SIMILAR PATTERNS OF AMINO ACIDS FOR 6HLO_A_GBQA1501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		5 ASN A 191
ILE A 211
ILE A 215
VAL A 128
ILE A 102
 CIT  A1000 (-3.3A)
None
None
None
None
 1.26A 6hloA-1aj8A:
undetectable		 6hloA-1aj8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1enf ENTEROTOXIN H

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 ASN A  22
ILE A 142
GLU A 122
VAL A 209
ILE A 164
 None
 1.32A 6hloA-1enfA:
undetectable		 6hloA-1enfA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 ILE A  80
ILE A 264
GLU A 282
VAL A 102
ILE A 261
 None
None
None
None
FAD  A 699 (-3.7A)
 1.00A 6hloA-1fcdA:
4.1		 6hloA-1fcdA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 123
GLN A 559
VAL A 564
ILE A 567
MET A 528
 None
None
FAD  A 600 (-4.5A)
None
None
 1.10A 6hloA-1gpeA:
3.4		 6hloA-1gpeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 ASN A1136
ILE A1133
ILE A1117
VAL A1149
ILE A1214
 None
 1.34A 6hloA-1ha5A:
undetectable		 6hloA-1ha5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ILE A 261
ILE A 331
GLU A 457
VAL A 344
ILE A 347
 None
 1.21A 6hloA-1hr7A:
undetectable		 6hloA-1hr7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 ILE A 741
ILE A 738
GLU A 719
VAL A 732
ILE A 696
 None
 1.30A 6hloA-1k25A:
undetectable		 6hloA-1k25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A 459
ILE A 394
GLU A 453
VAL A 387
ILE A 390
 None
 1.46A 6hloA-1m2wA:
4.3		 6hloA-1m2wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		5 ILE A 451
TRP A 193
GLU A 427
VAL A 433
ILE A 405
 None
 1.46A 6hloA-1nj8A:
2.9		 6hloA-1nj8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ASN B 239
ILE B 189
GLU B 153
VAL B 159
ILE B 164
 None
 1.25A 6hloA-1pjmB:
undetectable		 6hloA-1pjmB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 151
ILE A 148
GLU A 201
VAL A 206
ILE A 225
 None
 1.38A 6hloA-1pv9A:
undetectable		 6hloA-1pv9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbq 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE
HOMOLOG

(Mycoplasma
pneumoniae) 		PF01812
(5-FTHF_cyc-lig) 		5 ILE A  29
ILE A 161
GLU A  21
VAL A  56
ILE A 139
 None
 1.44A 6hloA-1sbqA:
undetectable		 6hloA-1sbqA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjj ACTININ

(Gallus gallus) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		5 ASN A 261
ILE A 131
ILE A 132
GLU A  71
ILE A 128
 None
 1.23A 6hloA-1sjjA:
3.2		 6hloA-1sjjA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 ASN A  16
ILE A 239
ILE A 235
VAL A 144
ILE A 190
 None
 1.45A 6hloA-1spxA:
6.4		 6hloA-1spxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		5 ILE A 270
GLN A 197
GLU A 202
VAL A 219
ILE A 253
 None
 1.49A 6hloA-1ta3A:
undetectable		 6hloA-1ta3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		5 ILE A 100
ILE A  98
GLU A 106
VAL A  83
ILE A  62
 None
 1.43A 6hloA-1twwA:
undetectable		 6hloA-1twwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B

(Pyrococcus
horikoshii) 		PF01008
(IF-2B) 		5 ILE A 126
ILE A 182
GLU A 157
VAL A 138
ILE A 113
 None
 1.30A 6hloA-1vb5A:
5.7		 6hloA-1vb5A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		5 ILE A 131
ILE A 135
GLU A  75
VAL A  80
ILE A  84
 None
 1.27A 6hloA-1vgmA:
undetectable		 6hloA-1vgmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans) 		PF01960
(ArgJ) 		5 ILE B 333
ILE B 329
GLU B 339
VAL B 305
ILE B 309
 None
 1.28A 6hloA-1vraB:
undetectable		 6hloA-1vraB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 154
ILE A 151
GLU A 204
VAL A 209
ILE A 228
 None
 1.25A 6hloA-1wy2A:
undetectable		 6hloA-1wy2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		5 ASN A  71
ILE A 302
ILE A 303
GLU A 255
ILE A 299
 None
 1.21A 6hloA-1xr6A:
undetectable		 6hloA-1xr6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE

(Entamoeba
histolytica) 		PF05770
(Ins134_P3_kin) 		5 ILE X 106
ILE X 102
GLU X 255
VAL X 287
ILE X 108
 None
 1.36A 6hloA-1z2oX:
2.7		 6hloA-1z2oX:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 ILE A 551
ILE A 550
GLU A 342
VAL A 385
ILE A 428
 None
 1.48A 6hloA-1z7eA:
4.3		 6hloA-1z7eA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		5 ILE A 299
ILE A 115
GLU A 233
VAL A 190
ILE A 297
 None
 1.31A 6hloA-2bbvA:
undetectable		 6hloA-2bbvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irp PUTATIVE ALDOLASE
CLASS 2 PROTEIN
AQ_1979

(Aquifex
aeolicus) 		PF00596
(Aldolase_II) 		5 ILE A  36
ILE A  47
TRP A  28
GLU A 194
VAL A  98
 None
 1.39A 6hloA-2irpA:
undetectable		 6hloA-2irpA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0u ATP-DEPENDENT RNA
HELICASE DDX48

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 237
ILE A  79
GLN A  71
GLU A 317
MET A 183
 None
 1.27A 6hloA-2j0uA:
undetectable		 6hloA-2j0uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4g HYALURONOGLUCOSAMINI
DASE

(Bacteroides
thetaiotaomicron) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 ASN A 488
ILE A 384
ILE A 382
GLN A 149
GLU A 134
 None
 1.21A 6hloA-2j4gA:
2.1		 6hloA-2j4gA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kj8 PUTATIVE PROPHAGE
CPS-53 INTEGRASE

(Escherichia
coli) 		PF14659
(Phage_int_SAM_3) 		5 ILE A  38
ILE A  41
GLU A  80
ILE A  42
MET A 103
 None
 1.24A 6hloA-2kj8A:
undetectable		 6hloA-2kj8A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lg1 A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00169
(PH) 		5 ILE A 164
ILE A 166
GLU A 151
VAL A 127
ILE A 167
 None
 1.40A 6hloA-2lg1A:
undetectable		 6hloA-2lg1A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n03 PLECTIN

(Homo sapiens) 		PF00681
(Plectin) 		5 ASN A4442
ILE A4486
VAL A4469
ILE A4458
MET A4435
 None
 1.43A 6hloA-2n03A:
undetectable		 6hloA-2n03A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2x HYPOTHETICAL PROTEIN

(Mesorhizobium
loti) 		PF13242
(Hydrolase_like) 		5 TRP A  17
GLU A  19
VAL A  96
ILE A  54
MET A  60
 None
 1.49A 6hloA-2o2xA:
4.8		 6hloA-2o2xA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvo UNCHARACTERIZED
PROTEIN AF_1382

(Archaeoglobus
fulgidus) 		no annotation 5 ILE A  21
ILE A  17
GLU A  63
VAL A  31
ILE A  36
 None
 1.43A 6hloA-2qvoA:
undetectable		 6hloA-2qvoA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rff PUTATIVE
NUCLEOTIDYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01909
(NTP_transf_2) 		5 ILE A  54
ILE A  77
GLU A  34
VAL A  22
ILE A  21
 None
 1.20A 6hloA-2rffA:
undetectable		 6hloA-2rffA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		5 ASN A 509
ILE A 503
ILE A 470
VAL A 499
ILE A 466
 None
 1.43A 6hloA-2xa7A:
undetectable		 6hloA-2xa7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aly PUTATIVE
UNCHARACTERIZED
PROTEIN ST0753

(Sulfurisphaera
tokodaii) 		PF13456
(RVT_3) 		5 ASN A 121
ILE A  25
ILE A   3
GLU A  61
ILE A   2
 None
 1.23A 6hloA-3alyA:
undetectable		 6hloA-3alyA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		5 ASN A  85
ILE A  93
GLU A 137
VAL A 150
ILE A 101
 None
 1.26A 6hloA-3axxA:
undetectable		 6hloA-3axxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 ILE A 189
ILE A 218
TRP A 205
GLU A 209
VAL A 214
 None
 1.10A 6hloA-3b1rA:
4.2		 6hloA-3b1rA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		5 ILE A 377
ILE A 413
GLU A  21
VAL A  53
ILE A 375
 None
 1.34A 6hloA-3d6nA:
undetectable		 6hloA-3d6nA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8m BASEPLATE PROTEIN,
RECEPTOR BINDING
PROTEIN

(Lactococcus
phage TP901-1;
Lactococcus
virus P2) 		PF08931
(Caudo_bapla_RBP) 		5 ASN A 159
ILE A 136
ILE A 134
VAL A 109
ILE A 142
 None
 1.38A 6hloA-3d8mA:
undetectable		 6hloA-3d8mA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dom RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 2
RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
PF06331
(Tfb5) 		5 ASN B  55
ILE B  23
GLU A 455
VAL B  42
ILE B  30
 None
 1.43A 6hloA-3domB:
undetectable		 6hloA-3domB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		5 ILE A  50
ILE A  47
GLU A  76
VAL A  39
ILE A  42
 None
 1.20A 6hloA-3e96A:
undetectable		 6hloA-3e96A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkj PUTATIVE
PHOSPHOSUGAR
ISOMERASES

(Salmonella
enterica) 		PF01380
(SIS) 		5 ILE A  15
ILE A  11
GLU A  22
VAL A  73
ILE A 101
 None
 1.40A 6hloA-3fkjA:
4.1		 6hloA-3fkjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 ILE A 221
ILE A 242
GLU A 265
VAL A 227
ILE A 229
 None
 1.23A 6hloA-3gq9A:
undetectable		 6hloA-3gq9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		5 ILE A 216
GLN A 247
GLU A 226
VAL A 229
ILE A 269
 None
 1.23A 6hloA-3gveA:
undetectable		 6hloA-3gveA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 205
GLU A 277
VAL A 236
ILE A 237
MET A 130
 None
None
None
None
PO4  A 901 (-4.0A)
 1.18A 6hloA-3h2xA:
undetectable		 6hloA-3h2xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhh TRANSCRIPTIONAL
REGULATOR, PADR
FAMILY

(Enterococcus
faecalis) 		PF03551
(PadR) 		5 ILE A  29
ILE A  32
GLU A  54
VAL A  15
ILE A  18
 None
 1.19A 6hloA-3hhhA:
undetectable		 6hloA-3hhhA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjz TRANSALDOLASE B

(Prochlorococcus
marinus) 		PF00923
(TAL_FSA) 		5 ILE A  88
ILE A  91
GLU A  99
VAL A  96
ILE A  92
 None
None
NA  A 340 ( 2.9A)
None
None
 1.23A 6hloA-3hjzA:
undetectable		 6hloA-3hjzA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 ASN A1594
ILE A1387
GLU A1310
VAL A1316
ILE A1019
 None
 1.45A 6hloA-3hmjA:
3.5		 6hloA-3hmjA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		5 ASN A 195
ILE A 237
ILE A 234
VAL A 223
ILE A 245
 None
 1.34A 6hloA-3i6rA:
undetectable		 6hloA-3i6rA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k49 MRNA-BINDING PROTEIN
PUF3

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 793
ILE A 794
GLU A 767
VAL A 778
ILE A 782
 None
 1.48A 6hloA-3k49A:
undetectable		 6hloA-3k49A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn3 PUTATIVE PERIPLASMIC
PROTEIN

(Wolinella
succinogenes) 		PF12849
(PBP_like_2) 		5 ILE A 225
ILE A 222
GLN A 231
VAL A  78
ILE A 202
 None
 1.28A 6hloA-3kn3A:
undetectable		 6hloA-3kn3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtj HOMOSERINE
DEHYDROGENASE

(Thiobacillus
denitrificans) 		PF00742
(Homoserine_dh)
PF01842
(ACT)
PF03447
(NAD_binding_3) 		5 ASN A 112
ILE A 207
ILE A 211
VAL A 131
ILE A 138
 None
 1.39A 6hloA-3mtjA:
5.9		 6hloA-3mtjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		5 ILE A 311
ILE A 308
GLU A 328
VAL A 291
ILE A 294
 None
 1.27A 6hloA-3nowA:
undetectable		 6hloA-3nowA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		5 ILE A 209
ILE A 237
GLN A 212
VAL A 340
ILE A 220
 None
 1.37A 6hloA-3pc3A:
undetectable		 6hloA-3pc3A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pra FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00254
(FKBP_C) 		5 ILE A 145
ILE A 143
GLU A   3
VAL A   8
ILE A  10
 None
 1.19A 6hloA-3praA:
undetectable		 6hloA-3praA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prb FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00254
(FKBP_C) 		5 ILE A 145
ILE A 143
GLU A   3
VAL A   8
ILE A  10
 None
 1.17A 6hloA-3prbA:
undetectable		 6hloA-3prbA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ren GLYCOSYL HYDROLASE,
FAMILY 8

(Clostridium
perfringens) 		PF01270
(Glyco_hydro_8) 		5 ILE A 276
ILE A 273
GLU A 302
VAL A 310
ILE A 313
 None
 1.46A 6hloA-3renA:
undetectable		 6hloA-3renA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 ILE A 221
ILE A 242
GLU A 265
VAL A 227
ILE A 229
 None
 1.21A 6hloA-3sucA:
undetectable		 6hloA-3sucA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 ILE A   3
GLN A  33
GLU A  29
VAL A  24
ILE A  40
 None
 1.34A 6hloA-3uqzA:
5.6		 6hloA-3uqzA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 ILE A  64
ILE A  67
GLU A  84
VAL A  82
ILE A  80
 None
 1.42A 6hloA-3vthA:
undetectable		 6hloA-3vthA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		5 ILE A 202
ILE A 200
GLU A 254
VAL A 257
ILE A 259
 None
 1.35A 6hloA-3wq1A:
undetectable		 6hloA-3wq1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ILE A 350
ILE A 347
GLU A 380
VAL A 386
ILE A 342
 None
 1.45A 6hloA-3zhyA:
7.6		 6hloA-3zhyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE

(Thermotoga
maritima) 		PF00544
(Pec_lyase_C) 		5 ASN A 156
ILE A  72
ILE A  94
GLU A  63
VAL A  66
 None
 1.30A 6hloA-3zscA:
undetectable		 6hloA-3zscA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5p PROTEIN MXIA

(Shigella
flexneri) 		PF00771
(FHIPEP) 		5 ILE A 602
ILE A 606
GLU A 624
VAL A 621
ILE A 619
 None
 1.45A 6hloA-4a5pA:
undetectable		 6hloA-4a5pA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 ASN A 528
ILE A 458
ILE A 456
GLU A 476
ILE A 455
 None
 1.11A 6hloA-4byfA:
undetectable		 6hloA-4byfA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Corynebacterium
glutamicum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 ILE A 253
ILE A 255
GLN A 204
GLU A 114
ILE A 144
 None
 1.47A 6hloA-4dbhA:
undetectable		 6hloA-4dbhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE

(Staphylococcus
aureus) 		PF00162
(PGK) 		5 ILE A  47
ILE A  48
GLU A 169
VAL A  16
ILE A  54
 None
 1.49A 6hloA-4dg5A:
3.2		 6hloA-4dg5A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exr PUTATIVE LIPOPROTEIN

(Clostridioides
difficile) 		PF03413
(PepSY) 		5 ILE A 178
ILE A 189
GLU A  87
VAL A 162
ILE A 180
 None
 1.39A 6hloA-4exrA:
undetectable		 6hloA-4exrA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix7 RE55538P

(Drosophila
melanogaster) 		PF10523
(BEN) 		5 ILE A 257
ILE A 326
GLU A 270
VAL A 264
ILE A 288
 None
 1.39A 6hloA-4ix7A:
undetectable		 6hloA-4ix7A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjn REGULATORY PROTEIN
SIR3

(Saccharomyces
cerevisiae) 		PF01426
(BAH) 		5 ILE K 192
ILE K 189
GLU K 206
VAL K 211
ILE K 187
 None
 1.25A 6hloA-4jjnK:
undetectable		 6hloA-4jjnK:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		5 ILE A 171
ILE A 265
GLU A 164
VAL A 195
ILE A 159
 None
 1.32A 6hloA-4kp2A:
2.4		 6hloA-4kp2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 ASN A 305
ILE A 270
ILE A 272
VAL A 374
ILE A 376
 None
 1.40A 6hloA-4qnlA:
2.1		 6hloA-4qnlA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2a NETRIN RECEPTOR
UNC5A

(Homo sapiens) 		PF07679
(I-set) 		5 ILE A 142
ILE A 144
GLU A  51
VAL A  61
ILE A  55
 None
 1.35A 6hloA-4v2aA:
undetectable		 6hloA-4v2aA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ILE A 613
ILE A 610
GLU A 509
VAL A 580
ILE A 590
 None
 1.24A 6hloA-4woeA:
undetectable		 6hloA-4woeA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		5 ILE A 165
ILE A  28
GLU A  59
VAL A  56
ILE A  27
 None
None
48H  A 302 (-2.7A)
None
None
 1.34A 6hloA-4y4nA:
3.2		 6hloA-4y4nA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybh ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF08205
(C2-set_2)
PF13895
(Ig_2) 		5 ILE A 318
ILE A 320
GLU A 245
VAL A 255
ILE A 291
 None
 1.44A 6hloA-4ybhA:
undetectable		 6hloA-4ybhA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zck GTP-BINDING PROTEIN
TYPA/BIPA

(Escherichia
coli) 		PF00679
(EFG_C) 		5 ILE A 572
ILE A 523
GLU A 363
VAL A 578
ILE A 587
 None
 1.47A 6hloA-4zckA:
undetectable		 6hloA-4zckA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Colwellia
psychrerythraea) 		PF01791
(DeoC) 		5 ILE A 165
GLU A 100
VAL A 195
ILE A 158
MET A 121
 None
None
GOL  A 303 ( 4.9A)
None
None
 1.39A 6hloA-5c5yA:
undetectable		 6hloA-5c5yA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 ASN A 337
ILE A 390
GLU A  45
VAL A  32
ILE A 370
 None
 1.18A 6hloA-5cerA:
undetectable		 6hloA-5cerA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A

(Staphylococcus
aureus;
Bacillus sp.
HIL-Y85/54728) 		PF02216
(B)
PF02441
(Flavoprotein) 		5 ILE A  15
ILE A  88
GLU A  65
VAL A  40
ILE A  13
 None
 1.40A 6hloA-5h75A:
5.9		 6hloA-5h75A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ASN A 329
ILE A 474
GLU A 462
VAL A 469
MET A 304
 None
 1.46A 6hloA-5itgA:
3.1		 6hloA-5itgA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix3 DIAMINE
N-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF13302
(Acetyltransf_3) 		5 ASN A 122
ILE A  84
ILE A  83
GLU A  99
VAL A  56
 None
 1.40A 6hloA-5ix3A:
undetectable		 6hloA-5ix3A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		5 ASN A 176
ILE A 146
GLU A 125
VAL A 164
ILE A  21
 None
 1.42A 6hloA-5jheA:
2.7		 6hloA-5jheA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsr CCMP

(Synechococcus
elongatus) 		no annotation 5 ILE A  48
ILE A  46
TRP A  39
GLU A  76
ILE A  68
 None
 1.49A 6hloA-5lsrA:
undetectable		 6hloA-5lsrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n15 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		5 ASN A 286
ILE A 261
GLU A 230
VAL A 225
ILE A 222
 None
 1.35A 6hloA-5n15A:
undetectable		 6hloA-5n15A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		5 ILE A  45
ILE A  41
GLU A  95
VAL A  62
ILE A   8
 None
 1.45A 6hloA-5nckA:
undetectable		 6hloA-5nckA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 ILE T 141
ILE T 143
GLU T 226
ILE T 144
MET T  97
 None
 1.24A 6hloA-5ojsT:
undetectable		 6hloA-5ojsT:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u02 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		no annotation 5 ASN A 413
GLU A 434
VAL A 446
ILE A 483
MET A 415
 None
 1.49A 6hloA-5u02A:
undetectable		 6hloA-5u02A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		5 ILE A 248
ILE A 250
GLU A 242
VAL A 274
ILE A 276
 None
None
None
CL  A 502 ( 4.4A)
None
 1.35A 6hloA-5upyA:
undetectable		 6hloA-5upyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		5 ASN A 941
ILE A 757
GLU A 777
VAL A 782
ILE A 787
 None
 1.33A 6hloA-5xvmA:
5.8		 6hloA-5xvmA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		5 ASN A 196
ILE A 304
GLU A 273
VAL A 282
ILE A 298
 None
 1.44A 6hloA-5xzbA:
undetectable		 6hloA-5xzbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C

(Flavobacterium
johnsoniae) 		no annotation 5 ASN C 301
ILE C 377
ILE C 374
TRP C  85
MET C 360
 None
 1.42A 6hloA-6btmC:
5.0		 6hloA-6btmC:
undetectable