SIMILAR PATTERNS OF AMINO ACIDS FOR 6HU9_C_PCFC607

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bui STAPHYLOKINASE

(Staphylococcus
phage 42D.m) 		PF02821
(Staphylokinase) 		5 ALA C  67
TYR C  63
TYR C  62
PHE C  47
VAL C  45
 None
 1.41A 6hu9C-1buiC:
undetectable		 6hu9C-1buiC:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg8 PROTEIN (HEMOGLOBIN)

(Dasyatis akajei) 		PF00042
(Globin) 		5 TRP B  15
ALA B  70
PHE B 128
PHE B 129
VAL B 132
 None
 1.24A 6hu9C-1cg8B:
0.9		 6hu9C-1cg8B:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		5 PHE L 139
ALA L 184
TYR L 185
PHE L 143
PHE L 207
 None
 1.25A 6hu9C-1kfuL:
undetectable		 6hu9C-1kfuL:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouu HEMOGLOBIN I

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		5 TRP B  15
ALA B  74
THR B  10
PHE B 133
VAL B 137
 None
 1.38A 6hu9C-1ouuB:
undetectable		 6hu9C-1ouuB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmv PEROXIREDOXIN-2

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 ALA A 155
THR A  53
PHE A  58
PHE A  41
VAL A  39
 None
 1.42A 6hu9C-1qmvA:
undetectable		 6hu9C-1qmvA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		5 MET A 186
ALA A 183
THR A 239
PHE A 358
VAL A 353
 None
 1.46A 6hu9C-1qw5A:
1.8		 6hu9C-1qw5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		5 PHE A  16
MET A  18
ALA A  17
TYR A  59
VAL A 284
 None
 1.33A 6hu9C-1to3A:
undetectable		 6hu9C-1to3A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor;
Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 PHE A 192
ALA A 153
PHE B 261
PHE B 394
VAL A 162
 None
 1.35A 6hu9C-1tqyA:
undetectable		 6hu9C-1tqyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 ALA A 394
TYR A 395
PHE A 356
PHE A 355
VAL A 352
 None
 1.23A 6hu9C-1ukcA:
undetectable		 6hu9C-1ukcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5z HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00271
(Helicase_C) 		5 PHE A 825
MET A 759
TYR A 779
PHE A 777
VAL A 804
 None
 1.38A 6hu9C-1z5zA:
2.4		 6hu9C-1z5zA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z63 HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 PHE A 825
MET A 759
TYR A 779
PHE A 777
VAL A 804
 None
 1.38A 6hu9C-1z63A:
2.1		 6hu9C-1z63A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo2 NUCLEAR TRANSPORT
FACTOR 2

(Cryptosporidium
parvum) 		PF02136
(NTF2) 		5 TYR A  22
TYR A  21
PHE A  69
PHE A 102
VAL A  92
 None
 1.46A 6hu9C-1zo2A:
undetectable		 6hu9C-1zo2A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zu4 FTSY

(Mycoplasma
mycoides) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 PHE A 199
MET A 216
ALA A 217
THR A 249
VAL A 227
 None
 1.50A 6hu9C-1zu4A:
1.3		 6hu9C-1zu4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		5 ALA X  98
TYR X 102
PHE X  65
PHE X  52
VAL X  57
 None
 1.37A 6hu9C-2bq8X:
undetectable		 6hu9C-2bq8X:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fus FUMARASE C

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 TRP A 204
MET A 289
ALA A 292
THR A 168
PHE A 383
 None
 1.47A 6hu9C-2fusA:
4.3		 6hu9C-2fusA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR

(Escherichia
coli) 		PF03466
(LysR_substrate) 		5 MET A 285
ALA A 286
THR A 162
PHE A 105
PHE A 101
 None
 1.33A 6hu9C-2hxrA:
undetectable		 6hu9C-2hxrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1m MYOSIN-BINDING
PROTEIN C,
CARDIAC-TYPE

(Homo sapiens) 		PF07679
(I-set) 		5 ALA A  26
TYR A  54
PHE A  28
PHE A  89
VAL A  18
 None
 1.38A 6hu9C-2k1mA:
undetectable		 6hu9C-2k1mA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT

(Lactobacillus
plantarum) 		PF00890
(FAD_binding_2) 		5 ALA A   7
THR A  76
PHE A  83
PHE A  93
VAL A  92
 None
 1.48A 6hu9C-2lfcA:
undetectable		 6hu9C-2lfcA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		5 ALA A 161
TYR A 158
PHE A 190
PHE A 174
VAL A   9
 None
 1.18A 6hu9C-2no5A:
undetectable		 6hu9C-2no5A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		5 PHE A 111
TYR A  96
PHE A 100
PHE A 149
VAL A 152
 None
 1.47A 6hu9C-2pbgA:
undetectable		 6hu9C-2pbgA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vla RESTRICTION
ENDONUCLEASE R.BPUJI

(Bacillus
pumilus) 		PF11564
(BpuJI_N) 		5 PHE A 115
TYR A 258
PHE A 269
PHE A 260
VAL A 125
 None
 1.46A 6hu9C-2vlaA:
undetectable		 6hu9C-2vlaA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG

(Escherichia
coli) 		PF13483
(Lactamase_B_3) 		5 TRP A 154
PHE A  62
ALA A 128
PHE A 141
VAL A 113
 None
 1.50A 6hu9C-2wymA:
undetectable		 6hu9C-2wymA:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yiu CYTOCHROME B

(Paracoccus
denitrificans) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 TRP A  44
PHE A 374
TYR A 117
TYR A 118
PHE A 367
 None
 1.16A 6hu9C-2yiuA:
5.0		 6hu9C-2yiuA:
44.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 PHE A 165
ALA A 160
THR A 151
PHE A 218
VAL A 167
 None
 1.18A 6hu9C-2yr0A:
undetectable		 6hu9C-2yr0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
ALPHA

(Cavia porcellus) 		PF00042
(Globin) 		5 ALA A  69
THR A  13
PHE A 128
PHE A 129
VAL A 132
 None
 1.11A 6hu9C-3a0gA:
undetectable		 6hu9C-3a0gA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv6 METAL-DEPENDENT
HYDROLASE

(Vibrio cholerae) 		PF13483
(Lactamase_B_3) 		5 TRP A 154
PHE A  62
ALA A 128
PHE A 141
VAL A 113
 None
 1.47A 6hu9C-3bv6A:
undetectable		 6hu9C-3bv6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmc NTF2-LIKE PROTEIN

(Trichormus
variabilis) 		PF12680
(SnoaL_2) 		5 MET A  46
THR A  41
PHE A  62
PHE A  63
VAL A  66
 None
 1.03A 6hu9C-3dmcA:
undetectable		 6hu9C-3dmcA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es5 PUTATIVE CAPSID
PROTEIN

(Penicillium
stoloniferum
virus F) 		no annotation 5 PHE A 117
ALA A 121
TYR A 125
TYR A 143
PHE A 179
 None
 1.42A 6hu9C-3es5A:
1.6		 6hu9C-3es5A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h1l CYTOCHROME B

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		7 TRP C  31
PHE C  96
TYR C 104
TYR C 105
THR C 315
PHE C 326
VAL C 330
 PEE  C2007 ( 3.1A)
PEE  C2007 (-3.9A)
PEE  C2007 (-3.5A)
PEE  C2007 ( 4.3A)
None
PEE  C2007 ( 4.8A)
PEE  C2007 ( 4.7A)
 1.37A 6hu9C-3h1lC:
5.3		 6hu9C-3h1lC:
52.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h1l CYTOCHROME B

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		7 TRP C  31
PHE C  96
TYR C 104
TYR C 105
THR C 317
PHE C 326
VAL C 330
 PEE  C2007 ( 3.1A)
PEE  C2007 (-3.9A)
PEE  C2007 (-3.5A)
PEE  C2007 ( 4.3A)
PEE  C2007 (-3.3A)
PEE  C2007 ( 4.8A)
PEE  C2007 ( 4.7A)
 0.39A 6hu9C-3h1lC:
5.3		 6hu9C-3h1lC:
52.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 5 PHE A 296
MET A 257
ALA A 256
THR A  27
PHE A 408
 None
 1.33A 6hu9C-3hkaA:
undetectable		 6hu9C-3hkaA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd8 NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		PF02460
(Patched)
PF12349
(Sterol-sensing)
PF16414
(NPC1_N) 		5 PHE A1038
ALA A 885
TYR A1081
PHE A 395
PHE A 402
 None
 1.43A 6hu9C-3jd8A:
3.7		 6hu9C-3jd8A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE

(Mus musculus) 		PF00266
(Aminotran_5) 		5 PHE A 174
MET A 108
ALA A 111
THR A 267
PHE A 244
 None
 1.23A 6hu9C-3kgwA:
undetectable		 6hu9C-3kgwA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3f PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		5 TYR X 654
TYR X 660
THR X 605
PHE X 600
VAL X 646
 None
 1.49A 6hu9C-3l3fX:
2.4		 6hu9C-3l3fX:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkb HEMOGLOBIN SUBUNIT
BETA

(Isurus
oxyrinchus) 		PF00042
(Globin) 		5 ALA B  64
THR B  14
PHE B 123
PHE B 124
VAL B 127
 None
 1.19A 6hu9C-3mkbB:
undetectable		 6hu9C-3mkbB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osj PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		PF00427
(PBS_linker_poly) 		5 PHE A 390
TYR A 286
THR A 295
PHE A 319
VAL A 320
 None
 1.32A 6hu9C-3osjA:
undetectable		 6hu9C-3osjA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbc PEROXIREDOXIN TSA1

(Saccharomyces
cerevisiae) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 ALA A 151
THR A  49
PHE A  54
PHE A  70
VAL A  68
 None
 1.49A 6hu9C-3sbcA:
undetectable		 6hu9C-3sbcA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g5e 2,4,6-TRICHLOROPHENO
L 4-MONOOXYGENASE

(Cupriavidus
pinatubonensis) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 PHE A 207
ALA A 278
PHE A 218
PHE A 154
VAL A 205
 None
 1.49A 6hu9C-4g5eA:
1.7		 6hu9C-4g5eA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 ALA B  82
TYR B  71
TYR B  69
THR B  50
PHE B  46
 None
 1.49A 6hu9C-4k3jB:
undetectable		 6hu9C-4k3jB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		5 MET A 177
ALA A 176
TYR A 311
PHE A 305
VAL A 285
 None
 1.47A 6hu9C-4lglA:
undetectable		 6hu9C-4lglA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llr TRYPAREDOXIN
PEROXIDASE

(Trypanosoma
cruzi) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 ALA A 156
THR A  54
PHE A  59
PHE A  42
VAL A  40
 None
 1.35A 6hu9C-4llrA:
undetectable		 6hu9C-4llrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		5 PHE A 104
ALA A 185
TYR A 183
PHE A 154
VAL A 167
 None
 1.20A 6hu9C-4lomA:
undetectable		 6hu9C-4lomA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2z GH62
ARABINOFURANOSIDASE

(Podospora
anserina) 		PF03664
(Glyco_hydro_62) 		5 PHE A 178
TYR A 117
TYR A 127
THR A 129
PHE A 108
 None
 1.48A 6hu9C-4n2zA:
undetectable		 6hu9C-4n2zA:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pd4 CYTOCHROME B

(Saccharomyces
cerevisiae) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		10 TRP C  29
PHE C  94
MET C  97
ALA C  98
TYR C 102
TYR C 103
THR C 317
PHE C 326
PHE C 327
VAL C 330
 3PH  C4006 (-3.6A)
3PH  C4006 ( 4.8A)
3PH  C4006 ( 4.1A)
3PH  C4006 (-3.6A)
3PH  C4006 (-3.3A)
3PH  C4006 (-4.9A)
3PH  C4006 (-3.3A)
None
3PH  C4006 ( 4.9A)
3PH  C4006 ( 4.4A)
 0.35A 6hu9C-4pd4C:
5.6		 6hu9C-4pd4C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4poi PUTATIVE PERIPLASMIC
PROTEIN

(Bacteroides
caccae) 		PF11396
(PepSY_like) 		5 ALA A 103
TYR A 106
PHE A 139
PHE A 137
VAL A 129
 None
 1.36A 6hu9C-4poiA:
undetectable		 6hu9C-4poiA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		5 PHE A 190
TYR A 123
TYR A 133
THR A 135
PHE A 114
 None
 1.49A 6hu9C-4pviA:
undetectable		 6hu9C-4pviA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		5 TYR A 382
THR A 340
PHE A 333
PHE A 332
VAL A 288
 None
 1.48A 6hu9C-4x9eA:
2.3		 6hu9C-4x9eA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 5 ALA A 303
THR A 365
PHE A 333
PHE A 349
VAL A 337
 None
 1.47A 6hu9C-4xj6A:
undetectable		 6hu9C-4xj6A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 203
ALA A 204
PHE A 365
PHE A 363
VAL A 178
 None
 1.48A 6hu9C-4zslA:
undetectable		 6hu9C-4zslA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		5 PHE A 237
TYR A 177
TYR A 187
THR A 189
PHE A 168
 None
 1.44A 6hu9C-5b6tA:
undetectable		 6hu9C-5b6tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 ALA A 971
THR A1056
PHE A1084
PHE A1072
VAL A1004
 None
 1.36A 6hu9C-5f7uA:
undetectable		 6hu9C-5f7uA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 MET B 789
THR B 649
PHE B 807
PHE B 588
VAL B 276
 None
 1.29A 6hu9C-5nd1B:
undetectable		 6hu9C-5nd1B:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nmi CYTOCHROME B

(Bos taurus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 TRP C  30
TYR C 103
TYR C 104
PHE C 325
VAL C 329
 PEE  C 504 ( 3.6A)
PEE  C 504 (-3.2A)
PEE  C 504 (-4.4A)
PEE  C 504 (-4.6A)
PEE  C 504 ( 4.1A)
 0.27A 6hu9C-5nmiC:
4.8		 6hu9C-5nmiC:
50.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B
HETERODISULFIDE
REDUCTASE, SUBUNIT C

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG)
PF13183
(Fer4_8) 		5 MET C 119
ALA C 118
THR B  58
PHE B  48
VAL B  47
 None
 1.42A 6hu9C-5odrC:
undetectable		 6hu9C-5odrC:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35

(Homo sapiens) 		no annotation 5 PHE A 893
MET A 461
ALA A 458
THR A 594
VAL A 851
 None
None
None
EDO  A1005 (-4.6A)
None
 1.22A 6hu9C-5txkA:
undetectable		 6hu9C-5txkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		5 ALA A 100
TYR A 104
PHE A  67
PHE A  54
VAL A  59
 NAG  A 401 (-3.5A)
None
None
None
None
 1.38A 6hu9C-5uq6A:
undetectable		 6hu9C-5uq6A:
21.71