SIMILAR PATTERNS OF AMINO ACIDS FOR 6HU9_S_PCFS603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		4 GLN A 196
GLY A 194
VAL A 207
SER A  78
 PLP  A 363 (-3.2A)
PLP  A 363 ( 4.6A)
None
PLP  A 363 (-2.7A)
 1.05A 6hu9S-1bt4A:
0.0
6hu9q-1bt4A:
undetectable		 6hu9S-1bt4A:
13.64
6hu9q-1bt4A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		4 GLY A 151
VAL A 264
SER A  75
LYS A  78
 None
None
DFP  A 401 (-1.6A)
DFP  A 401 ( 4.2A)
 1.00A 6hu9S-1ci9A:
0.0
6hu9q-1ci9A:
undetectable		 6hu9S-1ci9A:
10.67
6hu9q-1ci9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j30 144AA LONG
HYPOTHETICAL
RUBRERYTHRIN

(Sulfurisphaera
tokodaii) 		PF02915
(Rubrerythrin) 		4 GLY A  59
PHE A  58
HIS A  56
SER A  21
 None
None
FE  A 401 (-3.2A)
None
 1.07A 6hu9S-1j30A:
0.0
6hu9q-1j30A:
undetectable		 6hu9S-1j30A:
19.57
6hu9q-1j30A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k85 CHITINASE A1

(Bacillus
circulans) 		PF00041
(fn3) 		4 GLY A 597
PHE A 622
VAL A 624
SER A 641
 None
 0.78A 6hu9S-1k85A:
0.0
6hu9q-1k85A:
undetectable		 6hu9S-1k85A:
16.00
6hu9q-1k85A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLN A 184
GLY A 136
HIS A 137
VAL A 133
 None
 0.99A 6hu9S-1ko0A:
0.0
6hu9q-1ko0A:
undetectable		 6hu9S-1ko0A:
10.90
6hu9q-1ko0A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 GLY A 816
PHE A 818
VAL A 874
SER A 820
 None
 1.06A 6hu9S-1mhsA:
0.0
6hu9q-1mhsA:
1.2		 6hu9S-1mhsA:
6.73
6hu9q-1mhsA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi4 HYPOTHETICAL PROTEIN
YHBO

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		4 GLY A  94
PHE A  34
VAL A  28
SER A  37
 None
 0.99A 6hu9S-1oi4A:
0.0
6hu9q-1oi4A:
0.0		 6hu9S-1oi4A:
19.08
6hu9q-1oi4A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oij PUTATIVE
ALKYLSULFATASE ATSK

(Pseudomonas
putida) 		PF02668
(TauD) 		4 GLN C 235
GLY C 213
HIS C 108
VAL C 111
 None
None
NA  C1300 ( 3.7A)
None
 0.98A 6hu9S-1oijC:
0.0
6hu9q-1oijC:
undetectable		 6hu9S-1oijC:
19.53
6hu9q-1oijC:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLY A 437
PHE A 459
HIS A 464
SER A 450
 None
 0.84A 6hu9S-1q8iA:
0.0
6hu9q-1q8iA:
undetectable		 6hu9S-1q8iA:
8.58
6hu9q-1q8iA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		4 GLN A 256
GLY A 253
PHE A 229
VAL A 441
 None
EPH  A4000 ( 4.4A)
None
None
 1.07A 6hu9S-1r20A:
undetectable
6hu9q-1r20A:
undetectable		 6hu9S-1r20A:
18.67
6hu9q-1r20A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz6 CYTOCHROME C
PEROXIDASE

(Marinobacter
hydrocarbonoclasticus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 GLY A 231
PHE A 233
VAL A 235
SER A 267
 None
None
None
CIT  A 503 (-2.6A)
 0.99A 6hu9S-1rz6A:
undetectable
6hu9q-1rz6A:
0.0		 6hu9S-1rz6A:
14.85
6hu9q-1rz6A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5r GROWTH-ARREST-SPECIF
IC PROTEIN 2

(Mus musculus) 		PF02187
(GAS2) 		4 GLN A  36
GLY A  37
PHE A  47
VAL A  58
 None
 1.00A 6hu9S-1v5rA:
undetectable
6hu9q-1v5rA:
undetectable		 6hu9S-1v5rA:
16.83
6hu9q-1v5rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3x PUTATIVE
CYTIDYLYLTRANSFERASE

(Thermosynechococcus
elongatus) 		PF05419
(GUN4)
PF16416
(GUN4_N) 		4 GLN A 168
GLY A 210
HIS A 211
SER A 159
 None
 1.07A 6hu9S-1z3xA:
undetectable
6hu9q-1z3xA:
2.4		 6hu9S-1z3xA:
17.26
6hu9q-1z3xA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN

(Mus musculus) 		PF04564
(U-box)
PF12895
(ANAPC3) 		5 GLN A 105
GLY A 102
PHE A  99
HIS A  98
VAL A  95
 SO4  A1306 (-3.2A)
None
None
None
None
 1.28A 6hu9S-2c2lA:
undetectable
6hu9q-2c2lA:
0.9		 6hu9S-2c2lA:
14.92
6hu9q-2c2lA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3b PPIASE

(Aspergillus
fumigatus) 		PF00160
(Pro_isomerase) 		4 PHE A  56
HIS A  57
VAL A 157
SER A  54
 None
 1.00A 6hu9S-2c3bA:
undetectable
6hu9q-2c3bA:
undetectable		 6hu9S-2c3bA:
19.19
6hu9q-2c3bA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE

(Mus musculus) 		PF02485
(Branch) 		4 GLY A 386
PHE A 383
VAL A 406
LYS A 355
 None
 1.02A 6hu9S-2gamA:
undetectable
6hu9q-2gamA:
0.0		 6hu9S-2gamA:
13.98
6hu9q-2gamA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 GLY A  22
PHE A  18
HIS A  21
LYS A  49
 None
 0.97A 6hu9S-2genA:
undetectable
6hu9q-2genA:
undetectable		 6hu9S-2genA:
18.46
6hu9q-2genA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		4 GLN A 287
GLY A 364
HIS A 258
SER A 371
 None
None
ZN  A1000 (-3.2A)
None
 0.80A 6hu9S-2gsnA:
undetectable
6hu9q-2gsnA:
undetectable		 6hu9S-2gsnA:
11.24
6hu9q-2gsnA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 263
PHE A 313
VAL A 322
SER A 268
 None
 0.93A 6hu9S-2jiiA:
undetectable
6hu9q-2jiiA:
0.2		 6hu9S-2jiiA:
12.54
6hu9q-2jiiA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksm MYCOBACTERIUM
TUBERCULOSIS
RV0899/MT0922/OMPATB

(Mycobacterium
tuberculosis) 		PF04972
(BON) 		4 GLY A  95
PHE A  97
HIS A 125
VAL A 126
 None
 1.03A 6hu9S-2ksmA:
undetectable
6hu9q-2ksmA:
undetectable		 6hu9S-2ksmA:
16.94
6hu9q-2ksmA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzn DNA PRIMASE

(Staphylococcus
aureus) 		PF00772
(DnaB) 		4 GLN A 568
GLY A 567
VAL A 560
SER A 573
 None
 0.98A 6hu9S-2lznA:
undetectable
6hu9q-2lznA:
1.4		 6hu9S-2lznA:
22.38
6hu9q-2lznA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzn DNA PRIMASE

(Staphylococcus
aureus) 		PF00772
(DnaB) 		4 GLN A 568
GLY A 567
VAL A 562
SER A 573
 None
 1.03A 6hu9S-2lznA:
undetectable
6hu9q-2lznA:
1.4		 6hu9S-2lznA:
22.38
6hu9q-2lznA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noq 60S RIBOSOMAL
PROTEIN L11-B

(Saccharomyces
cerevisiae) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		4 GLY H 102
PHE H 101
VAL H 129
SER H 118
 None
 1.06A 6hu9S-2noqH:
undetectable
6hu9q-2noqH:
undetectable		 6hu9S-2noqH:
17.37
6hu9q-2noqH:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 GLY A  45
HIS A  44
VAL A  39
SER A  24
 None
 1.05A 6hu9S-2nyfA:
undetectable
6hu9q-2nyfA:
0.3		 6hu9S-2nyfA:
11.76
6hu9q-2nyfA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0w HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT

(Homo sapiens) 		PF10394
(Hat1_N) 		4 GLY A  61
PHE A  60
HIS A  57
LYS A 110
 None
 0.83A 6hu9S-2p0wA:
undetectable
6hu9q-2p0wA:
undetectable		 6hu9S-2p0wA:
13.66
6hu9q-2p0wA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		4 GLY A 281
PHE A 264
HIS A 280
SER A 266
 None
 1.07A 6hu9S-2varA:
undetectable
6hu9q-2varA:
undetectable		 6hu9S-2varA:
15.18
6hu9q-2varA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 GLN A 168
GLY A 195
VAL A 185
SER A 248
 None
 0.92A 6hu9S-2vgiA:
undetectable
6hu9q-2vgiA:
undetectable		 6hu9S-2vgiA:
10.65
6hu9q-2vgiA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 GLY A  95
PHE A  91
HIS A  97
VAL A 129
 None
 1.08A 6hu9S-2w21A:
undetectable
6hu9q-2w21A:
undetectable		 6hu9S-2w21A:
13.03
6hu9q-2w21A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z59 PROTEIN ADRM1

(Mus musculus) 		PF04683
(Proteasom_Rpn13) 		4 GLY A  29
PHE A 107
VAL A  93
SER A  32
 None
 0.89A 6hu9S-2z59A:
undetectable
6hu9q-2z59A:
undetectable		 6hu9S-2z59A:
19.13
6hu9q-2z59A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo sapiens) 		PF02373
(JmjC) 		4 GLN A1133
GLY A1128
VAL A1268
SER A1154
 None
None
None
OGA  A1501 (-2.7A)
 0.80A 6hu9S-3avsA:
undetectable
6hu9q-3avsA:
undetectable		 6hu9S-3avsA:
10.12
6hu9q-3avsA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 4 GLN A 472
PHE A  56
HIS A  57
VAL A  74
 None
 1.01A 6hu9S-3c8vA:
undetectable
6hu9q-3c8vA:
undetectable		 6hu9S-3c8vA:
13.21
6hu9q-3c8vA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr8 YNCA

(Salmonella
enterica) 		PF13420
(Acetyltransf_4) 		4 GLY A 135
PHE A 136
HIS A 132
VAL A 138
 None
None
None
CL  A1431 (-4.0A)
 1.00A 6hu9S-3dr8A:
undetectable
6hu9q-3dr8A:
undetectable		 6hu9S-3dr8A:
19.84
6hu9q-3dr8A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqp HEMOGLOBIN SUBUNIT
BETA-A/B

(Felis catus) 		PF00042
(Globin) 		4 GLY B 119
PHE B 118
HIS B 116
VAL B 113
 None
 1.08A 6hu9S-3gqpB:
undetectable
6hu9q-3gqpB:
undetectable		 6hu9S-3gqpB:
18.62
6hu9q-3gqpB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 GLN A 278
GLY A 275
PHE A 276
VAL A 268
 None
 1.05A 6hu9S-3hx3A:
undetectable
6hu9q-3hx3A:
undetectable		 6hu9S-3hx3A:
15.50
6hu9q-3hx3A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		4 GLY A  19
PHE A  15
HIS A  16
VAL A  22
 None
 1.07A 6hu9S-3hxwA:
undetectable
6hu9q-3hxwA:
undetectable		 6hu9S-3hxwA:
12.97
6hu9q-3hxwA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2c PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Encephalitozoon
cuniculi) 		PF00160
(Pro_isomerase) 		4 GLN A 114
PHE A  56
VAL A 155
SER A  54
 None
 0.87A 6hu9S-3k2cA:
undetectable
6hu9q-3k2cA:
undetectable		 6hu9S-3k2cA:
20.11
6hu9q-3k2cA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmc PEPTIDASE,
ZINC-DEPENDENT

(Methanocorpusculum
labreanum) 		PF07998
(Peptidase_M54) 		4 GLY A 156
PHE A 155
HIS A 153
LYS A  90
 None
None
ZN  A 212 (-3.4A)
None
 1.03A 6hu9S-3lmcA:
undetectable
6hu9q-3lmcA:
undetectable		 6hu9S-3lmcA:
19.59
6hu9q-3lmcA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		4 GLY A  95
PHE A  93
HIS A  92
SER A 218
 None
 0.88A 6hu9S-3mfqA:
undetectable
6hu9q-3mfqA:
undetectable		 6hu9S-3mfqA:
15.16
6hu9q-3mfqA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 GLY A 996
PHE A1006
HIS A1005
VAL A 929
 None
 0.98A 6hu9S-3nzuA:
undetectable
6hu9q-3nzuA:
1.8		 6hu9S-3nzuA:
7.11
6hu9q-3nzuA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLN D 294
PHE D 312
HIS D 314
SER D 307
 None
 0.97A 6hu9S-3oaaD:
undetectable
6hu9q-3oaaD:
undetectable		 6hu9S-3oaaD:
13.41
6hu9q-3oaaD:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyf CRISPR-ASSOCIATED
PROTEIN

(Sulfolobus
solfataricus) 		PF09651
(Cas_APE2256) 		4 PHE A  93
HIS A   4
VAL A 159
SER A 120
 None
 1.06A 6hu9S-3qyfA:
undetectable
6hu9q-3qyfA:
undetectable		 6hu9S-3qyfA:
14.56
6hu9q-3qyfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1j ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycobacterium
avium) 		PF02668
(TauD) 		4 GLN A 224
GLY A 202
HIS A  99
VAL A 102
 None
None
FE  A 299 (-3.3A)
None
 0.89A 6hu9S-3r1jA:
undetectable
6hu9q-3r1jA:
undetectable		 6hu9S-3r1jA:
12.72
6hu9q-3r1jA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 GLN A 250
GLY A 254
VAL A 282
SER A 262
 None
 1.07A 6hu9S-3sdqA:
undetectable
6hu9q-3sdqA:
1.6		 6hu9S-3sdqA:
8.24
6hu9q-3sdqA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD

(Mycobacterium
marinum) 		PF02668
(TauD) 		4 GLN A 226
GLY A 204
HIS A  98
VAL A 101
 None
None
FE  A 299 (-3.3A)
None
 0.94A 6hu9S-3swtA:
undetectable
6hu9q-3swtA:
undetectable		 6hu9S-3swtA:
13.43
6hu9q-3swtA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3l TABLYSIN 15

(Tabanus yao) 		PF00188
(CAP) 		4 GLN C 191
GLY C 104
PHE C 188
SER C 161
 None
 1.03A 6hu9S-3u3lC:
undetectable
6hu9q-3u3lC:
undetectable		 6hu9S-3u3lC:
15.96
6hu9q-3u3lC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubl GLUTATHIONE
TRANSFERASE

(Leptospira
interrogans) 		PF13417
(GST_N_3) 		4 GLY A 156
PHE A 157
HIS A 159
VAL A 162
 None
 0.98A 6hu9S-3ublA:
undetectable
6hu9q-3ublA:
undetectable		 6hu9S-3ublA:
17.89
6hu9q-3ublA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v69 PROTEIN FILIA

(Mus musculus) 		PF16005
(MOEP19) 		4 GLN A   8
GLY A  59
PHE A  55
HIS A  61
 None
 1.05A 6hu9S-3v69A:
undetectable
6hu9q-3v69A:
undetectable		 6hu9S-3v69A:
16.55
6hu9q-3v69A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		4 GLY A  82
HIS A  85
VAL A  88
SER A 168
 None
None
None
SQS  A 401 (-3.1A)
 0.94A 6hu9S-3vzbA:
undetectable
6hu9q-3vzbA:
undetectable		 6hu9S-3vzbA:
12.36
6hu9q-3vzbA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE

(Methanocaldococcus
jannaschii) 		PF05889
(SepSecS) 		4 GLN A  41
GLY A  44
VAL A 289
SER A 231
 None
LLP  A 234 ( 4.3A)
None
LLP  A 234 ( 2.9A)
 1.06A 6hu9S-3wksA:
undetectable
6hu9q-3wksA:
undetectable		 6hu9S-3wksA:
12.37
6hu9q-3wksA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyw GLUTATHIONE
S-TRANSFERASE

(Nilaparvata
lugens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 GLN A 208
GLY A 205
PHE A 206
VAL A   8
 None
 0.91A 6hu9S-3wywA:
undetectable
6hu9q-3wywA:
1.6		 6hu9S-3wywA:
17.13
6hu9q-3wywA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zto NUCLEOSIDE
DIPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00334
(NDK) 		4 GLY A 111
PHE A 110
VAL A  10
SER A 105
 None
 0.98A 6hu9S-3ztoA:
undetectable
6hu9q-3ztoA:
undetectable		 6hu9S-3ztoA:
17.48
6hu9q-3ztoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crw PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6

(Homo sapiens) 		PF00271
(Helicase_C) 		4 GLY B 372
PHE B 369
VAL B 365
SER B 349
 None
None
GOL  B1801 ( 4.3A)
None
 1.04A 6hu9S-4crwB:
undetectable
6hu9q-4crwB:
undetectable		 6hu9S-4crwB:
21.23
6hu9q-4crwB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvy DIOXYGENASE
RV3406/MT3514

(Mycobacterium
tuberculosis) 		PF02668
(TauD) 		4 GLN A 222
GLY A 200
HIS A  97
VAL A 100
 None
None
FE  A1293 (-3.4A)
None
 0.94A 6hu9S-4cvyA:
undetectable
6hu9q-4cvyA:
undetectable		 6hu9S-4cvyA:
14.54
6hu9q-4cvyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 GLN A 273
GLY A 270
VAL A  29
SER A 294
 None
 1.06A 6hu9S-4djiA:
undetectable
6hu9q-4djiA:
undetectable		 6hu9S-4djiA:
10.69
6hu9q-4djiA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B

(Mus musculus) 		PF02373
(JmjC) 		4 GLN A1377
GLY A1372
VAL A1512
SER A1398
 None
None
None
OGA  A1700 (-2.8A)
 0.89A 6hu9S-4eyuA:
undetectable
6hu9q-4eyuA:
undetectable		 6hu9S-4eyuA:
10.74
6hu9q-4eyuA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdj NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 GLN A 350
GLY A 408
PHE A 422
VAL A 420
 None
 1.03A 6hu9S-4gdjA:
undetectable
6hu9q-4gdjA:
undetectable		 6hu9S-4gdjA:
14.95
6hu9q-4gdjA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		4 GLY A 329
HIS A 320
VAL A 373
SER A 163
 FAD  A 501 (-3.0A)
None
None
None
 1.00A 6hu9S-4hb9A:
undetectable
6hu9q-4hb9A:
undetectable		 6hu9S-4hb9A:
13.51
6hu9q-4hb9A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 GLY B 184
PHE B 124
VAL B 213
SER B 252
 None
 0.91A 6hu9S-4i0wB:
undetectable
6hu9q-4i0wB:
undetectable		 6hu9S-4i0wB:
12.06
6hu9q-4i0wB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9y E3 SUMO-PROTEIN
LIGASE RANBP2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 GLN A 111
PHE A  53
VAL A 152
SER A  51
 None
 1.00A 6hu9S-4i9yA:
undetectable
6hu9q-4i9yA:
undetectable		 6hu9S-4i9yA:
18.82
6hu9q-4i9yA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ily CHITOSANASE

(Streptomyces
sp. SirexAA-E) 		PF01374
(Glyco_hydro_46) 		4 GLY A 203
PHE A 211
HIS A 202
SER A 213
 None
 0.99A 6hu9S-4ilyA:
undetectable
6hu9q-4ilyA:
undetectable		 6hu9S-4ilyA:
11.98
6hu9q-4ilyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycolicibacterium
smegmatis) 		PF02668
(TauD) 		4 GLN A 219
GLY A 197
HIS A  95
VAL A  98
 None
None
FE  A 401 (-3.5A)
None
 0.96A 6hu9S-4j5iA:
undetectable
6hu9q-4j5iA:
undetectable		 6hu9S-4j5iA:
14.53
6hu9q-4j5iA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 4 GLY H  94
VAL H 169
SER H 122
LYS H 149
 None
 0.96A 6hu9S-4l0oH:
undetectable
6hu9q-4l0oH:
undetectable		 6hu9S-4l0oH:
14.25
6hu9q-4l0oH:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 GLY A 330
PHE A  53
HIS A  52
VAL A  55
 None
 0.66A 6hu9S-4lb0A:
undetectable
6hu9q-4lb0A:
undetectable		 6hu9S-4lb0A:
11.37
6hu9q-4lb0A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx6 TRAP-TYPE
C4-DICARBOXYLATE:H+
SYMPORT SYSTEM
SUBSTRATE-BINDING
COMPONENT DCTP

(Shewanella
oneidensis) 		PF03480
(DctP) 		4 GLN A  53
GLY A  52
VAL A  44
SER A 222
 None
None
SIN  A 401 (-4.7A)
None
 1.05A 6hu9S-4mx6A:
undetectable
6hu9q-4mx6A:
undetectable		 6hu9S-4mx6A:
14.97
6hu9q-4mx6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuq CADHERIN-2

(Mus musculus) 		PF00028
(Cadherin) 		4 GLN A  45
GLY A  40
PHE A  74
VAL A  95
 None
 0.97A 6hu9S-4nuqA:
undetectable
6hu9q-4nuqA:
undetectable		 6hu9S-4nuqA:
16.89
6hu9q-4nuqA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Shewanella
loihica) 		PF03480
(DctP) 		4 GLN A  50
GLY A  49
VAL A  41
SER A 219
 None
 1.03A 6hu9S-4o7mA:
undetectable
6hu9q-4o7mA:
undetectable		 6hu9S-4o7mA:
16.29
6hu9q-4o7mA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pt4 DNA-BINDING PROTEIN
HU HOMOLOG

(Mycobacterium
tuberculosis) 		PF00216
(Bac_DNA_binding) 		4 GLN A  84
GLY A  46
PHE A  47
VAL A  42
 None
 0.99A 6hu9S-4pt4A:
undetectable
6hu9q-4pt4A:
undetectable		 6hu9S-4pt4A:
16.67
6hu9q-4pt4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiu NITRONATE
MONOOXYGENASE FAMILY
PROTEIN

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		4 GLY A 135
PHE A 132
HIS A 133
SER A 111
 None
None
FMN  A 401 (-3.3A)
None
 1.04A 6hu9S-4qiuA:
undetectable
6hu9q-4qiuA:
undetectable		 6hu9S-4qiuA:
12.17
6hu9q-4qiuA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 GLN A 232
PHE A 235
VAL A 240
SER A 209
 None
 1.00A 6hu9S-4tr6A:
undetectable
6hu9q-4tr6A:
undetectable		 6hu9S-4tr6A:
13.75
6hu9q-4tr6A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 5 GLN E 280
GLY E 279
PHE E 224
VAL E 222
SER E 227
 None
 1.46A 6hu9S-4whbE:
undetectable
6hu9q-4whbE:
undetectable		 6hu9S-4whbE:
15.47
6hu9q-4whbE:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 GLY A 437
HIS A 435
VAL A 419
SER A 423
 None
 0.99A 6hu9S-4xhbA:
undetectable
6hu9q-4xhbA:
undetectable		 6hu9S-4xhbA:
8.98
6hu9q-4xhbA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk1 PHOSPHOSERINE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		4 GLN A 196
GLY A 194
VAL A 207
SER A  78
 LLP  A 197 ( 3.1A)
LLP  A 197 ( 4.5A)
None
LLP  A 197 ( 2.4A)
 1.05A 6hu9S-4xk1A:
undetectable
6hu9q-4xk1A:
undetectable		 6hu9S-4xk1A:
13.11
6hu9q-4xk1A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		4 GLN A 233
GLY A 211
HIS A 104
VAL A 107
 None
None
FE  A 401 ( 3.2A)
EPE  A 403 (-4.2A)
 0.96A 6hu9S-4y0eA:
undetectable
6hu9q-4y0eA:
undetectable		 6hu9S-4y0eA:
14.95
6hu9q-4y0eA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zba PCURE2P8

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLY A 116
PHE A 119
VAL A 123
SER A 175
 None
None
ACT  A 302 (-4.4A)
None
 0.98A 6hu9S-4zbaA:
undetectable
6hu9q-4zbaA:
undetectable		 6hu9S-4zbaA:
16.44
6hu9q-4zbaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a20 MAJOR TAIL PROTEIN
GP17.1

(Bacillus phage
SPP1) 		PF06199
(Phage_tail_2) 		4 GLY H 109
PHE H 108
VAL H  94
SER H  17
 None
 1.07A 6hu9S-5a20H:
undetectable
6hu9q-5a20H:
undetectable		 6hu9S-5a20H:
19.75
6hu9q-5a20H:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		4 HIS B 115
VAL B  47
SER B 111
LYS B  83
 None
 0.97A 6hu9S-5a7vB:
undetectable
6hu9q-5a7vB:
undetectable		 6hu9S-5a7vB:
14.79
6hu9q-5a7vB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2

(Mus musculus) 		PF06046
(Sec6) 		4 GLN A 557
GLY A 558
PHE A 559
SER A 565
 None
 1.06A 6hu9S-5b86A:
undetectable
6hu9q-5b86A:
2.9		 6hu9S-5b86A:
9.76
6hu9q-5b86A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctm BETA-LACTAMASE

(Bacillus
pumilus) 		PF00905
(Transpeptidase) 		4 GLN A 228
GLY A 238
PHE A 252
VAL A 201
 None
 1.02A 6hu9S-5ctmA:
undetectable
6hu9q-5ctmA:
undetectable		 6hu9S-5ctmA:
14.61
6hu9q-5ctmA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		4 GLY A 185
PHE A 187
VAL A 191
SER A 282
 None
 1.00A 6hu9S-5e9jA:
undetectable
6hu9q-5e9jA:
undetectable		 6hu9S-5e9jA:
18.40
6hu9q-5e9jA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		4 GLY A 185
PHE A 187
VAL A 191
SER A 282
 None
 0.93A 6hu9S-5e9wA:
undetectable
6hu9q-5e9wA:
undetectable		 6hu9S-5e9wA:
17.13
6hu9q-5e9wA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxv HISTONE DEMETHYLASE
UTY

(Homo sapiens) 		PF02373
(JmjC) 		4 GLN A1080
GLY A1075
VAL A1215
SER A1101
 None
None
None
MN  A2346 ( 4.6A)
 0.76A 6hu9S-5fxvA:
undetectable
6hu9q-5fxvA:
undetectable		 6hu9S-5fxvA:
11.57
6hu9q-5fxvA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		4 GLY A 717
PHE A 714
VAL A 710
LYS A 670
 U  U  85 ( 3.0A)
None
None
C  U 101 ( 2.8A)
 0.93A 6hu9S-5gamA:
undetectable
6hu9q-5gamA:
undetectable		 6hu9S-5gamA:
9.50
6hu9q-5gamA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A 192
PHE A 194
VAL A 159
SER A 134
 FAD  A 601 (-3.8A)
None
None
None
 0.98A 6hu9S-5i1wA:
undetectable
6hu9q-5i1wA:
undetectable		 6hu9S-5i1wA:
10.55
6hu9q-5i1wA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY B 744
PHE B 793
VAL B 799
SER B 749
 None
6U7  B1001 (-4.3A)
None
None
 0.81A 6hu9S-5kkrB:
undetectable
6hu9q-5kkrB:
undetectable		 6hu9S-5kkrB:
16.39
6hu9q-5kkrB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 4 GLY A  97
HIS A  96
VAL A  94
SER A 394
 None
 0.73A 6hu9S-5m3xA:
undetectable
6hu9q-5m3xA:
undetectable		 6hu9S-5m3xA:
undetectable
6hu9q-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mak R7

(synthetic
construct) 		no annotation 4 GLN A 142
GLY A 146
PHE A 145
VAL A 184
 None
 0.96A 6hu9S-5makA:
undetectable
6hu9q-5makA:
undetectable		 6hu9S-5makA:
17.31
6hu9q-5makA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oup PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 4 GLN A 618
GLY A 615
VAL A 496
LYS A 780
 None
 0.82A 6hu9S-5oupA:
undetectable
6hu9q-5oupA:
undetectable		 6hu9S-5oupA:
undetectable
6hu9q-5oupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t79 ALDO-KETO REDUCTASE,
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		4 GLY A 166
PHE A 135
VAL A 157
SER A  95
 None
 1.05A 6hu9S-5t79A:
undetectable
6hu9q-5t79A:
undetectable		 6hu9S-5t79A:
16.17
6hu9q-5t79A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 4 GLY B 362
PHE B 363
VAL B 189
SER B 180
 None
 1.05A 6hu9S-5txrB:
undetectable
6hu9q-5txrB:
undetectable		 6hu9S-5txrB:
undetectable
6hu9q-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 GLY A 325
PHE A 327
VAL A 331
SER A 299
 None
 1.07A 6hu9S-5w21A:
undetectable
6hu9q-5w21A:
0.1		 6hu9S-5w21A:
undetectable
6hu9q-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 GLY A 648
PHE A 650
VAL A 654
SER A 641
 None
 1.00A 6hu9S-5wugA:
undetectable
6hu9q-5wugA:
undetectable		 6hu9S-5wugA:
undetectable
6hu9q-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwo ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF05291
(Bystin) 		4 GLN A 276
GLY A 320
PHE A 321
VAL A 326
 None
 1.04A 6hu9S-5wwoA:
undetectable
6hu9q-5wwoA:
undetectable		 6hu9S-5wwoA:
13.08
6hu9q-5wwoA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN

(Pyrobaculum
calidifontis) 		no annotation 4 GLN A 124
GLY A 230
PHE A 231
HIS A 278
 None
None
TLA  A 301 ( 4.1A)
None
 1.02A 6hu9S-5xvhA:
undetectable
6hu9q-5xvhA:
undetectable		 6hu9S-5xvhA:
undetectable
6hu9q-5xvhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y39 RAGULATOR COMPLEX
PROTEIN LAMTOR1
RAGULATOR COMPLEX
PROTEIN LAMTOR5

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 GLY E 163
HIS E 161
VAL E 166
SER A 144
 None
 0.97A 6hu9S-5y39E:
undetectable
6hu9q-5y39E:
undetectable		 6hu9S-5y39E:
undetectable
6hu9q-5y39E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 4 GLN A 727
GLY A 815
VAL A 871
SER A 864
 None
 1.05A 6hu9S-5yimA:
undetectable
6hu9q-5yimA:
0.7		 6hu9S-5yimA:
undetectable
6hu9q-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG

(Homo sapiens) 		no annotation 4 GLY A  77
PHE A  74
HIS A  76
SER A  81
 None
 0.99A 6hu9S-6au8A:
undetectable
6hu9q-6au8A:
undetectable		 6hu9S-6au8A:
13.43
6hu9q-6au8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Legionella
pneumophila) 		no annotation 4 GLY A  41
PHE A  43
VAL A  45
SER A  36
 None
 1.06A 6hu9S-6cktA:
undetectable
6hu9q-6cktA:
undetectable		 6hu9S-6cktA:
undetectable
6hu9q-6cktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 GLN i 276
GLY i 320
PHE i 321
VAL i 326
 None
 1.05A 6hu9S-6faii:
undetectable
6hu9q-6faii:
undetectable		 6hu9S-6faii:
undetectable
6hu9q-6faii:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 GLN A 108
GLY A  63
PHE A  64
VAL A  66
 None
 1.01A 6hu9S-6fhwA:
undetectable
6hu9q-6fhwA:
0.9		 6hu9S-6fhwA:
undetectable
6hu9q-6fhwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 4 GLY B 658
PHE B 711
HIS B 710
VAL B 713
 None
None
CLA  B1239 (-4.1A)
None
 0.98A 6hu9S-6fosB:
undetectable
6hu9q-6fosB:
undetectable		 6hu9S-6fosB:
undetectable
6hu9q-6fosB:
undetectable