SIMILAR PATTERNS OF AMINO ACIDS FOR 6HU9_E_PCFE202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7n SYNAPSIN II

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		4 ILE A 315
VAL A 388
ARG A 316
ASP A 403
 None
 0.98A 6hu9a-1i7nA:
undetectable
6hu9e-1i7nA:
undetectable		 6hu9a-1i7nA:
18.72
6hu9e-1i7nA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 GLN A 161
ILE A  14
ALA A 224
VAL A 223
 None
 0.74A 6hu9a-1khoA:
0.0
6hu9e-1khoA:
0.0		 6hu9a-1khoA:
19.78
6hu9e-1khoA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		4 GLN A 245
ALA A 265
VAL A 262
ASP A 240
 None
 0.85A 6hu9a-1ks8A:
0.3
6hu9e-1ks8A:
0.5		 6hu9a-1ks8A:
23.24
6hu9e-1ks8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqw PEPTIDE DEFORMYLASE
PDF1

(Staphylococcus
aureus) 		PF01327
(Pep_deformylase) 		4 ILE A 135
ALA A  74
VAL A  75
ARG A  38
 None
 0.98A 6hu9a-1lqwA:
undetectable
6hu9e-1lqwA:
undetectable		 6hu9a-1lqwA:
16.10
6hu9e-1lqwA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 TYR A 400
ALA A 193
VAL A 194
ARG A 192
 None
 1.01A 6hu9a-1pemA:
0.0
6hu9e-1pemA:
0.1		 6hu9a-1pemA:
20.94
6hu9e-1pemA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Chlamydomonas
reinhardtii) 		PF00355
(Rieske) 		4 TYR C 128
ILE C 118
ALA C 161
ASP C 196
 None
 0.93A 6hu9a-1q90C:
undetectable
6hu9e-1q90C:
undetectable		 6hu9a-1q90C:
12.62
6hu9e-1q90C:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 ILE A 193
ALA A  79
VAL A  78
ARG A  80
 None
None
None
SF4  A 637 (-3.8A)
 0.83A 6hu9a-1su7A:
1.8
6hu9e-1su7A:
undetectable		 6hu9a-1su7A:
22.37
6hu9e-1su7A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		4 ILE A 160
ALA A 174
VAL A 171
ASP A 139
 GOL  A 219 ( 4.7A)
None
None
None
 1.06A 6hu9a-1vpxA:
undetectable
6hu9e-1vpxA:
undetectable		 6hu9a-1vpxA:
18.63
6hu9e-1vpxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 601
ALA A 691
VAL A 692
MET A 695
 None
 0.86A 6hu9a-1xfdA:
undetectable
6hu9e-1xfdA:
undetectable		 6hu9a-1xfdA:
21.43
6hu9e-1xfdA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 GLN B 419
ALA B 513
VAL B 512
ARG B 510
 ADX  B2700 (-3.9A)
None
None
None
 1.03A 6hu9a-1xnjB:
undetectable
6hu9e-1xnjB:
0.6		 6hu9a-1xnjB:
19.00
6hu9e-1xnjB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yii ANNEXIN A5

(Gallus gallus) 		PF00191
(Annexin) 		4 GLN A 220
VAL A 240
ARG A 245
ASP A 211
 None
 1.00A 6hu9a-1yiiA:
0.0
6hu9e-1yiiA:
0.8		 6hu9a-1yiiA:
19.22
6hu9e-1yiiA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF05833
(FbpA)
PF09239
(Topo-VIb_trans) 		4 ILE A 187
ALA A  29
ARG A  30
ASP A 382
 None
 1.02A 6hu9a-1z5aA:
0.0
6hu9e-1z5aA:
0.9		 6hu9a-1z5aA:
22.09
6hu9e-1z5aA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 ALA A 292
VAL A 291
ARG A 293
ASP A 519
 None
 1.03A 6hu9a-2ahwA:
undetectable
6hu9e-2ahwA:
0.6		 6hu9a-2ahwA:
22.75
6hu9e-2ahwA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byo LIPOPROTEIN LPPX

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		4 ALA A 184
VAL A 171
ARG A 183
ASP A 140
 LNL  A1217 ( 4.1A)
HXA  A1215 ( 4.4A)
None
None
 0.99A 6hu9a-2byoA:
undetectable
6hu9e-2byoA:
undetectable		 6hu9a-2byoA:
19.35
6hu9e-2byoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk8 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE

(Mus musculus) 		PF05158
(RNA_pol_Rpc34) 		4 TYR A  71
ILE A  35
ALA A  48
VAL A  49
 None
 1.03A 6hu9a-2dk8A:
undetectable
6hu9e-2dk8A:
undetectable		 6hu9a-2dk8A:
10.43
6hu9e-2dk8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A  14
ALA A  73
VAL A  95
ARG A  74
 None
 0.83A 6hu9a-2eklA:
undetectable
6hu9e-2eklA:
undetectable		 6hu9a-2eklA:
19.93
6hu9e-2eklA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 GLN A 159
VAL A  93
ARG A  95
MET A  91
 None
 1.07A 6hu9a-2g28A:
undetectable
6hu9e-2g28A:
undetectable		 6hu9a-2g28A:
18.54
6hu9e-2g28A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		4 TYR A 251
VAL A  82
ARG A 190
ASP A 290
 None
None
SUC  A2064 (-3.4A)
SUC  A2064 (-2.9A)
 1.02A 6hu9a-2gduA:
undetectable
6hu9e-2gduA:
undetectable		 6hu9a-2gduA:
21.59
6hu9e-2gduA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 TYR A 233
ALA A 292
VAL A 293
ARG A 295
 None
 0.76A 6hu9a-2hxgA:
undetectable
6hu9e-2hxgA:
undetectable		 6hu9a-2hxgA:
23.35
6hu9e-2hxgA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 139
ALA A 152
VAL A 153
ARG A 151
 None
 1.03A 6hu9a-2ji9A:
undetectable
6hu9e-2ji9A:
0.0		 6hu9a-2ji9A:
22.67
6hu9e-2ji9A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpm TWO-COMPONENT
RESPONSE REGULATOR

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		4 ILE A  58
ALA A  72
VAL A  71
ASP A  94
 None
 1.01A 6hu9a-2lpmA:
undetectable
6hu9e-2lpmA:
undetectable		 6hu9a-2lpmA:
14.11
6hu9e-2lpmA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ILE A 465
ALA A 246
VAL A 247
ASP A 470
 None
 0.87A 6hu9a-2o3jA:
undetectable
6hu9e-2o3jA:
undetectable		 6hu9a-2o3jA:
21.62
6hu9e-2o3jA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0a SYNAPSIN-3

(Homo sapiens) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		4 ILE A 293
VAL A 366
ARG A 294
ASP A 381
 None
None
SO4  A 702 (-4.1A)
None
 0.96A 6hu9a-2p0aA:
undetectable
6hu9e-2p0aA:
undetectable		 6hu9a-2p0aA:
18.06
6hu9e-2p0aA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Bacillus
halodurans) 		PF01715
(IPPT) 		4 ILE A 305
ALA A  24
VAL A  21
ARG A  26
 None
 1.06A 6hu9a-2qgnA:
undetectable
6hu9e-2qgnA:
undetectable		 6hu9a-2qgnA:
19.66
6hu9e-2qgnA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 GLN A 419
ALA A 513
VAL A 512
ARG A 510
 ADX  A 100 (-3.6A)
None
None
None
 1.04A 6hu9a-2qjfA:
undetectable
6hu9e-2qjfA:
undetectable		 6hu9a-2qjfA:
19.60
6hu9e-2qjfA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsf DNA REPAIR PROTEIN
RAD4

(Saccharomyces
cerevisiae) 		PF03835
(Rad4)
PF10403
(BHD_1)
PF10405
(BHD_3) 		4 ALA A 280
VAL A 319
ARG A 281
ASP A 418
 None
 0.91A 6hu9a-2qsfA:
undetectable
6hu9e-2qsfA:
undetectable		 6hu9a-2qsfA:
20.79
6hu9e-2qsfA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ran ANNEXIN V

(Rattus
norvegicus) 		PF00191
(Annexin) 		4 GLN A 218
VAL A 238
ARG A 243
ASP A 209
 None
 1.06A 6hu9a-2ranA:
undetectable
6hu9e-2ranA:
undetectable		 6hu9a-2ranA:
18.91
6hu9e-2ranA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 ALA A  53
VAL A  54
ARG A  56
MET A  57
 None
None
SO4  A 324 (-2.8A)
None
 0.66A 6hu9a-2rbcA:
undetectable
6hu9e-2rbcA:
undetectable		 6hu9a-2rbcA:
22.38
6hu9e-2rbcA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 143
ILE A 101
ALA A 376
ASP A 387
 None
 1.02A 6hu9a-2vd5A:
undetectable
6hu9e-2vd5A:
2.6		 6hu9a-2vd5A:
22.08
6hu9e-2vd5A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgp DUAL SPECIFICITY
PROTEIN PHOSPHATASE
14

(Homo sapiens) 		PF00782
(DSPc) 		4 GLN A  70
TYR A  73
ALA A  42
VAL A  41
 None
 1.02A 6hu9a-2wgpA:
undetectable
6hu9e-2wgpA:
undetectable		 6hu9a-2wgpA:
18.20
6hu9e-2wgpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLN A 252
ILE A 300
VAL A 206
MET A 207
 None
None
None
GOL  A1726 ( 4.0A)
 1.06A 6hu9a-2x40A:
undetectable
6hu9e-2x40A:
undetectable		 6hu9a-2x40A:
20.64
6hu9e-2x40A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		no annotation 4 TYR A 213
ILE A 229
ALA A 238
VAL A 235
 None
 1.05A 6hu9a-3aqoA:
undetectable
6hu9e-3aqoA:
undetectable		 6hu9a-3aqoA:
19.84
6hu9e-3aqoA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00294
(PfkB) 		4 TYR A  68
ILE A  72
ALA A  40
ASP A  13
 None
 0.99A 6hu9a-3bf5A:
undetectable
6hu9e-3bf5A:
undetectable		 6hu9a-3bf5A:
19.96
6hu9e-3bf5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		4 GLN A 102
ILE A  94
ALA A 237
VAL A 236
 None
 1.02A 6hu9a-3bwnA:
1.8
6hu9e-3bwnA:
undetectable		 6hu9a-3bwnA:
21.64
6hu9e-3bwnA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		4 ILE A  21
ALA A  94
VAL A 121
ASP A 152
 None
None
None
SO4  A 346 (-3.3A)
 0.87A 6hu9a-3cerA:
undetectable
6hu9e-3cerA:
undetectable		 6hu9a-3cerA:
20.93
6hu9e-3cerA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		4 GLN A  28
ILE A   6
ALA A  56
VAL A  53
 None
 0.98A 6hu9a-3dp9A:
undetectable
6hu9e-3dp9A:
undetectable		 6hu9a-3dp9A:
17.58
6hu9e-3dp9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 GLN A 258
ILE A 349
VAL A 224
ASP A 398
 None
None
None
NA  A 574 (-3.8A)
 1.01A 6hu9a-3hwwA:
undetectable
6hu9e-3hwwA:
undetectable		 6hu9a-3hwwA:
20.85
6hu9e-3hwwA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A  14
ALA A  88
VAL A  89
ASP A 287
 None
None
None
PO4  A 509 ( 4.4A)
 1.07A 6hu9a-3ifrA:
undetectable
6hu9e-3ifrA:
undetectable		 6hu9a-3ifrA:
22.41
6hu9e-3ifrA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y BL21
ML43

(Homo sapiens;
Homo sapiens) 		PF00829
(Ribosomal_L21p)
no annotation 		4 GLN b 127
ILE S 200
ALA S  97
VAL S 108
 None
 1.04A 6hu9a-3j7yb:
undetectable
6hu9e-3j7yb:
undetectable		 6hu9a-3j7yb:
14.23
6hu9e-3j7yb:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m92 PROTEIN YCIN

(Shigella
flexneri) 		PF10692
(DUF2498) 		4 ILE A  20
ALA A  63
VAL A  64
MET A  67
 None
 1.06A 6hu9a-3m92A:
undetectable
6hu9e-3m92A:
undetectable		 6hu9a-3m92A:
10.49
6hu9e-3m92A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 TYR A 847
ILE A 777
ALA A 323
VAL A 322
 None
None
OBN  A   1 (-3.2A)
OBN  A   1 (-3.2A)
 1.00A 6hu9a-3n23A:
1.9
6hu9e-3n23A:
0.3		 6hu9a-3n23A:
19.48
6hu9e-3n23A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		4 GLN A  62
ALA A  52
VAL A  53
MET A  56
 None
 1.05A 6hu9a-3nd0A:
undetectable
6hu9e-3nd0A:
undetectable		 6hu9a-3nd0A:
26.22
6hu9e-3nd0A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9p ACKA

(Mycobacterium
avium) 		PF00871
(Acetate_kinase) 		4 ILE A 130
ALA A 123
VAL A 122
ARG A 124
 None
 1.02A 6hu9a-3r9pA:
undetectable
6hu9e-3r9pA:
0.4		 6hu9a-3r9pA:
21.95
6hu9e-3r9pA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A  87
VAL A  88
ARG A  86
ASP A 282
 None
None
SO4  A 390 (-3.9A)
None
 1.01A 6hu9a-3s5sA:
undetectable
6hu9e-3s5sA:
undetectable		 6hu9a-3s5sA:
22.70
6hu9e-3s5sA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2l PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
fragilis) 		PF13149
(Mfa_like_1) 		4 GLN A 289
ILE A 134
ALA A 207
VAL A 208
 None
GOL  A 332 (-4.5A)
None
None
 0.91A 6hu9a-3t2lA:
undetectable
6hu9e-3t2lA:
undetectable		 6hu9a-3t2lA:
20.20
6hu9e-3t2lA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdy SINGLE-STRANDED
DNA-BINDING PROTEIN
SSBB

(Bacillus
subtilis) 		PF00436
(SSB) 		4 ALA A  32
VAL A  33
ARG A  10
ASP A 104
 None
 0.97A 6hu9a-3vdyA:
undetectable
6hu9e-3vdyA:
undetectable		 6hu9a-3vdyA:
12.07
6hu9e-3vdyA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 TYR A 265
ALA A 366
VAL A 385
ARG A 367
 None
 1.04A 6hu9a-3wa1A:
undetectable
6hu9e-3wa1A:
undetectable		 6hu9a-3wa1A:
20.79
6hu9e-3wa1A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE

(Actinidia
chinensis) 		PF01761
(DHQ_synthase) 		4 ILE A  27
VAL A 145
MET A 146
ASP A 123
 None
None
NAD  A1381 (-4.0A)
NAD  A1381 (-3.0A)
 1.01A 6hu9a-3zokA:
undetectable
6hu9e-3zokA:
undetectable		 6hu9a-3zokA:
20.55
6hu9e-3zokA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxy SUBTILISIN-LIKE
PROTEIN

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		4 ILE A  88
ALA A 108
VAL A 109
ARG A 107
 None
 0.90A 6hu9a-3zxyA:
undetectable
6hu9e-3zxyA:
undetectable		 6hu9a-3zxyA:
20.86
6hu9e-3zxyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvl PHB DEPOLYMERASE
PHAZ7

(Paucimonas
lemoignei) 		PF01674
(Lipase_2) 		4 TYR A  92
ILE A 114
ALA A 134
VAL A 133
 None
 1.01A 6hu9a-4bvlA:
undetectable
6hu9e-4bvlA:
undetectable		 6hu9a-4bvlA:
20.73
6hu9e-4bvlA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus
subtilis) 		PF01048
(PNP_UDP_1) 		4 ILE A  57
ALA A 227
VAL A 226
MET A 223
 None
 0.99A 6hu9a-4daoA:
undetectable
6hu9e-4daoA:
undetectable		 6hu9a-4daoA:
19.18
6hu9e-4daoA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 195
ALA A 188
VAL A 189
ARG A 187
 None
 1.06A 6hu9a-4eutA:
2.5
6hu9e-4eutA:
undetectable		 6hu9a-4eutA:
21.50
6hu9e-4eutA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		4 GLN A 177
ILE A 103
ALA A 252
VAL A 251
 None
 1.08A 6hu9a-4g1uA:
undetectable
6hu9e-4g1uA:
undetectable		 6hu9a-4g1uA:
22.18
6hu9e-4g1uA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 ILE A 199
ALA A 225
VAL A 244
ASP A 139
 None
 1.05A 6hu9a-4gvlA:
undetectable
6hu9e-4gvlA:
undetectable		 6hu9a-4gvlA:
22.24
6hu9e-4gvlA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		4 ILE A 199
ALA A 225
VAL A 244
ASP A 139
 None
 1.02A 6hu9a-4gx0A:
1.9
6hu9e-4gx0A:
undetectable		 6hu9a-4gx0A:
23.13
6hu9e-4gx0A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		4 ILE A  18
ALA A 138
ARG A 137
ASP A 277
 None
 1.04A 6hu9a-4h0pA:
undetectable
6hu9e-4h0pA:
0.4		 6hu9a-4h0pA:
23.03
6hu9e-4h0pA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLN A 328
ILE A 174
ALA A 334
VAL A 351
 PXM  A 609 ( 3.9A)
None
None
None
 1.05A 6hu9a-4ha6A:
undetectable
6hu9e-4ha6A:
undetectable		 6hu9a-4ha6A:
23.57
6hu9e-4ha6A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		4 GLN A 298
ILE A  83
ALA A 111
ASP A 170
 None
LMS  A 401 (-4.2A)
LMS  A 401 (-3.4A)
None
 1.05A 6hu9a-4injA:
undetectable
6hu9e-4injA:
undetectable		 6hu9a-4injA:
18.68
6hu9e-4injA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k49 ESTERASE YDII

(Escherichia
coli) 		no annotation 4 GLN C  78
ILE C   2
ALA C  69
VAL C  68
 None
 1.04A 6hu9a-4k49C:
undetectable
6hu9e-4k49C:
undetectable		 6hu9a-4k49C:
11.99
6hu9e-4k49C:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		4 ILE A  58
ALA A 229
VAL A 228
MET A 225
 None
None
EDO  A 307 ( 4.4A)
None
 0.99A 6hu9a-4ldnA:
undetectable
6hu9e-4ldnA:
undetectable		 6hu9a-4ldnA:
17.24
6hu9e-4ldnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 TYR A 253
ALA A  88
VAL A  85
ASP A  21
 None
None
None
GOL  A 503 (-2.8A)
 1.03A 6hu9a-4ls5A:
undetectable
6hu9e-4ls5A:
undetectable		 6hu9a-4ls5A:
22.53
6hu9e-4ls5A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mix PUTATIVE
INSECTICIDAL TOXIN

(Photorhabdus
asymbiotica) 		PF04488
(Gly_transf_sug) 		4 TYR A2194
ILE A2166
ALA A2316
VAL A2317
 None
 0.83A 6hu9a-4mixA:
undetectable
6hu9e-4mixA:
undetectable		 6hu9a-4mixA:
20.26
6hu9e-4mixA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 4 GLN A 879
TYR A 876
ILE A 839
ALA A 885
 None
 1.05A 6hu9a-4nuzA:
3.0
6hu9e-4nuzA:
undetectable		 6hu9a-4nuzA:
21.16
6hu9e-4nuzA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofy PROTEIN SYG-2

(Caenorhabditis
elegans) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 ILE D 218
ALA D 211
VAL D 163
ARG D 219
 None
 0.93A 6hu9a-4ofyD:
undetectable
6hu9e-4ofyD:
undetectable		 6hu9a-4ofyD:
19.48
6hu9e-4ofyD:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 4 GLN A 230
ILE A 171
ALA A 479
VAL A 476
 None
 1.08A 6hu9a-4ofzA:
undetectable
6hu9e-4ofzA:
1.0		 6hu9a-4ofzA:
20.79
6hu9e-4ofzA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLN A 354
ILE A  59
ALA A 154
VAL A 178
 None
 1.04A 6hu9a-4pf1A:
undetectable
6hu9e-4pf1A:
undetectable		 6hu9a-4pf1A:
19.91
6hu9e-4pf1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 ILE A 582
ALA A 524
VAL A 558
MET A 557
 None
 1.03A 6hu9a-4ppmA:
undetectable
6hu9e-4ppmA:
undetectable		 6hu9a-4ppmA:
21.49
6hu9e-4ppmA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		4 GLN A 333
TYR A  90
ILE A 142
VAL A 325
 GOL  A 406 (-4.7A)
GOL  A 406 (-4.7A)
None
None
 0.76A 6hu9a-4q3oA:
undetectable
6hu9e-4q3oA:
undetectable		 6hu9a-4q3oA:
21.85
6hu9e-4q3oA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 TYR A 234
ALA A 293
VAL A 294
ARG A 296
 None
 0.68A 6hu9a-4r1pA:
undetectable
6hu9e-4r1pA:
undetectable		 6hu9a-4r1pA:
20.00
6hu9e-4r1pA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		4 ILE A 330
ALA A 237
VAL A 234
ARG A 239
 None
 1.01A 6hu9a-4r3aA:
0.8
6hu9e-4r3aA:
undetectable		 6hu9a-4r3aA:
21.74
6hu9e-4r3aA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 TYR A 439
ILE A 440
ALA A 447
ASP A 125
 None
 0.97A 6hu9a-4rhhA:
1.6
6hu9e-4rhhA:
undetectable		 6hu9a-4rhhA:
23.04
6hu9e-4rhhA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF13407
(Peripla_BP_4) 		4 GLN A 263
VAL A 157
ARG A 168
ASP A 115
 RIP  A 401 (-3.2A)
None
RIP  A 401 (-2.9A)
RIP  A 401 (-2.8A)
 1.07A 6hu9a-4ry0A:
undetectable
6hu9e-4ry0A:
undetectable		 6hu9a-4ry0A:
19.04
6hu9e-4ry0A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315

(Staphylococcus
aureus) 		PF02645
(DegV) 		4 GLN A 127
ILE A 118
ALA A 230
VAL A 229
 None
OLA  A 301 (-3.7A)
OLA  A 301 ( 3.1A)
None
 0.98A 6hu9a-4x9xA:
undetectable
6hu9e-4x9xA:
undetectable		 6hu9a-4x9xA:
18.61
6hu9e-4x9xA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Streptococcus
mutans) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLN A 236
ILE A  96
ARG A 192
ASP A 313
 None
 1.05A 6hu9a-4xb3A:
undetectable
6hu9e-4xb3A:
undetectable		 6hu9a-4xb3A:
21.83
6hu9e-4xb3A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)

(Chaetomium) 		PF13472
(Lipase_GDSL_2) 		4 GLN A 134
TYR A 269
ILE A 265
VAL A 181
 None
 1.06A 6hu9a-4xvhA:
undetectable
6hu9e-4xvhA:
undetectable		 6hu9a-4xvhA:
21.55
6hu9e-4xvhA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynh SPINDLE ASSEMBLY
ABNORMAL PROTEIN 5

(Caenorhabditis
elegans) 		no annotation 4 ILE A 232
ALA A 215
VAL A 218
ARG A 216
 None
 1.00A 6hu9a-4ynhA:
undetectable
6hu9e-4ynhA:
undetectable		 6hu9a-4ynhA:
7.46
6hu9e-4ynhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 TYR A 854
ILE A 784
ALA A 330
VAL A 329
 None
 1.06A 6hu9a-5aw4A:
2.4
6hu9e-5aw4A:
undetectable		 6hu9a-5aw4A:
19.57
6hu9e-5aw4A:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 394
ALA A 366
ARG A 390
ASP A   9
 None
 1.04A 6hu9a-5bswA:
undetectable
6hu9e-5bswA:
undetectable		 6hu9a-5bswA:
22.86
6hu9e-5bswA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdj RUBISCO LARGE
SUBUNIT-BINDING
PROTEIN SUBUNIT
ALPHA, CHLOROPLASTIC

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		4 GLN A 290
ILE A 369
ALA A 347
ARG A 345
 None
 0.88A 6hu9a-5cdjA:
undetectable
6hu9e-5cdjA:
undetectable		 6hu9a-5cdjA:
17.56
6hu9e-5cdjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 TYR A1425
ALA A1410
ARG A1421
ASP A1481
 None
 1.06A 6hu9a-5cwvA:
undetectable
6hu9e-5cwvA:
1.1		 6hu9a-5cwvA:
21.59
6hu9e-5cwvA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 GLN A 399
ALA A 132
VAL A 131
ASP A 151
 None
 0.94A 6hu9a-5eawA:
undetectable
6hu9e-5eawA:
undetectable		 6hu9a-5eawA:
19.91
6hu9e-5eawA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		4 ILE A 688
VAL A 693
ARG A 690
ASP A 524
 None
 0.95A 6hu9a-5ed8A:
undetectable
6hu9e-5ed8A:
undetectable		 6hu9a-5ed8A:
19.40
6hu9e-5ed8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 TYR B 265
ALA B 366
VAL B 385
ARG B 367
 None
 1.04A 6hu9a-5fozB:
undetectable
6hu9e-5fozB:
undetectable		 6hu9a-5fozB:
22.30
6hu9e-5fozB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ILE B 457
VAL B 487
ARG B 485
ASP B 597
 KR0  B1985 (-4.0A)
None
None
None
 1.00A 6hu9a-5fq6B:
undetectable
6hu9e-5fq6B:
undetectable		 6hu9a-5fq6B:
21.61
6hu9e-5fq6B:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ILE A 109
ALA A  70
VAL A  71
ASP A 115
 None
 1.05A 6hu9a-5gvaA:
undetectable
6hu9e-5gvaA:
undetectable		 6hu9a-5gvaA:
19.00
6hu9e-5gvaA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 TYR A 714
ALA A 736
VAL A 737
ARG A 735
 None
 1.06A 6hu9a-5h42A:
undetectable
6hu9e-5h42A:
undetectable		 6hu9a-5h42A:
19.19
6hu9e-5h42A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		4 ILE B 361
ALA A 105
VAL A 104
ARG B 381
 None
 1.07A 6hu9a-5hftB:
undetectable
6hu9e-5hftB:
undetectable		 6hu9a-5hftB:
16.79
6hu9e-5hftB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		4 ILE A 315
ALA A  20
VAL A  21
ASP A 276
 None
 0.92A 6hu9a-5hn4A:
undetectable
6hu9e-5hn4A:
undetectable		 6hu9a-5hn4A:
21.04
6hu9e-5hn4A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hop LMO0182 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 TYR A  94
ILE A 113
ARG A 117
ASP A 157
 None
 1.04A 6hu9a-5hopA:
undetectable
6hu9e-5hopA:
1.8		 6hu9a-5hopA:
19.09
6hu9e-5hopA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		4 TYR A 307
ALA A 412
VAL A 411
ASP A 343
 None
 1.03A 6hu9a-5jcnA:
undetectable
6hu9e-5jcnA:
undetectable		 6hu9a-5jcnA:
23.68
6hu9e-5jcnA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 ILE A  81
ALA A 773
VAL A 772
ASP A 783
 None
 1.05A 6hu9a-5nd1A:
undetectable
6hu9e-5nd1A:
undetectable		 6hu9a-5nd1A:
undetectable
6hu9e-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o77 OMPK35

(Klebsiella
pneumoniae) 		no annotation 4 ILE A 262
ALA A 248
VAL A 223
ASP A 114
 None
 0.89A 6hu9a-5o77A:
undetectable
6hu9e-5o77A:
undetectable		 6hu9a-5o77A:
undetectable
6hu9e-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		4 ILE A 344
ALA A 354
VAL A 366
ARG A 353
 None
 0.94A 6hu9a-5tprA:
1.3
6hu9e-5tprA:
undetectable		 6hu9a-5tprA:
22.72
6hu9e-5tprA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		4 ILE A 344
ALA A 354
VAL A 366
ASP A 262
 None
 0.87A 6hu9a-5tprA:
1.3
6hu9e-5tprA:
undetectable		 6hu9a-5tprA:
22.72
6hu9e-5tprA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE

(Vibrio
parahaemolyticus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 341
ILE A 313
ALA A 319
VAL A 320
 None
None
FAD  A 501 ( 4.0A)
None
 1.05A 6hu9a-5u1oA:
undetectable
6hu9e-5u1oA:
undetectable		 6hu9a-5u1oA:
21.70
6hu9e-5u1oA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 4 ILE A 246
ALA A 232
VAL A 231
ARG A 249
 None
 1.05A 6hu9a-5wmmA:
undetectable
6hu9e-5wmmA:
undetectable		 6hu9a-5wmmA:
undetectable
6hu9e-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		4 ILE A 472
ALA A 603
VAL A 606
ASP A 466
 None
 0.87A 6hu9a-5y7oA:
undetectable
6hu9e-5y7oA:
undetectable		 6hu9a-5y7oA:
18.85
6hu9e-5y7oA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		no annotation 4 ILE A 227
ALA A 273
VAL A 274
ASP A  86
 None
 1.00A 6hu9a-5zbqA:
2.6
6hu9e-5zbqA:
0.8		 6hu9a-5zbqA:
undetectable
6hu9e-5zbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 4 GLN A  47
ILE A 236
ALA A  84
VAL A  81
 None
 0.94A 6hu9a-6b5iA:
undetectable
6hu9e-6b5iA:
undetectable		 6hu9a-6b5iA:
undetectable
6hu9e-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 4 ILE X 148
ALA X 221
VAL X 217
ASP X 533
 None
 0.96A 6hu9a-6elqX:
undetectable
6hu9e-6elqX:
undetectable		 6hu9a-6elqX:
undetectable
6hu9e-6elqX:
undetectable