SIMILAR PATTERNS OF AMINO ACIDS FOR 6HLP_A_GAWA1501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckm MRNA CAPPING ENZYME

(Paramecium
bursaria
Chlorella virus
1) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		5 PRO A 196
ILE A 199
ILE A 198
VAL A  79
ILE A 191
 None
 1.13A 6hlpA-1ckmA:
undetectable		 6hlpA-1ckmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE

(Bacillus
subtilis) 		PF14562
(Endonuc_BglI) 		5 ASN A  36
ILE A 126
VAL A 210
ILE A 137
PRO A 250
 None
 1.10A 6hlpA-1dmuA:
undetectable		 6hlpA-1dmuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		5 ASN A 214
ILE A 273
VAL A 331
THR A 330
ILE A 327
 None
 1.19A 6hlpA-1g1aA:
2.4		 6hlpA-1g1aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g71 DNA PRIMASE

(Pyrococcus
furiosus) 		PF01896
(DNA_primase_S) 		5 ILE A 152
ILE A 154
THR A 310
ILE A 141
PHE A  27
 None
 1.07A 6hlpA-1g71A:
undetectable		 6hlpA-1g71A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqz ACTIN-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00241
(Cofilin_ADF) 		5 ILE 1  81
THR 1  31
ILE 1  22
PHE 1  55
PHE 1  52
 None
 1.19A 6hlpA-1hqz1:
undetectable		 6hlpA-1hqz1:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1

(Saccharomyces
cerevisiae) 		PF00398
(RrnaAD) 		5 PRO A 226
ILE A 227
ILE A 205
VAL A  28
ILE A  32
 None
 1.12A 6hlpA-1i4wA:
2.7		 6hlpA-1i4wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi8 DNAB INTEIN

(Synechocystis
sp. PCC 6803) 		PF14890
(Intein_splicing) 		5 ILE A  58
ILE A 126
THR A  61
PHE A  75
PRO A  96
 None
 1.05A 6hlpA-1mi8A:
undetectable		 6hlpA-1mi8A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6b PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		5 ILE A  22
ILE A  62
VAL A  34
ILE A  65
PHE A  29
 None
 1.20A 6hlpA-1o6bA:
4.3		 6hlpA-1o6bA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN

(Pseudomonas
aeruginosa) 		PF13433
(Peripla_BP_5) 		5 ILE A 177
ILE A 175
VAL A 205
THR A 204
ILE A 146
 None
 1.00A 6hlpA-1qnlA:
5.7		 6hlpA-1qnlA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		5 ILE A  55
VAL A  44
ILE A  42
PHE A  29
PRO A 472
 None
 1.02A 6hlpA-1r6vA:
4.0		 6hlpA-1r6vA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbq 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
HOMOLOG

(Mycoplasma
pneumoniae) 		PF01812
(5-FTHF_cyc-lig) 		5 ILE A  29
ILE A 161
VAL A  56
ILE A 139
PHE A 109
 None
 1.13A 6hlpA-1sbqA:
undetectable		 6hlpA-1sbqA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Streptomyces
avermitilis) 		PF00903
(Glyoxalase) 		5 ILE A 335
VAL A 282
THR A 281
ILE A 278
PHE A  44
 None
 1.20A 6hlpA-1t47A:
undetectable		 6hlpA-1t47A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE BETA
SUBUNIT

(Klebsiella
oxytoca) 		PF02288
(Dehydratase_MU) 		5 ASN B  78
ILE B 132
VAL B  91
ILE B  65
PHE B  47
 None
 1.20A 6hlpA-1uc4B:
undetectable		 6hlpA-1uc4B:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa3 2-KETO-3-DEOXY-6-PHO
SPHOGLUCONATE
ALDOLASE

(Thermotoga
maritima) 		PF01081
(Aldolase) 		5 ILE A  87
VAL A  70
THR A  71
ILE A  96
HIS A  91
 None
 1.18A 6hlpA-1wa3A:
3.4		 6hlpA-1wa3A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 PRO A  86
ILE A  87
ILE A  90
VAL A 126
ILE A 125
 None
 0.89A 6hlpA-1wz2A:
undetectable		 6hlpA-1wz2A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5n HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  95
ILE A  65
VAL A  19
THR A  92
ILE A  93
 None
 1.16A 6hlpA-1x5nA:
undetectable		 6hlpA-1x5nA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  13
ILE A  78
VAL A 106
THR A 107
ILE A 110
 None
 0.93A 6hlpA-1y6jA:
6.1		 6hlpA-1y6jA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0n 5'-AMP-ACTIVATED
PROTEIN KINASE,
BETA-1 SUBUNIT

(Rattus
norvegicus) 		PF16561
(AMPK1_CBM) 		5 PRO A 140
ILE A 141
ILE A 152
VAL A 149
PHE A 127
 None
 1.09A 6hlpA-1z0nA:
undetectable		 6hlpA-1z0nA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0v PUTATIVE PROTEASE LA
HOMOLOG TYPE

(Archaeoglobus
fulgidus) 		PF05362
(Lon_C) 		5 PRO A 588
ILE A 566
VAL A 549
THR A 550
ILE A 553
 None
 1.08A 6hlpA-1z0vA:
undetectable		 6hlpA-1z0vA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		5 ASN A 322
ILE A 371
VAL A 312
ILE A 329
PRO A  27
 None
 0.97A 6hlpA-2ggqA:
undetectable		 6hlpA-2ggqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 PRO A 270
ILE A 269
ILE A 271
THR A 232
ILE A 233
 None
 1.06A 6hlpA-2iceA:
undetectable		 6hlpA-2iceA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcb 5-FORMYLTETRAHYDROFO
LATE CYCLO-LIGASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01812
(5-FTHF_cyc-lig) 		5 PRO A  61
ILE A  63
ILE A  62
THR A  50
ILE A  49
 None
 1.14A 6hlpA-2jcbA:
undetectable		 6hlpA-2jcbA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnx CALCIUM BINDING
PROTEIN 2

(Entamoeba
histolytica) 		PF13499
(EF-hand_7) 		5 ILE A 124
VAL A 109
ILE A 113
PHE A 100
PHE A 104
 None
 0.98A 6hlpA-2jnxA:
undetectable		 6hlpA-2jnxA:
13.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ksb SUBSTANCE-P RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 ILE A 113
THR A 201
TRP A 261
HIS A 265
PRO A 271
 None
 1.17A 6hlpA-2ksbA:
25.9		 6hlpA-2ksbA:
62.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ksb SUBSTANCE-P RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 PRO A 112
ILE A 113
TRP A 261
HIS A 265
PRO A 271
 None
 0.92A 6hlpA-2ksbA:
25.9		 6hlpA-2ksbA:
62.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ksb SUBSTANCE-P RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 VAL A 200
THR A 201
ILE A 204
HIS A 265
PHE A 264
 None
 1.13A 6hlpA-2ksbA:
25.9		 6hlpA-2ksbA:
62.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7s IG-LIKE REPEAT
DOMAIN PROTEIN 1

(Leptospira
interrogans) 		PF02368
(Big_2) 		5 ILE A  79
ILE A  82
THR A  28
ILE A   8
PHE A  31
 None
 1.09A 6hlpA-2n7sA:
undetectable		 6hlpA-2n7sA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		5 ILE A  40
VAL A  26
THR A 363
PHE A 373
PRO A 423
 None
 1.09A 6hlpA-2nlzA:
undetectable		 6hlpA-2nlzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		5 PRO A 167
VAL A  35
THR A  34
ILE A 130
PHE A   9
 None
 1.18A 6hlpA-2o2zA:
4.6		 6hlpA-2o2zA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy POTENTIAL
COPPER-TRANSPORTING
ATPASE

(Bacillus
subtilis) 		PF00403
(HMA) 		5 ASN A  19
ILE A  21
VAL A  43
THR A  42
ILE A   9
 None
 1.18A 6hlpA-2voyA:
undetectable		 6hlpA-2voyA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1

(Streptococcus
parasanguinis) 		no annotation 5 ILE A 266
ILE A 242
VAL A 284
THR A 283
ILE A 269
 None
 1.19A 6hlpA-2x12A:
undetectable		 6hlpA-2x12A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E2 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF00943
(Alpha_E2_glycop) 		5 ILE B 319
ILE B 321
VAL B 233
ILE B 231
PRO B 139
 None
 1.06A 6hlpA-2xfbB:
undetectable		 6hlpA-2xfbB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfc E2 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF00943
(Alpha_E2_glycop) 		5 ILE B 319
ILE B 321
VAL B 233
ILE B 231
PRO B 139
 None
 1.07A 6hlpA-2xfcB:
undetectable		 6hlpA-2xfcB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 ASN A 274
ILE A 276
ILE A 251
PHE A 256
PHE A 284
 None
 1.19A 6hlpA-2z80A:
undetectable		 6hlpA-2z80A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 328
ILE A 327
VAL A 310
THR A 316
ILE A 308
 None
 1.17A 6hlpA-3dh9A:
2.5		 6hlpA-3dh9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3h IMMUNOMODULATORY
PROTEIN LING ZHI-8

(Ganoderma
lucidum) 		PF09259
(Fve) 		5 ILE A  86
ILE A  34
VAL A  54
THR A  91
ILE A  92
 None
 1.05A 6hlpA-3f3hA:
undetectable		 6hlpA-3f3hA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gu3 METHYLTRANSFERASE

(Bacillus cereus) 		PF13847
(Methyltransf_31) 		5 ASN A  32
ILE A  37
VAL A  41
ILE A 109
PRO A  88
 None
 1.13A 6hlpA-3gu3A:
4.6		 6hlpA-3gu3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2

(Phytolacca
dioica) 		PF00161
(RIP) 		5 ASN A  90
PRO A 115
ILE A  88
VAL A 100
THR A  98
 None
 1.18A 6hlpA-3h5kA:
undetectable		 6hlpA-3h5kA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwf TRANSCRIPTION
REGULATOR RPIR
FAMILY

(Staphylococcus
epidermidis) 		PF01418
(HTH_6) 		5 ILE A   8
VAL A  59
THR A  60
ILE A   4
PHE A  64
 None
 1.14A 6hlpA-3iwfA:
undetectable		 6hlpA-3iwfA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtj 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Yersinia pestis) 		PF02348
(CTP_transf_3) 		5 PRO A 106
ILE A 109
ILE A 108
VAL A  97
ILE A 184
 None
 1.09A 6hlpA-3jtjA:
2.7		 6hlpA-3jtjA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		5 ILE A 134
ILE A 177
VAL A 146
ILE A 178
PHE A 236
 None
 1.09A 6hlpA-3m1rA:
3.6		 6hlpA-3m1rA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n40 P62 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF00943
(Alpha_E2_glycop)
PF01563
(Alpha_E3_glycop) 		5 ILE P 319
ILE P 321
VAL P 233
ILE P 231
PRO P 139
 None
 1.08A 6hlpA-3n40P:
undetectable		 6hlpA-3n40P:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oam 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Vibrio cholerae) 		PF02348
(CTP_transf_3) 		5 PRO A 106
ILE A 109
ILE A 108
VAL A  97
ILE A 184
 None
 1.09A 6hlpA-3oamA:
2.6		 6hlpA-3oamA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 PRO A 125
ILE A 128
VAL A 225
PHE A 228
HIS A 300
 None
 1.20A 6hlpA-3omnA:
5.6		 6hlpA-3omnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7m MALATE DEHYDROGENASE

(Francisella
tularensis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 107
VAL A  75
THR A   7
PHE A  33
PRO A  40
 None
 1.19A 6hlpA-3p7mA:
7.2		 6hlpA-3p7mA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qac 11S GLOBULIN SEED
STORAGE PROTEIN

(Amaranthus
hypochondriacus) 		PF00190
(Cupin_1) 		5 ASN A 168
ILE A 162
ILE A  74
HIS A 148
PRO A  88
 None
 1.16A 6hlpA-3qacA:
undetectable		 6hlpA-3qacA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb RNA-EDITING COMPLEX
PROTEIN MP42
MP18 RNA EDITING
COMPLEX PROTEIN

(Trypanosoma
brucei;
Trypanosoma
brucei) 		no annotation
PF00436
(SSB) 		5 ILE C 301
VAL C 335
THR C 334
PHE C 332
PRO D 103
 None
 1.17A 6hlpA-3stbC:
undetectable		 6hlpA-3stbC:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE

(Pantoea
ananatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASN A 388
PRO A 365
ILE A 385
VAL A  23
ILE A 333
 None
 1.09A 6hlpA-3t6cA:
undetectable		 6hlpA-3t6cA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Lactobacillus
acidophilus) 		PF00215
(OMPdecase) 		5 PRO A 186
ILE A 230
ILE A 184
VAL A   5
ILE A 211
 None
 1.20A 6hlpA-3tfxA:
undetectable		 6hlpA-3tfxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up6 HYPOTHETICAL PROTEIN
BACOVA_04078

(Bacteroides
ovatus) 		no annotation 5 ILE A 291
ILE A 306
VAL A 339
THR A 340
ILE A 350
 None
 1.05A 6hlpA-3up6A:
undetectable		 6hlpA-3up6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		5 ASN A 507
ILE A 473
VAL A 491
THR A 492
ILE A 458
 None
 1.16A 6hlpA-3zppA:
undetectable		 6hlpA-3zppA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acz ENDO-ALPHA-MANNOSIDA
SE

(Bacteroides
thetaiotaomicron) 		PF16317
(Glyco_hydro_99) 		5 ILE B 322
VAL B 281
THR B 325
ILE B 324
PHE B 191
 None
 1.18A 6hlpA-4aczB:
undetectable		 6hlpA-4aczB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 ILE A 262
ILE A 406
VAL A 273
ILE A 277
PHE A 295
 None
 1.12A 6hlpA-4ay2A:
2.1		 6hlpA-4ay2A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 PRO A  83
ILE A  82
ILE A  84
VAL A  50
ILE A  76
 None
None
CAS  A  73 ( 4.3A)
None
CAS  A  73 ( 4.3A)
 1.15A 6hlpA-4b09A:
4.5		 6hlpA-4b09A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbv COME

(Streptococcus
pneumoniae) 		PF00072
(Response_reg)
PF04397
(LytTR) 		5 PRO A  30
ILE A  29
ILE A  31
THR A 128
ILE A 125
 None
 1.16A 6hlpA-4cbvA:
5.8		 6hlpA-4cbvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		5 PRO A 306
ILE A 305
ILE A 307
ILE A 301
PRO A 236
 None
 1.20A 6hlpA-4eysA:
undetectable		 6hlpA-4eysA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 ILE B  43
ILE B  39
VAL B  94
THR B  95
ILE B  96
 None
 1.12A 6hlpA-4g7eB:
undetectable		 6hlpA-4g7eB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hf7 PUTATIVE
ACYLHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13472
(Lipase_GDSL_2) 		5 ASN A  78
ILE A 232
VAL A 110
ILE A 149
PRO A 216
 None
 1.17A 6hlpA-4hf7A:
4.5		 6hlpA-4hf7A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16227
(DUF4886) 		5 ASN A 142
ILE A 144
ILE A 106
VAL A 120
ILE A  37
 None
 1.07A 6hlpA-4i8iA:
3.5		 6hlpA-4i8iA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN

(Chaetomium
thermophilum) 		PF00557
(Peptidase_M24) 		5 PRO A 107
ILE A 108
VAL A  79
THR A  78
ILE A 110
 None
 1.17A 6hlpA-4ipaA:
undetectable		 6hlpA-4ipaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iws PA0254

(Pseudomonas
aeruginosa) 		PF01977
(UbiD) 		5 ILE A 189
ILE A 191
VAL A 156
ILE A 192
PRO A 111
 None
 1.15A 6hlpA-4iwsA:
undetectable		 6hlpA-4iwsA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 144
ILE A 117
VAL A 243
THR A 244
ILE A 247
 None
 0.95A 6hlpA-4ln1A:
7.8		 6hlpA-4ln1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF02934
(GatB_N) 		5 ILE B 250
ILE B 254
ILE B 251
PHE B 193
PHE B 202
 None
 1.15A 6hlpA-4n0iB:
undetectable		 6hlpA-4n0iB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n13 PHOSPHATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Borreliella
burgdorferi) 		PF12849
(PBP_like_2) 		5 ASN A 227
ILE A 224
VAL A 235
THR A 236
ILE A 239
 None
 1.08A 6hlpA-4n13A:
undetectable		 6hlpA-4n13A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh1 CASEIN KINASE II
SUBUNIT BETA

(Homo sapiens) 		PF01214
(CK_II_beta) 		5 ILE C  53
VAL C  25
TRP C   9
PHE C  13
PHE C  22
 None
 1.12A 6hlpA-4nh1C:
undetectable		 6hlpA-4nh1C:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh1 CASEIN KINASE II
SUBUNIT BETA

(Homo sapiens) 		PF01214
(CK_II_beta) 		5 ILE C  83
VAL C  25
TRP C   9
PHE C  13
PHE C  22
 None
 1.11A 6hlpA-4nh1C:
undetectable		 6hlpA-4nh1C:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		5 ASN A 415
ILE A 455
VAL A 424
THR A 425
ILE A 428
 None
 1.13A 6hlpA-4o2xA:
undetectable		 6hlpA-4o2xA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		5 ASN A 126
ILE A 323
VAL A 337
ILE A 107
PRO A 317
 None
 1.12A 6hlpA-4ovjA:
undetectable		 6hlpA-4ovjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		5 PRO A 434
ILE A 437
ILE A 436
VAL A 453
ILE A 429
 None
 1.04A 6hlpA-4pxnA:
3.8		 6hlpA-4pxnA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY

(Pyrobaculum
calidifontis) 		PF01930
(Cas_Cas4) 		5 PRO A  55
ILE A  58
ILE A  57
VAL A 182
ILE A 186
 None
 0.99A 6hlpA-4r5qA:
undetectable		 6hlpA-4r5qA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xav GLIOMEDIN

(Mus musculus) 		PF02191
(OLF) 		5 ASN A 306
PRO A 538
ILE A 304
THR A 302
ILE A 301
 None
 1.10A 6hlpA-4xavA:
undetectable		 6hlpA-4xavA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		5 ILE A 276
VAL A 228
THR A 229
ILE A 153
PHE A 189
 None
 1.10A 6hlpA-4xscA:
undetectable		 6hlpA-4xscA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yef 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1

(Rattus
norvegicus) 		PF16561
(AMPK1_CBM) 		5 PRO A 140
ILE A 141
ILE A 152
VAL A 149
PHE A 127
 None
 1.15A 6hlpA-4yefA:
undetectable		 6hlpA-4yefA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4p REPEBODY

(synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 PRO A  14
ILE A  12
VAL A  31
THR A  32
ILE A   9
 None
 1.14A 6hlpA-5b4pA:
undetectable		 6hlpA-5b4pA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtu PRP28

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 PRO A 551
ILE A 552
ILE A 602
PHE A 555
PRO A 627
 None
 1.17A 6hlpA-5dtuA:
undetectable		 6hlpA-5dtuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezv 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1

(Homo sapiens) 		PF04739
(AMPKBI)
PF16561
(AMPK1_CBM) 		5 PRO B 140
ILE B 141
ILE B 152
VAL B 149
PHE B 127
 None
 1.12A 6hlpA-5ezvB:
undetectable		 6hlpA-5ezvB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASN A  66
ILE A  82
VAL A 152
ILE A  94
PRO A 138
 None
 1.16A 6hlpA-5fr8A:
undetectable		 6hlpA-5fr8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASN A 413
ILE A 461
ILE A 458
TRP A 452
PHE A 427
 NAG  A 814 (-2.6A)
None
None
None
None
 1.20A 6hlpA-5gs0A:
undetectable		 6hlpA-5gs0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv1 ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		5 PRO A  16
ILE A  14
ILE A  13
THR A 272
PHE A 259
 None
 1.13A 6hlpA-5gv1A:
undetectable		 6hlpA-5gv1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyg ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		5 PRO A  16
ILE A  14
ILE A  13
THR A 272
PHE A 259
 None
 1.11A 6hlpA-5gygA:
undetectable		 6hlpA-5gygA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		5 ASN A 207
ILE A 181
ILE A 180
VAL A 191
ILE A  27
 None
 0.91A 6hlpA-5hfjA:
2.5		 6hlpA-5hfjA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm9 MAMO PROTEASE DOMAIN

(Magnetospirillum
magneticum) 		PF13365
(Trypsin_2) 		5 ILE A 166
VAL A 211
THR A 210
ILE A 197
PRO A 130
 None
 1.09A 6hlpA-5hm9A:
undetectable		 6hlpA-5hm9A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3

(Mus musculus) 		PF07496
(zf-CW)
PF13589
(HATPase_c_3) 		5 ILE A 266
ILE A  52
VAL A 273
ILE A 268
PRO A 245
 None
 1.13A 6hlpA-5ix1A:
undetectable		 6hlpA-5ix1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 ILE A 328
VAL A 196
THR A 197
ILE A 267
PRO A 201
 None
None
None
None
6GA  A1015 ( 4.4A)
 1.19A 6hlpA-5j6sA:
undetectable		 6hlpA-5j6sA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		5 PRO A 472
ILE A  38
VAL A  16
ILE A 483
PHE A 469
 None
 1.20A 6hlpA-5jjhA:
undetectable		 6hlpA-5jjhA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		5 ILE A 154
VAL A 129
THR A 130
ILE A 133
PHE A 174
 None
 1.14A 6hlpA-5jxfA:
undetectable		 6hlpA-5jxfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		5 ASN A 142
VAL A 154
THR A 175
ILE A 174
PRO A 159
 None
 1.20A 6hlpA-5k9tA:
undetectable		 6hlpA-5k9tA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp9 EPN-01*

(Thermotoga
maritima;
Human
immunodeficiency
virus 1) 		PF01081
(Aldolase) 		5 ILE B  85
VAL B  68
THR B  69
ILE B  94
HIS B  89
 None
 1.17A 6hlpA-5kp9B:
3.1		 6hlpA-5kp9B:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		5 ASN A  42
ILE A  44
VAL A 218
PHE A 238
PRO A  92
 None
 1.19A 6hlpA-5l9wA:
undetectable		 6hlpA-5l9wA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltg AUTOPHAGY-RELATED
PROTEIN 18

(Ogataea angusta) 		no annotation 5 ILE A 270
THR A 239
ILE A 247
HIS A 221
PRO A 179
 None
None
None
FLC  A 602 (-3.8A)
None
 1.07A 6hlpA-5ltgA:
undetectable		 6hlpA-5ltgA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ILE A  12
VAL A  51
ILE A  10
PHE A 412
PRO A 537
 None
 1.15A 6hlpA-5m2nA:
undetectable		 6hlpA-5m2nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 ASN A  58
ILE A  74
VAL A 144
ILE A  86
PRO A 130
 None
 1.19A 6hlpA-5mzsA:
undetectable		 6hlpA-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8u LIPOATE-PROTEIN
LIGASE 1

(Plasmodium
falciparum) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 ASN A 115
ILE A 179
ILE A 154
ILE A 134
HIS A 175
 None
 1.02A 6hlpA-5t8uA:
undetectable		 6hlpA-5t8uA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv7 PUTATIVE
PEPTIDOGLYCAN-BINDIN
G/HYDROLYSING
PROTEIN

(Clostridioides
difficile) 		PF01471
(PG_binding_1) 		5 ILE A 117
ILE A 125
VAL A 106
ILE A 115
TRP A 188
 None
 1.20A 6hlpA-5tv7A:
undetectable		 6hlpA-5tv7A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhd DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Mycobacterium
tuberculosis) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		5 PRO A 163
ILE A 162
VAL A  73
THR A  74
ILE A  77
 None
 0.87A 6hlpA-5uhdA:
undetectable		 6hlpA-5uhdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 5 ILE A 130
THR A 213
TRP A 327
PHE A 330
PRO A 338
 89F  A1201 (-4.3A)
89F  A1201 (-3.9A)
89F  A1201 (-3.6A)
89F  A1201 (-4.1A)
None
 1.04A 6hlpA-5v54A:
26.6		 6hlpA-5v54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zib -

(-) 		no annotation 5 PRO A 488
ILE A 487
VAL A 479
THR A 478
PRO A 524
 None
 0.72A 6hlpA-5zibA:
10.5		 6hlpA-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zic -

(-) 		no annotation 5 PRO A 488
ILE A 487
VAL A 479
THR A 478
PRO A 524
 None
 0.75A 6hlpA-5zicA:
5.0		 6hlpA-5zicA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 5 VAL A 615
THR A 616
ILE A 850
PHE A 866
PHE A 845
 None
 1.20A 6hlpA-6d6vA:
undetectable		 6hlpA-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 ASN A 158
PRO A 171
ILE A 172
ILE A 170
ILE A 363
 None
 1.11A 6hlpA-6f5dA:
2.4		 6hlpA-6f5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 ASN A 445
GLN A 436
HIS A 384
TYR A  58
 None
 1.30A 6hlpA-1tz7A:
0.1		 6hlpA-1tz7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASN A 381
GLN A 326
HIS A 508
TYR A 489
 None
 1.48A 6hlpA-1w93A:
4.6		 6hlpA-1w93A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 218
GLN A 181
TYR A 438
MET A 242
 None
BES  A1950 (-4.1A)
BES  A1950 (-4.3A)
None
 0.88A 6hlpA-2yd0A:
0.0		 6hlpA-2yd0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 ASN A 112
GLN A  68
TYR A 475
MET A  24
 None
None
None
GOL  A 656 (-4.7A)
 1.29A 6hlpA-2zwsA:
0.0		 6hlpA-2zwsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 324
HIS A 376
TYR A 182
MET A 120
 None
 1.41A 6hlpA-3hn7A:
4.1		 6hlpA-3hn7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASN A 327
HIS A 376
TYR A 182
MET A 120
 None
 1.29A 6hlpA-3hn7A:
4.1		 6hlpA-3hn7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ASN A 304
GLN A 429
TYR A  12
MET A 209
 None
 1.33A 6hlpA-3lkdA:
3.7		 6hlpA-3lkdA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 248
GLN A 211
TYR A 477
MET A 275
 None
 0.86A 6hlpA-4fysA:
0.0		 6hlpA-4fysA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 GLN A 356
HIS A 301
TYR A 108
MET A 540
 None
 0.89A 6hlpA-4lglA:
2.8		 6hlpA-4lglA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 330
GLN A 293
TYR A 549
MET A 354
 None
LYS  A1102 ( 4.3A)
None
None
 1.06A 6hlpA-4pj6A:
0.0		 6hlpA-4pj6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 234
GLN A 197
TYR A 452
MET A 258
 None
 0.81A 6hlpA-4wz9A:
1.1		 6hlpA-4wz9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 ASN A 243
GLN A 206
TYR A 472
MET A 270
 None
ILE  A1024 (-3.2A)
SO4  A1032 ( 4.1A)
None
 0.78A 6hlpA-6bv2A:
1.3		 6hlpA-6bv2A:
undetectable