SIMILAR PATTERNS OF AMINO ACIDS FOR 6HLO_A_GBQA1501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		5 PRO A 548
ILE A 571
TYR A 541
HIS A 542
THR A 524
 PRO  A 548 ( 1.1A)
ILE  A 571 ( 0.7A)
TYR  A 541 ( 1.3A)
HIS  A 542 ( 1.0A)
THR  A 524 ( 0.9A)
 1.29A 6hloA-1v0fA:
0.0		 6hloA-1v0fA:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ksb SUBSTANCE-P RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TYR A 196
THR A 201
TRP A 261
PHE A 264
HIS A 265
MET A 295
 None
 1.05A 6hloA-2ksbA:
25.8		 6hloA-2ksbA:
62.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 PRO A  29
TYR A 239
HIS A 238
THR A 233
HIS A 223
 None
 1.46A 6hloA-2yrrA:
2.1		 6hloA-2yrrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		5 TYR A 360
HIS A 303
TRP A 245
HIS A 218
PHE A 276
 None
 1.39A 6hloA-4gl3A:
0.3		 6hloA-4gl3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hiz ENDOSIALIDASE

(Enterobacteria
phage phi92) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		5 PRO A 389
ILE A 412
TYR A 382
HIS A 383
THR A 363
 None
None
None
None
EDO  A 813 (-4.5A)
 1.38A 6hloA-4hizA:
0.0		 6hloA-4hizA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		5 PRO A 170
ILE A  70
THR A 216
PHE A 145
PHE A  33
 G3P  A 407 (-4.2A)
None
G3P  A 407 ( 4.5A)
None
G3P  A 407 (-4.4A)
 1.45A 6hloA-4pfbA:
0.6		 6hloA-4pfbA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 PRO A 641
ILE A 331
THR A 607
PHE A 622
PHE A 609
 None
 1.49A 6hloA-4u90A:
0.0		 6hloA-4u90A:
21.56