SIMILAR PATTERNS OF AMINO ACIDS FOR 6HRJ_A_010A302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLU A 350
GLU A 368
GLU A 415
PHE A 413
 None
 1.23A 6hrjA-1fepA:
0.0		 6hrjA-1fepA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mql HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLU B  81
GLU B  67
GLU B  74
PHE B  70
 None
 1.33A 6hrjA-1mqlB:
undetectable		 6hrjA-1mqlB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzd COATOMER GAMMA
SUBUNIT

(Bos taurus) 		PF08752
(COP-gamma_platf)
PF16381
(Coatomer_g_Cpla) 		4 GLU A 862
GLU A 782
GLU A 863
PHE A 783
 None
 1.46A 6hrjA-1pzdA:
0.0		 6hrjA-1pzdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN

(Halothiobacillus
neapolitanus) 		PF00101
(RuBisCO_small) 		4 GLU M  75
LYS M  60
GLU M  66
PHE M  63
 None
 1.01A 6hrjA-1svdM:
0.0		 6hrjA-1svdM:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzt PROTEIN ISCX

(Escherichia
coli) 		PF04384
(Fe-S_assembly) 		4 GLU A  55
LYS A  52
GLU A  51
PHE A  29
 GLU  A  55 ( 0.6A)
LYS  A  52 ( 0.0A)
GLU  A  51 ( 0.6A)
PHE  A  29 ( 1.3A)
 1.38A 6hrjA-2bztA:
undetectable		 6hrjA-2bztA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLU A 591
LYS A 595
GLU A 596
GLU A 589
 None
 1.45A 6hrjA-2i0eA:
0.0		 6hrjA-2i0eA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n76 DE NOVO DESIGNED
PROTEIN LFR1

(synthetic
construct) 		no annotation 4 GLU A  76
LYS A  72
GLU A  75
GLU A  79
 None
 0.85A 6hrjA-2n76A:
0.4		 6hrjA-2n76A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE

(Salmonella
enterica) 		PF03352
(Adenine_glyco) 		4 GLU A  25
LYS A  30
GLU A  33
GLU A  20
 None
 1.30A 6hrjA-2ofkA:
0.0		 6hrjA-2ofkA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus;
Chikungunya
virus) 		PF01589
(Alpha_E1_glycop)
PF00943
(Alpha_E2_glycop) 		4 GLU B 230
LYS B 318
GLU B 232
GLU A 109
 None
 1.14A 6hrjA-2xfbB:
0.0		 6hrjA-2xfbB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3b ATP-DEPENDENT
PROTEASE HSLV

(Bacillus
subtilis) 		PF00227
(Proteasome) 		4 GLU A  83
LYS A  86
GLU A  87
GLU A  72
 None
 1.41A 6hrjA-2z3bA:
0.0		 6hrjA-2z3bA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		4 GLU A 440
GLU A 488
GLU A 492
PHE A 489
 None
 1.40A 6hrjA-3ckbA:
undetectable		 6hrjA-3ckbA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 420
LYS A 255
GLU A 264
PHE A 418
 None
 1.43A 6hrjA-3e60A:
undetectable		 6hrjA-3e60A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLU B  81
GLU B  67
GLU B  74
PHE B  70
 None
 1.32A 6hrjA-3eykB:
undetectable		 6hrjA-3eykB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		4 GLU A 200
LYS A 163
GLU A 184
PHE A 197
 None
 1.39A 6hrjA-3ftbA:
undetectable		 6hrjA-3ftbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7v PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1377C

(Streptococcus
mutans) 		PF01300
(Sua5_yciO_yrdC) 		4 GLU A 146
GLU A  17
GLU A 141
PHE A  16
 None
 1.30A 6hrjA-3l7vA:
undetectable		 6hrjA-3l7vA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on6 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		4 GLU A 390
LYS A 385
GLU A 378
PHE A 383
 EDO  A 491 (-3.6A)
None
None
None
 1.25A 6hrjA-3on6A:
undetectable		 6hrjA-3on6A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 417
GLU A 470
GLU A 474
PHE A 471
 None
 1.31A 6hrjA-3qnkA:
undetectable		 6hrjA-3qnkA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7g PROTEIN SPIRE
HOMOLOG 1
FORMIN-2

(Homo sapiens;
Homo sapiens) 		PF16474
(KIND)
no annotation 		4 GLU A 148
LYS B1707
GLU A 146
GLU A 154
 None
 1.21A 6hrjA-3r7gA:
undetectable		 6hrjA-3r7gA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 GLU A 387
LYS A 415
GLU A 383
PHE A 379
 None
 1.13A 6hrjA-3snhA:
2.2		 6hrjA-3snhA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		4 GLU A 266
GLU A 201
GLU A 338
PHE A 204
 None
 1.42A 6hrjA-3sqnA:
undetectable		 6hrjA-3sqnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		4 GLU A 438
GLU A 709
GLU A 589
PHE A 707
 None
 1.30A 6hrjA-3w5fA:
undetectable		 6hrjA-3w5fA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho7 HSLVU COMPLEX
PROTEOLYTIC SUBUNIT,
PUTATIVE

(Trypanosoma
brucei) 		PF00227
(Proteasome) 		4 GLU A  77
LYS A  80
GLU A  81
GLU A  66
 None
 1.25A 6hrjA-4ho7A:
undetectable		 6hrjA-4ho7A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncj DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 GLU A   4
LYS A  81
GLU A  76
GLU A  23
 None
 1.31A 6hrjA-4ncjA:
undetectable		 6hrjA-4ncjA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqr 3,5-EPIMERASE/4-REDU
CTASE

(Arabidopsis
thaliana) 		PF04321
(RmlD_sub_bind) 		4 GLU A 209
GLU A 275
GLU A 278
PHE A 276
 None
 0.96A 6hrjA-4qqrA:
2.2		 6hrjA-4qqrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 GLU A 287
LYS A 843
GLU A 365
PHE A 769
 None
 1.37A 6hrjA-5aw4A:
undetectable		 6hrjA-5aw4A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN

(Bacillus
thuringiensis) 		PF13424
(TPR_12) 		4 GLU A 370
LYS A 366
GLU A 405
PHE A 397
 None
 1.30A 6hrjA-5dbkA:
undetectable		 6hrjA-5dbkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 GLU A 609
GLU A 434
GLU A 441
PHE A 438
 None
 1.01A 6hrjA-5i4eA:
undetectable		 6hrjA-5i4eA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLU A  53
LYS A  57
GLU A  58
GLU A  77
 None
 1.37A 6hrjA-5l3sA:
undetectable		 6hrjA-5l3sA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 1

(Mus musculus) 		PF02251
(PA28_alpha)
PF02252
(PA28_beta) 		4 GLU A 218
LYS A 166
GLU A 211
PHE A 170
 None
 1.27A 6hrjA-5mx5A:
undetectable		 6hrjA-5mx5A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		4 GLU A  29
GLU A  13
GLU A 339
PHE A  15
 None
 1.26A 6hrjA-5v1sA:
undetectable		 6hrjA-5v1sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 GLU A  90
LYS A  86
GLU A  89
GLU A  93
 None
 0.97A 6hrjA-5wu7A:
undetectable		 6hrjA-5wu7A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 LYS A 207
GLU A 211
GLU A 229
PHE A 226
 None
 1.28A 6hrjA-5xwyA:
undetectable		 6hrjA-5xwyA:
11.80