SIMILAR PATTERNS OF AMINO ACIDS FOR 6HLP_A_GAWA1501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 ASN A 445
GLN A 436
HIS A 384
TYR A  58
 None
 1.30A 6hlpA-1tz7A:
0.1		 6hlpA-1tz7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASN A 381
GLN A 326
HIS A 508
TYR A 489
 None
 1.48A 6hlpA-1w93A:
4.6		 6hlpA-1w93A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 218
GLN A 181
TYR A 438
MET A 242
 None
BES  A1950 (-4.1A)
BES  A1950 (-4.3A)
None
 0.88A 6hlpA-2yd0A:
0.0		 6hlpA-2yd0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 ASN A 112
GLN A  68
TYR A 475
MET A  24
 None
None
None
GOL  A 656 (-4.7A)
 1.29A 6hlpA-2zwsA:
0.0		 6hlpA-2zwsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 324
HIS A 376
TYR A 182
MET A 120
 None
 1.41A 6hlpA-3hn7A:
4.1		 6hlpA-3hn7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 327
HIS A 376
TYR A 182
MET A 120
 None
 1.29A 6hlpA-3hn7A:
4.1		 6hlpA-3hn7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ASN A 304
GLN A 429
TYR A  12
MET A 209
 None
 1.33A 6hlpA-3lkdA:
3.7		 6hlpA-3lkdA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 248
GLN A 211
TYR A 477
MET A 275
 None
 0.86A 6hlpA-4fysA:
0.0		 6hlpA-4fysA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 GLN A 356
HIS A 301
TYR A 108
MET A 540
 None
 0.89A 6hlpA-4lglA:
2.8		 6hlpA-4lglA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 330
GLN A 293
TYR A 549
MET A 354
 None
LYS  A1102 ( 4.3A)
None
None
 1.06A 6hlpA-4pj6A:
0.0		 6hlpA-4pj6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 234
GLN A 197
TYR A 452
MET A 258
 None
 0.81A 6hlpA-4wz9A:
1.1		 6hlpA-4wz9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 ASN A 243
GLN A 206
TYR A 472
MET A 270
 None
ILE  A1024 (-3.2A)
SO4  A1032 ( 4.1A)
None
 0.78A 6hlpA-6bv2A:
1.3		 6hlpA-6bv2A:
undetectable