SIMILAR PATTERNS OF AMINO ACIDS FOR 6HU9_N_PCFN606_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnu ACTOPHORIN

(Acanthamoeba
polyphaga) 		PF00241
(Cofilin_ADF) 		5 PHE A  65
ALA A  63
TYR A  62
THR A 100
VAL A 128
 None
 1.34A 6hu9N-1cnuA:
0.0		 6hu9N-1cnuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 MET A 250
ALA A 251
TYR A 255
PHE A 272
VAL A 338
 None
 1.04A 6hu9N-1eu1A:
0.0		 6hu9N-1eu1A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 MET A 180
MET A 229
ALA A 179
TYR A 177
THR A 436
 None
 1.09A 6hu9N-1gzkA:
0.5		 6hu9N-1gzkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		5 ALA A 191
THR A   3
PHE A  48
VAL A 182
TYR A  70
 None
 1.32A 6hu9N-1igoA:
0.0		 6hu9N-1igoA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		5 ALA A 112
TYR A  95
PHE A  65
VAL A  40
VAL A  29
 None
 1.18A 6hu9N-1j71A:
0.0		 6hu9N-1j71A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus) 		PF00704
(Glyco_hydro_18) 		5 MET A 235
MET A 329
ALA A 328
TYR A   1
VAL A 355
 None
 1.29A 6hu9N-1ljyA:
0.0		 6hu9N-1ljyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 PHE A 281
MET A 314
PHE A 208
VAL A 249
VAL A 246
 None
 1.38A 6hu9N-1lq2A:
0.0		 6hu9N-1lq2A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pci PROCARICAIN

(Carica papaya) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 TYR A  88
PHE A  28
VAL A  31
VAL A  34
TYR A  74
 None
 1.49A 6hu9N-1pciA:
0.0		 6hu9N-1pciA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		5 MET A 186
ALA A 183
THR A 239
PHE A 358
VAL A 353
 None
 1.50A 6hu9N-1qw5A:
0.0		 6hu9N-1qw5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3

(Homo sapiens) 		PF02214
(BTB_2) 		5 PHE A 120
TYR A  61
PHE A  97
VAL A  94
VAL A  90
 None
 1.26A 6hu9N-1s1gA:
undetectable		 6hu9N-1s1gA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		5 PHE A  16
MET A  18
ALA A  17
TYR A  59
VAL A 284
 None
 1.35A 6hu9N-1to3A:
undetectable		 6hu9N-1to3A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a79 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY A
MEMBER 2

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF02214
(BTB_2) 		5 PHE B 126
MET B 125
MET B 123
ALA B 122
PHE B  54
 None
 1.44A 6hu9N-2a79B:
undetectable		 6hu9N-2a79B:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 PHE A  60
ALA A  17
TYR A  14
VAL A  28
VAL A  53
 None
 1.41A 6hu9N-2cvzA:
undetectable		 6hu9N-2cvzA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		5 ALA A  26
THR A  33
PHE A  41
VAL A  44
TYR A 143
 None
PGO  A 601 (-3.8A)
None
None
None
 1.33A 6hu9N-2e7yA:
undetectable		 6hu9N-2e7yA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13407
(Peripla_BP_4) 		5 PHE A 117
ALA A 113
TYR A 108
THR A 274
VAL A 239
 None
 1.26A 6hu9N-2fn9A:
undetectable		 6hu9N-2fn9A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ALA A 387
TYR A 389
PHE A 450
VAL A 432
VAL A 436
 None
 1.50A 6hu9N-2hpiA:
undetectable		 6hu9N-2hpiA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		5 ALA A 161
TYR A 158
PHE A 174
VAL A   9
VAL A 115
 None
 1.13A 6hu9N-2no5A:
undetectable		 6hu9N-2no5A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz0 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3

(Homo sapiens) 		PF02214
(BTB_2)
PF11601
(Shal-type) 		5 PHE B 120
TYR B  61
PHE B  97
VAL B  94
VAL B  90
 None
 1.34A 6hu9N-2nz0B:
undetectable		 6hu9N-2nz0B:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 ALA A  82
TYR A 125
THR A 121
PHE A  30
VAL A  41
 None
None
COA  A 500 (-3.1A)
COA  A 500 ( 4.5A)
None
 1.47A 6hu9N-2ozgA:
undetectable		 6hu9N-2ozgA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p31 GLUTATHIONE
PEROXIDASE 7

(Homo sapiens) 		PF00255
(GSHPx) 		5 ALA A  66
TYR A  64
TYR A 108
PHE A 144
VAL A 163
 None
 1.28A 6hu9N-2p31A:
undetectable		 6hu9N-2p31A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 PHE A 165
ALA A 160
THR A 151
PHE A 218
VAL A 167
 None
 1.17A 6hu9N-2yr0A:
undetectable		 6hu9N-2yr0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 MET A 194
ALA A 193
THR A 587
VAL A 578
TYR A 220
 None
None
None
MGD  A1246 (-3.9A)
MD1  A1245 (-3.5A)
 1.43A 6hu9N-3egwA:
undetectable		 6hu9N-3egwA:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h1l CYTOCHROME B

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		7 TRP C  31
PHE C  96
TYR C 104
TYR C 105
THR C 315
VAL C 330
TYR C 359
 PEE  C2007 ( 3.1A)
PEE  C2007 (-3.9A)
PEE  C2007 (-3.5A)
PEE  C2007 ( 4.3A)
None
PEE  C2007 ( 4.7A)
None
 1.42A 6hu9N-3h1lC:
undetectable		 6hu9N-3h1lC:
52.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h1l CYTOCHROME B

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		7 TRP C  31
PHE C  96
TYR C 104
TYR C 105
THR C 317
VAL C 330
TYR C 359
 PEE  C2007 ( 3.1A)
PEE  C2007 (-3.9A)
PEE  C2007 (-3.5A)
PEE  C2007 ( 4.3A)
PEE  C2007 (-3.3A)
PEE  C2007 ( 4.7A)
None
 0.43A 6hu9N-3h1lC:
undetectable		 6hu9N-3h1lC:
52.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 5 PHE A 296
MET A 257
ALA A 256
THR A  27
PHE A 408
 None
 1.34A 6hu9N-3hkaA:
undetectable		 6hu9N-3hkaA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ii7 KELCH-LIKE PROTEIN 7

(Homo sapiens) 		PF01344
(Kelch_1) 		5 ALA A 525
THR A 552
PHE A 484
VAL A 477
VAL A 426
 EDO  A 955 (-3.9A)
None
None
EDO  A 955 (-4.0A)
None
 1.40A 6hu9N-3ii7A:
undetectable		 6hu9N-3ii7A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A  17
THR A 331
PHE A 289
VAL A 117
VAL A   6
 None
 1.38A 6hu9N-3iwaA:
undetectable		 6hu9N-3iwaA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		5 ALA A 329
THR A 363
PHE A 149
VAL A  38
TYR A  62
 None
 1.45A 6hu9N-3lopA:
undetectable		 6hu9N-3lopA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzo LIN2634 PROTEIN

(Listeria
innocua) 		PF12917
(HD_2) 		5 MET A 175
ALA A 176
TYR A 180
PHE A  43
VAL A  55
 None
 1.26A 6hu9N-3mzoA:
undetectable		 6hu9N-3mzoA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ALA A  17
TYR A 509
VAL A 503
VAL A 523
TYR A 587
 None
None
None
None
FMT  A 805 (-4.8A)
 1.34A 6hu9N-3o5aA:
undetectable		 6hu9N-3o5aA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		5 ALA A 264
TYR A 623
THR A 625
VAL A 266
VAL A 301
 None
 1.20A 6hu9N-3ohnA:
undetectable		 6hu9N-3ohnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 ALA A 351
THR A 343
VAL A 329
VAL A 325
TYR A 288
 None
None
None
None
HEA  A   2 (-4.6A)
 1.42A 6hu9N-3omnA:
undetectable		 6hu9N-3omnA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		5 THR A  92
PHE A  87
VAL A 110
VAL A 135
TYR A 350
 None
 1.40A 6hu9N-3oqbA:
undetectable		 6hu9N-3oqbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 PHE A 157
ALA A 160
TYR A 161
TYR A 178
VAL A 262
 None
None
SSN  A 461 (-4.9A)
None
None
 1.50A 6hu9N-3q8nA:
undetectable		 6hu9N-3q8nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 174
PHE A 222
VAL A 152
VAL A 218
TYR A 196
 None
 1.46A 6hu9N-3qwbA:
undetectable		 6hu9N-3qwbA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sim PROTEIN, FAMILY 18
CHITINASE

(Crocus vernus) 		PF00704
(Glyco_hydro_18) 		5 PHE A  35
ALA A  36
THR A 108
VAL A  80
VAL A  32
 None
 1.35A 6hu9N-3simA:
undetectable		 6hu9N-3simA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B

(Erysipelothrix
rhusiopathiae) 		PF05737
(Collagen_bind) 		5 PHE A 290
TYR A 294
THR A 296
VAL A 278
VAL A 227
 None
 1.32A 6hu9N-3v10A:
undetectable		 6hu9N-3v10A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		5 MET A 331
ALA A 334
TYR A 338
TYR A 339
THR A 342
 None
 1.28A 6hu9N-4c1oA:
undetectable		 6hu9N-4c1oA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
subtilis) 		PF02350
(Epimerase_2) 		5 PHE A 220
MET A 219
ALA A 222
TYR A 327
VAL A 259
 None
 1.32A 6hu9N-4fkzA:
undetectable		 6hu9N-4fkzA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 ALA B  82
TYR B  71
TYR B  69
THR B  50
PHE B  46
 None
 1.46A 6hu9N-4k3jB:
undetectable		 6hu9N-4k3jB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		5 PHE A 104
ALA A 185
TYR A 183
PHE A 154
VAL A 167
 None
 1.24A 6hu9N-4lomA:
undetectable		 6hu9N-4lomA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pd4 CYTOCHROME B

(Saccharomyces
cerevisiae) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		12 TRP C  29
PHE C  94
MET C  95
MET C  97
ALA C  98
TYR C 102
TYR C 103
THR C 317
PHE C 327
VAL C 330
VAL C 334
TYR C 359
 3PH  C4006 (-3.6A)
3PH  C4006 ( 4.8A)
None
3PH  C4006 ( 4.1A)
3PH  C4006 (-3.6A)
3PH  C4006 (-3.3A)
3PH  C4006 (-4.9A)
3PH  C4006 (-3.3A)
3PH  C4006 ( 4.9A)
3PH  C4006 ( 4.4A)
None
None
 0.38A 6hu9N-4pd4C:
undetectable		 6hu9N-4pd4C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		5 MET A 309
ALA A 312
TYR A 316
TYR A 317
THR A 320
 None
 1.22A 6hu9N-4rhhA:
undetectable		 6hu9N-4rhhA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry8 PERIPLASMIC BINDING
PROTEIN

(Pseudothermotoga
lettingae) 		PF13407
(Peripla_BP_4) 		5 MET A 223
ALA A 222
THR A 205
VAL A 246
VAL A 267
 None
 1.37A 6hu9N-4ry8A:
undetectable		 6hu9N-4ry8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydo UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF00432
(Prenyltrans) 		5 PHE B 435
TYR B 206
TYR B 205
PHE B 563
TYR B 259
 None
 1.47A 6hu9N-4ydoB:
undetectable		 6hu9N-4ydoB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 MET A 615
ALA A 618
TYR A 341
VAL A 686
VAL A 577
 None
 1.39A 6hu9N-4zohA:
undetectable		 6hu9N-4zohA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		5 MET C 564
ALA C 566
THR C 391
VAL C 544
VAL C  48
 None
 1.26A 6hu9N-5aa5C:
2.9		 6hu9N-5aa5C:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		5 MET A1326
ALA A1328
THR A1271
VAL A1302
VAL A1300
 None
 0.93A 6hu9N-5b16A:
undetectable		 6hu9N-5b16A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 5 MET E 175
ALA E 173
TYR E   6
PHE E  34
VAL E 160
 None
 1.30A 6hu9N-5dbjE:
undetectable		 6hu9N-5dbjE:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF01798
(Nop)
PF01269
(Fibrillarin) 		5 TYR E  82
TYR E 151
THR E  90
VAL E 143
TYR A 114
 SAH  E 301 (-4.9A)
None
SAH  E 301 (-3.2A)
None
None
 1.41A 6hu9N-5ginE:
undetectable		 6hu9N-5ginE:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 PHE A 613
ALA A 609
TYR A 605
TYR A 969
TYR A 575
 None
 1.25A 6hu9N-5h42A:
undetectable		 6hu9N-5h42A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		5 ALA A 711
THR A 673
VAL A 718
VAL A 477
TYR A 746
 None
 1.40A 6hu9N-5hlbA:
undetectable		 6hu9N-5hlbA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6s ENDOGLUCANASE

(Talaromyces
verruculosus) 		PF00150
(Cellulase) 		5 TRP A 282
PHE A  57
ALA A 284
TYR A 291
VAL A  86
 None
 1.31A 6hu9N-5i6sA:
undetectable		 6hu9N-5i6sA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i77 ENDO-BETA-1,
4-GLUCANASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		5 TRP A 300
PHE A  75
ALA A 302
TYR A 309
VAL A 104
 PEG  A 403 ( 4.1A)
None
None
None
None
 1.26A 6hu9N-5i77A:
undetectable		 6hu9N-5i77A:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nmi CYTOCHROME B

(Bos taurus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 TRP C  30
MET C  96
TYR C 103
TYR C 104
TYR C 358
 PEE  C 504 ( 3.6A)
PEE  C 504 (-4.5A)
PEE  C 504 (-3.2A)
PEE  C 504 (-4.4A)
None
 0.58A 6hu9N-5nmiC:
undetectable		 6hu9N-5nmiC:
50.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nmi CYTOCHROME B

(Bos taurus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 TRP C  30
TYR C 103
TYR C 104
VAL C 329
TYR C 358
 PEE  C 504 ( 3.6A)
PEE  C 504 (-3.2A)
PEE  C 504 (-4.4A)
PEE  C 504 ( 4.1A)
None
 0.31A 6hu9N-5nmiC:
undetectable		 6hu9N-5nmiC:
50.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 ALA A 116
THR A 134
PHE A 154
VAL A 143
VAL A 151
 None
 1.50A 6hu9N-5wdxA:
undetectable		 6hu9N-5wdxA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Homo sapiens) 		no annotation 5 ALA C  29
THR C 287
PHE C 320
VAL C  13
VAL C 324
 None
 1.41A 6hu9N-5zcsC:
undetectable		 6hu9N-5zcsC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B

(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation
no annotation 		5 PHE C  77
MET C  80
ALA C  79
PHE F  23
VAL A  16
 None
 1.43A 6hu9N-6cfwC:
undetectable		 6hu9N-6cfwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 5 PHE A 193
TYR A 175
PHE A 217
VAL A 224
VAL A 255
 None
 1.36A 6hu9N-6fheA:
undetectable		 6hu9N-6fheA:
undetectable