SIMILAR PATTERNS OF AMINO ACIDS FOR 6HU9_Q_PCFQ202_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b12 SIGNAL PEPTIDASE I

(Escherichia
coli) 		PF00717
(Peptidase_S24)
PF10502
(Peptidase_S26) 		4 TYR A 283
ALA A 259
ARG A 282
ASP A 276
 None
 1.12A 6hu9m-1b12A:
undetectable
6hu9q-1b12A:
undetectable		 6hu9m-1b12A:
18.94
6hu9q-1b12A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		4 TYR A 287
ILE A 231
ALA A 250
ASP A  32
 None
 1.04A 6hu9m-1cvmA:
undetectable
6hu9q-1cvmA:
undetectable		 6hu9m-1cvmA:
21.81
6hu9q-1cvmA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebp EPO RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		4 ILE A 174
ALA A 198
ARG A 155
MET A 200
 None
 1.05A 6hu9m-1ebpA:
undetectable
6hu9q-1ebpA:
undetectable		 6hu9m-1ebpA:
17.29
6hu9q-1ebpA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eom ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F3

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		4 TYR A 274
ILE A 271
ALA A 283
ARG A 285
 None
 1.16A 6hu9m-1eomA:
undetectable
6hu9q-1eomA:
undetectable		 6hu9m-1eomA:
19.93
6hu9q-1eomA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN

(Pyrococcus
horikoshii) 		PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3) 		4 ALA A 152
ARG A 154
MET A 155
ASP A 120
 None
 1.03A 6hu9m-1j08A:
0.0
6hu9q-1j08A:
undetectable		 6hu9m-1j08A:
18.15
6hu9q-1j08A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		4 TYR A 228
ALA A 330
ARG A 331
ASP A 341
 None
 0.96A 6hu9m-1jkmA:
0.0
6hu9q-1jkmA:
0.0		 6hu9m-1jkmA:
22.81
6hu9q-1jkmA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9x GAMMA-GLUTAMYL
HYDROLASE

(Homo sapiens) 		PF07722
(Peptidase_C26) 		4 TYR A 274
ILE A 273
ALA A  45
ARG A  46
 None
 1.14A 6hu9m-1l9xA:
undetectable
6hu9q-1l9xA:
undetectable		 6hu9m-1l9xA:
18.53
6hu9q-1l9xA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 TYR A 465
ILE A 541
ALA A 536
MET A 534
 None
 1.15A 6hu9m-1lxtA:
0.0
6hu9q-1lxtA:
undetectable		 6hu9m-1lxtA:
23.42
6hu9q-1lxtA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		4 ILE A 432
ALA A 439
ARG A 435
ASP A 408
 None
 0.99A 6hu9m-1n7uA:
undetectable
6hu9q-1n7uA:
undetectable		 6hu9m-1n7uA:
22.10
6hu9q-1n7uA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A 182
ALA A  44
MET A 178
ASP A  37
 None
 1.14A 6hu9m-1ofeA:
0.0
6hu9q-1ofeA:
0.0		 6hu9m-1ofeA:
16.88
6hu9q-1ofeA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Chlamydomonas
reinhardtii) 		PF00355
(Rieske) 		4 TYR C 128
ILE C 118
ALA C 161
ASP C 196
 None
 0.96A 6hu9m-1q90C:
undetectable
6hu9q-1q90C:
undetectable		 6hu9m-1q90C:
12.62
6hu9q-1q90C:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		4 ILE A 222
ALA A 196
ARG A 193
ASP A 227
 GOL  A 480 (-4.3A)
None
None
None
 1.11A 6hu9m-1qd1A:
0.0
6hu9q-1qd1A:
undetectable		 6hu9m-1qd1A:
20.19
6hu9q-1qd1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 ILE A 412
ALA A 532
ARG A 531
ASP A 228
 None
 1.04A 6hu9m-1su7A:
0.9
6hu9q-1su7A:
0.0		 6hu9m-1su7A:
22.37
6hu9q-1su7A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		4 ILE A1672
ALA A1726
MET A1730
ASP A1736
 None
 1.07A 6hu9m-1u4qA:
1.0
6hu9q-1u4qA:
2.0		 6hu9m-1u4qA:
18.99
6hu9q-1u4qA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		4 TYR A 370
ILE A  69
ALA A 205
ASP A 307
 CIT  A1649 (-4.5A)
None
None
None
 1.14A 6hu9m-1w8oA:
undetectable
6hu9q-1w8oA:
undetectable		 6hu9m-1w8oA:
22.99
6hu9q-1w8oA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 TYR A 195
ILE A 184
ALA A 165
ARG A 186
 None
 1.15A 6hu9m-1yx2A:
undetectable
6hu9q-1yx2A:
undetectable		 6hu9m-1yx2A:
21.97
6hu9q-1yx2A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF05833
(FbpA)
PF09239
(Topo-VIb_trans) 		4 ILE A 187
ALA A  29
ARG A  30
ASP A 382
 None
 1.10A 6hu9m-1z5aA:
undetectable
6hu9q-1z5aA:
0.9		 6hu9m-1z5aA:
22.09
6hu9q-1z5aA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		4 ILE A  33
ALA A 153
ARG A 152
ASP A 185
 None
 1.10A 6hu9m-2g85A:
undetectable
6hu9q-2g85A:
undetectable		 6hu9m-2g85A:
23.03
6hu9q-2g85A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1
METHYLTRANSFERASE 1

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF12176
(MtaB)
PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 TYR A 368
ILE A 404
ALA A 409
ASP B   3
 None
 1.10A 6hu9m-2i2xA:
0.0
6hu9q-2i2xA:
0.0		 6hu9m-2i2xA:
20.72
6hu9q-2i2xA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 TYR A 215
ILE A 590
ALA A 568
ARG A 569
 None
 1.15A 6hu9m-2iukA:
undetectable
6hu9q-2iukA:
0.0		 6hu9m-2iukA:
21.31
6hu9q-2iukA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 TYR A 357
ILE A 143
ALA A 262
ASP A 272
 None
 1.09A 6hu9m-2ptsA:
2.2
6hu9q-2ptsA:
0.2		 6hu9m-2ptsA:
21.52
6hu9q-2ptsA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 ILE A 282
ALA A 277
ARG A 276
ASP A 270
 None
None
NI  A1615 (-4.5A)
NI  A1615 (-3.9A)
 1.14A 6hu9m-2uvfA:
undetectable
6hu9q-2uvfA:
undetectable		 6hu9m-2uvfA:
23.78
6hu9q-2uvfA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		4 TYR A 194
ILE A 193
ALA A 296
ARG A 190
 None
 1.17A 6hu9m-2vatA:
undetectable
6hu9q-2vatA:
undetectable		 6hu9m-2vatA:
22.46
6hu9q-2vatA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 143
ILE A 101
ALA A 376
ASP A 387
 None
 1.03A 6hu9m-2vd5A:
undetectable
6hu9q-2vd5A:
2.6		 6hu9m-2vd5A:
22.08
6hu9q-2vd5A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gloeobacter
violaceus;
Gloeobacter
violaceus) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		4 TYR B  94
ILE A   8
ALA A  13
ASP B  86
 None
 1.16A 6hu9m-2vjtB:
undetectable
6hu9q-2vjtB:
undetectable		 6hu9m-2vjtB:
14.79
6hu9q-2vjtB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		4 TYR A 551
ILE A 271
ARG A 535
ASP A  18
 None
 1.17A 6hu9m-2wokA:
1.4
6hu9q-2wokA:
undetectable		 6hu9m-2wokA:
21.17
6hu9q-2wokA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ILE A 173
ALA A 144
MET A 137
ASP A  92
 None
 1.17A 6hu9m-2wyhA:
2.5
6hu9q-2wyhA:
undetectable		 6hu9m-2wyhA:
20.78
6hu9q-2wyhA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 TYR A  68
ILE A  87
ALA A 100
ASP A  64
 None
 0.91A 6hu9m-2x0qA:
undetectable
6hu9q-2x0qA:
undetectable		 6hu9m-2x0qA:
22.45
6hu9q-2x0qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 TYR A  49
ILE A   7
ALA A  20
MET A  23
 None
 1.03A 6hu9m-2yyyA:
undetectable
6hu9q-2yyyA:
undetectable		 6hu9m-2yyyA:
19.78
6hu9q-2yyyA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 ILE A  50
ALA A  96
ARG A  42
ASP A  26
 None
 1.06A 6hu9m-3abzA:
1.6
6hu9q-3abzA:
undetectable		 6hu9m-3abzA:
20.05
6hu9q-3abzA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay3 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Chromohalobacter
salexigens) 		PF01370
(Epimerase) 		4 TYR A 149
ILE A 155
ALA A  96
ARG A  98
 None
 1.12A 6hu9m-3ay3A:
undetectable
6hu9q-3ay3A:
undetectable		 6hu9m-3ay3A:
19.25
6hu9q-3ay3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00294
(PfkB) 		4 TYR A  68
ILE A  72
ALA A  40
ASP A  13
 None
 1.04A 6hu9m-3bf5A:
0.7
6hu9q-3bf5A:
undetectable		 6hu9m-3bf5A:
19.96
6hu9q-3bf5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvm ENTEROTOXIN TYPE C-3

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 TYR A 174
ILE A 168
ALA A 163
ARG A 164
ASP A 199
 None
 1.45A 6hu9m-3bvmA:
undetectable
6hu9q-3bvmA:
undetectable		 6hu9m-3bvmA:
17.58
6hu9q-3bvmA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 ILE A 424
ALA A 115
ARG A 116
ASP A 531
 None
 1.07A 6hu9m-3cdiA:
undetectable
6hu9q-3cdiA:
1.7		 6hu9m-3cdiA:
22.63
6hu9q-3cdiA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 TYR A 455
ILE A  42
ALA A 374
ARG A 432
 None
 0.99A 6hu9m-3clwA:
undetectable
6hu9q-3clwA:
undetectable		 6hu9m-3clwA:
23.26
6hu9q-3clwA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpx AMINOPEPTIDASE, M42
FAMILY

(Cytophaga
hutchinsonii) 		PF05343
(Peptidase_M42) 		4 ILE A  82
ALA A  12
MET A  66
ASP A 253
 None
 1.16A 6hu9m-3cpxA:
undetectable
6hu9q-3cpxA:
undetectable		 6hu9m-3cpxA:
21.40
6hu9q-3cpxA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		4 ALA A 315
ARG A 331
MET A 327
ASP A  34
 None
 1.10A 6hu9m-3dhuA:
undetectable
6hu9q-3dhuA:
undetectable		 6hu9m-3dhuA:
21.01
6hu9q-3dhuA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		4 ILE A  13
ALA A   8
ARG A  10
ASP A 253
 None
 1.15A 6hu9m-3dpiA:
undetectable
6hu9q-3dpiA:
undetectable		 6hu9m-3dpiA:
19.85
6hu9q-3dpiA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 TYR A  90
ILE A  91
ALA A  50
ARG A  53
 None
None
None
CL  A 536 (-4.3A)
 0.99A 6hu9m-3fddA:
undetectable
6hu9q-3fddA:
1.6		 6hu9m-3fddA:
21.42
6hu9q-3fddA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 ILE A 401
ALA A  92
ARG A  93
ASP A 508
 None
 1.13A 6hu9m-3gmeA:
undetectable
6hu9q-3gmeA:
undetectable		 6hu9m-3gmeA:
22.51
6hu9q-3gmeA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9d MICROTUBULE-ASSOCIAT
ED PROTEIN 1A/1B,
LIGHT CHAIN 3,
PUTATIVE

(Trypanosoma
brucei) 		PF02991
(Atg8) 		4 TYR A  97
ILE A  33
ALA A  20
ARG A  24
 None
 1.13A 6hu9m-3h9dA:
undetectable
6hu9q-3h9dA:
undetectable		 6hu9m-3h9dA:
11.24
6hu9q-3h9dA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwe CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN

(Thermosynechococcus
elongatus) 		PF00132
(Hexapep) 		4 ILE A 146
ALA A 127
ARG A 128
ASP A  85
 None
 1.06A 6hu9m-3kweA:
undetectable
6hu9q-3kweA:
undetectable		 6hu9m-3kweA:
15.89
6hu9q-3kweA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE

(Staphylococcus
saprophyticus) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 TYR A 118
ILE A 123
ALA A  85
ASP A  75
 None
 1.09A 6hu9m-3l8mA:
undetectable
6hu9q-3l8mA:
undetectable		 6hu9m-3l8mA:
17.07
6hu9q-3l8mA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		4 ILE A 104
ALA A 234
ARG A 100
ASP A 327
 None
 1.16A 6hu9m-3majA:
undetectable
6hu9q-3majA:
undetectable		 6hu9m-3majA:
22.18
6hu9q-3majA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzo LIN2634 PROTEIN

(Listeria
innocua) 		PF12917
(HD_2) 		4 ILE A  16
ALA A  31
ARG A  18
ASP A 137
 None
None
CA  A 301 (-4.1A)
CA  A 301 (-2.7A)
 1.16A 6hu9m-3mzoA:
undetectable
6hu9q-3mzoA:
undetectable		 6hu9m-3mzoA:
18.78
6hu9q-3mzoA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0m OXALATE
DECARBOXYLASE OXDC

(Bacillus
subtilis) 		PF00190
(Cupin_1) 		4 TYR A 320
ALA A 289
ARG A 290
ASP A  41
 None
 1.06A 6hu9m-3s0mA:
undetectable
6hu9q-3s0mA:
undetectable		 6hu9m-3s0mA:
21.17
6hu9q-3s0mA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 TYR A 637
ILE A 671
ALA A 559
ASP A 570
 None
 1.07A 6hu9m-3sdqA:
undetectable
6hu9q-3sdqA:
undetectable		 6hu9m-3sdqA:
20.76
6hu9q-3sdqA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sen CASKIN-1

(Homo sapiens) 		PF00536
(SAM_1) 		4 ILE A 112
ALA A 134
ARG A 136
ASP A  46
 None
 1.10A 6hu9m-3senA:
undetectable
6hu9q-3senA:
undetectable		 6hu9m-3senA:
13.52
6hu9q-3senA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sil SIALIDASE

(Salmonella
enterica) 		PF13859
(BNR_3) 		4 ILE A  49
ALA A  71
ARG A  72
ASP A 149
 None
 1.17A 6hu9m-3silA:
undetectable
6hu9q-3silA:
undetectable		 6hu9m-3silA:
19.89
6hu9q-3silA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urz UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13174
(TPR_6) 		4 TYR A 130
ILE A 133
ALA A 112
MET A 116
 None
None
CSX  A 109 ( 3.8A)
None
 0.98A 6hu9m-3urzA:
undetectable
6hu9q-3urzA:
undetectable		 6hu9m-3urzA:
15.40
6hu9q-3urzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 TYR A  35
ILE A 474
ALA A 479
ARG A 481
 None
 1.05A 6hu9m-3vrbA:
undetectable
6hu9q-3vrbA:
undetectable		 6hu9m-3vrbA:
23.24
6hu9q-3vrbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w79 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		4 TYR A 180
ILE A 181
ALA A 146
MET A 102
 None
None
FMN  A 301 (-3.3A)
FMN  A 301 (-3.2A)
 1.04A 6hu9m-3w79A:
undetectable
6hu9q-3w79A:
undetectable		 6hu9m-3w79A:
16.82
6hu9q-3w79A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsb FARNESYLTRANSFERASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF00494
(SQS_PSY) 		4 TYR A  35
ILE A  49
ALA A  59
ASP A  28
 None
 1.15A 6hu9m-3wsbA:
undetectable
6hu9q-3wsbA:
undetectable		 6hu9m-3wsbA:
20.89
6hu9q-3wsbA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE

(Trichoderma
reesei) 		PF00704
(Glyco_hydro_18) 		4 ILE X 210
ALA X 222
MET X 257
ASP X 129
 None
None
ACT  X1288 ( 4.9A)
ACT  X1288 (-2.9A)
 1.07A 6hu9m-4ac1X:
undetectable
6hu9q-4ac1X:
undetectable		 6hu9m-4ac1X:
19.55
6hu9q-4ac1X:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2

(Homo sapiens) 		PF00995
(Sec1) 		4 TYR A 410
ILE A 411
ARG A 414
ASP A 384
 None
 1.03A 6hu9m-4ccaA:
undetectable
6hu9q-4ccaA:
undetectable		 6hu9m-4ccaA:
20.83
6hu9q-4ccaA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans) 		PF10275
(Peptidase_C65) 		4 TYR B 272
ILE B 271
ALA B  92
ARG B  80
 None
 1.06A 6hu9m-4dhiB:
undetectable
6hu9q-4dhiB:
undetectable		 6hu9m-4dhiB:
19.48
6hu9q-4dhiB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans;
Homo sapiens) 		PF10275
(Peptidase_C65) 		4 TYR A 272
ILE A 271
ALA A  92
ARG A  80
 None
 0.95A 6hu9m-4dhzA:
undetectable
6hu9q-4dhzA:
undetectable		 6hu9m-4dhzA:
19.63
6hu9q-4dhzA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE

(Staphylococcus
aureus) 		PF00494
(SQS_PSY) 		4 ILE A  47
ALA A  42
ARG A  45
MET A  15
 None
None
3RX  A 301 ( 3.9A)
None
 1.11A 6hu9m-4ea1A:
undetectable
6hu9q-4ea1A:
undetectable		 6hu9m-4ea1A:
19.46
6hu9q-4ea1A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A  37
ILE A  72
ALA A 178
ARG A 180
 None
 1.15A 6hu9m-4eziA:
undetectable
6hu9q-4eziA:
undetectable		 6hu9m-4eziA:
22.00
6hu9q-4eziA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		4 ILE A  18
ALA A 138
ARG A 137
ASP A 277
 None
 1.00A 6hu9m-4h0pA:
undetectable
6hu9q-4h0pA:
undetectable		 6hu9m-4h0pA:
23.03
6hu9q-4h0pA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 727
ILE A 889
ALA A 919
ARG A 920
 None
 1.15A 6hu9m-4iugA:
undetectable
6hu9q-4iugA:
undetectable		 6hu9m-4iugA:
21.19
6hu9q-4iugA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 727
ILE A 889
ALA A 921
ARG A 920
 None
 1.08A 6hu9m-4iugA:
undetectable
6hu9q-4iugA:
undetectable		 6hu9m-4iugA:
21.19
6hu9q-4iugA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1v MOB KINASE ACTIVATOR
1A

(Homo sapiens) 		PF03637
(Mob1_phocein) 		4 TYR A 114
ILE A 115
ALA A 160
ARG A 157
 None
 1.11A 6hu9m-4j1vA:
1.6
6hu9q-4j1vA:
undetectable		 6hu9m-4j1vA:
16.44
6hu9q-4j1vA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 TYR A  60
ILE A  67
ALA A  90
ASP A 237
 None
 0.79A 6hu9m-4je0A:
undetectable
6hu9q-4je0A:
undetectable		 6hu9m-4je0A:
20.41
6hu9q-4je0A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		4 TYR A 177
ILE A 137
ALA A 132
ARG A 130
 None
 1.12A 6hu9m-4lsbA:
undetectable
6hu9q-4lsbA:
undetectable		 6hu9m-4lsbA:
18.63
6hu9q-4lsbA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		4 TYR A 177
ILE A 137
ALA A 132
ASP A 169
 None
 0.90A 6hu9m-4lsbA:
undetectable
6hu9q-4lsbA:
undetectable		 6hu9m-4lsbA:
18.63
6hu9q-4lsbA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh1 CASEIN KINASE II
SUBUNIT BETA

(Homo sapiens) 		PF01214
(CK_II_beta) 		4 TYR C  87
ILE C  88
ALA C  95
ASP C  28
 None
 1.12A 6hu9m-4nh1C:
undetectable
6hu9q-4nh1C:
undetectable		 6hu9m-4nh1C:
16.96
6hu9q-4nh1C:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 TYR A 989
ALA A 929
ARG A 930
ASP A 958
 None
 0.67A 6hu9m-4ogcA:
undetectable
6hu9q-4ogcA:
0.5		 6hu9m-4ogcA:
19.19
6hu9q-4ogcA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Mesorhizobium
japonicum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ILE A 148
ALA A 112
MET A 133
ASP A 181
 None
 1.06A 6hu9m-4om8A:
undetectable
6hu9q-4om8A:
undetectable		 6hu9m-4om8A:
20.33
6hu9q-4om8A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phb UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF14262
(Cthe_2159) 		4 TYR A 110
ILE A 111
ARG A 152
ASP A 142
 None
None
None
GD  A 403 (-2.5A)
 1.16A 6hu9m-4phbA:
undetectable
6hu9q-4phbA:
undetectable		 6hu9m-4phbA:
19.92
6hu9q-4phbA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 TYR A 439
ILE A 440
ALA A 447
ASP A 125
 None
 0.90A 6hu9m-4rhhA:
undetectable
6hu9q-4rhhA:
undetectable		 6hu9m-4rhhA:
23.04
6hu9q-4rhhA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpf HOMOSERINE KINASE

(Yersinia pestis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A 190
ALA A 185
ARG A 188
ASP A  18
 None
 1.17A 6hu9m-4rpfA:
undetectable
6hu9q-4rpfA:
undetectable		 6hu9m-4rpfA:
21.58
6hu9q-4rpfA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uap GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN

(Clostridium
perfringens) 		no annotation 4 TYR A 117
ILE A  73
ALA A 131
ASP A 103
 None
 1.14A 6hu9m-4uapA:
undetectable
6hu9q-4uapA:
undetectable		 6hu9m-4uapA:
15.48
6hu9q-4uapA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		4 TYR A 155
ILE A  76
ALA A  39
ASP A 482
 None
 1.01A 6hu9m-4xhcA:
undetectable
6hu9q-4xhcA:
undetectable		 6hu9m-4xhcA:
21.16
6hu9q-4xhcA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkm XYLOSE ISOMERASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 TYR A 152
ALA A 166
ARG A 167
ASP A 104
 None
 1.14A 6hu9m-4xkmA:
undetectable
6hu9q-4xkmA:
undetectable		 6hu9m-4xkmA:
19.43
6hu9q-4xkmA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A  65
ILE A 438
ALA A 277
ARG A 279
 None
None
None
FAD  A 601 (-3.6A)
 1.13A 6hu9m-4ynuA:
undetectable
6hu9q-4ynuA:
undetectable		 6hu9m-4ynuA:
23.85
6hu9q-4ynuA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 TYR A 317
ILE A 387
ALA A 382
ARG A 384
 None
 1.10A 6hu9m-4zzhA:
undetectable
6hu9q-4zzhA:
undetectable		 6hu9m-4zzhA:
19.77
6hu9q-4zzhA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 TYR D  83
ILE D 365
ALA D 359
ARG D 361
 None
 0.93A 6hu9m-5a6bD:
undetectable
6hu9q-5a6bD:
undetectable		 6hu9m-5a6bD:
21.00
6hu9q-5a6bD:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 394
ALA A 366
ARG A 390
ASP A   9
 None
 1.01A 6hu9m-5bswA:
undetectable
6hu9q-5bswA:
undetectable		 6hu9m-5bswA:
22.86
6hu9q-5bswA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 ILE A 700
ALA A 717
ARG A 720
ASP A1068
 None
 1.12A 6hu9m-5cjuA:
undetectable
6hu9q-5cjuA:
undetectable		 6hu9m-5cjuA:
19.50
6hu9q-5cjuA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 TYR A1425
ALA A1410
ARG A1421
ASP A1481
 None
 0.96A 6hu9m-5cwvA:
undetectable
6hu9q-5cwvA:
1.1		 6hu9m-5cwvA:
21.59
6hu9q-5cwvA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		4 ILE A 114
ALA A  74
ARG A  75
ASP A 515
 None
 0.94A 6hu9m-5d6aA:
undetectable
6hu9q-5d6aA:
0.6		 6hu9m-5d6aA:
21.38
6hu9q-5d6aA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5daa D-AMINO ACID
AMINOTRANSFERASE

(Bacillus sp.
YM-1) 		PF01063
(Aminotran_4) 		4 ILE A 144
ALA A  53
ARG A  50
ASP A 207
 None
None
PLP  A 285 (-2.7A)
None
 1.06A 6hu9m-5daaA:
undetectable
6hu9q-5daaA:
undetectable		 6hu9m-5daaA:
17.59
6hu9q-5daaA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3e LARGE EXOPROTEIN
INVOLVED IN HEME
UTILIZATION OR
ADHESION

(Yersinia
kristensenii) 		no annotation 4 TYR B 272
ILE B 274
ALA B 211
ASP B 220
 None
 1.12A 6hu9m-5e3eB:
undetectable
6hu9q-5e3eB:
undetectable		 6hu9m-5e3eB:
10.89
6hu9q-5e3eB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3v ADENYLOSUCCINATE
LYASE

(Salmonella
enterica) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 TYR A 357
ILE A 143
ALA A 262
ASP A 272
 None
 1.11A 6hu9m-5e3vA:
1.6
6hu9q-5e3vA:
undetectable		 6hu9m-5e3vA:
21.13
6hu9q-5e3vA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftt NETRIN RECEPTOR
UNC5D

(Rattus
norvegicus) 		PF00090
(TSP_1)
PF07679
(I-set) 		4 TYR A  62
ILE A 234
ALA A 186
ASP A 129
 None
 1.06A 6hu9m-5fttA:
undetectable
6hu9q-5fttA:
undetectable		 6hu9m-5fttA:
18.60
6hu9q-5fttA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fz5 TRANSCRIPTION
INITIATION FACTOR
IIB

(Saccharomyces
cerevisiae) 		PF00382
(TFIIB)
PF08271
(TF_Zn_Ribbon) 		4 TYR M 154
ILE M 133
ALA M 128
ASP M 159
 None
 1.14A 6hu9m-5fz5M:
undetectable
6hu9q-5fz5M:
undetectable		 6hu9m-5fz5M:
21.26
6hu9q-5fz5M:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 TYR B1425
ALA B1410
ARG B1421
ASP B1481
 None
 1.00A 6hu9m-5hb4B:
0.0
6hu9q-5hb4B:
0.8		 6hu9m-5hb4B:
15.73
6hu9q-5hb4B:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE

(Thermococcus
kodakarensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 TYR A 111
ILE A  89
ALA A  85
ARG A  86
 None
 1.15A 6hu9m-5hwsA:
undetectable
6hu9q-5hwsA:
undetectable		 6hu9m-5hwsA:
21.11
6hu9q-5hwsA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ILE A 328
ALA A 335
ARG A 345
ASP A 893
 None
6GA  A1015 (-4.7A)
None
None
 0.93A 6hu9m-5j6sA:
undetectable
6hu9q-5j6sA:
undetectable		 6hu9m-5j6sA:
20.56
6hu9q-5j6sA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0w SEC71

(Chaetomium
thermophilum) 		PF09802
(Sec66) 		4 TYR A  36
ILE A  59
ALA A 121
MET A 117
 None
 1.03A 6hu9m-5l0wA:
undetectable
6hu9q-5l0wA:
undetectable		 6hu9m-5l0wA:
15.36
6hu9q-5l0wA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mw7 PROTEIN JAGGED-2

(Homo sapiens) 		PF00008
(EGF)
PF01414
(DSL)
PF07657
(MNNL) 		4 TYR A  29
ALA A 115
ARG A 114
ASP A 176
 None
 1.00A 6hu9m-5mw7A:
undetectable
6hu9q-5mw7A:
undetectable		 6hu9m-5mw7A:
18.72
6hu9q-5mw7A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhb XYLOSE ISOMERASE

(Piromyces sp.
E2) 		no annotation 4 TYR A 151
ALA A 165
ARG A 166
ASP A 103
 None
 1.11A 6hu9m-5nhbA:
undetectable
6hu9q-5nhbA:
undetectable		 6hu9m-5nhbA:
20.90
6hu9q-5nhbA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		4 ILE A 344
ALA A 354
ARG A 353
ASP A 262
 None
 0.99A 6hu9m-5tprA:
undetectable
6hu9q-5tprA:
undetectable		 6hu9m-5tprA:
22.72
6hu9q-5tprA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 TYR C 863
ILE C 839
ALA C 667
ARG C 668
 None
 1.06A 6hu9m-5tw1C:
undetectable
6hu9q-5tw1C:
undetectable		 6hu9m-5tw1C:
19.23
6hu9q-5tw1C:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		4 TYR A1939
ILE A1956
ALA A1951
ASP A1983
 None
 1.13A 6hu9m-5xbfA:
undetectable
6hu9q-5xbfA:
1.7		 6hu9m-5xbfA:
21.48
6hu9q-5xbfA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 ILE A 487
ALA A 560
ARG A 559
ASP A 482
 None
 1.04A 6hu9m-5yj6A:
undetectable
6hu9q-5yj6A:
undetectable		 6hu9m-5yj6A:
undetectable
6hu9q-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 257
ILE A 245
ALA A 282
ASP A 265
 None
 1.12A 6hu9m-6emkA:
undetectable
6hu9q-6emkA:
0.0		 6hu9m-6emkA:
undetectable
6hu9q-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 TYR B 279
ILE B 282
ALA B 359
MET B 365
 None
 1.13A 6hu9m-6f42B:
undetectable
6hu9q-6f42B:
undetectable		 6hu9m-6f42B:
undetectable
6hu9q-6f42B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1o -

(-) 		no annotation 4 TYR A   4
ILE A  35
ALA A  30
ARG A  32
 None
 0.96A 6hu9m-6g1oA:
undetectable
6hu9q-6g1oA:
undetectable		 6hu9m-6g1oA:
undetectable
6hu9q-6g1oA:
undetectable