 303
GLY X 305
VAL X 155
 None
 1.42A 6hu9L-5evyX:
undetectable
6hu9P-5evyX:
undetectable
6hu9T-5evyX:
undetectable		 6hu9L-5evyX:
21.19
6hu9P-5evyX:
19.24
6hu9T-5evyX:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez1 PUTATIVE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
HP_0175

(Helicobacter
pylori) 		PF00639
(Rotamase) 		5 ASP A 178
TYR A 235
GLY A 209
SER A 202
ALA A 205
 None
 1.46A 6hu9L-5ez1A:
undetectable
6hu9P-5ez1A:
undetectable
6hu9T-5ez1A:
undetectable		 6hu9L-5ez1A:
22.25
6hu9P-5ez1A:
23.33
6hu9T-5ez1A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		5 ASP A 341
TYR A 800
VAL A 819
GLY A 821
SER A 390
 None
None
None
None
5WP  A 901 ( 3.7A)
 1.38A 6hu9L-5fbuA:
undetectable
6hu9P-5fbuA:
undetectable
6hu9T-5fbuA:
undetectable		 6hu9L-5fbuA:
19.72
6hu9P-5fbuA:
12.83
6hu9T-5fbuA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE
PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF00227
(Proteasome)
PF00227
(Proteasome) 		5 ASP K   2
GLY L 118
SER L  84
ASN K  33
VAL L 121
 None
 1.47A 6hu9L-5fmgK:
undetectable
6hu9P-5fmgK:
undetectable
6hu9T-5fmgK:
undetectable		 6hu9L-5fmgK:
17.32
6hu9P-5fmgK:
20.83
6hu9T-5fmgK:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 SER A 165
VAL A 673
GLY A 664
SER A 623
ALA A 618
 None
 1.42A 6hu9L-5fp2A:
undetectable
6hu9P-5fp2A:
undetectable
6hu9T-5fp2A:
undetectable		 6hu9L-5fp2A:
22.14
6hu9P-5fp2A:
15.68
6hu9T-5fp2A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 GLY A 270
SER A 272
ALA A 431
ASN A 168
VAL A 301
 None
None
None
NAD  A 700 ( 3.0A)
IAC  A 701 ( 4.1A)
 1.18A 6hu9L-5iuwA:
undetectable
6hu9P-5iuwA:
undetectable
6hu9T-5iuwA:
undetectable		 6hu9L-5iuwA:
23.30
6hu9P-5iuwA:
15.97
6hu9T-5iuwA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 MET A 173
GLY A 270
SER A 272
ALA A 431
VAL A 301
 NAD  A 700 (-3.9A)
None
None
None
IAC  A 701 ( 4.1A)
 1.41A 6hu9L-5iuwA:
undetectable
6hu9P-5iuwA:
undetectable
6hu9T-5iuwA:
undetectable		 6hu9L-5iuwA:
23.30
6hu9P-5iuwA:
15.97
6hu9T-5iuwA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 ASP A 132
SER A 131
GLY A 176
SER A 180
VAL A 170
 None
None
None
None
NAD  A 501 (-4.8A)
 1.39A 6hu9L-5jcnA:
undetectable
6hu9P-5jcnA:
undetectable
6hu9T-5jcnA:
undetectable		 6hu9L-5jcnA:
24.44
6hu9P-5jcnA:
18.34
6hu9T-5jcnA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 ASP A 475
SER A 474
GLY A 284
ALA A 217
VAL A 395
 None
 1.33A 6hu9L-5k8gA:
undetectable
6hu9P-5k8gA:
undetectable
6hu9T-5k8gA:
undetectable		 6hu9L-5k8gA:
22.30
6hu9P-5k8gA:
16.35
6hu9T-5k8gA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 SER A 877
GLY A 712
ALA A 777
ASN A 850
VAL A 709
 None
 1.31A 6hu9L-5kdxA:
undetectable
6hu9P-5kdxA:
undetectable
6hu9T-5kdxA:
undetectable		 6hu9L-5kdxA:
19.84
6hu9P-5kdxA:
12.21
6hu9T-5kdxA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 5 ASP A 558
GLY A 338
SER A 399
ALA A 396
ASN A 693
 None
 1.46A 6hu9L-5m41A:
undetectable
6hu9P-5m41A:
undetectable
6hu9T-5m41A:
undetectable		 6hu9L-5m41A:
undetectable
6hu9P-5m41A:
undetectable
6hu9T-5m41A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP1
CAPSID SUBUNIT VP3
CAPSID SUBUNIT VP0

(Parechovirus A;
Parechovirus A;
Parechovirus A) 		no annotation
no annotation
PF00073
(Rhv) 		5 ASP B 184
SER A  35
GLY C 178
ALA C 258
ASN C 213
 None
 1.38A 6hu9L-5mjvB:
undetectable
6hu9P-5mjvB:
undetectable
6hu9T-5mjvB:
undetectable		 6hu9L-5mjvB:
22.30
6hu9P-5mjvB:
21.62
6hu9T-5mjvB:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 VAL A 208
GLY A 210
ALA A 695
ASN A 220
VAL A 216
 None
 1.13A 6hu9L-5nqdA:
undetectable
6hu9P-5nqdA:
undetectable
6hu9T-5nqdA:
undetectable		 6hu9L-5nqdA:
undetectable
6hu9P-5nqdA:
undetectable
6hu9T-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 5 ASP A 358
SER A 357
VAL A 258
SER A  53
ALA A  49
 None
 1.07A 6hu9L-5nvaA:
undetectable
6hu9P-5nvaA:
undetectable
6hu9T-5nvaA:
undetectable		 6hu9L-5nvaA:
undetectable
6hu9P-5nvaA:
undetectable
6hu9T-5nvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 5 SER A 107
VAL A 380
GLY A 385
SER A 388
ALA A 391
 None
 1.40A 6hu9L-5nvaA:
undetectable
6hu9P-5nvaA:
undetectable
6hu9T-5nvaA:
undetectable		 6hu9L-5nvaA:
undetectable
6hu9P-5nvaA:
undetectable
6hu9T-5nvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sx4 PANITUMUMAB FAB
HEAVY CHAIN
EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens;
Homo sapiens) 		no annotation
PF01030
(Recep_L_domain) 		5 ASP J 100
GLY M 471
SER M 474
ALA M 477
ASN J  60
 None
 1.28A 6hu9L-5sx4J:
undetectable
6hu9P-5sx4J:
undetectable
6hu9T-5sx4J:
undetectable		 6hu9L-5sx4J:
22.83
6hu9P-5sx4J:
20.50
6hu9T-5sx4J:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t43 LIPOCALIN-1

(Homo sapiens) 		PF00061
(Lipocalin) 		5 SER A  58
VAL A  24
GLY A 112
SER A 101
ALA A  86
 None
 1.16A 6hu9L-5t43A:
undetectable
6hu9P-5t43A:
undetectable
6hu9T-5t43A:
undetectable		 6hu9L-5t43A:
19.71
6hu9P-5t43A:
22.40
6hu9T-5t43A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsb MEMBRANE PROTEIN

(Bordetella
bronchiseptica) 		PF02535
(Zip) 		5 VAL A 137
GLY A 267
SER A 103
ALA A 104
VAL A 273
 None
 1.33A 6hu9L-5tsbA:
undetectable
6hu9P-5tsbA:
undetectable
6hu9T-5tsbA:
undetectable		 6hu9L-5tsbA:
19.07
6hu9P-5tsbA:
21.29
6hu9T-5tsbA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgw ISOASPARTYL
DIPEPTIDASE

(Colwellia
psychrerythraea) 		no annotation 5 TYR A 134
VAL A 104
SER A 292
ALA A 259
VAL A 100
 None
 1.48A 6hu9L-5xgwA:
undetectable
6hu9P-5xgwA:
undetectable
6hu9T-5xgwA:
undetectable		 6hu9L-5xgwA:
undetectable
6hu9P-5xgwA:
undetectable
6hu9T-5xgwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 ASP A 419
GLY A  20
SER A  25
ALA A  28
VAL A  46
 None
 1.42A 6hu9L-5xwbA:
undetectable
6hu9P-5xwbA:
undetectable
6hu9T-5xwbA:
undetectable		 6hu9L-5xwbA:
23.54
6hu9P-5xwbA:
18.43
6hu9T-5xwbA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 SER A1664
TYR A1646
GLY A1690
SER A1694
VAL A1650
 None
 1.17A 6hu9L-5y29A:
undetectable
6hu9P-5y29A:
undetectable
6hu9T-5y29A:
undetectable		 6hu9L-5y29A:
undetectable
6hu9P-5y29A:
undetectable
6hu9T-5y29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 5 SER A 187
MET A 185
VAL A  71
GLY A 134
ALA A 130
 None
 1.39A 6hu9L-6b5fA:
undetectable
6hu9P-6b5fA:
undetectable
6hu9T-6b5fA:
undetectable		 6hu9L-6b5fA:
21.35
6hu9P-6b5fA:
21.41
6hu9T-6b5fA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 ASP A  93
SER A  92
TYR A  66
VAL A  69
SER A  79
 None
 1.39A 6hu9L-6c9mA:
undetectable
6hu9P-6c9mA:
undetectable
6hu9T-6c9mA:
undetectable		 6hu9L-6c9mA:
undetectable
6hu9P-6c9mA:
undetectable
6hu9T-6c9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6grw -

(-) 		no annotation 5 TYR A 121
VAL A 196
ALA A 276
ASN A 144
VAL A 199
 None
 1.33A 6hu9L-6grwA:
undetectable
6hu9P-6grwA:
undetectable
6hu9T-6grwA:
undetectable		 6hu9L-6grwA:
undetectable
6hu9P-6grwA:
undetectable
6hu9T-6grwA:
undetectable